Lynn R Goldin

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Telomere length and heavy-chain mutation status in familial chronic lymphocytic leukemia
    Naoko Ishibe
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, MSC 7236, Rockville, MD 20892, USA
    Leuk Res 26:791-4. 2002
  2. pmc Patterns of autoimmunity and subsequent chronic lymphocytic leukemia in Nordic countries
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Blood 108:292-6. 2006
  3. pmc Genomewide linkage screen for Waldenstrom macroglobulinemia susceptibility loci in high-risk families
    Mary L McMaster
    Genetic Epidemiology Branch, Bethesda, MD, 20892 7236, USA
    Am J Hum Genet 79:695-701. 2006
  4. pmc Precursors to lymphoproliferative malignancies
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, 6120 Executive Blvd, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 22:533-9. 2013
  5. pmc Germline and somatic JAK2 mutations and susceptibility to chronic myeloproliferative neoplasms
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
    Genome Med 1:55. 2009
  6. pmc Environment And Genetics in Lung cancer Etiology (EAGLE) study: an integrative population-based case-control study of lung cancer
    Maria Teresa Landi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
    BMC Public Health 8:203. 2008
  7. ncbi request reprint Family studies in chronic lymphocytic leukaemia and other lymphoproliferative tumours
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Br J Haematol 139:774-9. 2007
  8. pmc Autoimmunity and lymphomagenesis
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Int J Cancer 124:1497-502. 2009
  9. pmc Elevated risk of chronic lymphocytic leukemia and other indolent non-Hodgkin's lymphomas among relatives of patients with chronic lymphocytic leukemia
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Bethesda, MD 20892, USA
    Haematologica 94:647-53. 2009
  10. pmc Highly increased familial risks for specific lymphoma subtypes
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Br J Haematol 146:91-4. 2009

Detail Information

Publications57

  1. ncbi request reprint Telomere length and heavy-chain mutation status in familial chronic lymphocytic leukemia
    Naoko Ishibe
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, MSC 7236, Rockville, MD 20892, USA
    Leuk Res 26:791-4. 2002
    ..Our results suggest that telomere length is associated with V(H) gene mutation status and provides further evidence that the biological basis of familial B-CLL is similar to that of sporadic patients...
  2. pmc Patterns of autoimmunity and subsequent chronic lymphocytic leukemia in Nordic countries
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Blood 108:292-6. 2006
    ....
  3. pmc Genomewide linkage screen for Waldenstrom macroglobulinemia susceptibility loci in high-risk families
    Mary L McMaster
    Genetic Epidemiology Branch, Bethesda, MD, 20892 7236, USA
    Am J Hum Genet 79:695-701. 2006
    ..The findings from this first linkage analysis of families at high risk for WM represent important progress toward identifying gene(s) that modulate susceptibility to WM and toward understanding its complex etiology...
  4. pmc Precursors to lymphoproliferative malignancies
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, 6120 Executive Blvd, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 22:533-9. 2013
    ..A key focus for current work is to identify markers that predict progression to malignancy...
  5. pmc Germline and somatic JAK2 mutations and susceptibility to chronic myeloproliferative neoplasms
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
    Genome Med 1:55. 2009
    ..The somatic mutation occurs primarily on one particular germline JAK2 haplotype, which may account for as much as 50% of the risk to first-degree relatives. This finding provides new directions for unraveling the pathogenesis of MPN...
  6. pmc Environment And Genetics in Lung cancer Etiology (EAGLE) study: an integrative population-based case-control study of lung cancer
    Maria Teresa Landi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
    BMC Public Health 8:203. 2008
    ..A new framework of research is needed to address the challenges offered by this complex disease...
  7. ncbi request reprint Family studies in chronic lymphocytic leukaemia and other lymphoproliferative tumours
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Br J Haematol 139:774-9. 2007
    ..The ability to conduct large scale genomic studies will play an important role in detecting susceptibility genes for CLL over the next few years and thereby help to delineate aetiological pathways...
  8. pmc Autoimmunity and lymphomagenesis
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Int J Cancer 124:1497-502. 2009
    ..Finally, we discuss the future directions involving a combination of population and molecular studies that are needed to better define underlying biological mechanisms...
