Raphaela Goldbach-Mansky

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Diurnal secretion of growth hormone, cortisol, and dehydroepiandrosterone in pre- and perimenopausal women with active rheumatoid arthritis: a pilot case-control study
    Marc R Blackman
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Arthritis Res Ther 9:R73. 2007
  2. doi request reprint IL-1 blockade in autoinflammatory syndromes
    Adriana A Jesus
    Translational Autoinflammatory Disease Section, National Institute of Arthritis, Musculoskeletal and Skin diseases NIAMS, National Institutes of Health, Bethesda, Maryland 20982 email
    Annu Rev Med 65:223-44. 2014
  3. pmc Immunology in clinic review series; focus on autoinflammatory diseases: update on monogenic autoinflammatory diseases: the role of interleukin (IL)-1 and an emerging role for cytokines beyond IL-1
    R Goldbach-Mansky
    Translational Autoinflammatory Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Exp Immunol 167:391-404. 2012
  4. ncbi request reprint New concepts in the treatment of rheumatoid arthritis
    Raphaela Goldbach-Mansky
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Med 54:197-216. 2003
  5. pmc A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 Trap) in patients with familial cold autoinflammatory syndrome
    Raphaela Goldbach-Mansky
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    Arthritis Rheum 58:2432-42. 2008
  6. ncbi request reprint Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition
    Raphaela Goldbach-Mansky
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 355:581-92. 2006
  7. pmc Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial
    Raphaela Goldbach-Mansky
    National Institute of Arthritis and Musculoskeletal and Skin Diseases and Clinical Center, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892 0001, USA
    Ann Intern Med 151:229-40, W49-51. 2009
  8. pmc Autoinflammation: the prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses
    Raphaela Goldbach-Mansky
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 124:1141-9; quiz 1150-1. 2009
  9. pmc Blocking interleukin-1 in rheumatic diseases
    Raphaela Goldbach-Mansky
    National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 1182:111-23. 2009
  10. pmc Current status of understanding the pathogenesis and management of patients with NOMID/CINCA
    Raphaela Goldbach-Mansky
    Translational Autoinflammatory Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health, Building 10, Room 6D 47B, 10 Center Drive, Bethesda, MD 20892, USA
    Curr Rheumatol Rep 13:123-31. 2011

Detail Information

Publications47

  1. pmc Diurnal secretion of growth hormone, cortisol, and dehydroepiandrosterone in pre- and perimenopausal women with active rheumatoid arthritis: a pilot case-control study
    Marc R Blackman
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Arthritis Res Ther 9:R73. 2007
    ..Whether these changes contribute to rheumatoid cachexia remains to be determined. Trial registration number: NCT00034060...
  2. doi request reprint IL-1 blockade in autoinflammatory syndromes
    Adriana A Jesus
    Translational Autoinflammatory Disease Section, National Institute of Arthritis, Musculoskeletal and Skin diseases NIAMS, National Institutes of Health, Bethesda, Maryland 20982 email
    Annu Rev Med 65:223-44. 2014
    ....
  3. pmc Immunology in clinic review series; focus on autoinflammatory diseases: update on monogenic autoinflammatory diseases: the role of interleukin (IL)-1 and an emerging role for cytokines beyond IL-1
    R Goldbach-Mansky
    Translational Autoinflammatory Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Exp Immunol 167:391-404. 2012
    ..OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Allergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases...
  4. ncbi request reprint New concepts in the treatment of rheumatoid arthritis
    Raphaela Goldbach-Mansky
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Med 54:197-216. 2003
    ..We review clinical evidence supporting these therapeutic approaches. Diagnostic and therapeutic challenges are highlighted, and a decision tree to guide treatment in patients with early or established RA is provided...
  5. pmc A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 Trap) in patients with familial cold autoinflammatory syndrome
    Raphaela Goldbach-Mansky
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    Arthritis Rheum 58:2432-42. 2008
    ..This pilot study was conducted to assess the safety and efficacy of rilonacept (IL-1 Trap), a long-acting IL-1 receptor fusion protein, in patients with FCAS...
  6. ncbi request reprint Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition
    Raphaela Goldbach-Mansky
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 355:581-92. 2006
    ..Many patients have mutations in the cold-induced autoinflammatory syndrome 1 (CIAS1) gene, encoding cryopyrin, a protein that regulates inflammation...
  7. pmc Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial
    Raphaela Goldbach-Mansky
    National Institute of Arthritis and Musculoskeletal and Skin Diseases and Clinical Center, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892 0001, USA
    Ann Intern Med 151:229-40, W49-51. 2009
    ..Extracts of the medicinal plant Tripterygium wilfordii Hook F (TwHF) have been used in China for centuries to treat a spectrum of inflammatory diseases...
