T E Goldberg

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Some fairly obvious distinctions between schizophrenia and bipolar disorder
    T E Goldberg
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Schizophr Res 39:127-32; discussion 161-2. 1999
  2. ncbi request reprint Genes and the parsing of cognitive processes
    Terry E Goldberg
    Clinical Brain Disorders Branch, GCAPP, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Trends Cogn Sci 8:325-35. 2004
  3. ncbi request reprint Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia
    Terry E Goldberg
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 60:889-96. 2003
  4. ncbi request reprint Prefrontal neurons and the genetics of schizophrenia
    D R Weinberger
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 50:825-44. 2001
  5. ncbi request reprint Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression
    R E Straub
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, NIH, US Department of Health and Human Services, Bethesda, MD 20892 1379, USA
    Mol Psychiatry 12:854-69. 2007
  6. ncbi request reprint Effects of dextroamphetamine on cognitive performance and cortical activation
    V S Mattay
    Clinical Brain Disorders Branch, Intramural Research Program, Laboratory of Diagnostic Radiology Research, Office of Intramural Research, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, 20892, USA
    Neuroimage 12:268-75. 2000
  7. ncbi request reprint Continuous performance test and schizophrenia: a test of stimulus-response compatibility, working memory, response readiness, or none of the above?
    B Elvevåg
    Clinical Brain Disorders Branch, NIMH, Bethesda, MD 20892, USA
    Am J Psychiatry 157:772-80. 2000
  8. ncbi request reprint Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited
    J H Callicott
    Clinical Brain Disorders Branch, IRP, NIMH Laboratory of Diagnostic Radiology Research, CC, NIH, Bethesda, MD 20892 1389, USA
    Cereb Cortex 10:1078-92. 2000
  9. ncbi request reprint Duration judgements in patients with schizophrenia
    B Elvevåg
    Clinical Brain Disorders Branch, NIMH NIH, Bethesda, MD 20892, USA
    Psychol Med 33:1249-61. 2003
  10. ncbi request reprint Paired-associate learning and memory interference in schizophrenia
    B Elvevåg
    Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Room 4S235 MSC 1379, Building 10, Bethesda, MD 20892, USA
    Neuropsychologia 38:1565-75. 2000

Collaborators

Detail Information

Publications78

  1. ncbi request reprint Some fairly obvious distinctions between schizophrenia and bipolar disorder
    T E Goldberg
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Schizophr Res 39:127-32; discussion 161-2. 1999
    ..However, questions remain, including the effects of state and medications, and the conclusion that I reach does not exclude the possibility that the two disorders share some but not all etiologic or pathophysiologic features...
  2. ncbi request reprint Genes and the parsing of cognitive processes
    Terry E Goldberg
    Clinical Brain Disorders Branch, GCAPP, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Trends Cogn Sci 8:325-35. 2004
    ..As such it may be necessary to view cognition in novel ways, based on constraints imposed by genomics and neurobiology, in order to increase the effect size of genotypic influences on cognition...
  3. ncbi request reprint Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia
    Terry E Goldberg
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 60:889-96. 2003
    ..Cognitive dysfunction in the working memory domain seems to be under genetic control and is a candidate intermediate phenotype in schizophrenia. Genes that affect working memory processing may contribute to risk for schizophrenia...
  4. ncbi request reprint Prefrontal neurons and the genetics of schizophrenia
    D R Weinberger
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 50:825-44. 2001
    ....
  5. ncbi request reprint Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression
    R E Straub
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, NIH, US Department of Health and Human Services, Bethesda, MD 20892 1379, USA
    Mol Psychiatry 12:854-69. 2007
    ..These coincident results implicate GAD1 in the etiology of schizophrenia and suggest that the mechanism involves altered cortical GABA inhibitory activity, perhaps modulated by dopaminergic function...
  6. ncbi request reprint Effects of dextroamphetamine on cognitive performance and cortical activation
    V S Mattay
    Clinical Brain Disorders Branch, Intramural Research Program, Laboratory of Diagnostic Radiology Research, Office of Intramural Research, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, 20892, USA
    Neuroimage 12:268-75. 2000
    ..These heterogeneic effects of dextroamphetamine may be explained by genetic variations that interact with the effects of dextroamphetamine...