  9. pmc Elevated risk of chronic lymphocytic leukemia and other indolent non-Hodgkin's lymphomas among relatives of patients with chronic lymphocytic leukemia
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Bethesda, MD 20892, USA
    Haematologica 94:647-53. 2009
    ....
  10. pmc Highly increased familial risks for specific lymphoma subtypes
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Br J Haematol 146:91-4. 2009
    ..These results imply that germline susceptibility genes are specific to lymphoma subtype...
  11. ncbi request reprint Familial aggregation and heterogeneity of non-Hodgkin lymphoma in population-based samples
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7236, Bethesda, MD 20892 7236, USA
    Cancer Epidemiol Biomarkers Prev 14:2402-6. 2005
    ..We estimate that the absolute lifetime risk for a first-degree relative of an NHL case to develop NHL is 3.6% (compared with a population risk of 2.1%) and higher if the index case had an aggressive subtype of NHL...
  12. ncbi request reprint Familial aggregation of Hodgkin lymphoma and related tumors
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7236, USA
    Cancer 100:1902-8. 2004
    ..However, the spectrum of malignancies associated with common genetic etiology and the effects of gender and age on familial risk have not been established...
  13. pmc Familial chronic lymphocytic leukemia
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892 7236, USA
    Curr Opin Hematol 17:350-5. 2010
    ..However, predisposing germline mutations have not been identified. We will discuss the spectrum of conditions associated with CLL in families and the advances in identifying the underlying susceptibility genes...
  14. ncbi request reprint A genome scan of 18 families with chronic lymphocytic leukaemia
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, 6120 Executive Boulevard, Room 7008, MSC 7236, Bethesda, MD 20892 7236, USA
    Br J Haematol 121:866-73. 2003
    ..Four of these six regions (6q, 13q, 12 and 17p) coincide with areas where cytogenetic abnormalities are frequently observed in CLL tumour cells and are, therefore, strong candidate regions for containing germ line changes...
  15. ncbi request reprint Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Blood 104:1850-4. 2004
    ..We conclude that the familial component of CLL is shared with other lymphoproliferative malignances, suggesting common genetic pathways. However, because clinically diagnosed CLL is uncommon, absolute excess risk to relatives is small...
  16. pmc Common occurrence of monoclonal B-cell lymphocytosis among members of high-risk CLL families
    Lynn R Goldin
    Genetic Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Br J Haematol 151:152-8. 2010
    ..Our findings show that MBL occurs at a very high rate in high risk CLL families. Both the age and gender distribution of MBL are parallel to CLL, implying a shared inherited risk...
  17. pmc Familial aggregation of acute myeloid leukemia and myelodysplastic syndromes
    Lynn R Goldin
    Genetic Epidemiology Branch, DCEG, NCI, 6120 Executive Blvd, Room 7124, MSC 7236, Bethesda, MD 20892 7236, USA
    J Clin Oncol 30:179-83. 2012
    ..Apart from rare pedigrees with multiple cases of acute myeloid leukemia (AML), there is limited data on familial aggregation of AML and myelodysplastic syndromes (MDSs) in the population...
  18. ncbi request reprint Analysis of metabolic syndrome phenotypes in Framingham Heart Study families from Genetic Analysis Workshop 13
    Lynn R Goldin
    Genetic Epidemiology Branch, DCEG, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7236, USA
    Genet Epidemiol 25:S78-89. 2003
    ..Over 40 genome-wide linkage analyses were conducted. Despite the broad range of approaches, several regions of the genome were repeatedly identified across multiple analyses...
  19. ncbi request reprint Autoimmunity and susceptibility to Hodgkin lymphoma: a population-based case-control study in Scandinavia
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
    J Natl Cancer Inst 98:1321-30. 2006
    ..In contrast, there are limited data on risk of Hodgkin lymphoma following autoimmune diseases and almost no data addressing whether there is a familial association between the conditions...
  20. pmc A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma
    Maria Teresa Landi
    Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Hum Genet 85:679-91. 2009
    ..In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma...
