D Goldman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The genetics of addictions: uncovering the genes
    David Goldman
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852, USA
    Nat Rev Genet 6:521-32. 2005
  2. ncbi request reprint A functionally deficient DRD2 variant [Ser311Cys] is not linked to alcoholism and substance abuse
    D Goldman
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Alcohol 16:47-52. 1998
  3. ncbi request reprint Alcoholism is associated with GALR3 but not two other galanin receptor genes
    I Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Genes Brain Behav 6:473-81. 2007
  4. ncbi request reprint A tryptophan hydroxylase gene marker for suicidality and alcoholism
    D A Nielsen
    Section of Molecular Genetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 55:593-602. 1998
  5. ncbi request reprint Identification of a naturally occurring Pro15-Ser15 substitution in the serotonin5A receptor gene in alcoholics and healthy volunteers
    N Iwata
    Laboratory of Neurogenetics, DICBR, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892 8110, USA
    Brain Res Mol Brain Res 58:217-20. 1998
  6. pmc Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA
    Mol Psychiatry 16:1139-46. 2011
  7. ncbi request reprint Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, -1438G/A
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 4:89-92. 1999
  8. ncbi request reprint An Asian-Native American paternal lineage identified by RPS4Y resequencing and by microsatellite haplotyping
    A W Bergen
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
    Ann Hum Genet 63:63-80. 1999
  9. pmc Fatty-acid amide hydrolase polymorphisms and post-traumatic stress disorder after penetrating brain injury
    M Pardini
    Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, MD, USA
    Transl Psychiatry 2:e75. 2012
  10. ncbi request reprint Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women
    F Ducci
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852, USA
    Mol Psychiatry 13:334-47. 2008

Detail Information

Publications92

  1. ncbi request reprint The genetics of addictions: uncovering the genes
    David Goldman
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852, USA
    Nat Rev Genet 6:521-32. 2005
    ....
  2. ncbi request reprint A functionally deficient DRD2 variant [Ser311Cys] is not linked to alcoholism and substance abuse
    D Goldman
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Alcohol 16:47-52. 1998
    ..The implication is that a DRD2 variant that dramatically impairs receptor function was not sufficient to significantly alter alcoholism vulnerability in a relatively large and also genetically and environmentally homogeneous sample...
  3. ncbi request reprint Alcoholism is associated with GALR3 but not two other galanin receptor genes
    I Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Genes Brain Behav 6:473-81. 2007
    ..6) as compared with the effect of either GAL (2.0) or GALR3 alone (1.6). There was no effect of GALR1 or GALR2 on alcoholism risk. This evidence suggests that GALR3 mediates the alcoholism-related actions of galanin...
  4. ncbi request reprint A tryptophan hydroxylase gene marker for suicidality and alcoholism
    D A Nielsen
    Section of Molecular Genetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 55:593-602. 1998
    ..We previously reported that, in Finns, TPH genotype was associated with suicidality, a pathophysiological mechanism that may involve impaired impulse control...
  5. ncbi request reprint Identification of a naturally occurring Pro15-Ser15 substitution in the serotonin5A receptor gene in alcoholics and healthy volunteers
    N Iwata
    Laboratory of Neurogenetics, DICBR, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892 8110, USA
    Brain Res Mol Brain Res 58:217-20. 1998
    ..Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively (p=n.s.)...
  6. pmc Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA
    Mol Psychiatry 16:1139-46. 2011
    ..Our results may have pharmacogenetic implications for 5-HT3 therapeutic antagonists such as ondansetron...
  7. ncbi request reprint Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, -1438G/A
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 4:89-92. 1999
    ..However, these results should be treated with caution until replicated because of the possibility of false-positive findings in case-control association studies...
  8. ncbi request reprint An Asian-Native American paternal lineage identified by RPS4Y resequencing and by microsatellite haplotyping
    A W Bergen
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
    Ann Hum Genet 63:63-80. 1999
    ..These lineages were independently supported by the haplotypes defined solely by YSTR alleles, demonstrating the haplotypes constructed from YSTRs can evaluate population diversity, admixture and phylogeny...
