D Gius

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Redox signaling in cancer biology
    David Gius
    Antioxid Redox Signal 8:1249-52. 2006
  2. ncbi request reprint Redox-sensitive signaling factors and antioxidants: how tumor cells respond to ionizing radiation
    David Gius
    Molecular Radiation Oncology Section, National Cancer Institute NIH, Bethesda, MD 20892, USA
    J Nutr 134:3213S-3214S. 2004
  3. pmc SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression
    Kristi Muldoon Jacobs
    Molecular Radiation Oncology, Center for Cancer Research, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Biol Sci 4:291-9. 2008
  4. ncbi request reprint Thermal stress and the disruption of redox-sensitive signalling and transcription factor activation: possible role in radiosensitization
    D Gius
    Molecular Radiation Oncology Section, Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Hyperthermia 20:213-23. 2004
  5. ncbi request reprint The epigenome as a molecular marker and target
    David Gius
    Molecular Radiation Oncology Section, Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1002, USA
    Cancer 104:1789-93. 2005
  6. ncbi request reprint Profiling microdissected epithelium and stroma to model genomic signatures for cervical carcinogenesis accommodating for covariates
    David Gius
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 67:7113-23. 2007
  7. ncbi request reprint Heat shock and the activation of AP-1 and inhibition of NF-kappa B DNA-binding activity: possible role of intracellular redox status
    D Mattson
    Section of Molecular Radiation Oncology, Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Int J Hyperthermia 20:224-33. 2004
  8. ncbi request reprint Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-kappaB activation in HeLa cells occur via a mechanism involving p38 MAP kinase
    C M Bradbury
    Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 61:7689-96. 2001
  9. ncbi request reprint Thioredoxin reductase as a novel molecular target for cancer therapy
    Phuongmai Nguyen
    Molecular Radiation Oncology Section, Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Cancer Lett 236:164-74. 2006
  10. doi request reprint DNMT1 as a molecular target in a multimodality-resistant phenotype in tumor cells
    Mark V Mishra
    Radiation Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Mol Cancer Res 6:243-9. 2008

Detail Information

Publications47

  1. ncbi request reprint Redox signaling in cancer biology
    David Gius
    Antioxid Redox Signal 8:1249-52. 2006
    ..This Forum is directed at understanding possible redox signaling mechanisms governing cellular radiation response, tumor growth, and response to therapy, as well as the role of nitric oxide in cancer biology...
  2. ncbi request reprint Redox-sensitive signaling factors and antioxidants: how tumor cells respond to ionizing radiation
    David Gius
    Molecular Radiation Oncology Section, National Cancer Institute NIH, Bethesda, MD 20892, USA
    J Nutr 134:3213S-3214S. 2004
  3. pmc SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression
    Kristi Muldoon Jacobs
    Molecular Radiation Oncology, Center for Cancer Research, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Biol Sci 4:291-9. 2008
    ..As such, we propose that SIRT3 and FOXO3a comprise a potential mitochondrial signaling cascade response pathway...
  4. ncbi request reprint Thermal stress and the disruption of redox-sensitive signalling and transcription factor activation: possible role in radiosensitization
    D Gius
    Molecular Radiation Oncology Section, Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Hyperthermia 20:213-23. 2004
    ....
  5. ncbi request reprint The epigenome as a molecular marker and target
    David Gius
    Molecular Radiation Oncology Section, Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1002, USA
    Cancer 104:1789-93. 2005
    ..Perhaps more noteworthy is that DNMT genes may be found to be novel molecular targets for new factor-specific anticancer agents. This idea will be addressed...
  6. ncbi request reprint Profiling microdissected epithelium and stroma to model genomic signatures for cervical carcinogenesis accommodating for covariates
    David Gius
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 67:7113-23. 2007
    ....
  7. ncbi request reprint Heat shock and the activation of AP-1 and inhibition of NF-kappa B DNA-binding activity: possible role of intracellular redox status
    D Mattson
    Section of Molecular Radiation Oncology, Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Int J Hyperthermia 20:224-33. 2004
    ....
