Research Topics
Species | Nitin GogtaySummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychosesNitin Gogtay
Child Psychiatry Branch, National Institute of Mental Health NIH, Building 10, Room 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892 1600, USA
Arch Gen Psychiatry 61:17-22. 2004..We hypothesized that cortical GM loss would occur in patients with COS but not in adolescents with atypical psychoses...- Structural brain MRI abnormalities in healthy siblings of patients with childhood-onset schizophreniaNitin Gogtay
Child Psychiatry Branch, National Institute of Mental Health, NationalInstitutes of Health, Bethesda, MD 20892 1600, USA
Am J Psychiatry 160:569-71. 2003.... 
Dynamic mapping of human cortical development during childhood through early adulthoodNitin Gogtay
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:8174-9. 2004..Direct comparison with normal cortical development may help understanding of some neurodevelopmental disorders such as childhood-onset schizophrenia or autism...- Remission status and cortical thickness in childhood-onset schizophreniaDeanna K Greenstein
Child Psychiatry Branch, National Institute of Mental Health National Institutes of Health, Bethesda, MD 20892 1600, USA
J Am Acad Child Adolesc Psychiatry 47:1133-40. 2008..We hypothesized that total, frontal, temporal, and parietal gray matter thickness would be greater in patients who subsequently remit... - Cortical brain development in nonpsychotic siblings of patients with childhood-onset schizophreniaNitin Gogtay
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bldg 10, Bethesda, MD 20892, USA
Arch Gen Psychiatry 64:772-80. 2007..Nonpsychotic siblings of COS probands could help evaluate whether the cortical GM abnormalities are familial/trait markers... - Childhood onset schizophrenia: cortical brain abnormalities as young adultsDeanna Greenstein
Child Psychiatry Branch, NIMH NIH, Bethesda, MD 20892, USA
J Child Psychol Psychiatry 47:1003-12. 2006.... - General absence of abnormal cortical asymmetry in childhood-onset schizophrenia: a longitudinal studyJennifer L Bakalar
Child Psychiatry Branch, NIMH, NIH, Rm 3N202, Bethesda, MD 20892 1600, USA
Schizophr Res 115:12-6. 2009..Recent studies show dynamic changes in brain asymmetry during childhood and adolescence. We hypothesized that COS patients would show a lack of normal development of asymmetry and decreased overall asymmetry... - Dynamic mapping of hippocampal development in childhood onset schizophreniaTom F Nugent
Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
Schizophr Res 90:62-70. 2007.... - Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controlsArmin Raznahan
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MA 20892, USA
Neuroimage 57:1517-23. 2011..These findings suggest that cortical abnormalities in pedigrees affected by schizophrenia may be contributed to by a disruption of dopaminergic infleunces on cortical maturation... 
Delayed white matter growth trajectory in young nonpsychotic siblings of patients with childhood-onset schizophreniaNitin Gogtay
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Arch Gen Psychiatry 69:875-84. 2012..As reported before for gray matter, WM growth may also be an age-specific endophenotype that shows compensatory normalization with age...- Dynamic mapping of cortical development before and after the onset of pediatric bipolar illnessNitin Gogtay
Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
J Child Psychol Psychiatry 48:852-62. 2007..We report the first prospective study of cortical brain development in pediatric bipolar illness for 9 male children, visualized before and after illness onset... - Effects of clozapine and olanzapine on cortical thickness in childhood-onset schizophreniaAnand Mattai
Child Psychiatry Branch, NIMH, NIH, Bethesda, MD, 20892 1600, United States
Schizophr Res 116:44-8. 2010..Although clozapine remains the most effective antipsychotic medication in treatment-refractory cases, it is unknown whether it has a differential effect on GM development... - Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patientsAnand Mattai
Child Psychiatry Branch, National Institutes of Health, Bethesda, MD 20892, USA