  7. ncbi request reprint Continuous performance test and schizophrenia: a test of stimulus-response compatibility, working memory, response readiness, or none of the above?
    B Elvevåg
    Clinical Brain Disorders Branch, NIMH, Bethesda, MD 20892, USA
    Am J Psychiatry 157:772-80. 2000
    ..The authors administered variations of two types of cognitive tasks to patients with schizophrenia (N=20) and normal comparison subjects (N=30) to test four possible cognitive mechanisms that might account for such abnormalities...
  8. ncbi request reprint Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited
    J H Callicott
    Clinical Brain Disorders Branch, IRP, NIMH Laboratory of Diagnostic Radiology Research, CC, NIH, Bethesda, MD 20892 1389, USA
    Cereb Cortex 10:1078-92. 2000
    ..These data suggest that under certain conditions the physiological ramifications of dorsal PFC neuronal pathology in schizophrenia includes exaggerated and inefficient cortical activity, especially of dorsal PFC...
  9. ncbi request reprint Duration judgements in patients with schizophrenia
    B Elvevåg
    Clinical Brain Disorders Branch, NIMH NIH, Bethesda, MD 20892, USA
    Psychol Med 33:1249-61. 2003
    ..However, the timing intervals that patients have been evaluated on in prior studies vary considerably in magnitude (e.g. 1 s, 1 min, 1 h etc.)...
  10. ncbi request reprint Paired-associate learning and memory interference in schizophrenia
    B Elvevåg
    Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Room 4S235 MSC 1379, Building 10, Bethesda, MD 20892, USA
    Neuropsychologia 38:1565-75. 2000
    ..We suggest that the susceptibility to these interference effects in patients with schizophrenia is not a specific problem in cognition, but rather one that is confounded by general memory problems...
  11. ncbi request reprint Relative risk for cognitive impairments in siblings of patients with schizophrenia
    M F Egan
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 50:98-107. 2001
    ..Using this dimensional approach to subdividing schizophrenia may reduce the clinical and genetic heterogeneity of schizophrenia and improve the power of genetic studies...
  12. ncbi request reprint Memory for temporal order in patients with schizophrenia
    B Elvevåg
    Clinical Brain Disorders Branch, National Institutes of Mental Health National Institute of Health, Bethesda, MD 20892, USA
    Schizophr Res 46:187-93. 2000
    ..e., recall). It is possible that both impairments are due to some third process that underlies and aids in the reconstruction of episodes...
  13. ncbi request reprint Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality
    J W Buckholtz
    Neuroimaging Core Facility, National Institute for Mental Health, NIH, DHHS, Bethesda, MD 20892 1365, USA
    Mol Psychiatry 13:313-24. 2008
    ....
  14. ncbi request reprint An investigation of the integrity of semantic boundaries in schizophrenia
    B Elvevåg
    Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Room 4S235, MSC 1379, Building 10, Bethesda, MD 20892, USA
    Schizophr Res 53:187-98. 2002
    ..Moreover, this study indicates that patients do not 'fail' semantic tasks (e.g. priming) because of globally disorganized decision-making: here their capability to make precise distinctions between representations was intact...
  15. ncbi request reprint Relative risk of neurological signs in siblings of patients with schizophrenia
    M F Egan
    Clinical Brain Disorders Branch, Intramural Research Program, NIMH, National Institutes of Health, Bethesda, MD, USA
    Am J Psychiatry 158:1827-34. 2001
    ..The authors' goal was to investigate the strength of this possible genetic component...
  16. ncbi request reprint Short-term memory for serial order in schizophrenia: a detailed examination of error types
    B Elvevåg
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Neuropsychology 15:128-35. 2001
    ..Schizophrenic patients' limited short-term memory span may be due to greater forgetting during recall and not to a selective deficit in the mechanisms responsible for maintaining serial order information...