  8. ncbi request reprint Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-kappaB activation in HeLa cells occur via a mechanism involving p38 MAP kinase
    C M Bradbury
    Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 61:7689-96. 2001
    ..Taken together, these results suggest that p38 MAPK is a target involved in indomethacin-induced radiosensitization and that NF-kappaB may be one downstream target in this process...
  9. ncbi request reprint Thioredoxin reductase as a novel molecular target for cancer therapy
    Phuongmai Nguyen
    Molecular Radiation Oncology Section, Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Cancer Lett 236:164-74. 2006
    ..Based on these results we believe TR is a potential molecular target and discuss potential clinical possibilities...
  10. doi request reprint DNMT1 as a molecular target in a multimodality-resistant phenotype in tumor cells
    Mark V Mishra
    Radiation Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Mol Cancer Res 6:243-9. 2008
    ....
  11. ncbi request reprint Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach
    David Gius
    Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Cell 6:361-71. 2004
    ..In addition, a 75 kb cluster of metallothionein genes was coordinately regulated...
  12. pmc BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression
    Phuongmai Nguyen
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell Biol 28:6720-9. 2008
    ..Thus, we propose that BORIS acts as a platform upon which BAT3 and SET1A assemble and exert effects upon chromatin structure and gene expression...
  13. ncbi request reprint Inhibition of cyclooxygenase-2 with NS-398 and the prevention of radiation-induced transformation, micronuclei formation and clonogenic cell death in C3H 10T1/2 cells
    K S Bisht
    Molecular Radiation Oncology Section, Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Int J Radiat Biol 79:879-88. 2003
    ..These data suggest a possible role of COX-2 both in IR-mediated cellular transformation processes and cell death...
  14. ncbi request reprint Inhibition of nuclear factor-kappaB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinoma
    Carter Van Waes
    Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 63:1400-12. 2005
    ....
  15. ncbi request reprint BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer
    Christina M Annunziata
    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Clin Cancer Res 13:6585-92. 2007
    ..We hypothesized that elevated expression in ovarian cancer of the BAG family of prosurvival proteins and associated partners would be associated with clinical features of aggressiveness in ovarian cancer...
  16. ncbi request reprint Thioredoxin reductase as a potential molecular target for anticancer agents that induce oxidative stress
    Deedee K Smart
    Molecular Radiation Oncology Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Res 64:6716-24. 2004
    ..Finally, IV-2-treated cells showed increased tumor cell death when treated with H2O2 and IR. These results identify TR as a potential target to enhance the cytotoxic effects of agents that induce oxidative stress, including IR...
  17. ncbi request reprint Oxidative stress, redox, and the tumor microenvironment
    John A Cook
    Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Semin Radiat Oncol 14:259-66. 2004
    ..With respect to the radiation treatment of cancer, components of the cellular redox armamentarium may be targeted to enhance cell killing in the case of tumors and/or protection in the case of normal tissues...
  18. pmc Patterns of care for women with cervical cancer in the United States
    Edward L Trimble
    National Cancer Institute, Surgery Section, Bethesda, Maryland 20892 7436, USA
    Cancer 113:743-9. 2008
    ..This analysis was initiated to determine any systemic changes in management of cervical cancers...
  19. pmc SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress
    Hyun Seok Kim
    Genetics of Development and Disease Branch, NIDDK, NIH, Bethesda, MD 20892, USA
    Cancer Cell 17:41-52. 2010
    ..Finally, human breast and other human cancer specimens exhibit reduced SIRT3 levels. These results identify SIRT3 as a genomically expressed, mitochondria-localized tumor suppressor...
  20. pmc Molecular and clinical responses in a pilot study of gefitinib with paclitaxel and radiation in locally advanced head-and-neck cancer
    Carter Van Waes
    Head and Neck Surgery Branch, National Institute of Deafness and Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Int J Radiat Oncol Biol Phys 77:447-54. 2010
    ....