Am J Psychiatry 168:427-35. 2011..In the present study, the authors examined hippocampal volumes in relation to age for patients with childhood-onset schizophrenia, their nonpsychotic healthy siblings, and healthy comparison subjects... - Childhood-onset schizophrenia: A double-blind, randomized clozapine-olanzapine comparisonPhilip Shaw
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1500, USA
Arch Gen Psychiatry 63:721-30. 2006..The psychiatrist has a limited evidence base to guide treatment, particularly as there are no trials in children comparing atypical antipsychotics, the mainstay of current treatment... - Lack of evidence for elevated obstetric complications in childhood onset schizophreniaAnna E Ordoñez
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 58:10-5. 2005..We hypothesized that by extrapolation, patients with childhood-onset schizophrenia (COS), with very early onset and very severe illness, would have had more numerous or more salient OC compared with their healthy siblings... - Cerebellar development in childhood onset schizophrenia and non-psychotic siblingsDeanna Greenstein
Child Psychiatry Branch, NIMH NIH, Bethesda, MD, USA
Psychiatry Res 193:131-7. 2011..Sibling trajectories may represent a trait marker, although the effect size for volumetric differences in early adulthood may be small... - Sleep disturbances in childhood-onset schizophreniaAnand A Mattai
Child Psychiatry Branch, IRP, National Institute of Mental Health, NIH, Bethesda, MD 20892-1600, USA
Schizophr Res 86:123-9. 2006..As there are numerous health implications of poor sleep, clinicians should have a low threshold for treating sleep disturbances in this population... - Adjunctive use of lithium carbonate for the management of neutropenia in clozapine-treated childrenAnand Mattai
Child Psychiatry Branch, NIMH, NIH, MD 20892 1600, USA
Hum Psychopharmacol 24:584-9. 2009..In children, the rate of neutropenia is higher when compared to adults. We decided to explore the use of lithium to manage neutropenia in childhood-onset schizophrenia (COS) through a systematic audit of COS cases... - Progressive brain volume loss during adolescence in childhood-onset schizophreniaAlexandra L Sporn
Child Psychiatry Branch, NIMH, Bldg 10, Rm 3N202, Bethesda, MD 20892, USA
Am J Psychiatry 160:2181-9. 2003..This study examined the rate of loss in cortical gray matter volume in relation to age and clinical status in adolescent patients over a follow-up period of 2-6 years... - How does your cortex grow?Armin Raznahan
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 31:7174-7. 2011..Knowing of these developmental dissociations, and further specifying their timing and sex-biases, provides potent new research targets for basic and clinical neuroscience... - Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophreniaAnand A Mattai
Child Psychiatry Branch, National Institute of Mental Health NIH, 10 Center Drive, Bethesda, MD 20892, USA
J Am Acad Child Adolesc Psychiatry 50:697-704. 2011..Here we present a replication with nonoverlapping groups of healthy full siblings and healthy controls... - Looking for childhood schizophrenia: case series of false positivesCatherine Stayer
Child Psychiatry Branch, NIMH, Bethesda, MD 20892-1600, USA
J Am Acad Child Adolesc Psychiatry 43:1026-9. 2004..16). These cases illustrate that transient psychotic illnesses can be misdiagnosed as childhood-onset schizophrenia. Proper identification can prevent years of inappropriate therapies... - Pervasive developmental disorder and childhood-onset schizophrenia: comorbid disorder or a phenotypic variant of a very early onset illness?Alexandra L Sporn
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 55:989-94. 2004..In this study, we compared evidence for premorbid PDD as a nonspecific manifestation of impaired neurodevelopment seen in schizophrenia, or as an independent risk factor for COS... - Tolerability of transcranial direct current stimulation in childhood-onset schizophreniaAnand Mattai
Child Psychiatry Branch, National Institutes of Health, Bethesda, Maryland 20892, USA
Brain Stimul 4:275-80. 2011..In recent years, transcranial direct current stimulation (tDCS) has been used to study and treat many neuropsychiatric conditions. However, information regarding its tolerability in the pediatric population is lacking... - Stimulant drug treatment in childhood-onset schizophrenia with comorbid ADHD: an open-label case seriesJulia W Tossell
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Room 3N202, Bethesda, MD 20892, USA