  8. pmc Autoinflammation: the prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses
    Raphaela Goldbach-Mansky
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 124:1141-9; quiz 1150-1. 2009
    ....
  9. pmc Blocking interleukin-1 in rheumatic diseases
    Raphaela Goldbach-Mansky
    National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 1182:111-23. 2009
    ....
  10. pmc Current status of understanding the pathogenesis and management of patients with NOMID/CINCA
    Raphaela Goldbach-Mansky
    Translational Autoinflammatory Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health, Building 10, Room 6D 47B, 10 Center Drive, Bethesda, MD 20892, USA
    Curr Rheumatol Rep 13:123-31. 2011
    ....
  11. ncbi request reprint The evaluation of bone damage in rheumatoid arthritis with magnetic resonance imaging
    R Goldbach-Mansky
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Clin Exp Rheumatol 21:S50-3. 2003
    ....
  12. pmc An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist
    Ivona Aksentijevich
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    N Engl J Med 360:2426-37. 2009
    ..We report a disorder caused by mutations of IL1RN, which encodes the interleukin-1-receptor antagonist, with prominent involvement of skin and bone...
  13. ncbi request reprint The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model
    Ivona Aksentijevich
    Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892 1820, USA
    Arthritis Rheum 56:1273-85. 2007
    ..This study was undertaken to investigate the structural effect of disease-causing mutations on cryopyrin, in order to gain better understanding of the impact of disease-associated mutations on protein function...
  14. doi request reprint Microarray-based gene expression profiling in patients with cryopyrin-associated periodic syndromes defines a disease-related signature and IL-1-responsive transcripts
    James E Balow
    Inflammatory Disease Section, National Human Genome Research Institute NHGRI, Bethesda, Maryland 20892 1820, USA
    Ann Rheum Dis 72:1064-70. 2013
    ..The molecular consequences of interleukin 1 inhibition were examined by comparing gene expression patterns in 16 CAPS patients before and after treatment with anakinra...
  15. doi request reprint The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
    Geun Shik Lee
    Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 492:123-7. 2012
    ..Taken together, these findings indicate that Ca(2+) and cAMP are two key molecular regulators of the NLRP3 inflammasome that have critical roles in the molecular pathogenesis of CAPS...
  16. pmc The spectrum of monogenic autoinflammatory syndromes: understanding disease mechanisms and use of targeted therapies
    Rachel L Glaser
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health Building 10, Room 6N 216A, 10 Center Drive, Bethesda, MD 20892, USA
    Curr Allergy Asthma Rep 8:288-98. 2008
    ....
  17. doi request reprint The spectrum of autoinflammatory diseases: recent bench to bedside observations
    John G Ryan
    Genetics and Genomics Branch, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Opin Rheumatol 20:66-75. 2008
    ..This article focuses on recent progress in our understanding of autoinflammatory syndromes, and how insights into these conditions have triggered the exploration of the role of innate immunity in common rheumatologic diseases...
  18. doi request reprint A173: Cerebrospinal Fluid Cytokines Correlate With Innate Immune Cells in Neonatal Onset Multisystem Inflammatory Disease (NOMID) Patients in Clinical Remission Treated With Anakinra
    Jackeline Rodriguez-Smith
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD
    Arthritis Rheumatol 66:S226. 2014
    ..Our objective is to examine whether CSF cytokines, particularly IL-6 and IP-10, correlate with CSF subpopulations of immune cells and CSF characteristics...
  19. pmc Sustained response and prevention of damage progression in patients with neonatal-onset multisystem inflammatory disease treated with anakinra: a cohort study to determine three- and five-year outcomes
    Cailin H Sibley
    Translational Autoinflammatory Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland
    Arthritis Rheum 64:2375-86. 2012
    ..However, the impact of long-term treatment has not been established. This study was undertaken to evaluate the long-term effect of anakinra on clinical and laboratory outcomes and safety in patients with NOMID...
  20. pmc Mutations in proteasome subunit β type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity
    Yin Liu
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    Arthritis Rheum 64:895-907. 2012
    ..We undertook this study to investigate the clinical phenotype, genetic cause, and immune dysregulation in 9 CANDLE syndrome patients...
  21. pmc Autoinflammatory disease reloaded: a clinical perspective
    Daniel L Kastner
    Laboratory of Clinical Investigation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 140:784-90. 2010
    ..Recent advances offer new opportunities for therapeutic intervention and suggest that the definition of what constitutes an autoinflammatory disease should be reassessed...
  22. ncbi request reprint A recurrent rash with fever and arthropathy
    Sharon E Jacob
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 1908, USA
    J Am Acad Dermatol 54:318-21. 2006
  23. pmc TNF downmodulates the function of human CD4+CD25hi T-regulatory cells
    Xavier Valencia
    Autoimmunity Branch, the Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of Health NIAMS NIH, Bethesda, MD 20892, USA
    Blood 108:253-61. 2006
    ..Thus, TNF has a novel action in modulating autoimmunity, by inhibiting CD4+CD25+ Treg activity...
