E I Ginns

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish
    E I Ginns
    Clinical Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:15531-6. 1998
  2. ncbi request reprint Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition
    W S Young
    Laboratory of Cell Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 4068, USA
    J Neuroendocrinol 8:847-53. 1996
  3. ncbi request reprint Chromosome 22q11.2 interstitial deletions among childhood-onset schizophrenics and "multidimensionally impaired"
    W Yan
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892 4405, USA
    Am J Med Genet 81:41-3. 1998
  4. ncbi request reprint Transgenic expression of green fluorescent protein in mouse oxytocin neurones
    W S Young
    Section on Neural Gene Expression, National Institute of Mental Health, Bethesda, MD 20892 4068, USA
    J Neuroendocrinol 11:935-9. 1999
  5. ncbi request reprint Targeted reduction of oxytocin expression provides insights into its physiological roles
    W S Young
    Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland, USA
    Adv Exp Med Biol 449:231-40. 1998
  6. ncbi request reprint Vasopressin V1b receptor knockout reduces aggressive behavior in male mice
    S R Wersinger
    Section on Neural Gene Expression, NIMH, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 7:975-84. 2002
  7. ncbi request reprint Association of an X-chromosome dodecamer insertional variant allele with mental retardation
    R A Philibert
    Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Mol Psychiatry 3:303-9. 1998
  8. ncbi request reprint Childhood-onset schizophrenia/autistic disorder and t(1;7) reciprocal translocation: identification of a BAC contig spanning the translocation breakpoint at 7q21
    W L Yan
    Child Psychiatry, National Institute of Mental Health, Bethesda, Maryland 20892 4405, USA
    Am J Med Genet 96:749-53. 2000
  9. ncbi request reprint Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit/hyperactivity disorder: genetic and brain morphometric analyses
    F X Castellanos
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1600, USA
    Mol Psychiatry 3:431-4. 1998
  10. pmc Genetic heterogeneity in type 1 Gaucher disease: multiple genotypes in Ashkenazic and non-Ashkenazic individuals
    S Tsuji
    Molecular Neurogenetics Unit, National Institute of Mental Health, ADAMHA, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 85:2349-52. 1988