J Child Adolesc Psychopharmacol 14:448-54. 2004..Our results suggest that ADHD comorbid with COS may be safely treated with a stimulant, once the psychosis is stabilized. A systematic investigation of this question may be warranted... - Clozapine treatment of childhood-onset schizophrenia: evaluation of effectiveness, adverse effects, and long-term outcomeAlexandra L Sporn
Child Psychiatry Branch, NIMH, Bethesda, MD, USA
J Am Acad Child Adolesc Psychiatry 46:1349-56. 2007..Here we evaluate these as well as other measures in an effort to find predictors of response to clozapine in our early-onset treatment-refractory population... - Childhood-onset schizophrenia: smooth pursuit eye-tracking dysfunction in family membersAlexandra Sporn
Child Psychiatry Branch, National Institute of Mental Health, National Institute of Health, Bldg 10, Rm 3N202, Bethesda, MD 20892, USA
Schizophr Res 73:243-52. 2005..Childhood-onset schizophrenia (COS), a severe form of the disorder, is of interest for etiologic studies. Smooth pursuit eye-tracking dysfunction (ETD) is a biological marker for schizophrenia... - Childhood onset schizophrenia: familial neurocognitive measuresPeter A Gochman
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room 3N202, Bethesda, MD 20892 1600, USA
Schizophr Res 71:43-7. 2004..Neurocognitive deficits which are seen in families of adult onset schizophrenic patients were examined in healthy family members of patients with childhood-onset schizophrenia (COS)... - Multidimensionally impaired: the good newsCatherine Stayer
Child Psychiatry Branch at the National Institute of Mental Health, Bethesda, MD 20892, USA
J Child Adolesc Psychopharmacol 15:510-9. 2005..CONCLUSION: C-GAS (which correctly classified 85.7% of good-outcome subjects) and CGI at baseline appear to predict outcome. On other variables, MDI subgroups were remarkably similar... - Hormonal correlates of clozapine-induced weight gain in psychotic children: an exploratory studyAlexandra L Sporn
Child Psychiatry Branch, NIMH, NIH, Bethesda, MD, USA
J Am Acad Child Adolesc Psychiatry 44:925-33. 2005..In this study, the authors examined six weight gain-related hormones in patients with childhood-onset schizophrenia (COS) after 6 weeks of clozapine treatment... - Childhood onset schizophrenia: support for a progressive neurodevelopmental disorderJudith L Rapoport
Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
Int J Dev Neurosci 29:251-8. 2011.... - Trajectories of anatomic brain development as a phenotypeJay N Giedd
Brain Imaging Unit, Child Psychiatry Branch NIMH, 10 Center Drive, MSC 1367 Bethesda, MD 20892, USA
Novartis Found Symp 289:101-12; discussion 112-8, 193-5. 2008.... - Neurodevelopmental trajectories of the human cerebral cortexPhilip Shaw
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 28:3586-94. 2008.... - Dynamic mapping of normal human hippocampal developmentNitin Gogtay
Child Psychiatry Branch, NIMH, Bethesda, Maryland 20892, USA
Hippocampus 16:664-72. 2006..These distinct developmental trajectories of hippocampal subregions may parallel differences in their functional development... - Psychotic symptoms and gray matter deficits in clinical pediatric populationsNitin Gogtay
Child Psychiatry Branch, National Institutes of Health, Building 10, Center Dr, Bethesda, MD 20892, USA
Schizophr Res 140:149-54. 2012..We explored the relationship of cortical GM thickness to psychotic phenotypes in children... - Lack of gender influence on cortical and subcortical gray matter development in childhood-onset schizophreniaBrian Weisinger
Child Psychiatry Branch, National Institutes of Mental Health, 10 3N202, 10 Center Drive, Bethesda, MD, USA
Schizophr Bull 39:52-8. 2013..The effect of sex on brain development in schizophrenia is poorly understood and studies to date have produced inconsistent results... - Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specifiedAnjene M Addington
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1600, USA
Biol Psychiatry 55:976-80. 2004..Childhood-onset schizophrenia (COS), defined as onset of psychotic symptoms by age 12 years, is a rare and severe form of the disorder that seems to be clinically and neurobiologically continuous with the adult disorder... - Longitudinally mapping the influence of sex and androgen signaling on the dynamics of human cortical maturation in adolescenceArmin Raznahan