  9. pmc Fatty-acid amide hydrolase polymorphisms and post-traumatic stress disorder after penetrating brain injury
    M Pardini
    Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, MD, USA
    Transl Psychiatry 2:e75. 2012
    ..In conclusion, our data suggest that FAAH has an important role in PTSD through modulation of aversive memories and point to both a novel therapeutic target and a possible risk marker for this condition...
  10. ncbi request reprint Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women
    F Ducci
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852, USA
    Mol Psychiatry 13:334-47. 2008
    ..Haplotype-based analysis of the MAOA gene appeared to strengthen the association, as compared to the MAOA-LPR locus alone. A MAOB haplotype was associated with alcoholism independently from ASPD...
  11. ncbi request reprint Autosomal, mitochondrial, and Y chromosome DNA variation in Finland: evidence for a male-specific bottleneck
    R A Kittles
    Section on Population Genetics and Linkage, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Phys Anthropol 108:381-99. 1999
    ..In contrast, high levels of genetic diversity for mtDNA and autosomal STRs may be the result of sex-biased gene flow and recent immigration to urban areas from established internal isolates within Finland...
  12. ncbi request reprint Genetics of alcoholism and substance abuse
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Psychiatr Clin North Am 22:289-99, viii. 1999
    ..These advances in the understanding of the genetics of addictive disorders should facilitate the development of specific pharmacotherapies and the more accurate targeting of therapies using molecular diagnostic approaches...
  13. pmc Dual origins of Finns revealed by Y chromosome haplotype variation
    R A Kittles
    Section on Population Genetics and Linkage, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Am J Hum Genet 62:1171-9. 1998
    ..Also, a northeastern to southwestern gradient of Y haplotype frequencies provides convincing evidence for recent male migration from rural areas into urban Finland...
  14. pmc COMT Val158Met and cognition: main effects and interaction with educational attainment
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892 9412, USA
    Genes Brain Behav 8:36-42. 2009
    ..Our study in Plains American Indians has shown that COMT Val158Met influences several aspects of cognition and some of its effects are moderated by educational adversity...
  15. ncbi request reprint An abundant proneurotensin polymorphism, 479A>G, and a test of its association with alcohol dependence in a Finnish population
    J Vanakoski
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20852, USA
    Alcohol Clin Exp Res 24:762-5. 2000
    ..Neurotensin receptors in the neurons of the ventral tegmental area facilitate dopamine release, making the neurotensin gene an excellent candidate gene for alcohol dependence and for other behaviors that involve reinforcement...
  16. pmc Prefrontal cortex lesions and MAO-A modulate aggression in penetrating traumatic brain injury
    M Pardini
    Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke NIH, Bethesda, MD, USA
    Neurology 76:1038-45. 2011
    ..This study investigates the interaction between brain lesion location and monoamine oxidase A (MAO-A) in the genesis of aggression in patients with penetrating traumatic brain injury (PTBI)...
  17. ncbi request reprint Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7
    D A Nielsen
    Section of Molecular Genetics, DICBR, NIAAA, National Institutes of Health, Rockville, MD 20852, USA
    Brain Res Mol Brain Res 45:145-8. 1997
    ..TPH mRNA was reverse-transcribed and sequenced. No aberrant splice products from the 779A or 779G TPH genes were detected nor were any other polymorphic nucleotides found...
  18. ncbi request reprint Prevalence and characteristics of trauma and posttraumatic stress disorder in a southwestern American Indian community
    R W Robin
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD USA
    Am J Psychiatry 154:1582-8. 1997
    ..The authors investigated the relationship between both the frequency and type of traumatic events and the prevalence of posttraumatic stress disorder (PTSD) in a Southwestern American Indian tribe...
  19. ncbi request reprint Association of low-voltage alpha EEG with a subtype of alcohol use disorders
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8110, USA
    Alcohol Clin Exp Res 23:1312-9. 1999
    ..e., the low-voltage alpha (LVA) trait, was associated with alcohol use disorders and anxiety disorders...
  20. ncbi request reprint Neurochemical individuality: genetic diversity among human dopamine and serotonin receptors and transporters
    A Cravchik
    Celera Genomics, 45 W Gude Dr, Rockville, MD 20850, USA
    Arch Gen Psychiatry 57:1105-14. 2000
    ..The purpose of this article is to present a preview of a developing new perspective in human behavior: the genetic variation of the brain or neurochemical individuality. Arch Gen Psychiatry. 2000;57:1105-1114...
