J J Goedert

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc HIV tropism and decreased risk of breast cancer
    Nancy A Hessol
    Department of Clinical Pharmacy, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e14349. 2010
  2. pmc Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins
    W Cozen
    Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA 90089 9175, USA
    Br J Cancer 108:1163-7. 2013
  3. pmc Delayed-type hypersensitivity in classic Kaposi sarcoma patients and controls
    R M Valenti
    Section of Hygiene, Department of Sciences for Health Promotion G D Alessandro, Universita degli Studi di Palermo, Palermo 90127, Italy
    Br J Cancer 104:433-6. 2011
  4. pmc Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study
    Roberto Flores
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
    J Transl Med 10:253. 2012
  5. pmc Impact of highly effective antiretroviral therapy on the risk for Hodgkin lymphoma among people with human immunodeficiency virus infection
    James J Goedert
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    Curr Opin Oncol 24:531-6. 2012
  6. pmc Screening the human exome: a comparison of whole genome and whole transcriptome sequencing
    Elizabeth T Cirulli
    Center for Human Genome Variation, Duke University School of Medicine, Box 91009, Durham, NC 27708, USA
    Genome Biol 11:R57. 2010
  7. pmc CD4 count at presentation for HIV care in the United States and Canada: are those over 50 years more likely to have a delayed presentation?
    Keri N Althoff
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA
    AIDS Res Ther 7:45. 2010
  8. pmc Risk of classic Kaposi sarcoma with exposures to plants and soils in Sicily
    James J Goedert
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
    Infect Agent Cancer 5:23. 2010
  9. ncbi Prevalence of conditions associated with human immunodeficiency and hepatitis virus infections among persons with haemophilia, 2001-2003
    J J Goedert
    Viral Epidemiology Branch, National Cancer Institute, Rockville, MD 20892, USA
    Haemophilia 11:516-28. 2005
  10. ncbi Reconstruction of the hepatitis C virus epidemic in the US hemophilia population, 1940-1990
    James J Goedert
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Am J Epidemiol 165:1443-53. 2007

Detail Information

Publications125 found, 100 shown here

  1. pmc HIV tropism and decreased risk of breast cancer
    Nancy A Hessol
    Department of Clinical Pharmacy, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e14349. 2010
    ..Based on these observations, we hypothesized that breast cancer risk would be lower among women with CXCR4-tropic HIV infection...
  2. pmc Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins
    W Cozen
    Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA 90089 9175, USA
    Br J Cancer 108:1163-7. 2013
    ..Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations. The gut microbiota plays a central role in immunity...
  3. pmc Delayed-type hypersensitivity in classic Kaposi sarcoma patients and controls
    R M Valenti
    Section of Hygiene, Department of Sciences for Health Promotion G D Alessandro, Universita degli Studi di Palermo, Palermo 90127, Italy
    Br J Cancer 104:433-6. 2011
    ..We tested whether KSHV-seropositive individuals or cases of classic KS (cKS), which typically originates in the leg, had differing delayed-type hypersensitivity (DTH) in the forearm or leg...
  4. pmc Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study
    Roberto Flores
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
    J Transl Med 10:253. 2012
    ..Except for obesity, determinants of non-ovarian systemic estrogen levels are undefined. We sought to identify members and functions of the intestinal microbial community associated with estrogen levels via enterohepatic recirculation...
  5. pmc Impact of highly effective antiretroviral therapy on the risk for Hodgkin lymphoma among people with human immunodeficiency virus infection
    James J Goedert
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    Curr Opin Oncol 24:531-6. 2012
    ..To estimate the impact of highly effective antiretroviral therapy (ART) on the incidence and prognosis of Hodgkin lymphoma among people with human immunodeficiency virus infection or AIDS (PWHA)...
  6. pmc Screening the human exome: a comparison of whole genome and whole transcriptome sequencing
    Elizabeth T Cirulli
    Center for Human Genome Variation, Duke University School of Medicine, Box 91009, Durham, NC 27708, USA
    Genome Biol 11:R57. 2010
    ..While whole-genome sequencing is the most complete, it remains sufficiently expensive that cost effective alternatives are important...
  7. pmc CD4 count at presentation for HIV care in the United States and Canada: are those over 50 years more likely to have a delayed presentation?
    Keri N Althoff
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA
    AIDS Res Ther 7:45. 2010
    ..10%, respectively). Due to the increasing proportion, consistently lower CD4 counts, and more advanced HIV disease in adults ≥50-year-old at first presentation for HIV care, renewed HIV testing efforts are needed...