  24. pmc Monogenic IL-1 mediated autoinflammatory and immunodeficiency syndromes: finding the right balance in response to danger signals
    Cailin Henderson
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Translational Autoinflammatory Disease Section, USA
    Clin Immunol 135:210-22. 2010
    ..The biologically active receptor for IL-1, shares signaling pathways with some pathogen recognition receptors, the Toll-like receptors (TLRs) which early on suggested an important role in innate immune function...
  25. ncbi request reprint De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases
    Ivona Aksentijevich
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 46:3340-8. 2002
    ....
  26. ncbi request reprint Arthropathy of neonatal onset multisystem inflammatory disease (NOMID/CINCA)
    Suvimol Chirathivat Hill
    Diagnostic Radiology, Warren G Magnuson Clinical Center, National Institutes of Health, 10 Center Drive, Rm N242, Bethesda, MD 20892, USA
    Pediatr Radiol 37:145-52. 2007
    ..Approximately 60% of NOMID patients have prominent arthropathy, most commonly involving the knees, the cause of which remains poorly understood...
  27. pmc Monogenic autoinflammatory diseases: disorders of amplified danger sensing and cytokine dysregulation
    Gina A Montealegre Sanchez
    Translational Autoinflammatory Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIAMS, National Institutes of Health NIH, Building 10, Room 6D47 B, 10 Center Drive, Bethesda, MD 20892, USA
    Rheum Dis Clin North Am 39:701-34. 2013
    ..The study of the pathogenesis of sterile inflammation in patients with autoinflammatory syndromes continues to uncover novel inflammatory pathways. ..
  28. doi request reprint A80: Skeletal Features of Neonatal-Onset Multisystem Inflammatory Disease (NOMID) on Anakinra Treatment: Long-Term Follow-up
    Hanna Kim
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD
    Arthritis Rheumatol 66:S113. 2014
    ..While blocking IL-1 with anakinra reduces organ-specific (central nervous system, inner ear, eye) and systemic inflammation (fever, rash, acute phase reactants), it has little effect on preexisting bone lesions...
  29. pmc Comprehensive immunophenotyping of cerebrospinal fluid cells in patients with neuroimmunological diseases
    Sungpil Han
    Neuroimmunological Diseases Unit, Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892
    J Immunol 192:2551-63. 2014
    ....
  30. ncbi request reprint Pilot clinical trial of intravenous doxycycline versus placebo for rheumatoid arthritis
    Stanley Pillemer
    National Institute of Dental and Craniofacial Research, Bethesda, Maryland 20892, USA
    J Rheumatol 30:41-3. 2003
    ..To screen for potential efficacy and assess the feasibility of intravenous (IV) doxycycline as a treatment for rheumatoid arthritis (RA)...
  31. pmc The anesthetic management of children with neonatal-onset multi-system inflammatory disease
    Christine F Lauro
    Department of Anesthesia and Surgical Services, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD 20892 1512, USA
    Anesth Analg 105:351-7. 2007
    ..As little is known about the anesthetic considerations of the disease, we sought to identify the main features and respective anesthetic and perioperative implications of NOMID...
  32. ncbi request reprint Periarticular bone findings in rheumatoid arthritis: T2-weighted versus contrast-enhanced T1-weighted MRI
    Lawrence Yao
    Diagnostic Radiology Department, National Institutes of Health, 10 Center Drive, Room 1C640, Bethesda, MD 20892 1182, USA
    AJR Am J Roentgenol 187:358-63. 2006
    ..Because it is known that MRI depicts abnormalities in the periarticular bone of patients with rheumatoid arthritis, we wanted to compare the outcomes of T2-weighted versus contrast-enhanced T1-weighted MRI techniques...
  33. pmc Monogenic autoinflammatory diseases: new insights into clinical aspects and pathogenesis
    Cailin Henderson
    Translational Autoinflammatory Disease Section, MSC 1560, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Curr Opin Rheumatol 22:567-78. 2010
    ..This article summarizes recent progress in the clinical aspects and understanding of the pathogenesis of this growing spectrum of diseases...
  34. doi request reprint National Institutes of Health Center for Human Immunology Conference, September 2009
    Robert B Nussenblatt
    Laboratory of Immunology, National Eye Institute, Maryland 20892, USA
    Ann N Y Acad Sci 1200:E1-23. 2010
    ..The human immunology meeting was held in the Clinical Center of the National Institutes of Health, Bethesda, Maryland, on September 3 and 4, 2009...