  21. ncbi request reprint Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population
    J C Long
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8110, USA jeff
    Am J Med Genet 81:216-21. 1998
    ..8) on chromosome 4p, near the beta1 GABA receptor gene. Interestingly, three loci in the alcohol dehydrogenase gene cluster on chromosome 4q showed evidence for linkage with two-point analyses, but not multipoint analysis...
  22. pmc Early life stress, MAOA, and gene-environment interactions predict behavioral disinhibition in children
    M A Enoch
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, MD 20892, USA
    Genes Brain Behav 9:65-74. 2010
    ..In a general population sample of prepubertal children, exposure to common stressors from pre-birth to 3 years predicted behavioral disinhibition, and MAOA-LPR- stressful life event interactions specifically predicted hyperactivity...
  23. ncbi request reprint Mu opioid receptor gene variants: lack of association with alcohol dependence
    A W Bergen
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852, USA
    Mol Psychiatry 2:490-4. 1997
    ....
  24. ncbi request reprint Relationship between a GABAA alpha 6 Pro385Ser substitution and benzodiazepine sensitivity
    N Iwata
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Am J Psychiatry 156:1447-9. 1999
    ..In this pilot study, they evaluated the contribution of this polymorphism to benzodiazepine sensitivity...
  25. ncbi request reprint Effects of alcohol use and gender on the dynamics of EKG time-series data
    P B DePetrillo
    Laboratory of Clinical Studies, Intramural Research Program, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 1256, USA
    Alcohol Clin Exp Res 23:745-50. 1999
    ..07 +/- 0.02,p < 0.011 for the eyes open condition. A gender effect was seen, with female subjects showing evidence of more complex heart rate dynamics than male subjects...
  26. ncbi request reprint No association of CCK and CCK(B) receptor polymorphisms with alcohol dependence
    J Vanakoski
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Psychiatry Res 102:1-7. 2001
    ..The role of the CCK(A) the receptor in alcohol dependence remains open until additional DNA sequence variants for this gene become available...
  27. ncbi request reprint The genetics of alcoholism and alcohol abuse
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 12420 Parklawn Drive, Park 5 Building, Room 451, MSC 8110, Bethesda, MD 20892 8110, USA
    Curr Psychiatry Rep 3:144-51. 2001
    ..All these advances in the understanding of the genetics of alcoholism should facilitate the development of more accurately targeted therapies using molecular diagnostic approaches...
  28. ncbi request reprint A functional polymorphism in the MAOA gene promoter (MAOA-LPR) predicts central dopamine function and body mass index
    F Ducci
    Laboratory of Neurogenetics, NIAAA, NIH, Rockville, MD 20852, USA
    Mol Psychiatry 11:858-66. 2006
    ..Finally, our work suggests that MAOA may be involved in the regulation of BMI. Independent samples are necessary to confirm this preliminary finding...
  29. pmc Effects of worldwide population subdivision on ALDH2 linkage disequilibrium
    R J Peterson
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8110 USA
    Genome Res 9:844-52. 1999
    ..These results suggest that simple models may not well predict patterns of linkage disequilibrium in human populations...
  30. ncbi request reprint Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C)
    J Lappalainen
    Laboratory of Neurogenetics, DICBR, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852, USA
    Genomics 27:274-9. 1995
    ....
  31. ncbi request reprint Neurocognitive impairment due to chronic alcohol consumption in an American Indian community
    C R Harris
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8110, USA
    J Stud Alcohol 64:458-66. 2003
    ....
  32. ncbi request reprint Alcohol use disorders and anxiety disorders: relation to the P300 event-related potential
    M A Enoch
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892 8110, USA
    Alcohol Clin Exp Res 25:1293-300. 2001
    ..We were particularly interested in looking at the subgroup of alcohol use disorders accompanied by anxiety disorders. This subgroup has previously been found to have diminished alpha amplitude in the resting EEG...
  33. ncbi request reprint Does a reduced sensitivity to bitter taste increase the risk of becoming nicotine addicted?