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 107:16988-93. 2010.... - Autism spectrum disorders and childhood-onset schizophrenia: clinical and biological contributions to a relation revisitedJudith Rapoport
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
J Am Acad Child Adolesc Psychiatry 48:10-8. 2009..To highlight emerging evidence for clinical and biological links between autism/pervasive developmental disorder (PDD) and schizophrenia, with particular attention to childhood-onset schizophrenia (COS)... - Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometryNitin Gogtay
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 105:15979-84. 2008..Growth rates were correlated with functional prognosis and were visualized as detailed 3D maps. Finally, these findings also confirm that the progressive GM deficits seen in schizophrenia are not the result of WM overgrowth... - Sexual dimorphism of brain developmental trajectories during childhood and adolescenceRhoshel K Lenroot
Child Psychiatry Branch of the National Institute of Mental Health, NIMH CHP 10 Center Drive, Bethesda, MD 20814 9692, USA
Neuroimage 36:1065-73. 2007..These sexually dimorphic trajectories confirm the importance of longitudinal data in studies of brain development and underline the need to consider sex matching in studies of brain development... - Childhood onset schizophrenia: high rate of visual hallucinationsChristopher N David
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1600, USA
J Am Acad Child Adolesc Psychiatry 50:681-686.e3. 2011..To document high rates and clinical correlates of nonauditory hallucinations in childhood onset schizophrenia (COS)... - Microduplications disrupting the MYT1L gene (2p25.3) are associated with schizophreniaYohan Lee
Child Psychiatry Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Psychiatr Genet 22:206-9. 2012..14%, odds ratio=16.6, P=0.01). This report adds to the growing body of literature implicating rare CNVs as risk factors for schizophrenia and shows that some risk CNVs are more common among extreme early-onset cases... - Clozapine-induced neutropenia in children: management with lithium carbonateAlexandra Sporn
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Child Adolesc Psychopharmacol 13:401-4. 2003..8-1.1 microg/mL. This report supports the use of adjunct lithium for clozapine-induced neutropenia as a safe and successful strategy in children... - IQ stabilization in childhood-onset schizophreniaPeter A Gochman
Child Psychiatry Branch, NIMH Bldg 10, Rm 3N202 Bethesda, MD 20892 1600, USA
Schizophr Res 77:271-7. 2005..To examine the long term IQ trajectory for childhood-onset schizophrenia (COS) in an expanded, prospective longitudinal study... - Absence of anatomic corpus callosal abnormalities in childhood-onset schizophrenia patients and healthy siblingsSarah L M Johnson
Child Psychiatry Branch, National Institute of Mental Health, 10 3N202, 10 Center Drive, Bethesda, MD 20892, USA
Psychiatry Res 211:11-6. 2013..These results suggest that CC development, at least at a macroscopic level, may not be a salient feature of schizophrenia... - Cortical brain development in schizophrenia: insights from neuroimaging studies in childhood-onset schizophreniaNitin Gogtay
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Schizophr Bull 34:30-6. 2008..Furthermore, the cortical GM loss is also shared by healthy full siblings of COS probands suggesting a genetic influence on the abnormal brain development... - Childhood psychiatric disorders as anomalies in neurodevelopmental trajectoriesPhilip Shaw
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
Hum Brain Mapp 31:917-25. 2010..Again taking ADHD as an example, we found that remission is associated with convergence to the template of typical development, whereas persistence is accompanied by progressive divergence away from typical trajectories... - Age of onset of schizophrenia: perspectives from structural neuroimaging studiesNitin Gogtay
Child Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD, USA
Schizophr Bull 37:504-13. 2011..The importance of examining trajectories of development and the need for future combined approaches, using multimodal imaging together with molecular studies is discussed... - Brain neuroplasticity in healthy, hyperactive and psychotic children: insights from neuroimagingJudith L Rapoport
Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
Neuropsychopharmacology 33:181-97. 2008.... - Mapping gray matter development: implications for typical development and vulnerability to psychopathologyNitin Gogtay
Child Psychiatry Branch, NIMH, NIH, Building 10, Rm 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892, USA
Brain Cogn 72:6-15. 2010..These time-lapse maps have also been used to study effects of genotype and medication on cortical maturation, presenting a powerful framework to study factors that influence the developing brain... - Clozapine use in children and adolescentsNitin Gogtay
Montreal Neurological Institute, Canada
Expert Opin Pharmacother 9:459-65. 2008..Although the role of clozapine is well established for treatment-resistant schizophrenia, it is rarely used in pediatric populations, mainly due to its potentially serious adverse effects... - Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controlsDeanna Greenstein
Child Psychiatry Branch, National Institutes of Health, National Institute of Mental Health, Bethesda MD, USA
Front Psychiatry 3:53. 2012.... - Clozapine-induced akathisia in children with schizophreniaNitin Gogtay
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Child Adolesc Psychopharmacol 12:347-9. 2002..Two cases of childhood-onset schizophrenia associated with clozapine-induced akathisia responsive to beta-blocker treatment are described. Akathisia should be considered in all cases of apparent nonresponse to atypical antipsychotics... - Treatment of early onset schizophrenia: recent trends, challenges and future considerationsNora S Vyas
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health Bethesda, MD, USA
Front Psychiatry 3:29. 2012..Indeed, early detection, identification of relevant biomarkers, coupled with advancing knowledge of the neurochemical and neuroanatomic pathways may help design informed and novel treatment strategies... - The discovery of population differences in network community structure: new methods and applications to brain functional networks in schizophreniaAaron Alexander-Bloch
Behavioural and Clinical Neuroscience Institute, Department of Psychiatry, University of Cambridge, Cambridge, UK
Neuroimage 59:3889-900. 2012..The methods that we propose are broadly applicable to other experimental contexts, both in neuroimaging and other areas of network science... - Brain development in healthy, hyperactive, and psychotic childrenNitin Gogtay
Child Psychiatry Branch, National Institute of Mental Health/NIH, Bldg 10, Room 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892-1600, USA
Arch Neurol 59:1244-8. 2002 - Mapping cortical change in Alzheimer's disease, brain development, and schizophreniaPaul M Thompson
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
Neuroimage 23:S2-18. 2004..Dynamically spreading waves of gray matter loss are tracked in dementia and schizophrenia, and these sequences are related to normally occurring changes in healthy subjects of various ages... - Longitudinal brain changes in early-onset psychosisCelso Arango
Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Madrid, Spain
Schizophr Bull 34:341-53. 2008..The association of risk genes involved in circuitries associated with schizophrenia and their relationship to developmental trajectories is another promising area of future research... - Dynamically spreading frontal and cingulate deficits mapped in adolescents with schizophreniaChristine N Vidal
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, David Geffen School of Medicine at UCLA, 90095-1769, USA
Arch Gen Psychiatry 63:25-34. 2006..CONCLUSION: Frontal and limbic regions may not be equally vulnerable to gray matter attrition, which is consistent with the cognitive, metabolic, and functional vulnerability of the frontal cortices in schizophrenia... - Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophreniaTom Walsh
Department of Medicine, University of Washington, Seattle, WA 98195, USA
Science 320:539-43. 2008..These results suggest that multiple, individually rare mutations altering genes in neurodevelopmental pathways contribute to schizophrenia... - Structural MRI and brain developmentPaul M Thompson
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, University of California, Los Angeles School of Medicine, Los Angeles, California 90095-1769, USA
Int Rev Neurobiol 67:285-323. 2005