Nitin Gogtay

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness
    Nitin Gogtay
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 48:852-62. 2007
  2. ncbi request reprint Dynamic mapping of normal human hippocampal development
    Nitin Gogtay
    Child Psychiatry Branch, NIMH, Bethesda, Maryland 20892, USA
    Hippocampus 16:664-72. 2006
  3. pmc Remission status and cortical thickness in childhood-onset schizophrenia
    Deanna K Greenstein
    Child Psychiatry Branch, National Institute of Mental Health National Institutes of Health, Bethesda, MD 20892 1600, USA
    J Am Acad Child Adolesc Psychiatry 47:1133-40. 2008
  4. pmc Risk factors for neutropenia in clozapine-treated children and adolescents with childhood-onset schizophrenia
    Kristin N Maher
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 23:110-6. 2013
  5. ncbi request reprint Cortical brain development in nonpsychotic siblings of patients with childhood-onset schizophrenia
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bldg 10, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:772-80. 2007
  6. ncbi request reprint Childhood-onset schizophrenia: A double-blind, randomized clozapine-olanzapine comparison
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1500, USA
    Arch Gen Psychiatry 63:721-30. 2006
  7. pmc General absence of abnormal cortical asymmetry in childhood-onset schizophrenia: a longitudinal study
    Jennifer L Bakalar
    Child Psychiatry Branch, NIMH, NIH, Rm 3N202, Bethesda, MD 20892 1600, USA
    Schizophr Res 115:12-6. 2009
  8. ncbi request reprint Dynamic mapping of hippocampal development in childhood onset schizophrenia
    Tom F Nugent
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Schizophr Res 90:62-70. 2007
  9. ncbi request reprint Childhood onset schizophrenia: cortical brain abnormalities as young adults
    Deanna Greenstein
    Child Psychiatry Branch, NIMH NIH, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 47:1003-12. 2006
  10. pmc Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls
    Armin Raznahan
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MA 20892, USA
    Neuroimage 57:1517-23. 2011

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness
    Nitin Gogtay
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 48:852-62. 2007
    ..We report the first prospective study of cortical brain development in pediatric bipolar illness for 9 male children, visualized before and after illness onset...
  2. ncbi request reprint Dynamic mapping of normal human hippocampal development
    Nitin Gogtay
    Child Psychiatry Branch, NIMH, Bethesda, Maryland 20892, USA
    Hippocampus 16:664-72. 2006
    ..These distinct developmental trajectories of hippocampal subregions may parallel differences in their functional development...
  3. pmc Remission status and cortical thickness in childhood-onset schizophrenia
    Deanna K Greenstein
    Child Psychiatry Branch, National Institute of Mental Health National Institutes of Health, Bethesda, MD 20892 1600, USA
    J Am Acad Child Adolesc Psychiatry 47:1133-40. 2008
    ..We hypothesized that total, frontal, temporal, and parietal gray matter thickness would be greater in patients who subsequently remit...
  4. pmc Risk factors for neutropenia in clozapine-treated children and adolescents with childhood-onset schizophrenia
    Kristin N Maher
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 23:110-6. 2013
    ..The purpose of this study was to retrospectively analyze rates of neutropenia and risk factors for neutropenia in hospitalized children and adolescents treated with clozapine...
  5. ncbi request reprint Cortical brain development in nonpsychotic siblings of patients with childhood-onset schizophrenia
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bldg 10, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:772-80. 2007
    ..Nonpsychotic siblings of COS probands could help evaluate whether the cortical GM abnormalities are familial/trait markers...
  6. ncbi request reprint Childhood-onset schizophrenia: A double-blind, randomized clozapine-olanzapine comparison
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1500, USA
    Arch Gen Psychiatry 63:721-30. 2006
    ..The psychiatrist has a limited evidence base to guide treatment, particularly as there are no trials in children comparing atypical antipsychotics, the mainstay of current treatment...