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 8110, USA
    Addict Behav 26:399-404. 2001
    ..875, 4 df; P=.003), suggesting that nontasters, who are not aversive to the bitter taste of cigarettes, may be more at risk for heavy smoking and therefore more vulnerable to nicotine addiction...
  34. pmc DRD1 5'UTR variation, sex and early infant stress influence ethanol consumption in rhesus macaques
    T K Newman
    Laboratory of Clinical and Translational Studies, NIAAA, Bethesda, MD, USA
    Genes Brain Behav 8:626-30. 2009
    ..Our work demonstrates a potential role for the dopamine D1 receptor gene in modulating alcohol consumption, especially in the context of early environmental stress...
  35. pmc Correlates of posttraumatic epilepsy 35 years following combat brain injury
    V Raymont
    Henry M Jackson Foundation, National Naval Medical Center, Bethesda, MD, USA
    Neurology 75:224-9. 2010
    ..The high prevalence (45%-53%) of posttraumatic epilepsy (PTE) in this unique cohort makes it valuable for study...
  36. pmc The Met66 allele of the functional Val66Met polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in systemic lupus erythematosus
    G Oroszi
    Laboratory of Neurogenetics, National Institute of Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Ann Rheum Dis 65:1330-5. 2006
    ..As cognitive function is commonly impaired in patients with systemic lupus erythematosus (SLE), the association of the BDNF Val66Met with neurocognitive function was studied...
  37. ncbi request reprint DNA melting analysis for detection of single nucleotide polymorphisms
    R H Lipsky
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, USA
    Clin Chem 47:635-44. 2001
    ..g., denaturing gradient gel electrophoresis and denaturing HPLC) are indirectly based on the principle of differential melting of heteroduplex DNA. We present a method for detecting SNPs that is directly based on this principle...
  38. ncbi request reprint Haplotype structure of inflammatory cytokines genes (IL1B, IL6 and TNF/LTA) in US Caucasians and African Americans
    I Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20852, USA
    Genes Immun 5:505-12. 2004
    ..This study demonstrates the utility of using gene haplotype maps and marker panels as tools for linkage studies on related phenotypes...
  39. ncbi request reprint The utility of the non-human primate; model for studying gene by environment interactions in behavioral research
    C S Barr
    NIAAA DICBR, NIH, Clinical Studies, Primate Unit, Bldg 112, Poolesville, MD 20837, USA
    Genes Brain Behav 2:336-40. 2003
    ....
  40. ncbi request reprint The role of 5-HTTLPR in choosing the lesser of two evils, the better of two goods: examining the impact of 5-HTTLPR genotype and tryptophan depletion in object choice
    K S Blair
    Department of Health and Human Services, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Room 300A, MSC 2670, Bethesda, MD 20892 2670, USA
    Psychopharmacology (Berl) 196:29-38. 2008
    ..The serotonin (5-HT) system is considered important for decision-making. However, its role in reward- and punishment-based processing has not yet been clearly determined...
  41. ncbi request reprint The role of genetic factors in the etiology of seasonal affective disorder and seasonality
    L Sher
    Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, MD 20892 1390, USA
    J Affect Disord 53:203-10. 1999
    ..Future research may clarify the role of different genes in the development of SAD...
  42. ncbi request reprint EEG phenotype in alcoholism: increased coherence in the depressive subtype
    G Winterer
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Acta Psychiatr Scand 108:51-60. 2003
    ..However, it is unclear whether alpha power and coherence differences reflect reversible toxic or withdrawal effects of alcohol...
  43. pmc Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations
    I Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    Mol Psychiatry 11:301-11. 2006
    ..Our results from two independent populations suggest that GAL may contribute to vulnerability to alcoholism, perhaps mediated by dimensional anxiety...
  44. pmc Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia
    M F Egan
    Clinical Brain Disorders Branch, Building 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:6917-22. 2001
    ..These data suggest that the COMT Val allele, because it increases prefrontal dopamine catabolism, impairs prefrontal cognition and physiology, and by this mechanism slightly increases risk for schizophrenia...
  45. ncbi request reprint Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder
    N E Rosenthal
    National Institute of Mental Health, Clinical Psychobiology Branch, Bethesda, MD 20892 1390, USA
    Mol Psychiatry 3:175-7. 1998
    ..02). The 5-HTTLPR short allele contributes to the trait of seasonality and is a risk factor for SAD, providing further evidence for a relationship between genetic variation in the 5-HT transporter (5-HTT) and behavior...
