M T Gladwin

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans
    M T Gladwin
    Critical Care Medicine Department of the Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:11482-7. 2000
  2. pmc Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity
    M T Gladwin
    Critical Care Medicine Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 104:937-45. 1999
  3. pmc Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery
    R O Cannon
    Cardiology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892 1650, USA
    J Clin Invest 108:279-87. 2001
  4. ncbi request reprint Nitric oxide transport on sickle cell hemoglobin: where does it bind?
    M T Gladwin
    Critical Care Medicine Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Res 35:175-80. 2001
  5. pmc Relative role of heme nitrosylation and beta-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation
    M T Gladwin
    Critical Care Medicine Department of the Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:9943-8. 2000
  6. ncbi request reprint Noninvasive determination of spatially resolved and time-resolved tissue perfusion in humans during nitric oxide inhibition and inhalation by use of a visible-reflectance hyperspectral imaging technique
    K J Zuzak
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda MD 20892-0510, USA
    Circulation 104:2905-10. 2001
  7. ncbi request reprint Nitric oxide therapy in sickle cell disease
    M T Gladwin
    Critical Care Medicine Department, Warren G. Magnuson Clinical Center, NIH, Bethesda, MD 20892-1662, USA
    Semin Hematol 38:333-42. 2001
  8. ncbi request reprint Regional cerebral hyperperfusion and nitric oxide pathway dysregulation in Fabry disease: reversal by enzyme replacement therapy
    D F Moore
    Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, Clinical Center, National Institutes of Health, Bethesda, MD 20892-1260, USA
    Circulation 104:1506-12. 2001
  9. pmc Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure
    M K Holly
    Renal Diagnostics and Therapeutics Unit, NIDDK, Bethesda, Maryland, USA
    Kidney Int 70:496-506. 2006
  10. ncbi request reprint Disorders of ciliary motility
    M J Cowan
    Department of Critical Care Medicine, National Institutes of Health, Bethesda, Maryland 20892 1662, USA
    Am J Med Sci 321:3-10. 2001

Collaborators

Detail Information

Publications13

  1. pmc Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans
    M T Gladwin
    Critical Care Medicine Department of the Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:11482-7. 2000
    ....
  2. pmc Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity
    M T Gladwin
    Critical Care Medicine Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 104:937-45. 1999
    ..The levels of nitrosylated hemoglobin are too low to affect overall hemoglobin oxygen affinity, but augmented NO transport to the microvasculature seems a promising strategy for improving microvascular perfusion...
  3. pmc Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery
    R O Cannon
    Cardiology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892 1650, USA
    J Clin Invest 108:279-87. 2001
    ..This effect may have application for the treatment of diseases characterized by endothelial dysfunction...
  4. ncbi request reprint Nitric oxide transport on sickle cell hemoglobin: where does it bind?
    M T Gladwin
    Critical Care Medicine Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Res 35:175-80. 2001
    ....
  5. pmc Relative role of heme nitrosylation and beta-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation
    M T Gladwin
    Critical Care Medicine Department of the Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:9943-8. 2000
    ....
  6. ncbi request reprint Noninvasive determination of spatially resolved and time-resolved tissue perfusion in humans during nitric oxide inhibition and inhalation by use of a visible-reflectance hyperspectral imaging technique
    K J Zuzak
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda MD 20892-0510, USA
    Circulation 104:2905-10. 2001
    ..This imaging method may provide an effective approach for time-resolved noninvasive monitoring of skin hemoglobin oxygen saturation and assessment of responses to therapeutic interventions in patients with vascular disease...
  7. ncbi request reprint Nitric oxide therapy in sickle cell disease
    M T Gladwin
    Critical Care Medicine Department, Warren G. Magnuson Clinical Center, NIH, Bethesda, MD 20892-1662, USA
    Semin Hematol 38:333-42. 2001
    ..While direct evidence for a clinical benefit of NO therapy in sickle cell disease has not been reported, studies are underway to determine if inhaled NO will reduce the substantial morbidity and mortality suffered by these patients...
  8. ncbi request reprint Regional cerebral hyperperfusion and nitric oxide pathway dysregulation in Fabry disease: reversal by enzyme replacement therapy
    D F Moore
    Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, Clinical Center, National Institutes of Health, Bethesda, MD 20892-1260, USA
    Circulation 104:1506-12. 2001
    ..CONCLUSIONS: These findings suggest a chronic alteration of the nitric oxide pathway in Fabry disease, with critical protein nitration that is reversible with enzyme replacement therapy...
  9. pmc Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure
    M K Holly
    Renal Diagnostics and Therapeutics Unit, NIDDK, Bethesda, Maryland, USA
    Kidney Int 70:496-506. 2006
    ..This model allowed us to use DIGE to find changes in urinary proteins and this approach identified a potential biomarker and drug target - meprin-1-alpha...
  10. ncbi request reprint Disorders of ciliary motility
    M J Cowan
    Department of Critical Care Medicine, National Institutes of Health, Bethesda, Maryland 20892 1662, USA
    Am J Med Sci 321:3-10. 2001
    ..Late stages of the disease may require surgical intervention for bronchiectasis or lung transplant for end-stage lung disease...
  11. ncbi request reprint Retinoic acid reduces p11 protein levels in bronchial epithelial cells by a posttranslational mechanism
    M T Gladwin
    Critical Care Medicine Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol Lung Cell Mol Physiol 279:L1103-9. 2000
    ..006). Therefore, RA reduces p11 protein expression and increases PLA(2) activity and AA release...
  12. pmc Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease
    M Aslan
    Department of Anesthesiology, Center for Free Radical Biology, Imaging Facility and Comprehensive Sickle Cell Disease Center, University of Alabama, Birmingham, AL 35233, USA
    Proc Natl Acad Sci U S A 98:15215-20. 2001
    ..This circulating XO can then bind avidly to vessel luminal cells and impair vascular function by creating an oxidative milieu and catalytically consuming (*)NO via O(2)( small middle dot-)-dependent mechanisms...
  13. ncbi request reprint Renal pathology in hemizygous sickle cell mice
    B A Diwan
    National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Toxicol Pathol 30:254-62. 2002
    ....