  17. ncbi request reprint Semantic clustering in verbal fluency: schizophrenic patients versus control participants
    B Elvevåg
    Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Bethesda, MD 20892, USA
    Psychol Med 32:909-17. 2002
    ..Schizophrenic patients generate fewer words than healthy controls during verbal fluency tasks. The structure of output may explain why patients generate fewer exemplars...
  18. ncbi request reprint A comparison of verbal fluency tasks in schizophrenic patients and normal controls
    B Elvevåg
    Clinical Brain Disorders Branch, National Institutes of Mental Health, National Institutes of Health, Room 4S235, MSC 1379, Building 10, Bethesda, MD 20892, USA
    Schizophr Res 51:119-26. 2001
    ..Our data revealed the presence of impairment in semantic and letter fluency tasks in schizophrenic patients consistent with previous reports, and also that patients were differentially impaired on semantic categories...
  19. ncbi request reprint Associating semantic space abnormalities with formal thought disorder in schizophrenia: use of triadic comparisons
    K A Tallent
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892-1379, USA
    J Clin Exp Neuropsychol 23:285-96. 2001
    ..Results suggest that thought disorder in schizophrenia is related to a disturbance in the organization of semantic networks...
  20. ncbi request reprint Relative risk of attention deficits in siblings of patients with schizophrenia
    M F Egan
    NIMH Nueorscience Research Center at St Elizabeth s Hospital, Washington, DC, USA
    Am J Psychiatry 157:1309-16. 2000
    ..To assess the suitability of impaired attention for use as an intermediate phenotype in genetic studies, the authors estimated the relative risk of impaired attention in a large group of siblings...
  21. pmc Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia
    M F Egan
    Clinical Brain Disorders Branch, Building 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:6917-22. 2001
    ..These data suggest that the COMT Val allele, because it increases prefrontal dopamine catabolism, impairs prefrontal cognition and physiology, and by this mechanism slightly increases risk for schizophrenia...
  22. ncbi request reprint COMT genotype and manic symptoms in schizophrenia
    Pamela DeRosse
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, and Harvard Partners Center for Genetics and Genomics, Boston, MA, United States
    Schizophr Res 87:28-31. 2006
    ..These data suggest that the effect of COMT variation may be associated with comorbid manic symptoms in SZ...
  23. ncbi request reprint Prefrontal electrophysiologic "noise" and catechol-O-methyltransferase genotype in schizophrenia
    Georg Winterer
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 60:578-84. 2006
    ....
  24. ncbi request reprint Intra-dimensional/extra-dimensional set-shifting performance in schizophrenia: impact of distractors
    Sandra Jazbec
    Clinical Brain Disorders Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Schizophr Res 89:339-49. 2007
    ....
  25. pmc Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex
    Stefano Marenco
    Genes and Cognition Program, Clinical Brain Disorders Branch, Intramural Research Program, Bldg 10, Rm 4S235, 10 Center Dr, NIMH, NIH, Bethesda, MD 20892, USA
    Am J Psychiatry 163:740-2. 2006
    ....
  26. ncbi request reprint The G72/G30 gene complex and cognitive abnormalities in schizophrenia
    Terry E Goldberg
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD, USA
    Neuropsychopharmacology 31:2022-32. 2006
    ..We present evidence that SNP variations in the G72 gene region increase risk of cognitive impairment in schizophrenia. SNP variations were not strongly associated with clinical diagnosis in family-based analyses...
  27. ncbi request reprint Brain regions underlying response inhibition and interference monitoring and suppression
    Giuseppe Blasi
    CBDB, GCAP, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Bethesda, MD 20982 1379, USA
    Eur J Neurosci 23:1658-64. 2006
    ..These results extend previous findings by suggesting regional functional specialization within a cortical network supporting cognitive control...
  28. pmc Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics
    Catherine M Diaz-Asper
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    NeuroRx 3:97-105. 2006
    ..Haplotype effects also may account for a modest percentage of the variance in test performance, and are an important area for future study...
  29. ncbi request reprint Neural mechanisms underlying probabilistic category learning in normal aging
    Francesco Fera
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Neurosci 25:11340-8. 2005
    ....