  21. pmc Ionizing radiation-induced oxidative stress alters miRNA expression
    Nicole L Simone
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    PLoS ONE 4:e6377. 2009
    ..Alterations in miRNA expression may occur following exposure to several stress-inducing anticancer agents including ionizing radiation, etoposide, and hydrogen peroxide (H(2)O(2))...
  22. doi request reprint Genomic and phenotypic analysis reveals a key role for CCN1 (CYR61) in BAG3-modulated adhesion and invasion
    Jareer N Kassis
    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Pathol 218:495-504. 2009
    ..We propose that BAG3 regulates CCN1 expression to regulate tumour cell adhesion and migration...
  23. ncbi request reprint Redox-sensitive signaling factors as a novel molecular targets for cancer therapy
    J Daniel Pennington
    Molecular Radiation Oncology Section, Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bldg 10, Room B3B69 9000 Rockville Pike, Bethesda, MD 20892, USA
    Drug Resist Updat 8:322-30. 2005
    ..It further suggests that redox-sensitive, signaling factors may be potential novel targets for drug discovery...
  24. ncbi request reprint Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity
    Edward G Mimnaugh
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Rockville, Maryland 20850, USA
    Mol Cancer Ther 3:551-66. 2004
    ....
  25. ncbi request reprint Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity
    Kheem S Bisht
    Radiation Oncology Branch and Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 1002, USA
    Cancer Res 63:8984-95. 2003
    ..This work shows that altered HSP90 function induces significant tumor cytotoxicity and radiosensitization, suggesting a potential therapeutic utility...
  26. pmc DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation
    Lunching Sun
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 68:2726-35. 2008
    ..These results suggest that DNMT1 and DNMT3B regulate BAG-1 expression via insulator protein DNA-binding and chromatin dynamics by regulating histone dimethylation...
  27. ncbi request reprint Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy
    J Daniel Pennington
    Molecular Radiation Oncology Section, Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Pharm Des 13:3368-77. 2007
    ..These observations suggest that redox-sensitive signaling factors may be potential novel molecular targets for drug discovery...
  28. ncbi request reprint DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16(ink4A) down-regulation
    Zhanjun Guo
    Radiation Biology and Oncology Branches, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA
    J Biomed Sci 15:163-8. 2008
    ..Our results indicate that mutant p53 loses its ability to suppress DNMT1 expression, and thus enhances methylation levels of the p16 ( ink4A ) promoter and subsequently down-regulates p16(ink4A )protein...
  29. pmc CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region
    Phuongmai Nguyen
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 68:5546-51. 2008
    ....
  30. ncbi request reprint Histone deacetylase inhibitor and demethylating agent chromatin compaction and the radiation response by cancer cells
    Gil Bar-Sela
    Radiation Oncology Branch, Radiation Oncology Sciences Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer J 13:65-9. 2007
    ..In this review, we discuss the potential for histone deacetylases inhibitors as radiosensitizing agents...
  31. doi request reprint High incidence of oral dysesthesias on a trial of gefitinib, Paclitaxel, and concurrent external beam radiation for locally advanced head and neck cancers
    Hadley Sharp
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    Am J Clin Oncol 31:557-60. 2008
    ....
  32. pmc Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms
    Jianjun Bao
    Translational Medicine Branch, NHLBI, NIH, Bethesda, Maryland, USA
    J Cell Biochem 110:238-47. 2010
    ..This overexpression effect, may partially account for previously observed divergent phenotypes attributed to SIRT3...
  33. ncbi request reprint In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor Triapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone)
    Christopher A Barker
    Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 12:2912-8. 2006
    ..Unlike previously investigated RR inhibitors, Triapine potently inhibits both RR holoenzymes. Therefore, the effects of Triapine on tumor cell radiosensitivity were investigated...