  21. ncbi request reprint Familial characteristics of autoimmune and hematologic disorders in 8,406 multiple myeloma patients: a population-based case-control study
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Int J Cancer 118:3095-8. 2006
    ..However, MM itself shows significant familial aggregation, implicating the etiologic importance of this type of hematological neoplasm and perhaps MGUS in germ line genes...
  22. pmc Linkage analysis of the GAW14 simulated dataset with microsatellite and single-nucleotide polymorphism markers in large pedigrees
    Xiaohong Rose Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
    BMC Genet 6:S14. 2005
    ..Finally, our results suggested that each linkage program had limitations in handling the large, complex pedigrees as well as a high-density SNP marker set...
  23. pmc Common genetic variants in candidate genes and risk of familial lymphoid malignancies
    Xueying Sharon Liang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Br J Haematol 146:418-23. 2009
    ..Polymorphisms in TNFSF10 were associated with both CLL and WM. Future replication and functional studies are needed to clarify the role of these genetic variants. Finally, our data further support the close association of WM and CLL...
  24. ncbi request reprint No evidence for anticipation in lymphoproliferative tumors in population-based samples
    Sarah E Daugherty
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS Room 511, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:1245-50. 2005
    ..This is the first study to consider the changes of incidence over time as a source of bias when evaluating anticipation in lymphoproliferative cancers...
  25. ncbi request reprint Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia
    David Ng
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892 7231, USA
    Blood 109:916-25. 2007
    ..In conclusion, we identified a novel candidate region that may predispose to familial CLL...
  26. pmc Obesity is associated with an increased risk of monoclonal gammopathy of undetermined significance among black and white women
    Ola Landgren
    Center for Cancer Research and Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 116:1056-9. 2010
    ..Our findings support the hypothesis that obesity is etiologically linked to myelomagenesis. The 2-fold excess of MGUS among blacks compared with whites of similar socioeconomic status supports a role for susceptibility genes in MGUS...
  27. pmc Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24,577 first-degree relatives of 11,039 patients with myeloproliferative neoplasms in Sweden
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7236, USA
    Blood 112:2199-204. 2008
    ..9; 0.9-3.8; P = .09). Our findings of 5- to 7-fold elevated risk of MPNs among first-degree relatives of MPN patients support the hypothesis that common, strong, shared susceptibility genes predispose to PV, ET, MF, and possibly CML...
  28. pmc Risk of plasma cell and lymphoproliferative disorders among 14621 first-degree relatives of 4458 patients with monoclonal gammopathy of undetermined significance in Sweden
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, and Center for Cancer Research, Medical Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Blood 114:791-5. 2009
    ..Among first-degree relatives of a nationwide MGUS cohort, we found elevated risks of MGUS, MM, LPL/WM, and CLL, supporting a role for germline susceptibility genes, shared environmental influences, or an interaction between both...
  29. ncbi request reprint Respiratory tract infections in the pathway to multiple myeloma: a population-based study in Scandinavia
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7236, USA
    Haematologica 91:1697-700. 2006
    ..7-fold (95%CI 1.0-3.0; p=0.05) and a 1.5-fold (95%CI 0.6-3.9) elevated MM risk, respectively. Pneumonia could be a trigger to the development of MM or a manifestation of immune disturbances in late-stage MGUS...
  30. pmc Mood disorders and risk of lung cancer in the EAGLE case-control study and in the U.S. Veterans Affairs inpatient cohort
    David E Capo-Ramos
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e42945. 2012
    ..Mood disorders may affect lung cancer risk. We evaluated this hypothesis in two large studies...
  31. pmc Risk of acute myeloid leukemia and myelodysplastic syndromes after multiple myeloma and its precursor disease (MGUS)
    Sham Mailankody
    Multiple Myeloma Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Blood 118:4086-92. 2011
    ..AML/MDS risk following MM was the same before/after the introduction of HDM-ASCT. Longer follow-up is needed to characterize second tumor risks in the IMiD era...