  8. pmc Risk of classic Kaposi sarcoma with exposures to plants and soils in Sicily
    James J Goedert
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
    Infect Agent Cancer 5:23. 2010
    ..Ecologic and in vitro studies suggest that exposures to plants or soil may influence risk of Kaposi sarcoma (KS)...
  9. ncbi Prevalence of conditions associated with human immunodeficiency and hepatitis virus infections among persons with haemophilia, 2001-2003
    J J Goedert
    Viral Epidemiology Branch, National Cancer Institute, Rockville, MD 20892, USA
    Haemophilia 11:516-28. 2005
    ....
  10. ncbi Reconstruction of the hepatitis C virus epidemic in the US hemophilia population, 1940-1990
    James J Goedert
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Am J Epidemiol 165:1443-53. 2007
    ....
  11. ncbi Human immunodeficiency and hepatitis virus infections and their associated conditions and treatments among people with haemophilia
    J J Goedert
    Viral Epidemiology Branch, National Cancer Institute, Rockville, MD, USA
    Haemophilia 10:205-10. 2004
    ..Most (72%) participants had received no anti-HCV therapy. Hepatic and haematological conditions are likely to increase during the coming years unless most adult haemophiliacs are successfully treated for HIV, HCV or both...
  12. ncbi Increased liver decompensation risk with atypical hepatitis C virus antibody levels
    J J Goedert
    Viral Epidemiology Branch, National Cancer Institute, Rockville, MD 20852, USA
    J Infect Dis 182:590-4. 2000
    ..Although the mechanisms for these associations are unknown, if these findings are verified in other populations, anti-c100(p) and anti-c22(p) might be valuable surrogate markers for liver decompensation risk...
  13. doi Treatment of classic Kaposi sarcoma with a nicotine dermal patch: a phase II clinical trial
    J J Goedert
    Viral Epidemiology Branch and Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    J Eur Acad Dermatol Venereol 22:1101-9. 2008
    ..Nicotine might be effective against KS because of its immunologic and vascular effects and because smoking is associated with a low risk of KS...
  14. ncbi End-stage liver disease in persons with hemophilia and transfusion-associated infections
    James J Goedert
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Blood 100:1584-9. 2002
    ..04-fold (95% CI, 1.03-1.06) per year of age. Thus, HIV is associated with a markedly increased risk of HCV-related ESLD for persons with hemophilia, particularly with HBV infection, low CD4(+) lymphocytes, or older age...
  15. pmc Risk of classical Kaposi sarcoma by plasma levels of Epstein-Barr virus antibodies, sCD26, sCD23 and sCD30
    Colleen Pelser
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
    Infect Agent Cancer 5:18. 2010
    ..To clarify the immunological alterations leading to classical Kaposi sarcoma (cKS) among people infected with KS-associated herpesvirus (KSHV)...
  16. ncbi Risk factors for classical Kaposi's sarcoma
    James J Goedert
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    J Natl Cancer Inst 94:1712-8. 2002
    ..Although all forms of KS are associated with the KS-associated herpesvirus (KSHV), classical KS occurs in a small fraction of KSHV-infected people. We sought to identify risk factors for classical KS in KSHV-infected individuals...
  17. pmc Prevalence of serologic reactivity against four strains of mouse mammary tumour virus among US women with breast cancer
    J J Goedert
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    Br J Cancer 94:548-51. 2006
    ..Thus, among women with breast cancer, we found no MMTV-specific antibodies. The upper 95% confidence limit implies that MMTV seroprevalence among breast cancer patients does not exceed 3%...
  18. ncbi High prevalence of antibodies against HERV-K10 in patients with testicular cancer but not with AIDS
    J J Goedert
    Viral Epidemiology Branch, National Cancer Institute, Rockville, Maryland 20852, USA
    Cancer Epidemiol Biomarkers Prev 8:293-6. 1999
    ..HIV and AIDS were not associated with HERV-K10 antibodies, thus, leaving their higher risk of testicular cancer unexplained...
  19. pmc Risk of breast, ovary, and uterine corpus cancers among 85,268 women with AIDS
    J J Goedert
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    Br J Cancer 95:642-8. 2006
    ..003), approaching the risk of the general population. We conclude that the cancer deficit reflected direct or indirect effects of HIV/AIDS and that anti-HIV therapy reduced these effects...
  20. ncbi Risk of germ cell tumors among men with HIV/acquired immunodeficiency syndrome
    James J Goedert
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:1266-9. 2007
    ..Men with HIV/acquired immunodeficiency syndrome (AIDS) are reported to be at increased risk for germ cell tumors (GCT), particularly testicular seminoma. We investigated correlates of this association to improve understanding of GCTs...