Collaborators

Detail Information

Publications23

  1. pmc A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish
    E I Ginns
    Clinical Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:15531-6. 1998
    ..These findings are consistent with the hypothesis that certain alleles could prevent or modify the clinical manifestations of BPAD and perhaps other related affective disorders...
  2. ncbi request reprint Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition
    W S Young
    Laboratory of Cell Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 4068, USA
    J Neuroendocrinol 8:847-53. 1996
    ..OT injection into the dams restores the milk injection in response to suckling. These results indicate an absolute requirement for oxytocin for successful milk injection, but not for mating, parturition and milk production, in mice...
  3. ncbi request reprint Chromosome 22q11.2 interstitial deletions among childhood-onset schizophrenics and "multidimensionally impaired"
    W Yan
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892 4405, USA
    Am J Med Genet 81:41-3. 1998
    ..quot; Fluorescent in situ hybridization screening of 32 COS and 21 multidimensionally impaired patients revealed 1 COS patient with an interstitial deletion spanning at least 2.5 megabases...
  4. ncbi request reprint Transgenic expression of green fluorescent protein in mouse oxytocin neurones
    W S Young
    Section on Neural Gene Expression, National Institute of Mental Health, Bethesda, MD 20892 4068, USA
    J Neuroendocrinol 11:935-9. 1999
    ..Other coding sequences should now be amenable to expression within oxytocin neurones to study their physiology...
  5. ncbi request reprint Targeted reduction of oxytocin expression provides insights into its physiological roles
    W S Young
    Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland, USA
    Adv Exp Med Biol 449:231-40. 1998
    ..These results indicate an absolute requirement for oxytocin for successful milk ejection, but not for mating, parturition and milk production, in mice. Furthermore, homozygous mutant mice show reduced aggression in some tests...
  6. ncbi request reprint Vasopressin V1b receptor knockout reduces aggressive behavior in male mice
    S R Wersinger
    Section on Neural Gene Expression, NIMH, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 7:975-84. 2002
    ..We suggest that V1bR antagonists could prove useful for treating aggressive behavior seen, for example, in dementias and traumatic brain injuries...
  7. ncbi request reprint Association of an X-chromosome dodecamer insertional variant allele with mental retardation
    R A Philibert
    Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Mol Psychiatry 3:303-9. 1998
    ..001) and treatment with antidepressants (P < 0.001). We conclude that the presence of this 12-bp variant confers significant susceptibility for mental retardation...
  8. ncbi request reprint Childhood-onset schizophrenia/autistic disorder and t(1;7) reciprocal translocation: identification of a BAC contig spanning the translocation breakpoint at 7q21
    W L Yan
    Child Psychiatry, National Institute of Mental Health, Bethesda, Maryland 20892 4405, USA
    Am J Med Genet 96:749-53. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:749-753, 2000. Published 2000 Wiley-Liss, Inc...
  9. ncbi request reprint Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit/hyperactivity disorder: genetic and brain morphometric analyses
    F X Castellanos
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1600, USA
    Mol Psychiatry 3:431-4. 1998
    ..These data do not support the reported association between DRD4*7R and the behavioral or brain morphometric phenotype associated with ADHD...
  10. pmc Genetic heterogeneity in type 1 Gaucher disease: multiple genotypes in Ashkenazic and non-Ashkenazic individuals
    S Tsuji
    Molecular Neurogenetics Unit, National Institute of Mental Health, ADAMHA, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 85:2349-52. 1988
    ....
  11. pmc Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease
    S L Winfield
    Clinical Neuroscience Branch, Intramural Research Program IRP, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Genome Res 7:1020-6. 1997
    ..Finally, cote1, a gene of unknown function lies most proximal to GBA. The possible contributions of these closely arrayed genes to the more atypical presentations of Gaucher disease is now under investigation...
  12. ncbi request reprint Glucosylsphingosine accumulation in mice and patients with type 2 Gaucher disease begins early in gestation
    E Orvisky
    Clinical Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Marvland 20892 4405, USA
    Pediatr Res 48:233-7. 2000
    ..These findings suggest that the accumulation of Glc-sph may be responsible for the rapid demise of mice with type 2 Gaucher disease and the devastating clinical course seen in patients with type 2 Gaucher disease...
  13. ncbi request reprint The structure and expression of the human neuroligin-3 gene
    R A Philibert
    Department of Psychiatry, University of Iowa, Rm 2 126b Psychiatry Research MEB, Iowa City, IA 52242 1000, USA
    Gene 246:303-10. 2000
    ..These findings suggest a possible role for the neuroligin gene in mental retardation and that the role of the gene in humans may differ from its role in rats...
  14. ncbi request reprint Monitoring the CNS pathology in aspartylglucosaminuria mice
    K Tenhunen
    Department of Human Molecular Genetics, National Public Health Institute Helsinki, Finland
    J Neuropathol Exp Neurol 57:1154-63. 1998
    ..Thus, the AGU knock-out mice represent an accurate model for AGU, both histopathologically and phenotypically...
  15. ncbi request reprint The genomic structure and developmental expression patterns of the human OPA-containing gene (HOPA)
    R A Philibert
    Department of Psychiatry, University of Iowa, Iowa City 52242 1000, USA
    Hum Genet 105:174-8. 1999
    ..We conclude that the delineation of the function of the HOPA gene locus merits further study...
  16. ncbi request reprint Signal sequence and DNA-mediated expression of human lysosomal alpha-galactosidase A
    S Tsuji
    Eur J Biochem 165:275-80. 1987
    ..This construct, pcD-AG502, encoded enzymatically active human alpha-galactosidase A in monkey COS cells...
  17. pmc Metaxin, a gene contiguous to both thrombospondin 3 and glucocerebrosidase, is required for embryonic development in the mouse: implications for Gaucher disease
    P Bornstein
    Department of Biochemistry, University of Washington, Seattle 98195, USA
    Proc Natl Acad Sci U S A 92:4547-51. 1995
    ..Clearly, the contiguous gene organization at this locus limits targeting strategies for the production of murine models of Gaucher disease...
  18. pmc Gene mapping and leader polypeptide sequence of human glucocerebrosidase: implications for Gaucher disease
    E I Ginns
    Proc Natl Acad Sci U S A 82:7101-5. 1985
    ..These results suggest that the type-specific protein polymorphisms in Gaucher disease result from mutations at this single locus, whose segregation might be followed by linkage to visible chromosomal heteromorphisms...
  19. ncbi request reprint Assignment of the gene coding for human beta-glucocerebrosidase to the region q21-q31 of chromosome 1 using monoclonal antibodies
    R A Barneveld
    Hum Genet 64:227-31. 1983
    ....
  20. pmc Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis
    T R Kyriakides
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    J Cell Biol 140:419-30. 1998
    ....
  21. ncbi request reprint Mice with an aspartylglucosaminuria mutation similar to humans replicate the pathophysiology in patients
    A Jalanko
    National Public Health Institute, Department of Human Molecular Genetics, Mannerheimintie 166, 00300 Helsinki, Finland
    Hum Mol Genet 7:265-72. 1998
    ..The phenotype mimics well AGU in humans, the patients characteristically showing only slowly progressive mental retardation and relatively mild skeletal abnormalities...
  22. ncbi request reprint Structure and organization of the human thrombospondin 3 gene (THBS3)
    K W Adolph
    Department of Biochemistry, University of Washington, Seattle 98195, USA
    Genomics 27:329-36. 1995
    ....
  23. ncbi request reprint Isolation and characterization of the human tyrosine hydroxylase gene: identification of 5' alternative splice sites responsible for multiple mRNAs
    K L O'Malley
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110
    Biochemistry 26:6910-4. 1987
    ..Ledley, F. D., Marvit, J., & Woo, S. L. C. (1986) Biochemistry 25, 743-749] genes indicates that although both probably evolved from a common ancestral gene, major changes in the size of introns have occurred since their divergence...