  46. ncbi request reprint Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28
    B Nakhai
    Section of Molecular Genetics, NIAAA, National Institutes of Health, Rockville, MD 20852, USA
    Biochem Biophys Res Commun 210:530-6. 1995
    ..This is the first report of a polymorphism in the human 5-HT1A receptor gene that alters the structure of the 5-HT1A receptor protein composition...
  47. ncbi request reprint Haplotype block and superblock structures of the alpha1-adrenergic receptor genes reveal echoes from the chromosomal past
    B Buzas
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, 12420 Parklawn Drive, Rockville, MD 20852, USA
    Mol Genet Genomics 272:519-29. 2004
    ..For both ADRA1A and ADRA1B, haplotype superstructures may represent a novel, higher-level hierarchy in the human genome, which may reduce redundancy of testing by further aggregation of genotype data...
  48. ncbi request reprint Pharmacogenetics of alcohol response and alcoholism: the interplay of genes and environmental factors in thresholds for alcoholism
    M Radel
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20892, USA
    Drug Metab Dispos 29:489-94. 2001
    ..Identification of genes for alcoholism vulnerability is important in the near future, not only for prevention, but also for development and targeting treatments...
  49. ncbi request reprint Mitochondrial aldehyde dehydrogenase polymorphism in Asian and American Indian populations: detection of new ALDH2 alleles
    A Novoradovsky
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20892, USA
    Alcohol Clin Exp Res 19:1105-10. 1995
    ..Thus, this second nonconservative ALDH2 substitution occurs within the sequence of the already inactive ALDH2(2) allele...
  50. ncbi request reprint Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorder
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 8110, USA
    Biol Psychiatry 49:385-8. 2001
    ..We hypothesized that the 5-HT2A promoter polymorphism, -1438G>A, previously associated with anorexia nervosa, would be more abundant in women with obsessive-compulsive disorder...
  51. ncbi request reprint Identification of tryptophan 2,3-dioxygenase RNA in rodent brain
    R Haber
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892
    J Neurochem 60:1159-62. 1993
    ..In addition, TDO sequences were found in RNA derived from rat brainstem, cerebellum, cortex, hypothalamus, and the remainder of the brain...
  52. ncbi request reprint Evolution of RPS4Y
    A W Bergen
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland, USA
    Mol Biol Evol 15:1412-9. 1998
    ..These data support a transposition event of ancestral primate RPS4X to the Y chromosome prior to the divergence of Prosimii...
  53. ncbi request reprint Overexpression of an epitope-tagged serotonin transporter in serotonin neurons of the dorsal raphe nucleus using a defective HSV-1 vector
    Yajin Ni
    Section of Molecular Neurobiology, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20892 8110, USA
    Behav Brain Res 138:133-43. 2003
    ..These data demonstrate that the levels of the 5HTT in 5HT neurons can be manipulated in the adult rodent brain using an HSV-1 vector...
  54. ncbi request reprint Inter-relationships of intermediate phenotypes for serotonin function, impulsivity, and a 5-HT2A candidate allele: His452Tyr
    C Reist
    Department of Psychiatry, Long Beach Veterans Affairs Medical Center, Long Beach, CA 90822, USA
    Mol Psychiatry 9:871-8. 2004
    ..10), suggesting that further study is warranted...
  55. ncbi request reprint Midbrain serotonin transporter binding potential measured with [11C]DASB is affected by serotonin transporter genotype
    M Reimold
    Department of Nuclear Medicine and PET Center, University of Tubingen, Tubingen, Germany
    J Neural Transm 114:635-9. 2007
    ..In vitro and in vivo evidence suggests that [(11)C]DASB, a new 5-HTT ligand offers some advantages over the ligands used in previous studies in measuring 5-HTT density independent of synaptic levels of serotonin...
  56. ncbi request reprint Gene-gene effects on central processing of aversive stimuli
    M N Smolka
    Department of Psychiatry, Technische Universitat Dresden, Dresden, Germany
    Mol Psychiatry 12:307-17. 2007
    ..Effects of 5-HTT and COMT genotypes did not affect brain processing of pleasant stimuli. These data indicate that functional brain imaging may be used to assess the interaction of multiple genes on the function of neuronal networks...