  21. ncbi Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types
    James J Goedert
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Int J Cancer 121:1092-7. 2007
    ..HAM/TSP risk did not differ consistently with common HLA types. Thus, ATL risk, but not HAM/TSP risk, was increased with higher prevalence HLA-B alleles. Perhaps breadth of cellular immunity affects risk of this viral leukemia/lymphoma...
  22. ncbi Lack of association of hepatitis C virus load and genotype with risk of end-stage liver disease in patients with human immunodeficiency virus coinfection
    J J Goedert
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
    J Infect Dis 184:1202-5. 2001
    ..8-5.6) with HCV genotype 1. Understanding the discordance between HCV load and ESLD, despite HIV's link to each of these, may help clarify the pathogenesis of HCV-related disease...
  23. ncbi Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS
    X Gao
    Intramural Research Support Program, Science Applications International Corporation Frederick and the National Cancer Institute, MD, USA
    N Engl J Med 344:1668-75. 2001
    ..We examined subtypes of HLA-B*35 in five cohorts and analyzed the relation of structural differences between HLA-B*35 subtypes to the risk of progression to AIDS...
  24. ncbi Plasma HIV viral load in patients with hemophilia and late-stage HIV disease: a measure of current immune suppression. Multicenter Hemophilia Cohort Study
    E A Engels
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20822, USA
    Ann Intern Med 131:256-64. 1999
    ..For patients infected with HIV, plasma HIV viral load in early disease predicts long-term prognosis. However, the implications of viral load measurements late in HIV disease are uncertain...
  25. ncbi Evidence for concurrent epidemics of human herpesvirus 8 and human immunodeficiency virus type 1 in US homosexual men: rates, risk factors, and relationship to Kaposi's sarcoma
    T R O'Brien
    Viral Epidemiology Branch, National Cancer Institute, EPS 8016, Rockville, MD 20852, USA
    J Infect Dis 180:1010-7. 1999
    ..5 months). This study shows an epidemic of HHV-8 among US homosexual men in the early 1980s that was associated with a high risk of developing KS...
  26. ncbi Spectrum of AIDS-associated malignant disorders
    J J Goedert
    Viral Epidemiology Branch, National Cancer Institute, Rockville, MD, USA
    Lancet 351:1833-9. 1998
    ..To clarify which types of cancer result from AIDS, we compared the cancer experiences of people with AIDS with those of the general population by matching population-based cancer and AIDS registries in the USA and Puerto Rico...
  27. pmc Correlates of high hepatitis C virus RNA load in a cohort of HIV-negative and HIV-positive individuals with haemophilia
    S M Gadalla
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    J Viral Hepat 18:161-9. 2011
    ..These findings may help identify individuals at increased risk of HCV treatment failure and progression to end-stage liver disease...
  28. ncbi Detection and quantification of Kaposi's sarcoma-associated herpesvirus to predict AIDS-associated Kaposi's sarcoma
    Eric A Engels
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
    AIDS 17:1847-51. 2003
    ..To identify immunologic and virologic predictors of AIDS-associated Kaposi's sarcoma (KS)...
  29. ncbi Latent class analysis of human herpesvirus 8 assay performance and infection prevalence in sub-saharan Africa and Malta
    E A Engels
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Int J Cancer 88:1003-8. 2000
    ..Prevalence was also high in Botswana (87% in Sans, an indigenous group, and 76% in Bantus), though Kaposi's sarcoma is not common, suggesting that additional co-factors besides HHV-8 are needed for development of Kaposi's sarcoma...
  30. ncbi Estimating the cumulative incidence of HIV infection among persons with haemophilia in the United States of America
    P S Rosenberg
    National Cancer Institute, Rockville, MD 20852, USA
    Stat Med 17:155-68. 1998
    ..The consistency of back-calculation and cohort data in haemophiliacs supports the use of back-calculation to estimate prevalence in other populations...
  31. ncbi Virus load and risk of heterosexual transmission of human immunodeficiency virus and hepatitis C virus by men with hemophilia. The Multicenter Hemophilia Cohort Study
    M Hisada
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    J Infect Dis 181:1475-8. 2000
    ..001). However, much larger studies are needed to clearly show whether HIV/HCV coinfection significantly increases the risk of HCV transmission to female partners...
  32. ncbi Identifying human herpesvirus 8 infection: performance characteristics of serologic assays
    E A Engels
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    J Acquir Immune Defic Syndr 23:346-54. 2000
    ..Overall, assays performed adequately for use in most epidemiologic investigations, but wider applications will require improved tests...
  33. pmc Consistent effects of TSG101 genetic variability on multiple outcomes of exposure to human immunodeficiency virus type 1
    Arman A Bashirova
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, National Cancer Institute, Frederick, Maryland 21702, USA
    J Virol 80:6757-63. 2006
    ..The data raise the hypothesis that noncoding variation in TSG101 affects the efficiency of TSG101-mediated release of viral particles from infected cells, thereby altering levels of plasma viral load and subsequent disease progression...