  32. pmc Identification of susceptibility loci for complex diseases in a case-control association study using the Genetic Analysis Workshop 14 dataset
    Kimberly F Kerstann
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
    BMC Genet 6:S102. 2005
    ..This result was most likely due to the method used for data simulation. In general, this study showed that conventional case-control association methods could detect disease loci responsible for the development of complex traits...
  33. ncbi request reprint Risk of second malignant neoplasms among lymphoma patients with a family history of cancer
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Int J Cancer 120:1099-102. 2007
    ..99, 95% CI: 0.73-5.39). Our observations suggest that genetic factors, as measured by positive family history of cancer, may be influential risk-factors for selected second tumors following lymphoproliferative disorders...
  34. pmc Infection in infancy and subsequent risk of developing lymphoma in children and young adults
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 117:1670-2. 2011
    ..Further studies are needed to determine whether this association is present among NHL occurring in older adults and if improved survival of patients with immune defects has contributed to the secular increases in incidence of NHLs...
  35. pmc Risk of monoclonal gammopathy of undetermined significance (MGUS) and subsequent multiple myeloma among African American and white veterans in the United States
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, Bethesda, MD 20892 7236, USA
    Blood 107:904-6. 2006
    ..In the largest study to date, we suggest that the excess risk of MM in African Americans results from an increase in risk of MGUS rather than an increased risk of progression from MGUS to MM...
  36. pmc Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression
    Melissa Rotunno
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e5652. 2009
    ..Our findings emphasize the necessity of post-GWAS fine mapping and SNP functional assessment to further elucidate cancer risk associations...
  37. pmc Increased risk for non-Hodgkin lymphoma in individuals with celiac disease and a potential familial association
    Ying Gao
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7236, USA
    Gastroenterology 136:91-8. 2009
    ..However, there are only limited data on risk in the current era of serologic testing and human leukocytes antigen typing to screen for CD. There is also no information on the role of family history of CD in relation to lymphoma risk...
  38. pmc Risk of cancer in first- and second-degree relatives of testicular germ cell tumor cases and controls
    Victoria M Chia
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Int J Cancer 124:952-7. 2009
    ..69, 95% CI: 0.51-0.94). Thus, this study suggests that there may be aggregation of cancer among families of men diagnosed with TGCT...
  39. ncbi request reprint High-density mapping and follow-up studies on chromosomal regions 1, 3, 6, 12, 13 and 17 in 28 families with chronic lymphocytic leukaemia
    David Ng
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, DHHS, Bethesda, MD 20892 7236, USA
    Br J Haematol 133:59-61. 2006
    ..2, 3q22.1, 3q26.2, 6q22.31-q23.2, 12q24.23, 14q32.13, 17p13.3. Chromosome 13q21.33 remains a region of interest with a P-value of 0.013 (marker D13S1291) and warrants additional molecular investigation as a susceptibility region for CLL...
  40. ncbi request reprint Prevalence of monoclonal gammopathy of undetermined significance among men in Ghana
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Bldg EPS Room 7110, Bethesda, MD 20892 7236, USA
    Mayo Clin Proc 82:1468-73. 2007
    ....
  41. pmc Genomic regions linked to alcohol consumption in the Framingham Heart Study
    Andrew W Bergen
    Core Genotyping Facility, Advanced Technology Center, National Cancer Institute, NIH, DHHS, Gaithersburg, Maryland, USA
    BMC Genet 4:S101. 2003
    ....
  42. pmc Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Blood 109:2198-201. 2007
    ..001). None of 9 other respiratory-tract infections was significantly associated with CLL risk. Pneumonia might be a potential CLL trigger or it could represent premalignant immune disruption preceding CLL...
  43. ncbi request reprint ATM mutations and protein expression are not associated with familial B-CLL cases
    Naoko Ishibe
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, MSC 7236, Bethesda, MD 20892, USA
    Leuk Res 27:973-5. 2003
  44. doi request reprint Current insight on trends, causes, and mechanisms of Hodgkin's lymphoma
    Neil E Caporaso
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer J 15:117-23. 2009
    ..These results emphasize an interaction between environmental and genetic risk factors in HL...