  7. pmc General absence of abnormal cortical asymmetry in childhood-onset schizophrenia: a longitudinal study
    Jennifer L Bakalar
    Child Psychiatry Branch, NIMH, NIH, Rm 3N202, Bethesda, MD 20892 1600, USA
    Schizophr Res 115:12-6. 2009
    ..Recent studies show dynamic changes in brain asymmetry during childhood and adolescence. We hypothesized that COS patients would show a lack of normal development of asymmetry and decreased overall asymmetry...
  8. ncbi request reprint Dynamic mapping of hippocampal development in childhood onset schizophrenia
    Tom F Nugent
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Schizophr Res 90:62-70. 2007
    ....
  9. ncbi request reprint Childhood onset schizophrenia: cortical brain abnormalities as young adults
    Deanna Greenstein
    Child Psychiatry Branch, NIMH NIH, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 47:1003-12. 2006
    ....
  10. pmc Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls
    Armin Raznahan
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MA 20892, USA
    Neuroimage 57:1517-23. 2011
    ..These findings suggest that cortical abnormalities in pedigrees affected by schizophrenia may be contributed to by a disruption of dopaminergic infleunces on cortical maturation...
  11. ncbi request reprint Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychoses
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health NIH, Building 10, Room 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892 1600, USA
    Arch Gen Psychiatry 61:17-22. 2004
    ..We hypothesized that cortical GM loss would occur in patients with COS but not in adolescents with atypical psychoses...
  12. doi request reprint Delayed white matter growth trajectory in young nonpsychotic siblings of patients with childhood-onset schizophrenia
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
    Arch Gen Psychiatry 69:875-84. 2012
    ..As reported before for gray matter, WM growth may also be an age-specific endophenotype that shows compensatory normalization with age...
  13. pmc Effects of clozapine and olanzapine on cortical thickness in childhood-onset schizophrenia
    Anand Mattai
    Child Psychiatry Branch, NIMH, NIH, Bethesda, MD, 20892 1600, United States
    Schizophr Res 116:44-8. 2010
    ..Although clozapine remains the most effective antipsychotic medication in treatment-refractory cases, it is unknown whether it has a differential effect on GM development...
  14. pmc Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patients
    Anand Mattai
    Child Psychiatry Branch, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Psychiatry 168:427-35. 2011
    ..In the present study, the authors examined hippocampal volumes in relation to age for patients with childhood-onset schizophrenia, their nonpsychotic healthy siblings, and healthy comparison subjects...
  15. ncbi request reprint Lack of evidence for elevated obstetric complications in childhood onset schizophrenia
    Anna E Ordoñez
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 58:10-5. 2005
    ..We hypothesized that by extrapolation, patients with childhood-onset schizophrenia (COS), with very early onset and very severe illness, would have had more numerous or more salient OC compared with their healthy siblings...
  16. ncbi request reprint Pervasive developmental disorder and childhood-onset schizophrenia: comorbid disorder or a phenotypic variant of a very early onset illness?
    Alexandra L Sporn
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 55:989-94. 2004
    ..In this study, we compared evidence for premorbid PDD as a nonspecific manifestation of impaired neurodevelopment seen in schizophrenia, or as an independent risk factor for COS...
  17. pmc Cerebellar development in childhood onset schizophrenia and non-psychotic siblings
    Deanna Greenstein
    Child Psychiatry Branch, NIMH NIH, Bethesda, MD, USA
    Psychiatry Res 193:131-7. 2011
    ..Sibling trajectories may represent a trait marker, although the effect size for volumetric differences in early adulthood may be small...
  18. pmc Adjunctive use of lithium carbonate for the management of neutropenia in clozapine-treated children
    Anand Mattai
    Child Psychiatry Branch, NIMH, NIH, MD 20892 1600, USA
    Hum Psychopharmacol 24:584-9. 2009
    ..In children, the rate of neutropenia is higher when compared to adults. We decided to explore the use of lithium to manage neutropenia in childhood-onset schizophrenia (COS) through a systematic audit of COS cases...