  34. doi Host genetic influences on highly active antiretroviral therapy efficacy and AIDS-free survival
    Sher L Hendrickson
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
    J Acquir Immune Defic Syndr 48:263-71. 2008
    ..27; P=0.01). ARG influence after HAART suggests residual HIV-1 replication, and spread continues even in patients successfully suppressing detectable viral RNA...
  35. ncbi MCP-1-MCP-3-Eotaxin gene cluster influences HIV-1 transmission
    William S Modi
    SAIC Frederick and the Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, USA
    AIDS 17:2357-65. 2003
    ..An epidemiological analysis identified genetic variants influencing HIV-1 transmission and disease progression...
  36. pmc Regulatory polymorphisms in the interleukin-18 promoter are associated with hepatitis C virus clearance
    Ping An
    Laboratory of Genomic Diversity, Science Applications International Corportation Frederick, MD, USA
    J Infect Dis 198:1159-65. 2008
    ..77-11.6]) was also strongly associated with viral clearance. No association was found among those with hemophilia. These results suggest that IL18 promoter polymorphism may affect the outcome of HCV infection in certain groups...
  37. ncbi Risk factors for Kaposi's sarcoma among HHV-8 seropositive homosexual men with AIDS
    Eric Nawar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Int J Cancer 115:296-300. 2005
    ..Alternatively, our findings may reflect factors protective against KS in individuals infected with HHV-8. Future research should focus on identifying practical measures for countering KS that do not increase the risk of other diseases...
  38. ncbi T cell receptor excision circles and HIV-1 2-LTR episomal DNA to predict AIDS in patients not receiving effective therapy
    J J Goedert
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    AIDS 15:2245-50. 2001
    ..It is not known if measurement of either TREC or 2-LTR circles will complement HIV-1 viral load as an estimation of the risk of AIDS for patients who are receiving highly effective anti-HIV therapy...
  39. pmc Cancers associated with Kaposi's sarcoma (KS) in AIDS: a link between KS herpesvirus and immunoblastic lymphoma
    E A Engels
    Viral Epidemiology Branch and Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD, USA
    Br J Cancer 85:1298-303. 2001
    ..Our findings, and the previously demonstrated presence of KSHV in the histologically related primary effusion lymphoma, suggest that KSHV is involved in the pathogenesis of some immunoblastic lymphomas...
  40. ncbi Parvovirus B19 quiescence during the course of human immunodeficiency virus infection in persons with hemophilia
    J J Goedert
    Viral Epidemiology Branch, National Cancer Institute, Rockville, Maryland, USA
    Am J Hematol 56:248-51. 1997
    ..If primary B19 infection occurs after immune deficiency, however, the consequences may be more adverse...
  41. ncbi Trends in human immunodeficiency virus type 1 (HIV-1) load among HIV-1-infected children with hemophilia
    E A Engels
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    J Infect Dis 184:364-8. 2001
    ..In conclusion, those subjects had virus load trends similar to those in adults. Early virus loads were lower than those in vertically infected infants, which suggests that factors changing soon after birth affect viral replication...
  42. ncbi HLA-B Bw4 alleles and HIV-1 transmission in heterosexual couples
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    AIDS 21:225-9. 2007
    ..Genetic factors may play a role in the transmission of HIV-1. Because HLA-B alleles influence HIV-1 disease progression and viral levels, they might also influence HIV-1 transmission...
  43. ncbi Chronic hepatitis B and other correlates of spontaneous clearance of hepatitis C virus among HIV-infected people with hemophilia
    Lehida Melendez-Morales
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Rockville, MD 20852, USA
    AIDS 21:1631-6. 2007
    ..To identify correlates of spontaneous hepatitis C virus (HCV) clearance among people with human immunodeficiency virus (HIV) co-infection...
  44. pmc IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection
    Maureen P Martin
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, NCI Frederick, Frederick, Maryland, USA
    J Infect Dis 202:1749-53. 2010
    ..99), resistance to HIV infection (odds ratio, 0.97), or HIV disease progression (P > .05). This IL28B single-nucleotide polymorphism affects the immune response to HCV but not to HBV or HIV...
  45. ncbi Factors predictive of death among HIV-uninfected persons with haemophilia and other congenital coagulation disorders
    L S Diamondstone
    The Research Kitchen, San Francisco, CA, USA
    Haemophilia 8:660-7. 2002
    ..Better understanding, prevention and control of neutralizing antibodies and hepatitis infections may substantially improve longevity for people with haemophilia...