  30. ncbi request reprint Neurophysiological correlates of age-related changes in working memory capacity
    Venkata S Mattay
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Neurosci Lett 392:32-7. 2006
    ..As cognitive demand increases, however, they are pushed past a threshold beyond which physiological compensation cannot be made and, a decline in performance occurs...
  31. ncbi request reprint Cognitive control and semantics in schizophrenia: an integrated approach
    Jessica R Cohen
    Clinical Brain Disorders Branch, National Institutes of Mental Health NIH, Bldg 10 Rm 4S235, MSC 1379, Bethesda, MD 20892, USA
    Am J Psychiatry 162:1969-71. 2005
    ..The authors tested whether decisions about incongruencies in the representation and processing of semantic knowledge, thought to be related to cognitive control, are selectively impaired in schizophrenia...
  32. ncbi request reprint First- and second-generation antipsychotic medication and cognitive processing in schizophrenia
    Thomas W Weickert
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Psychiatry Rep 7:304-10. 2005
    ..In particular, the catechol-O-methyltransferase val108/158met polymorphism has been shown to predict working memory improvement after administration of antipsychotic medication to patients with schizophrenia...
  33. pmc Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia
    Joseph H Callicott
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:8627-32. 2005
    ....
  34. ncbi request reprint Tolcapone improves cognition and cortical information processing in normal human subjects
    Jose A Apud
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20854, USA
    Neuropsychopharmacology 32:1011-20. 2007
    ..Our results are consistent with data from animal studies and from computational models of the effects of selective enhancement of DA signaling in the prefrontal cortex...
  35. pmc DTNBP1 genotype influences cognitive decline in schizophrenia
    Katherine E Burdick
    Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, United States
    Schizophr Res 89:169-72. 2007
    ..The current study assessed the relationship between intellectual decline in schizophrenia and genetic variation in dysbindin-1 (DTNBP1)...
  36. pmc Neurobiology of cognitive aging: insights from imaging genetics
    Venkata S Mattay
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institute of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Biol Psychol 79:9-22. 2008
    ..Further, it is likely with early identification of susceptible individuals, early intervention through life-style changes and other methods could increase an individual's resilience to the effects of aging...
  37. ncbi request reprint Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:13393-401. 2007
    ..These findings add to the integration of dopaminergic signaling in basic cortical assemblies with their roles in specific human brain networks during the orchestration of information processing in WM...
  38. ncbi request reprint BDNF Val66Met polymorphism significantly affects d' in verbal recognition memory at short and long delays
    Terry E Goldberg
    Clinical Brain Disorders Branch, NIMH, Bethesda, MD 20892, USA
    Biol Psychol 77:20-4. 2008
    ..In sum, BDNF genotypes impacted "hits" in a recognition memory paradigm, findings consistent with the general notion that BDNF plays a prominent role in memory subprocesses thought to engage the medial temporal lobe...
  39. ncbi request reprint Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect?
    Terry E Goldberg
    Zucker Hillside Hospital, 7559 263rd Street, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 64:1115-22. 2007
    ..However, none of these studies included healthy controls undergoing repeated testing to assess the possibility that improvements might reflect simple practice effects...
  40. ncbi request reprint Amygdala activation in affective priming: a magnetoencephalogram study
    Maite Garolera
    Clinical Brain Disorders Branch, IRPP NIMH NIH DHHS, Bethesda, Maryland, USA
    Neuroreport 18:1449-53. 2007
    ..This study provides evidence for theta power changes in the amygdala and demonstrates that the analysis of brain oscillations provides a powerful tool to explore mechanisms implicated in emotional processing...
  41. pmc Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls
    Catherine M Diaz-Asper
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 63:72-9. 2008
    ..Recently, other single nucleotide polymorphisms (SNPs) across the gene have emerged as additional risk factors for schizophrenia: namely rs737865, rs165599, and rs2097603. In a large sample, we examined whether these SNPs affect WM...
  42. ncbi request reprint Frontal release signs and cognition in people with schizophrenia, their siblings and healthy controls
    Thomas M Hyde
    Clinical Brain Disorders Branch, Intramural Research Program, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    Br J Psychiatry 191:120-5. 2007
    ..Frontal release signs, a subset of neurological soft signs, are common in schizophrenia...
