Research Topics
Species | Andy GoldenSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Silence is golden: combining RNAi and live cell imaging to study cell cycle regulatory genes during Caenorhabditis elegans developmentAndy Golden
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 8 Center Dr Bethesda, MD 20892, USA
Methods 41:190-7. 2007..Here we discuss experimental approaches for studying cell cycle processes in the nematode Caenorhabditis elegans...
Protein phosphatase 5 is a negative regulator of separase function during cortical granule exocytosis in C. elegansChristopher T Richie
Laboratory of Biochemistry and Genetics, NIDDK, NIH, Bethesda, MD 20892, USA
J Cell Sci 124:2903-13. 2011..The identification of PPH-5 as a suppressor of separase suggests that a new phospho-regulatory pathway plays an important role in regulating anaphase functions of separase...- Components of the spindle assembly checkpoint regulate the anaphase-promoting complex during meiosis in Caenorhabditis elegansKathryn K Stein
Laboratory of Biochemistry and Genetics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
Genetics 175:107-23. 2007..These studies provide evidence that components of the spindle assembly checkpoint may regulate the metaphase-to-anaphase transition in the absence of spindle damage during C. elegans meiosis... - Functional redundancy of paralogs of an anaphase promoting complex/cyclosome subunit in Caenorhabditis elegans meiosisKathryn K Stein
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Genetics 186:1285-93. 2010..In sum, the two C. elegans APC5 paralogs have a redundant function during the meiotic divisions... - Inactivation of the C. elegans lipin homolog leads to ER disorganization and to defects in the breakdown and reassembly of the nuclear envelopeAndy Golden
The Laboratory of Biochemistry and Genetics and National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 8 Center Drive, Bethesda, MD 20892, USA
J Cell Sci 122:1970-8. 2009..These results uncover cellular processes affected by lipin in metazoa, and suggest that lipid synthesis has a role in NE dynamics... - The C. elegans Myt1 ortholog is required for the proper timing of oocyte maturationAnna E Burrows
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 8 Center Drive, Building 8, Room 323, Bethesda, MD 20892, USA
Development 133:697-709. 2006..Furthermore, co-depletion studies of CDK-1 and WEE-1.3 demonstrate that WEE-1.3 is dispensable in the absence of CDK-1, suggesting that CDK-1 is a major target of WEE-1.3 in C. elegans oocytes... - Hypothesis: Bifunctional mitochondrial proteins have centrosomal functionsAkilah Moore
Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive, and Kidney Diseases NIH, 8 Center Drive, Bethesda, MD 20892, USA
Environ Mol Mutagen 50:637-48. 2009..Throughout this discussion we attempt to demonstrate that a cell cannot live without mitochondria and study this issue from a nonenergetic perspective... - Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis IEdward S Davis
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0840, USA
Genetics 160:805-13. 2002..Further, chromosome segregation during meiosis I requires APC/C functions in addition to the release of sister chromatid cohesion... - Getting (chromosomes) loaded--a new role for timelessAndy Golden
Laboratory of Biochemistry and Genetics, NIDDK, NIH, Bethesda, MD 20892, USA
Dev Cell 5:7-9. 2003..The phenotypes of tim-1 mutants suggest that cohesin subunits load onto chromosomes in a stepwise manner. Whether TIM-1 is also involved in circadian rhythms is discussed... - Chromosome segregation: Aurora B gets TousledChristopher T Richie
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Curr Biol 15:R379-82. 2005.... - Cortical granule exocytosis in C. elegans is regulated by cell cycle components including separaseJOSHUA N BEMBENEK
University of Wisconsin Madison, Laboratory of Molecular Biology, 1525 Linden Drive, Madison, WI 53706, USA
Development 134:3837-48. 2007..These observations lead us to speculate that SEP-1 has two separable yet coordinated functions: to regulate cortical granule exocytosis and to mediate chromosome separation... - Developmental defects observed in hypomorphic anaphase-promoting complex mutants are linked to cell cycle abnormalitiesDiane C Shakes
Department of Biology, College of William and Mary, Williamsburg, Virginia 23187, USA
Development 130:1605-20. 2003.... - CDC-25.1 regulates germline proliferation in Caenorhabditis elegansNeville Ashcroft
Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, United Kingdom
Genesis 33:1-7. 2002..Germline precursors divide slowly and produce abnormally sized daughter cells. Only three to four rounds of germ-cell division occur before they die during the L3 and L4 larval stages... - The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryoDiane G Morton
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
Dev Biol 241:47-58. 2002..Our analysis indicates that the par-5 14-3-3 gene plays a crucial role in the early events leading to polarization of the C. elegans zygote...