  46. ncbi Risk of cancer in children with AIDS. AIDS-Cancer Match Registry Study Group
    R J Biggar
    VEB NCI, 6120 Executive Blvd, Room 8014, Bethesda, MD 20852
    JAMA 284:205-9. 2000
    ..Population-based data on cancers associated with acquired immunodeficiency syndrome (AIDS) in children are lacking...
  47. ncbi Comparison of viral load and human leukocyte antigen statistical and neural network predictive models for the rate of HIV-1 disease progression across two cohorts of homosexual men
    J P Ioannidis
    HIV Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Acquir Immune Defic Syndr Hum Retrovirol 20:129-36. 1999
    ..The correlation between viral load and HLA markers suggests a possible HLA effect on setting viral load levels...
  48. ncbi Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort
    M W Smith
    Science Applications International Corp Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
    Science 277:959-65. 1997
    ....
  49. pmc Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome
    Ann L Truelove
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD, USA
    Int J Immunogenet 35:255-64. 2008
    ..01-0.04). These results suggest that IL10 and IL20 gene variants influence HBV infection outcome and encourage the pursuit of further studies of these cytokines in HBV pathogenesis...
  50. ncbi Risk of T-cell lymphomas in persons with AIDS
    R J Biggar
    Viral Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA
    J Acquir Immune Defic Syndr 26:371-6. 2001
    ..HIV-related immunodeficiency could be important, but differences between the population developing AIDS and the general population (e. g., immigration from the Caribbean region for ATLL) might independently increase T-cell lymphoma risk...
  51. pmc Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10
    H D Shin
    Science Applications International Corporation Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
    Proc Natl Acad Sci U S A 97:14467-72. 2000
    ....
  52. ncbi Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome
    M Frisch
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 92:1500-10. 2000
    ..The purpose of our study was to determine if the high frequency of these cancers is due to lifestyle factors associated with both HPV and HIV infections or to immunosuppression following HIV infection...
  53. pmc KIR/HLA pleiotropism: protection against both HIV and opportunistic infections
    Ying Qi
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, National Cancer Institute, Frederick, Maryland, USA
    PLoS Pathog 2:e79. 2006
    ..The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS...
  54. ncbi Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcoma
    Elizabeth E Brown
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
    Cancer 107:2282-90. 2006
    ....
  55. pmc Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals
    Ping An
    Laboratory of Genomic Diversity, SAIC Frederick, Incorporated, National Cancer Institute, Frederick, Maryland, United States of America
    PLoS Genet 3:e19. 2007
    ....
  56. ncbi Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
    Maureen P Martin
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Inc, National Cancer Institute, P O Box B, Building 560, Frederick, Maryland 21702, USA
    Nat Genet 39:733-40. 2007
    ....
  57. pmc Modulating influence on HIV/AIDS by interacting RANTES gene variants
    Ping An
    Intramural Research Support Program, SAIC Frederick, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 99:10002-7. 2002
    ..The diminished transcription of RANTES afforded by the In1.1C regulatory allele is consistent with increased HIV-1 spread in vivo, leading to accelerated progression to AIDS...
  58. ncbi The Gambia Liver Cancer Study: Infection with hepatitis B and C and the risk of hepatocellular carcinoma in West Africa
    Gregory D Kirk
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Hepatology 39:211-9. 2004
    ..If HCV transmission is not perpetuated in future cohorts, focusing available resources on HB vaccination efforts could greatly ameliorate a major cause of cancer death in sub-Saharan Africa...
  59. pmc A case-control study reveals immunoregulatory gene haplotypes that influence inhibitor risk in severe haemophilia A
    J N Lozier
    Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD, USA
    Haemophilia 17:641-9. 2011
    ..8, P = 0.004). We replicate previous findings for IL10; identify new associations with IL1, IL2 and IL12; and identify a rare FVIII haplotype in caucasians that is associated with increased inhibitor risk...
  60. pmc Breast cancer risk in elderly women with systemic autoimmune rheumatic diseases: a population-based case-control study
    S M Gadalla
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Br J Cancer 100:817-21. 2009
    ..49, 95% CI=0.26-0.93) among women with SLE. These findings suggest that systemic inflammation may affect breast epithelial neoplasia...
  61. ncbi Vertical transmission of human immunodeficiency virus type 1: insights from studies of multiple pregnancies
    J J Goedert
    Viral Epidemiology Branch, National Cancer Institute, USA
    Acta Paediatr Suppl 421:56-9. 1997
    ....