  43. ncbi request reprint Factor analysis of neurocognitive tests in a large sample of schizophrenic probands, their siblings, and healthy controls
    Margo R Genderson
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, NIH, 10 Center Drive, CRC 7 5342, Bethesda, MD 20892, United States
    Schizophr Res 94:231-9. 2007
    ..Furthermore, these findings provide the first confirmation that cognitive structure is comparable in family members of schizophrenia patients, as well as in patients themselves and controls...
  44. pmc Quantifying incoherence in speech: an automated methodology and novel application to schizophrenia
    Brita Elvevåg
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda MD, United States
    Schizophr Res 93:304-16. 2007
    ..In conclusion, LSA can be used to assay disordered language production so as to both complement human clinical ratings as well as experimentally parse this incoherence in a theory-driven manner...
  45. doi request reprint Norms and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS)
    Richard S E Keefe
    Department of Psychiatry, Box 3207, Duke University Medical Center, Durham, North Carolina 27710, USA
    Schizophr Res 102:108-15. 2008
    ..An education-correction factor was calculated and recommended only for non-schizophrenia patients. Eight different verbal memory tests were found to have equivalent levels of difficulty...
  46. ncbi request reprint Dissociating the effects of Sternberg working memory demands in prefrontal cortex
    Mario Altamura
    Department of Biomedical Sciences, Psychiatry Unit, University of Foggia, Italy
    Psychiatry Res 154:103-14. 2007
    ..These results suggest the possibility that top-down modulation of attention or cognitive control at encoding and/or decisionmaking may be mediated by these areas...
  47. ncbi request reprint Differentiating allocation of resources and conflict detection within attentional control processing
    Giuseppe Blasi
    National Institute of Mental Health, National Institutes of Health, Bethesda, MA, USA
    Eur J Neurosci 25:594-602. 2007
    ....
  48. pmc Genetic variation in the DAOA gene complex: impact on susceptibility for schizophrenia and on cognitive performance
    Carolin Opgen-Rhein
    Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, United States
    Schizophr Res 103:169-77. 2008
    ..Our aim in this study was to investigate the relationship between DAOA variation and schizophrenia, and the influence of DAOA on cognitive performance...
  49. ncbi request reprint Effect of catechol-O-methyltransferase val158met genotype on attentional control
    Giuseppe Blasi
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 25:5038-45. 2005
    ..These results indicate that met allele load and presumably enhanced dopaminergic tone improve the "efficiency" of local circuit processing within the cingulate cortex and thereby its function during AC...
  50. ncbi request reprint Functional and effective frontotemporal connectivity and genetic risk for schizophrenia
    Georg Winterer
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 54:1181-92. 2003
    ..We sought to determine whether abnormalities of frontotemporal connectivity are trait markers of genetic risk for schizophrenia...
  51. ncbi request reprint Letter and category fluency in schizophrenic patients: a meta-analysis
    Christina E Bokat
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Room 4s 235, 10 Center Drive MSC 1379, Bethesda, MD 20892, USA
    Schizophr Res 64:73-8. 2003
    ....
  52. ncbi request reprint Autobiographical memory in schizophrenia: an examination of the distribution of memories
    Brita Elvevåg
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuropsychology 17:402-9. 2003
    ..It was concluded that patients' paucity of memories generated from the recent decade reflects encoding or acquisition problems, which may be associated with the illness period...
  53. ncbi request reprint Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 1384, USA
    J Neurosci 23:6690-4. 2003
    ..These data implicate a specific genetic mechanism for substantial normal variation in human declarative memory and suggest that the basic effects of BDNF signaling on hippocampal function in experimental animals are important in humans...
  54. ncbi request reprint Comparison of cognitive performances during a placebo period and an atypical antipsychotic treatment period in schizophrenia: critical examination of confounds
    Thomas W Weickert
    Clinical Brain Disorders Branch, National Institute of Mental Health NIH, Building 10 Room 4N202, MSC 1379, Bethesda, MD 20892, USA
    Neuropsychopharmacology 28:1491-500. 2003
    ..These findings suggest that relative to placebo withdrawal, atypicals improve cognitive performance in SC. However, this finding may not be specific to atypicals, since analogous studies of typicals have not been performed...