  35. pmc Deficiency of interleukin-1 receptor antagonist responsive to anakinra
    Charlotte Schnellbacher
    Division of Pediatrics, Miami Children s Hospital, Miami, FloridaDivision of Dermatology, Miami Children s Hospital, Miami, FloridaDivision of Dermatology, Columbia Hospital Nova Southeastern University, West Palm Beach, FloridaNational Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MarylandDivision of Rheumatology, Miami Children s Hospital, Miami, Florida
    Pediatr Dermatol 30:758-60. 2013
    ..Skin findings promptly improved upon initiation of treatment with anakinra (recombinant human IL-1 receptor antagonist), and the bony lesions and systemic inflammation resolved with continued therapy. ..
  36. pmc Monogenic autoinflammatory diseases: concept and clinical manifestations
    Adriana Almeida de Jesus
    Translational Autoinflammatory Diseases Section, National Institute of Arthritis, Musculoskeletal and Skin diseases NIAMS, National Institutes of Health NIH, Bethesda, MD 20814, USA
    Clin Immunol 147:155-74. 2013
    ..inflammatory disorders caused by mutations in proteasome components, the proteasome associated autoinflammatory syndromes (PRAAS) and 6. very rare conditions presenting with autoinflammation and immunodeficiency...
  37. pmc Homeostatic tissue responses in skin biopsies from NOMID patients with constitutive overproduction of IL-1β
    Pamela Aubert
    Translational Autoinflammatory Disease Section NIAMS NIH, Bethesda, MD, USA
    PLoS ONE 7:e49408. 2012
    ..Overall, the dysregulated genes and pathways suggest extensive "adaptive" mechanisms to control inflammation and maintain tissue homeostasis, likely triggered by chronic IL-1 release in the skin of patients with NOMID...
  38. pmc Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors
    Madson Q Almeida
    PDEGEN, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 20:165-75. 2011
    ....
  39. pmc Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is a disorder of innate immunity and Th1 activation responsive to IL-1 blockade
    Silvia Stojanov
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:7148-53. 2011
    ..IL-1 inhibition may thus be beneficial for treatment of PFAPA attacks, with IP-10/CXCL10 serving as a potential biomarker...
  40. pmc Anaphylactic reaction to anakinra in a rheumatoid arthritis patient intolerant to multiple nonbiologic and biologic disease-modifying antirheumatic drugs
    Ditina Desai
    Care Improvement Plus of Maryland, Inc, XLHealth Corporation, The Warehouse at Camden Yards, Baltimore, MD, USA
    Ann Pharmacother 43:967-72. 2009
    ..To report a case of probable anaphylaxis due to anakinra in a patient with rheumatoid arthritis and multiple drug allergies...
  41. pmc Novel anti-filamin-A antibody detects a secreted variant of filamin-A in plasma from patients with breast carcinoma and high-grade astrocytoma
    Ozge Alper
    Alper Biotech, LLC, Rockville, Maryland, USA
    Cancer Sci 100:1748-56. 2009
    ..Additional novel cancer biomarkers have been identified and are being developed alongside Alper-p280 for use in diagnosis of breast carcinoma and high-grade astrocytoma, and for use in the evaluation of therapeutic responses...
  42. ncbi request reprint Mutational analysis in neonatal-onset multisystem inflammatory disease: comment on the articles by Frenkel et al and Saito et al
    Ivona Aksentijevich
    Arthritis Rheum 54:2703-4; author reply 2704-5. 2006
  43. ncbi request reprint Use of biologics in rheumatoid arthritis: where are we going?
    Frank Pucino
    Howard University College of Pharmacy, Washington, DC 20059, USA
    Am J Health Syst Pharm 63:S19-41. 2006
    ..Biologic therapies that are currently under investigation in early- and late-phase clinical trials are summarized at the end of this report...
  44. ncbi request reprint Treatment of patients with neonatal-onset multisystem inflammatory disease/chronic infantile neurologic, cutaneous, articular syndrome: comment on the article by Matsubara et al
    Raphaela Goldbach-Mansky
    Arthritis Rheum 56:2099-101; author reply 2101-2. 2007
  45. ncbi request reprint Magnetic resonance imaging in the evaluation of bone damage in rheumatoid arthritis: a more precise image or just a more expensive one?
    Raphaela Goldbach-Mansky
    Arthritis Rheum 48:585-9. 2003
  46. ncbi request reprint Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders
    Isao Matsumoto
    Joslin Diabetes Center and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Arthritis Rheum 48:944-54. 2003
    ..We evaluated the generality of these observations in cohorts of patients with 12 different arthritic and chronic autoimmune diseases and in population-matched healthy control subjects...
  47. ncbi request reprint Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing
    David K Rhee
    Department of Genetics and Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Biol Chem 280:31325-32. 2005
    ..This suggests that formation of an intrachain disulfide bond is required for SPC-mediated cleavage and that SPC-mediated cleavage is essential to protein function...