  19. ncbi request reprint Multidimensionally impaired: the good news
    Catherine Stayer
    Child Psychiatry Branch at the National Institute of Mental Health, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 15:510-9. 2005
    ..Despite severe preadmission morbidity, some patients have successfully remained neuroleptic-free since discharge. Predictors of good versus poor outcome were sought...
  20. pmc How does your cortex grow?
    Armin Raznahan
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:7174-7. 2011
    ..Knowing of these developmental dissociations, and further specifying their timing and sex-biases, provides potent new research targets for basic and clinical neuroscience...
  21. ncbi request reprint Sleep disturbances in childhood-onset schizophrenia
    Anand A Mattai
    Child Psychiatry Branch, IRP, National Institute of Mental Health, NIH, Bethesda, MD 20892 1600, USA
    Schizophr Res 86:123-9. 2006
    ..As there are numerous health implications of poor sleep, clinicians should have a low threshold for treating sleep disturbances in this population...
  22. ncbi request reprint Looking for childhood schizophrenia: case series of false positives
    Catherine Stayer
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892 1600, USA
    J Am Acad Child Adolesc Psychiatry 43:1026-9. 2004
    ..16). These cases illustrate that transient psychotic illnesses can be misdiagnosed as childhood-onset schizophrenia. Proper identification can prevent years of inappropriate therapies...
  23. pmc Lack of gender influence on cortical and subcortical gray matter development in childhood-onset schizophrenia
    Brian Weisinger
    Child Psychiatry Branch, National Institutes of Mental Health, 10 3N202, 10 Center Drive, Bethesda, MD, USA
    Schizophr Bull 39:52-8. 2013
    ..The effect of sex on brain development in schizophrenia is poorly understood and studies to date have produced inconsistent results...
  24. pmc Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia
    Anand A Mattai
    Child Psychiatry Branch, National Institute of Mental Health NIH, 10 Center Drive, Bethesda, MD 20892, USA
    J Am Acad Child Adolesc Psychiatry 50:697-704. 2011
    ..Here we present a replication with nonoverlapping groups of healthy full siblings and healthy controls...
  25. pmc Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia
    Anand Mattai
    Child Psychiatry Branch, National Institutes of Health, Bethesda, Maryland 20892, USA
    Brain Stimul 4:275-80. 2011
    ..In recent years, transcranial direct current stimulation (tDCS) has been used to study and treat many neuropsychiatric conditions. However, information regarding its tolerability in the pediatric population is lacking...
  26. ncbi request reprint Childhood onset schizophrenia: familial neurocognitive measures
    Peter A Gochman
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room 3N202, Bethesda, MD 20892 1600, USA
    Schizophr Res 71:43-7. 2004
    ..Neurocognitive deficits which are seen in families of adult onset schizophrenic patients were examined in healthy family members of patients with childhood-onset schizophrenia (COS)...
  27. ncbi request reprint Childhood-onset schizophrenia: smooth pursuit eye-tracking dysfunction in family members
    Alexandra Sporn
    Child Psychiatry Branch, National Institute of Mental Health, National Institute of Health, Bldg 10, Rm 3N202, Bethesda, MD 20892, USA
    Schizophr Res 73:243-52. 2005
    ..Childhood-onset schizophrenia (COS), a severe form of the disorder, is of interest for etiologic studies. Smooth pursuit eye-tracking dysfunction (ETD) is a biological marker for schizophrenia...
  28. ncbi request reprint Clozapine treatment of childhood-onset schizophrenia: evaluation of effectiveness, adverse effects, and long-term outcome
    Alexandra L Sporn
    Child Psychiatry Branch, NIMH, Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 46:1349-56. 2007
    ..Here we evaluate these as well as other measures in an effort to find predictors of response to clozapine in our early-onset treatment-refractory population...
  29. ncbi request reprint Hormonal correlates of clozapine-induced weight gain in psychotic children: an exploratory study
    Alexandra L Sporn
    Child Psychiatry Branch, NIMH, NIH, Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 44:925-33. 2005
    ..In this study, the authors examined six weight gain-related hormones in patients with childhood-onset schizophrenia (COS) after 6 weeks of clozapine treatment...