  55. pmc Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine
    Venkata S Mattay
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Room 4s 235, Bethesda, MD 20982 1379, USA
    Proc Natl Acad Sci U S A 100:6186-91. 2003
    ..Further, individuals with the met/met catechol O-methyltransferase genotype appear to be at increased risk for an adverse response to amphetamine...
  56. ncbi request reprint Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorder
    Alessandro Bertolino
    Department of Psychiatry and Neurological Sciences, University of Bari, Italy
    Am J Psychiatry 160:483-9. 2003
    ..In addition, they assessed the relationship between N-acetylaspartate levels and working memory deficits...
  57. ncbi request reprint The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    Michael F Egan
    Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
    Cell 112:257-69. 2003
    ..These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF...
  58. pmc Habit and skill learning in schizophrenia: evidence of normal striatal processing with abnormal cortical input
    Thomas W Weickert
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Learn Mem 9:430-42. 2002
    ..The abnormal performance offset between patients with schizophrenia and controls in the absence of learning rate differences suggests that abnormal cortical processing provides altered input to normal striatal circuitry...
  59. ncbi request reprint Probed recall for serial order deficits in short-term memory in schizophrenic patients
    Brita Elvevåg
    Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Room 4S235, MSC 1379, Building 10, Bethesda, MD 20892, USA
    Schizophr Res 59:127-35. 2003
    ..If this is the case, we predicted that the group difference in the terminal positions could be eliminated through the use of a probed recall paradigm...
  60. ncbi request reprint The phonological similarity effect in short-term memory serial recall in schizophrenia
    Brita Elvevåg
    Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Building 10, Room 4S235 MSC 1379, Bethesda, MD 20892, USA
    Psychiatry Res 112:77-81. 2002
    ..e. order) errors with phonologically similar lists of items. We conclude that patients with schizophrenia employ recall strategies for phonologically similar items in short-term memory that are equivalent to those of healthy controls...
  61. ncbi request reprint Intermediate cognitive phenotypes associated with schizophrenia
    Michael F Egan
    Brain Disorders Branch, NIMH, Bethesda, MD, USA
    Methods Mol Med 77:163-97. 2003
  62. ncbi request reprint Preliminary experience with an ampakine (CX516) as a single agent for the treatment of schizophrenia: a case series
    Stefano Marenco
    Intramural Research Program, Clinical Brain Disorders Branch, National Institute of Mental Health, Building 10, Room 4S235, Bethesda, MD 20892, USA
    Schizophr Res 57:221-6. 2002
    ..No clear improvement in psychosis or in cognition was observed over the course of the study. CX516 at the doses tested did not appear to yield dramatic effects as a sole agent, but inference from this study is limited...
  63. ncbi request reprint Lack of false recognition in schizophrenia: a consequence of poor memory?
    Brita Elvevåg
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room 4S235, MSC 1379, Bethesda, MD 20892, USA
    Neuropsychologia 42:546-54. 2004
    ..We conclude that despite poor memory, patients with schizophrenia are not especially susceptible to interference from previous tasks and are not particularly prone to false recollections...
  64. ncbi request reprint Prefrontal broadband noise, working memory, and genetic risk for schizophrenia
    Georg Winterer
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Am J Psychiatry 161:490-500. 2004
    ..In the present study, the authors explored whether this particular physiological abnormality predicts working memory performance and is related to the genetic risk for schizophrenia...
  65. ncbi request reprint Reduced parahippocampal connectivity produces schizophrenia-like memory deficits in simulated neural circuits with reduced parahippocampal connectivity
    Lucia M Talamini
    Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands
    Arch Gen Psychiatry 62:485-93. 2005
    ..Episodic memory impairments are well characterized in schizophrenia, but their neural origin is unclear...