  45. ncbi request reprint Personal and family history of autoimmune diabetes mellitus and susceptibility to young-adult-onset Hodgkin lymphoma
    Ola Landgren
    Division of Hematology, Karolinska Hospital and Institutet, Stockholm, Sweden
    Int J Cancer 118:449-52. 2006
    ..0) history of diabetes mellitus. These findings suggests that characteristics of the immune system associated with conditions such as diabetes mellitus type I are of importance in the pathogenesis of young-adult-onset HL...
  46. pmc Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Bethesda, Maryland, USA
    Nat Genet 45:868-76. 2013
    ..3 (ODF1, P=5.40×10(-8)) and 5p15.33 (TERT, P=1.92×10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism...
  47. pmc Linkage analysis of anti-CCP levels as dichotomized and quantitative traits using GAW15 single-nucleotide polymorphism scan of NARAC families
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7236, Bethesda, Maryland 20892, USA
    BMC Proc 1:S107. 2007
    ..Our study also highlighted that quantitative trait linkage results are highly sensitive to phenotype transformation and analytic approaches...
  48. pmc Identifying rheumatoid arthritis susceptibility genes using high-dimensional methods
    Xueying Liang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, Maryland 20892, USA
    BMC Proc 3:S79. 2009
    ..We conclude that the three high-dimensional methods are useful as an initial screening for gene associations to identify promising genes for further modeling and additional replication studies...
  49. doi request reprint Autoimmune disease in individuals and close family members and susceptibility to non-Hodgkin's lymphoma
    Lene Mellemkjaer
    Danish Cancer Society, Copenhagen, Denmark
    Arthritis Rheum 58:657-66. 2008
    ..This study was initiated to evaluate the risks of NHL associated with a personal or family history of a wide range of autoimmune diseases...
  50. pmc A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia
    Gabrielle S Sellick
    Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, UK
    Blood 110:3326-33. 2007
    ..002). None of the regions coincided with areas of common chromosomal abnormalities frequently observed in CLL. These findings provide direct evidence for Mendelian predisposition to CLL and evidence for the location of disease loci...
  51. pmc Risk of lymphoproliferative disorders among first-degree relatives of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia patients: a population-based study in Sweden
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Blood 112:3052-6. 2008
    ..Our findings of highly increased risks of developing LPL/WM, NHL, CLL, and MGUS support the operation of shared susceptibility genes that predispose to LPL/WM and other lymphoproliferative disorders...
  52. ncbi request reprint Re: Familial clustering of Hodgkin lymphoma and multiple sclerosis
    Ola Landgren
    J Natl Cancer Inst 97:543-4; author reply 544-5. 2005
  53. ncbi request reprint Trinucleotide repeat dynamic mutation identifying susceptibility in familial and sporadic chronic lymphocytic leukaemia
    Rebecca L Auer
    Centre for Haematology, Institute of Cell and Molecular Science, Bart s and The London Queen Mary School of Medicine, London, UK
    Br J Haematol 136:73-9. 2007
    ..In addition, polymorphisms with prognostic significance were identified. These were high length (but not expanded) repeats at FRA11B (P = 0.01), ATXN1 (P = 0.032) and ATXN3 (P = 0.022), all associated with poor risk disease...
  54. ncbi request reprint Ascertainment and diagnostic accuracy for hematopoietic lymphoproliferative malignancies in Sweden 1964-2003
    Ingemar Turesson
    Section of Hematology, Department of Medicine, Malmo University Hospital, University of Lund, Malmo, Sweden
    Int J Cancer 121:2260-6. 2007
    ..However, we found under-ascertainment of patients with indolent LP tumors, particularly among patients diagnosed at older ages, with early-stage disease and diagnosed in earlier years...
  55. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
    Ricardo Segurado
    Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 73:49-62. 2003
    ..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region...
  56. ncbi request reprint No association of ARLTS1 polymorphisms and risk for familial chronic lymphocytic leukaemia
    David Ng
    Br J Haematol 137:173-5. 2007
  57. ncbi request reprint CXCR4 expression is associated with survival in familial chronic lymphocytic leukemia, but CD38 expression is not
    Naoko Ishibe
    Blood 100:1100-1. 2002