  57. ncbi request reprint Influence of psychological factors on risk of temporomandibular disorders
    G D Slade
    Australian Research Centre for Population Oral Health, Dental School, University of Adelaide, SA 5005, Australia
    J Dent Res 86:1120-5. 2007
    ..Psychological factors linked to pain sensitivity influenced TMD risk independently of the effects of the COMT haplotype on TMD risk...
  58. ncbi request reprint Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype
    N Ozaki
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Mol Psychiatry 8:933-6. 2003
    ..The four most clinically affected individuals--the two probands and their two slbs--had the I425V SERT gene gain-of-function mutation and were also homozygous for 5'-UTR SERT gene variant with greater transcriptional efficacy...
  59. ncbi request reprint COMT haplotypes suggest P2 promoter region relevance for schizophrenia
    M A Palmatier
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8005, USA
    Mol Psychiatry 9:859-70. 2004
    ..The previously described HindIII restriction site polymorphism, located within the P2 promoter, varies within all populations and may provide essential information in future studies of schizophrenia...
  60. ncbi request reprint Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation
    P R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
    Mol Psychiatry 10:631-6. 2005
    ..These findings implicate genetic involvement of BDNF in variation of human hippocampal volume and suggest that this effect may be greater among patients compared to healthy volunteers...
  61. ncbi request reprint Neurobiological correlates of the disposition and maintenance of alcoholism
    A Heinz
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charité Mitte CCM, Berlin, Germany
    Pharmacopsychiatry 36:S255-8. 2003
    ..New treatment options include pharmacological approaches and indicate that behavior or motivational therapy and the attendance of patient groups may equally reduce the relapse risk...
  62. ncbi request reprint Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa
    A W Bergen
    Biognosis US, Inc Dissolved From the Price Foundation Collaborative Group, Pittsburgh, PA, USA
    Mol Psychiatry 8:397-406. 2003
    ..05). The combined statistical genetic evidence suggests that HTR1D and OPRD1 or linked genes may be involved in the etiology of AN...
  63. ncbi request reprint Analysis of polymorphisms affecting immune complex handling in systemic lupus erythematosus
    K E Sullivan
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Rheumatology (Oxford) 42:446-52. 2003
    ..This is consistent with the classic finding of immune complex deposition in affected end organs. We wished to examine combinatorial effects of polymorphic variants of genes involved in immune complex clearance in susceptibility to lupus...
  64. ncbi request reprint A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus
    K K Kidd
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8005, USA
    Hum Genet 103:211-27. 1998
    ....
  65. ncbi request reprint 5-HT2A promoter polymorphism -1438G/A, anorexia nervosa, and obsessive-compulsive disorder
    M A Enoch
    Lancet 351:1785-6. 1998
  66. ncbi request reprint Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: relationships to monoamine metabolite concentrations in CSF of healthy volunteers
    E G Jönsson
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden
    Eur Arch Psychiatry Clin Neurosci 247:297-302. 1997
    ..Due to the uncertain functional relevance of the DNA polymorphism investigated and the many calculations performed, the results should be interpreted with caution until replicated...
  67. ncbi request reprint Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation
    M Burmeister
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109 0720, USA
    Nat Genet 12:376-84. 1996
    ..off..
  68. pmc Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism
    D A Nielsen
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcholism, Bethesda, MD 20892
    Am J Hum Genet 51:1366-71. 1992
    ..This region contains loci for several important genes, including those for Beckwith-Wiedemann syndrome and tyrosine hydroxylase...
  69. ncbi request reprint Use of chromosomally mapped and identified mouse brain proteins for behavioral genetic analysis of alcoholism
    D Goldman
    Prog Neuropsychopharmacol Biol Psychiatry 10:177-89. 1986
    ..6 protein) and ethanol intake. Though tentative, these findings illustrate the power of this approach for behavioral genetic analysis and may allow the biochemical genetic bases of these traits to be understood...