  66. ncbi request reprint The BDNF Val66Met polymorphism has a gender specific influence on planning ability in Parkinson's disease
    Thomas Foltynie
    Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    J Neurol 252:833-8. 2005
    ..We speculate that BDNF may interact with dopaminergic transmission and dopamine receptor stimulation in the frontostriatal circuitry, with subsequent consequences on cognition in Parkinson's disease...
  67. ncbi request reprint Levels of processing effects on recognition memory in patients with schizophrenia
    Brianna M Paul
    Clinical Brain Disorders Branch, National Institute of Mental Health, 10 Center Drive, MSC 1379, Bethesda MD 20892, USA
    Schizophr Res 74:101-10. 2005
    ..It also suggests that strategies that place constraints on the encoding processes used by patients may help improve the efficiency with which they learn and remember information...
  68. ncbi request reprint Identification of tone duration, line length, and letter position: an experimental approach to timing and working memory deficits in schizophrenia
    Brita Elvevåg
    Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Building 10, Rm 4S235, Building 10, MSC 1379, Bethesda, MD 20892, USA
    J Abnorm Psychol 113:509-21. 2004
    ..These findings do not support the notion of a global impairment in absolute identification in schizophrenia. However, the authors suggest that some aspect of temporal information processing is indeed disturbed in schizophrenia...
  69. ncbi request reprint Identification of separable cognitive factors in schizophrenia
    Keith H Nuechterlein
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, USA
    Schizophr Res 72:29-39. 2004
    ..These separable cognitive dimensions also have broader relevance to future research aimed at understanding the nature and structure of core cognitive deficits in schizophrenia...
  70. ncbi request reprint Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications
    Thomas W Weickert
    National Institutes of Health, National Institute of Mental Health, Clinical Brain Disorders Branch, Building 10, Room 4C 101, MSC 1379, Bethesda, MD 20892, USA
    Biol Psychiatry 56:677-82. 2004
    ..The present study tested the effects of several COMT polymorphisms on the cognitive response to antipsychotic medication in patients with schizophrenia...
  71. ncbi request reprint Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria
    Michael F Green
    Neuropsychiatric Institute, Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Biol Psychiatry 56:301-7. 2004
    ..The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia...
  72. pmc Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia
    Michael F Egan
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:12604-9. 2004
    ..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia...
  73. ncbi request reprint Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism
    Thomas Foltynie
    Cambridge Centre for Brain Repair, University of Cambridge, United Kingdom
    Mov Disord 19:885-91. 2004
    ..We suggest that polymorphisms of common genes, which regulate central nervous system dopaminergic transmission, can influence some of the phenotypic manifestations of PD...
  74. ncbi request reprint A meta-analysis and critical review of the effects of conventional neuroleptic treatment on cognition in schizophrenia: opening a closed book
    Aaron L Mishara
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 55:1013-22. 2004
    ..In this meta-analysis, we revisit the question of whether typical agents might have enhancing effects on cognition...
  75. ncbi request reprint The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 3270, Durham, NC 27710, USA
    Schizophr Res 68:283-97. 2004
    ..76) and healthy controls (r=0.90). These psychometric properties make the BACS a promising tool for assessing cognition repeatedly in patients with schizophrenia, especially in clinical trials of cognitive enhancement...
  76. ncbi request reprint Imaging genetic influences in human brain function
    Venkata S Mattay
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institute of Health, Department of Health and Human Services, Building 10, Center Drive, Room 4s 235, Bethesda, MD 20892 1379, USA
    Curr Opin Neurobiol 14:239-47. 2004
    ..The results also show that neuroimaging techniques can elucidate the influence of genes on brain function in relatively small sample populations, sometimes even in the absence of significant differences in behavioral measures...
  77. ncbi request reprint Dopaminergic modulation of cortical function in patients with Parkinson's disease
    Venkata S Mattay
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20982 1379, USA
    Ann Neurol 51:156-64. 2002
    ....
  78. ncbi request reprint Left inferior prefrontal cortex activation during a semantic decision-making task predicts the degree of semantic organization
    Alan Simmons
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, La Jolla, 92093 0603, USA
    Neuroimage 28:30-8. 2005
    ..This finding is consistent with the role of the IPFC in establishing self-generated semantic relationships between stimuli...