  30. doi request reprint Childhood onset schizophrenia: support for a progressive neurodevelopmental disorder
    Judith L Rapoport
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Int J Dev Neurosci 29:251-8. 2011
    ....
  31. ncbi request reprint Stimulant drug treatment in childhood-onset schizophrenia with comorbid ADHD: an open-label case series
    Julia W Tossell
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Room 3N202, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 14:448-54. 2004
    ..Our results suggest that ADHD comorbid with COS may be safely treated with a stimulant, once the psychosis is stabilized. A systematic investigation of this question may be warranted...
  32. doi request reprint Neurodevelopmental trajectories of the human cerebral cortex
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:3586-94. 2008
    ....
  33. pmc Trajectories of anatomic brain development as a phenotype
    Jay N Giedd
    Brain Imaging Unit, Child Psychiatry Branch NIMH, 10 Center Drive, MSC 1367 Bethesda, MD 20892, USA
    Novartis Found Symp 289:101-12; discussion 112-8, 193-5. 2008
    ....
  34. pmc Absence of anatomic corpus callosal abnormalities in childhood-onset schizophrenia patients and healthy siblings
    Sarah L M Johnson
    Child Psychiatry Branch, National Institute of Mental Health, 10 3N202, 10 Center Drive, Bethesda, MD 20892, USA
    Psychiatry Res 211:11-6. 2013
    ..These results suggest that CC development, at least at a macroscopic level, may not be a salient feature of schizophrenia...
  35. pmc Psychotic symptoms and gray matter deficits in clinical pediatric populations
    Nitin Gogtay
    Child Psychiatry Branch, National Institutes of Health, Building 10, Center Dr, Bethesda, MD 20892, USA
    Schizophr Res 140:149-54. 2012
    ..We explored the relationship of cortical GM thickness to psychotic phenotypes in children...
  36. pmc Dynamic mapping of human cortical development during childhood through early adulthood
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:8174-9. 2004
    ..Direct comparison with normal cortical development may help understanding of some neurodevelopmental disorders such as childhood-onset schizophrenia or autism...
  37. pmc Autism spectrum disorders and childhood-onset schizophrenia: clinical and biological contributions to a relation revisited
    Judith Rapoport
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Am Acad Child Adolesc Psychiatry 48:10-8. 2009
    ..To highlight emerging evidence for clinical and biological links between autism/pervasive developmental disorder (PDD) and schizophrenia, with particular attention to childhood-onset schizophrenia (COS)...
  38. pmc Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometry
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:15979-84. 2008
    ..Growth rates were correlated with functional prognosis and were visualized as detailed 3D maps. Finally, these findings also confirm that the progressive GM deficits seen in schizophrenia are not the result of WM overgrowth...
  39. pmc Sexual dimorphism of brain developmental trajectories during childhood and adolescence
    Rhoshel K Lenroot
    Child Psychiatry Branch of the National Institute of Mental Health, NIMH CHP 10 Center Drive, Bethesda, MD 20814 9692, USA
    Neuroimage 36:1065-73. 2007
    ..These sexually dimorphic trajectories confirm the importance of longitudinal data in studies of brain development and underline the need to consider sex matching in studies of brain development...
  40. pmc Longitudinally mapping the influence of sex and androgen signaling on the dynamics of human cortical maturation in adolescence
    Armin Raznahan
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:16988-93. 2010
    ....
  41. ncbi request reprint Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified
    Anjene M Addington
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1600, USA
    Biol Psychiatry 55:976-80. 2004
    ..Childhood-onset schizophrenia (COS), defined as onset of psychotic symptoms by age 12 years, is a rare and severe form of the disorder that seems to be clinically and neurobiologically continuous with the adult disorder...
  42. pmc Childhood onset schizophrenia: high rate of visual hallucinations
    Christopher N David
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1600, USA
    J Am Acad Child Adolesc Psychiatry 50:681-686.e3. 2011
    ..To document high rates and clinical correlates of nonauditory hallucinations in childhood onset schizophrenia (COS)...