  62. ncbi Tumor markers and treatments for Kaposi sarcoma
    Lesley A Anderson
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Rockville, MD 20852, USA
    AIDS 21:1637-9. 2007
  63. pmc Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus
    Timothy L Mosbruger
    Johns Hopkins University, Baltimore, MD, USA
    J Infect Dis 201:1371-80. 2010
    ..In this large-scale analysis of 1426 genotyped SNPs in 112 candidate genes, we identified 4 gene regions that are likely candidates for a role in HCV clearance or persistence in both African Americans and European Americans...
  64. doi Human herpesvirus 8 seroprevalence among children and adolescents in the United States
    Lesley A Anderson
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Pediatr Infect Dis J 27:661-4. 2008
    ..4%). K8.1 seropositivity was associated with asthma (odds ratio: 6.3; 95% confidence interval: 2.4-16.9) and hay fever (3.5; 1.1-11.0), and there were borderline associations with measures of crowding and low socioeconomic status...
  65. pmc Genetic protection against hepatitis B virus conferred by CCR5Delta32: Evidence that CCR5 contributes to viral persistence
    Chloe L Thio
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Virol 81:441-5. 2007
    ....
  66. pmc Comprehensive analysis of class I and class II HLA antigens and chronic hepatitis B virus infection
    Chloe L Thio
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Virol 77:12083-7. 2003
    ..The associations with class I alleles are consistent with a previously implicated role for CD8-mediated cytolytic-T-cell response in determining the outcome of an acute HBV infection...
  67. ncbi The incidence of Kaposi sarcoma among injection drug users with AIDS in the United States
    Jonnae O Atkinson
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20892, USA
    J Acquir Immune Defic Syndr 37:1282-7. 2004
    ..Thus, these data suggest that IDUs' risk of acquiring HHV-8, through needle sharing or other behaviors related to injection drug use, is low...
  68. ncbi Cause-specific mortality associated with HIV and HTLV-II infections among injecting drug users in the USA
    J J Goedert
    Viral Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
    AIDS 15:1295-302. 2001
    ..HTLV-II infection was not significantly associated with mortality from any cause, suggesting that it is not a significant human pathogen, even when present with HIV infection...
  69. pmc Socio-economic and other correlates of Kaposi sarcoma-associated herpesvirus seroprevalence among older adults in Sicily
    Colleen Pelser
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA
    J Med Virol 81:1938-44. 2009
    ..3, CI 0.1-0.9). Other demographic and household variables were unrelated to seroprevalence. From these data, KSHV in Sicily appears to be related to low socio-economic status, but micro-endemicity in small communities cannot be excluded...
  70. pmc Cancer burden in the HIV-infected population in the United States
    Meredith S Shiels
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    J Natl Cancer Inst 103:753-62. 2011
    ..We estimated the annual number of cancers in the HIV-infected population, both with and without AIDS, in the United States...
  71. pmc Proportions of Kaposi sarcoma, selected non-Hodgkin lymphomas, and cervical cancer in the United States occurring in persons with AIDS, 1980-2007
    Meredith S Shiels
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7059, Rockville, MD 20892, USA
    JAMA 305:1450-9. 2011
    ....
  72. pmc Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection
    Leslie W Chinn
    National Cancer Institute, Rockville, MD, USA
    J Infect Dis 202:1836-45. 2010
    ..Genes conferring a significant effect were termed HIV-dependency factors (HDFs)...
  73. pmc Examination of disease-based selection, demographic history and population structure in European Y-chromosome haplogroup I
    Efe Sezgin
    Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
    J Hum Genet 55:613-20. 2010
    ..Clearly, further studies on Y-chromosome candidate loci sequencing to discover functional variants and discern the roles of evolutionary factors are warranted...
  74. pmc Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression
    Sher L Hendrickson
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, USA
    PLoS ONE 5:e12862. 2010
    ..Mitochondrial pathogenesis occurs in HIV patients and genetically, mitochondrial DNA haplogroups with presumed functional differences have been associated with differential AIDS progression...
  75. ncbi Chlamydia pneumoniae infection and risk for lung cancer
    Anil K Chaturvedi
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 19:1498-505. 2010
    ....
  76. pmc Circulating serum free light chains as predictive markers of AIDS-related lymphoma
    Ola Landgren
    National Cancer Institute, National Institutes of Health, Center for Cancer Research, Medical Oncology Branch, 9000 Rockville Pike, Bldg 10 Room 13N240, Bethesda, MD, 20892, USA
    J Clin Oncol 28:773-9. 2010
    ..CONCLUSION Elevated FLCs may represent sensitive markers of polyclonal B-cell activation and dysfunction and could be useful for identifying HIV-infected persons at increased NHL risk...
  77. pmc Risk factors for classical Kaposi sarcoma in a population-based case-control study in Sicily
    Lesley A Anderson
    Infections and Immunoepidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute 6120 Executive Blvd, EPS 7068 Rockville, MD, USA
    Cancer Epidemiol Biomarkers Prev 17:3435-43. 2008
    ....