  34. ncbi request reprint Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation
    Shervin Karimpour
    Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Oncogene 21:6317-27. 2002
    ..These results identify a novel function of the TR enzyme as a signaling factor in the regulation of AP-1 activity via a cysteine motif located in the protein...
  35. ncbi request reprint 2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism
    Xiao Lin
    Section of Cancer Biology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer Res 63:3413-7. 2003
    ....
  36. ncbi request reprint Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology
    Douglas R Spitz
    B180 Medical Laboratories, Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242, USA
    Cancer Metastasis Rev 23:311-22. 2004
    ....
  37. ncbi request reprint Co-activation of ERK, NF-kappaB, and GADD45beta in response to ionizing radiation
    Tieli Wang
    Division of Radiation Oncology, Beckman Research Institute and City of Hope National Medical Center, Duarte, California 91010, USA
    J Biol Chem 280:12593-601. 2005
    ..Overall, these results demonstrate a possibility that NF-kappaB, ERK, and GADD45beta are able to coordinate in a loop-like signaling network to defend cells against the cytotoxicity induced by ionizing radiation...
  38. pmc Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
    Wenqiang Yu
    Center for Epigenetics and Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Nature 451:202-6. 2008
    ..Thus, natural antisense RNA may be a trigger for heterochromatin formation and DNA methylation in TSG silencing in tumorigenesis...
  39. ncbi request reprint Identification of chromosomal alterations important in the development of cervical intraepithelial neoplasia and invasive carcinoma using alignment of DNA microarray data
    Margaret A Fitzpatrick
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 103:458-62. 2006
    ..To use microarray data to reveal regions of potential chromosomal loss or gain important in cervical intraepithelial neoplasia (CIN) and invasive cervical cancer by identifying mRNA expression biases in contiguous chromosomal regions...
  40. ncbi request reprint Radiosensitizing and anti-proliferative effects of resveratrol in two human cervical tumor cell lines
    Imran Zoberi
    Section of Cancer Biology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Cancer Lett 175:165-73. 2002
    ..These results suggest that resveratrol alters both cell cycle progression and the cytotoxic response to IR in two cervical tumor cell lines...
  41. ncbi request reprint Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase
    Konjeti R Sekhar
    Dept of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Free Radic Biol Med 32:650-62. 2002
    ..These results also support the hypothesis that indomethacin-induced transcriptional activation of GCLC involves the redox-dependent release of KIAA0132 from Nrf2 followed by the nuclear translocation of Nrf2...
  42. ncbi request reprint A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF)
    Yoichi Ohiro
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    FEBS Lett 524:163-71. 2002
    ..The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway...
  43. ncbi request reprint Distinct effects of ionizing radiation on in vivo murine kidney and brain normal tissue gene expression
    Weiling Zhao
    Department of Radiation Oncology, Brain Tumor Center of Wake Forest University, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Clin Cancer Res 12:3823-30. 2006
    ..As such, the aim of the present study was to identify candidate genes involved in the development of radiation injury in the murine kidney and brain using microarray analysis...
  44. pmc Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53
    Yoichi Ohiro
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 23:322-34. 2003
    ..Thus, the accumulation of mutant p53 in tumor cells may contribute to tumorigenesis by inhibiting stress-inducible kinase pathways...
  45. ncbi request reprint The holy grail of radiation oncology: lessons learned from hyperthermia
    Shervin Karimpour
    Int J Radiat Oncol Biol Phys 55:3-4. 2003
  46. ncbi request reprint Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols
    Detcho A Stoyanovsky
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Chem Soc 127:15815-23. 2005
    ..We conclude that both thioredoxin and dihydrolipoic acid may be involved in the regulation of cellular S-nitrosothiols...
  47. ncbi request reprint Indomethacin and ibuprofen induce Hsc70 nuclear localization and activation of the heat shock response in HeLa cells
    Lucio Lagunas
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Biochem Biophys Res Commun 313:863-70. 2004
    ....