  43. pmc Microduplications disrupting the MYT1L gene (2p25.3) are associated with schizophrenia
    Yohan Lee
    Child Psychiatry Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Psychiatr Genet 22:206-9. 2012
    ..14%, odds ratio=16.6, P=0.01). This report adds to the growing body of literature implicating rare CNVs as risk factors for schizophrenia and shows that some risk CNVs are more common among extreme early-onset cases...
  44. ncbi request reprint Progressive brain volume loss during adolescence in childhood-onset schizophrenia
    Alexandra L Sporn
    Child Psychiatry Branch, NIMH, Bldg 10, Rm 3N202, Bethesda, MD 20892, USA
    Am J Psychiatry 160:2181-9. 2003
    ..This study examined the rate of loss in cortical gray matter volume in relation to age and clinical status in adolescent patients over a follow-up period of 2-6 years...
  45. ncbi request reprint Clozapine-induced neutropenia in children: management with lithium carbonate
    Alexandra Sporn
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Child Adolesc Psychopharmacol 13:401-4. 2003
    ..8-1.1 microg/mL. This report supports the use of adjunct lithium for clozapine-induced neutropenia as a safe and successful strategy in children...
  46. ncbi request reprint IQ stabilization in childhood-onset schizophrenia
    Peter A Gochman
    Child Psychiatry Branch, NIMH Bldg 10, Rm 3N202 Bethesda, MD 20892 1600, USA
    Schizophr Res 77:271-7. 2005
    ..To examine the long term IQ trajectory for childhood-onset schizophrenia (COS) in an expanded, prospective longitudinal study...
  47. doi request reprint Hippocampal shape abnormalities of patients with childhood-onset schizophrenia and their unaffected siblings
    Sarah L M Johnson
    Child Psychiatry Branch of the National Institute of Mental Health, Bethesda, MD 20892, USA
    J Am Acad Child Adolesc Psychiatry 52:527-536.e2. 2013
    ..The authors explored the nature and developmental trajectory of subregional shape abnormalities of the hippocampus in patients with childhood-onset schizophrenia (COS), their healthy siblings, and healthy volunteers...
  48. pmc Cortical brain development in schizophrenia: insights from neuroimaging studies in childhood-onset schizophrenia
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Schizophr Bull 34:30-6. 2008
    ..Furthermore, the cortical GM loss is also shared by healthy full siblings of COS probands suggesting a genetic influence on the abnormal brain development...
  49. pmc Age of onset of schizophrenia: perspectives from structural neuroimaging studies
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD, USA
    Schizophr Bull 37:504-13. 2011
    ..The importance of examining trajectories of development and the need for future combined approaches, using multimodal imaging together with molecular studies is discussed...
  50. ncbi request reprint Brain neuroplasticity in healthy, hyperactive and psychotic children: insights from neuroimaging
    Judith L Rapoport
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 33:181-97. 2008
    ....
  51. doi request reprint Childhood psychiatric disorders as anomalies in neurodevelopmental trajectories
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Hum Brain Mapp 31:917-25. 2010
    ..Again taking ADHD as an example, we found that remission is associated with convergence to the template of typical development, whereas persistence is accompanied by progressive divergence away from typical trajectories...
  52. pmc Mapping gray matter development: implications for typical development and vulnerability to psychopathology
    Nitin Gogtay
    Child Psychiatry Branch, NIMH, NIH, Building 10, Rm 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892, USA
    Brain Cogn 72:6-15. 2010
    ..These time-lapse maps have also been used to study effects of genotype and medication on cortical maturation, presenting a powerful framework to study factors that influence the developing brain...
  53. ncbi request reprint Clozapine use in children and adolescents
    Nitin Gogtay
    Montreal Neurological Institute, Canada
    Expert Opin Pharmacother 9:459-65. 2008
    ..Although the role of clozapine is well established for treatment-resistant schizophrenia, it is rarely used in pediatric populations, mainly due to its potentially serious adverse effects...