  78. ncbi Risk factors for human herpesvirus 8 infection among adults in the United States and evidence for sexual transmission
    Eric A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20892, USA
    J Infect Dis 196:199-207. 2007
    ..Human herpesvirus 8 (HHV-8) causes Kaposi sarcoma. In the United States, transmission routes for HHV-8 are uncertain...
  79. pmc Mitochondrial DNA haplogroups influence AIDS progression
    Sher L Hendrickson
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702 1201, USA
    AIDS 22:2429-39. 2008
    ....
  80. pmc Seroprevalence and risk factors for human herpesvirus 8 infection, rural Egypt
    Sam M Mbulaiteye
    National Cancer Institute, Bethesda, MD, USA
    Emerg Infect Dis 14:586-91. 2008
    ..1, 95% CI 0.3-16.4), but marginal for women (OR 1.5, 95% CI 1.0-2.5). Our findings suggest salivary and possible nosocomial HHV-8 transmission in rural Egypt...
  81. doi Cancer risk in people infected with human immunodeficiency virus in the United States
    Eric A Engels
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Int J Cancer 123:187-94. 2008
    ..These trends have led to a shift in the spectrum of cancer among HIV-infected persons...
  82. ncbi Hepatitis B and C virus infection and the risk of biliary tract cancer: a population-based study in China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 5024, MSC 7234, 6120 Executive Blvd, Bethesda, MD 20852 7234, USA
    Int J Cancer 122:1849-53. 2008
    ..In Shanghai, an HBV endemic area, chronic HBV infection was associated with a 2.4-fold risk of extrahepatic bile duct cancer. These results should be confirmed in other populations with varying risks of HBV and HCV infection...
  83. doi Geographic heterogeneity of prevalence of the human herpesvirus 8 in sub-Saharan Africa: clues about etiology
    Ruth M Pfeiffer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Ann Epidemiol 20:958-63. 2010
    ..We assessed HHV-8 seropositivity in several African countries with heterogeneous environments and varying KS incidence using a unified approach...
  84. ncbi Elevated risk of lung cancer among people with AIDS
    Anil K Chaturvedi
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 7072, Rockville, MD 20852, USA
    AIDS 21:207-13. 2007
    ..Lung cancer risk was compared between PWA and the general population and its relationship with immunosuppression was assessed. The likelihood that excess risk is explained by a high prevalence of smoking was also investigated...
  85. pmc Correlates of spontaneous clearance of hepatitis C virus among people with hemophilia
    Mingdong Zhang
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Blood 107:892-7. 2006
    ..These data highlight and clarify the importance of nongenetic determinants in spontaneous recovery from HCV infection...
  86. ncbi Correlates of Human Herpesvirus-8 DNA detection among adults in Italy without Kaposi sarcoma
    Elizabeth E Brown
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Rockville, MD 20852, USA
    Int J Epidemiol 34:1110-7. 2005
    ..The presence of Human Herpesvirus-8 (HHV8) DNA is predictive of Kaposi sarcoma (KS) among patients with HIV-associated or iatrogenic immunosuppression. However, correlates of HHV8-DNA detection in the general population remain undefined...
  87. pmc Reduced risk of prostate cancer in U.S. Men with AIDS
    Meredith S Shiels
    Infections and Immunoepidemiology Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 19:2910-5. 2010
    ..In the United States, prostate-specific antigen (PSA) screening is common and increases the detection of prostate cancer. We evaluated whether the prostate cancer deficit among men with AIDS reflects differential PSA screening...
  88. ncbi Antibodies to JC and BK viruses among persons with non-Hodgkin lymphoma
    Eric A Engels
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20892, USA
    Int J Cancer 117:1013-9. 2005
    ..Additional research is needed to determine whether JCV replication is decreased in individuals with NHL and whether these findings are consistent with an etiologic role for JCV in NHL...
  89. ncbi Immunoblastic lymphoma in persons with AIDS-associated Kaposi's sarcoma: a role for Kaposi's sarcoma-associated herpesvirus
    Eric A Engels
    Viral Epidemiology Branch, Division of Cancer and Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
    Mod Pathol 16:424-9. 2003
    ..We conclude that Kaposi's sarcoma-associated herpesvirus is present in some immunoblastic lymphomas in persons with AIDS-associated Kaposi's sarcoma...
  90. ncbi A common genetic variant in FCGR3A-V158F and risk of Kaposi sarcoma herpesvirus infection and classic Kaposi sarcoma
    Elizabeth E Brown
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 14:633-7. 2005
    ..05). Our findings suggest that gender differences could possibly modify the effect of FCGR3A on risk of KSHV infection and CKS. Additional studies are required to confirm these relationships and determine their etiologic significance...