  70. ncbi request reprint Fourteen genetically variant proteins of mouse brain: discovery of two new variants and chromosomal mapping of four loci
    D Goldman
    Biochem Genet 24:183-94. 1986
    ..In addition to these 13 genetically variant polypeptides, the positions of 12 other polypeptides which have been identified on 2DE gels of mouse brain are given...
  71. ncbi request reprint Mapping of a putative genetic locus determining ethanol intake in the mouse
    D Goldman
    Laboratory on Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892
    Brain Res 420:220-6. 1987
    ..When 19 distantly related inbred mouse strains were tested for ethanol acceptance and typed for LTW-4, it was again found that strains exhibiting the basic allele showed significantly higher ethanol acceptance...
  72. pmc Genetic mapping of the beta 1 GABA receptor gene to human chromosome 4, using a tetranucleotide repeat polymorphism
    M Dean
    Biological Carcinogenesis and Development Program Incorporated Dyncorp, Frederick, MD
    Am J Hum Genet 49:621-6. 1991
    ..These results affirm that sequence analysis of noncoding segments included within or adjacent to functional genes has value as a strategy to detect highly informative polymorphisms...
  73. ncbi request reprint C4A deficiency due to a 2 bp insertion is increased in patients with systemic lupus erythematosus
    K E Sullivan
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA
    J Rheumatol 26:2144-7. 1999
    ..We investigated whether a specific genetic cause of C4A deficiency, not associated with A1, B8, DR3, is found with increased frequency in SLE compared to controls...
  74. ncbi request reprint An in-frame deletion in the alpha(2C) adrenergic receptor is common in African--Americans
    J Feng
    Department of Molecular Genetics, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA
    Mol Psychiatry 6:168-72. 2001
    ..Although these data do not suggest an association of TIDRU(1) with schizophrenia, additional studies are needed to see whether TIDRU(1) confers a clinical phenotype...
  75. ncbi request reprint An osteopontin (SPP1) polymorphism is associated with systemic lupus erythematosus
    A C Forton
    The University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Hum Mutat 19:459. 2002
    ..Additional associations with renal disease and opportunisitic infections were suggested. This is the first phenotypic association with a polymorphic variant of osteopontin...
  76. pmc Evidence for a susceptibility gene for anorexia nervosa on chromosome 1
    D E Grice
    Department of Psychiatry, University of Pennsylvania, PA 19104, USA
    Am J Hum Genet 70:787-92. 2002
    ..03, at marker D1S3721 on chromosome 1p. The genotyping of additional markers in this region led to a peak multipoint NPL score of 3.45, thereby providing suggestive evidence for the presence of an AN-susceptibility locus on chromosome 1p...
  77. ncbi request reprint Interferon-gamma polymorphisms in systemic lupus erythematosus
    J Y Lee
    The Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Genes Immun 2:254-7. 2001
    ..Allele 2 appeared to be protective for arthritis. This suggests that genetic variation in interferon-gamma expression might influence the disease course...
  78. ncbi request reprint Validity of the CAGE questionnaire in an American Indian population
    A Saremi
    National Institute of Diabetes and Digestive Kidney Diseases, Phoenix, Arizona 85014, USA
    J Stud Alcohol 62:294-300. 2001
    ..The area under the ROC curve was 81% for men and 75% for women. CONCLUSIONS: These findings suggest that the CAGE questionnaire is a valid screening method, in this population, for identifying people likely to have alcohol dependence...
  79. ncbi request reprint Systematic screening for mutations in the glycine receptor alpha2 subunit gene (GLRA2) in patients with schizophrenia and other psychiatric diseases
    J Feng
    Department of Molecular Genetics, City of Hope National Medical Center Beckman Research Institute, Duarte, California 91010 3000, USA
    Psychiatr Genet 11:45-8. 2001
    ..These do not alter the structure or the expression of the protein. It is unlikely that mutations in the coding region and splice junction of GLRA2 gene are associated with schizophrenia and other psychiatric diseases...
  80. ncbi request reprint Scanning of estrogen receptor alpha (ERalpha) and thyroid hormone receptor alpha (TRalpha) genes in patients with psychiatric diseases: four missense mutations identified in ERalpha gene
    J Feng
    Department of Molecular Genetics, City of Hope National Medical Center, Duarte, California, USA
    Am J Med Genet 105:369-74. 2001
    ..7% and 0%, respectively). Further analyses are necessary to determine if the missense mutations identified in this study are associated with predisposition or outcome for either psychiatric or nonpsychiatric diseases...