  54. pmc Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls
    Deanna Greenstein
    Child Psychiatry Branch, National Institutes of Health, National Institute of Mental Health, Bethesda MD, USA
    Front Psychiatry 3:53. 2012
    ....
  55. ncbi request reprint Structural brain MRI abnormalities in healthy siblings of patients with childhood-onset schizophrenia
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, NationalInstitutes of Health, Bethesda, MD 20892 1600, USA
    Am J Psychiatry 160:569-71. 2003
    ....
  56. doi request reprint Treatments in context: transcranial direct current brain stimulation as a potential treatment in pediatric psychosis
    Christopher N David
    Child Psychiatry Branch, National Institute of Mental Health NIMH, National Institutes of Health NIH, Building 10, Room 3N202, 10 Center Drive, Bethesda, MD 20890, USA
    Expert Rev Neurother 13:447-58. 2013
    ..Transcranial direct current stimulation may provide a safe and effective adjuvant treatment for continued residual symptoms of schizophrenia...
  57. ncbi request reprint Clozapine-induced akathisia in children with schizophrenia
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Child Adolesc Psychopharmacol 12:347-9. 2002
    ..Two cases of childhood-onset schizophrenia associated with clozapine-induced akathisia responsive to beta-blocker treatment are described. Akathisia should be considered in all cases of apparent nonresponse to atypical antipsychotics...
  58. pmc Childhood onset schizophrenia and early onset schizophrenia spectrum disorders
    David I Driver
    Child Psychiatry Branch, National Institutes of Mental Health NIMH, National Institutes Health NIH, Building 10, Room 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892 1600, USA
    Child Adolesc Psychiatr Clin N Am 22:539-55. 2013
    ..Once a diagnosis is affirmed, aggressive medication treatment combined with family education and individual counseling may defer further deterioration. ..
  59. pmc Treatment of early onset schizophrenia: recent trends, challenges and future considerations
    Nora S Vyas
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health Bethesda, MD, USA
    Front Psychiatry 3:29. 2012
    ..Indeed, early detection, identification of relevant biomarkers, coupled with advancing knowledge of the neurochemical and neuroanatomic pathways may help design informed and novel treatment strategies...
  60. pmc The discovery of population differences in network community structure: new methods and applications to brain functional networks in schizophrenia
    Aaron Alexander-Bloch
    Behavioural and Clinical Neuroscience Institute, Department of Psychiatry, University of Cambridge, Cambridge, UK
    Neuroimage 59:3889-900. 2012
    ..The methods that we propose are broadly applicable to other experimental contexts, both in neuroimaging and other areas of network science...
  61. ncbi request reprint Brain development in healthy, hyperactive, and psychotic children
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health NIH, Bldg 10, Room 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892 1600, USA
    Arch Neurol 59:1244-8. 2002
  62. ncbi request reprint Mapping cortical change in Alzheimer's disease, brain development, and schizophrenia
    Paul M Thompson
    Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
    Neuroimage 23:S2-18. 2004
    ..Dynamically spreading waves of gray matter loss are tracked in dementia and schizophrenia, and these sequences are related to normally occurring changes in healthy subjects of various ages...
  63. ncbi request reprint Dynamically spreading frontal and cingulate deficits mapped in adolescents with schizophrenia
    Christine N Vidal
    Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, David Geffen School of Medicine at UCLA, 90095 1769, USA
    Arch Gen Psychiatry 63:25-34. 2006
    ....
  64. pmc Longitudinal brain changes in early-onset psychosis
    Celso Arango
    Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Schizophr Bull 34:341-53. 2008
    ..The association of risk genes involved in circuitries associated with schizophrenia and their relationship to developmental trajectories is another promising area of future research...
  65. ncbi request reprint Structural MRI and brain development
    Paul M Thompson
    Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1769, USA
    Int Rev Neurobiol 67:285-323. 2005
  66. doi request reprint Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia
    Tom Walsh
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Science 320:539-43. 2008
    ..These results suggest that multiple, individually rare mutations altering genes in neurodevelopmental pathways contribute to schizophrenia...