  91. ncbi Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity
    Gregory D Kirk
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:373-9. 2005
    ..7; 95% CI, 1.27-169). Our findings suggest that genetic modulation of carcinogen metabolism and DNA repair can alter susceptibility to HCC and that these effects may be modified by environmental factors...
  92. ncbi Increased hepatitis C virus load among injection drug users infected with human immunodeficiency virus and human T lymphotropic virus type II
    Michie Hisada
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20851, USA
    J Infect Dis 188:891-7. 2003
    ..50, 0.22, and 0.56 log(10) higher in HIV(+)/HTLV-II(-), HIV(-)/HTLV-II(+), and HIV(+)/HTLV-II(+) subjects, respectively. HTLV-II infection significantly increased HCV load in white subjects but not in other racial groups...
  93. ncbi Risk factors for Kaposi's sarcoma-associated herpesvirus infection among HIV-1-infected pregnant women in the USA
    James J Goedert
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20892, USA
    AIDS 17:425-33. 2003
    ..We sought to identify risk factors for infection with the Kaposi's Sarcoma-associated herpesvirus (KSHV) among pregnant women and to examine a reported association of KSHV with injecting drug use (IDU) and hepatitis C virus (HCV) infection...
  94. ncbi Effects of CCR5-Delta32 and CCR2-64I alleles on HIV-1 disease progression: the protection varies with duration of infection
    Stephanie A Mulherin
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, Rockville, MD 20852, USA
    AIDS 17:377-87. 2003
    ..To examine temporal variation in the effects of CCR5-Delta32 and CCR2-64I chemokine receptor gene polymorphisms on HIV-1 disease progression...
  95. ncbi Pleural and peritoneal lymphoma among people with AIDS in the United States
    Sam M Mbulaiteye
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    J Acquir Immune Defic Syndr 29:418-21. 2002
    ..To describe the occurrence and characteristics of pleural and peritoneal lymphoma in a large cohort of persons with AIDS in 11 regions in the United States...
  96. ncbi Virus markers associated with vertical transmission of human T lymphotropic virus type 1 in Jamaica
    Michie Hisada
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, 20852, USA
    Clin Infect Dis 34:1551-7. 2002
    ..Alternatively, the successful reduction of maternal provirus loads or maintenance of passive antibody levels in infants during breast-feeding may lower the risk of transmission...
  97. ncbi Prevalence of hepatitis C virus infection and risk for hepatocellular carcinoma and non-Hodgkin lymphoma in AIDS
    Eric A Engels
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, 6120 Executive Boulevard, EPS 8010, Rockville, MD 20892, USA
    J Acquir Immune Defic Syndr 31:536-41. 2002
    ..These data suggest an effect of HCV infection on HCC risk among adults with AIDS. On the other hand, NHL risk was not higher for groups in whom HCV infection was prevalent...
  98. ncbi Hepatitis C virus load and survival among injection drug users in the United States
    Michie Hisada
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Hepatology 42:1446-52. 2005
    ..98, 95% CI: 0.48-2.88). Non-black patients were at increased risk for ESLD death (RH(adj)= 2.76, 95% CI: 1.49-10.09). In conclusion, HCV RNA level is a predictor of ESLD death among persons with chronic HCV infection...
  99. ncbi Associations of classic Kaposi sarcoma with common variants in genes that modulate host immunity
    Elizabeth E Brown
    National Cancer Institute, 6120 Executive Boulevard, EPS 8005 MSC 7248 Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 15:926-34. 2006
    ..Among KSHV-seropositive Italians, CKS risk was associated with diplotypes of IL8RB and IL13, supporting laboratory evidence of immune-mediated pathogenesis...
  100. ncbi Risk factors for human herpesvirus 8 seropositivity in the AIDS Cancer Cohort Study
    Sam M Mbulaiteye
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Blvd, Executive Plaza South Rm 8006, Mail Stop Center 7248, Rockville, MD 20852, USA
    J Clin Virol 35:442-9. 2006
    ..Cigarette smoking has been associated with a decreased risk for AIDS-related and classical KS, but whether it is associated with decreased risk of human herpesvirus 8 (HHV-8) infection is unknown...
  101. ncbi Detection of kaposi sarcoma-associated herpesvirus DNA in saliva and buffy-coat samples from children with sickle cell disease in Uganda
    Sam M Mbulaiteye
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, Maryland, USA
    J Infect Dis 190:1382-6. 2004
    ..Detection was associated with K8.1 seropositivity, younger age, and high household density, indicating the importance of in-household person-to-person transmission, likely via saliva...