  81. ncbi request reprint Association of a 5-HT(5A) receptor polymorphism, Pro15Ser, to schizophrenia
    N Iwata
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Mol Psychiatry 6:217-9. 2001
    ....
  82. ncbi request reprint Genetic brain polypeptide variants in inbred mice and in mouse strains with high and low sensitivity to alcohol
    D Goldman
    Brain Res 341:130-8. 1985
    ..abstract truncated at 250 words)..
  83. ncbi request reprint Molecular cloning of mouse alcohol dehydrogenase-B2 cDNA: nucleotide sequences of the class III ADH genes evolve slowly even for silent substitutions
    M W Hur
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202 5122
    DNA Seq 3:167-75. 1992
    ..Our analysis of the nucleotide sequences demonstrates that this cannot be the entire explanation, since the rate of silent (synonymous) nucleotide substitutions is also lower in the class III ADHs than in the class I ADHs...
  84. ncbi request reprint Candidate gene analysis of the Price Foundation anorexia nervosa affected relative pair dataset
    A W Bergen
    Biognosis U S Inc, Gaithersburg, MD 20877, USA
    Curr Drug Targets CNS Neurol Disord 2:41-51. 2003
    ..S., Inc. and selected candidate gene findings in the AN-ARP dataset derived from that research program...
  85. ncbi request reprint Linkage mapping of human polymorphic proteins identified by two-dimensional electrophoresis
    D Goldman
    Laboratory on Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892
    Genomics 11:875-84. 1991
    ..These genetic linkages were achieved by classical linkage analysis of 2DE protein charge polymorphisms to the panel of RFLPs previously typed in nine pedigrees in the Centre D'Etude du Polymorphisme Humain (CEPH) collection...
  86. ncbi request reprint Isolation and structural characterization of the murine tryptophan hydroxylase gene
    J Stoll
    Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892
    J Neurosci Res 28:457-65. 1991
    ..Nine of the ten intron/exon boundaries of tryptophan hydroxylase are conserved with tyrosine hydroxylase and phenylalanine hydroxylase, further delineating the evolutionary relationship of these three genes...
  87. ncbi request reprint Characterization and chromosomal mapping of a cDNA encoding tryptophan hydroxylase from a mouse mastocytoma cell line
    J Stoll
    Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892
    Genomics 7:88-96. 1990
    ..Because TPH has been mapped to human chromosome 11, this assignment further defines regions of homology between these mouse and human chromosomes...
  88. pmc Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family
    J Boulter
    Molecular Neurobiology Laboratory, Salk Institute, San Diego, CA 92138
    Proc Natl Acad Sci U S A 84:7763-7. 1987
    ..These results indicate that the alpha 3, alpha 4, and beta 2 genes encode functional nicotinic acetylcholine receptor subunits that are expressed in the brain and peripheral nervous system...
  89. ncbi request reprint Cloning and comparative mapping of a human class III (chi) alcohol dehydrogenase cDNA
    P R Giri
    Laboratory on Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892
    Biochem Biophys Res Commun 164:453-60. 1989
    ..The derived protein sequence also differs at residue 166, where Tyr is found. This difference, due to a single base substitution, could result from cloning artifact, polymorphism, or two expressed class III ADH genes...
  90. ncbi request reprint Excess tryptophan hydroxylase 17 779C allele in surviving cotwins of monozygotic twin suicide victims
    A Roy
    Mental Health and Behavioral Science (116A, DVA New Jersey Health Care System, East Orange, NJ 07019, USA
    Neuropsychobiology 43:233-6. 2001
    ..CONCLUSION: These results, in a small sample, suggest the possibility that the 17 779C allele of the TPH gene may be associated with an increased risk of suicide. Further studies in larger samples are needed...
  91. ncbi request reprint Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor alpha-subunit
    J Boulter
    Nature 319:368-74. 1986
    ....
  92. ncbi request reprint Modification of human 5-HT(2C) receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution
    M Okada
    Department of Public Health, Faculty of Medicine, Osaka City University, Osaka, Japan
    Mol Psychiatry 9:55-64. 2004
    ....