E M Gillanders

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Evidence against PALB2 involvement in Icelandic breast cancer susceptibility
    Haukur Gunnarsson
    Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland
    J Negat Results Biomed 7:5. 2008
  2. pmc Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families
    Adalgeir Arason
    Department of Pathology, Landspitali LSH v Hringbraut, 101 Reykjavik, Iceland
    Breast Cancer Res 12:R50. 2010
  3. pmc Establishing an adjusted p-value threshold to control the family-wide type 1 error in genome wide association studies
    Priya Duggal
    Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD USA
    BMC Genomics 9:516. 2008
  4. pmc Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traits
    Alison P Klein
    Inherited Disease Research Branch, NHGRI NIH, Baltimore, MD, USA
    BMC Genet 6:S20. 2005
  5. pmc Identification of tag single-nucleotide polymorphisms in regions with varying linkage disequilibrium
    Priya Duggal
    Inherited Disease Research Branch, NHGRI NIH, Baltimore, MD, USA
    BMC Genet 6:S73. 2005
  6. pmc The value of molecular haplotypes in a family-based linkage study
    E M Gillanders
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
    Am J Hum Genet 79:458-68. 2006
  7. pmc GeneLink: a database to facilitate genetic studies of complex traits
    Elizabeth M Gillanders
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 8000, USA
    BMC Genomics 5:81. 2004
  8. pmc Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts
    Daphne W Bell
    Massachusetts General Hospital Cancer Center, Charlestown, MA, USA
    Int J Cancer 121:2661-7. 2007
  9. ncbi request reprint HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome
    J D Carpten
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 32:676-80. 2002
  10. ncbi request reprint Novel mutations in collagen VI genes: expansion of the Bethlem myopathy phenotype
    P C Scacheri
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurology 58:593-602. 2002

Research Grants

Collaborators

Detail Information

Publications10

  1. pmc Evidence against PALB2 involvement in Icelandic breast cancer susceptibility
    Haukur Gunnarsson
    Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland
    J Negat Results Biomed 7:5. 2008
    ..PALB2 appears not to be a significant factor in high-risk breast cancer families in Iceland and the 1592delT mutation is not seen to be associated with breast cancer in Iceland...
  2. pmc Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families
    Adalgeir Arason
    Department of Pathology, Landspitali LSH v Hringbraut, 101 Reykjavik, Iceland
    Breast Cancer Res 12:R50. 2010
    ..To follow up suggestive loci, an additional 13 families from other Nordic countries were genotyped for selected markers...
  3. pmc Establishing an adjusted p-value threshold to control the family-wide type 1 error in genome wide association studies
    Priya Duggal
    Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD USA
    BMC Genomics 9:516. 2008
    ..Many SNPs fall within regions of strong linkage disequilibrium (LD) ("blocks") and should not be considered "independent"...
  4. pmc Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traits
    Alison P Klein
    Inherited Disease Research Branch, NHGRI NIH, Baltimore, MD, USA
    BMC Genet 6:S20. 2005
    ..The presence of LD between markers may have led to an increased number of false positive regions but no clear relationship between regions of high LD and locations of false positive linkage signals was observed...
  5. pmc Identification of tag single-nucleotide polymorphisms in regions with varying linkage disequilibrium
    Priya Duggal
    Inherited Disease Research Branch, NHGRI NIH, Baltimore, MD, USA
    BMC Genet 6:S73. 2005
    ..In addition, we compared the selected SNPs in a multipoint linkage analysis for one region with strong LD. As the number of selected SNPs increased, the LOD score, mean information content, and type I error also increased...
  6. pmc The value of molecular haplotypes in a family-based linkage study
    E M Gillanders
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
    Am J Hum Genet 79:458-68. 2006
    ..Maximization of power, given an existing family set, can be particularly important for late-onset, often-fatal diseases such as cancer, for which informative families are difficult to collect...
  7. pmc GeneLink: a database to facilitate genetic studies of complex traits
    Elizabeth M Gillanders
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 8000, USA
    BMC Genomics 5:81. 2004
    ..To minimize the difficulties inherent in complex trait studies, we have developed GeneLink, a Web-accessible, password-protected Sybase database...
  8. pmc Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts
    Daphne W Bell
    Massachusetts General Hospital Cancer Center, Charlestown, MA, USA
    Int J Cancer 121:2661-7. 2007
    ....
  9. ncbi request reprint HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome
    J D Carpten
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 32:676-80. 2002
    ..Our findings suggest that HRPT2 is a tumor-suppressor gene, the inactivation of which is directly involved in predisposition to HPT-JT and in development of some sporadic parathyroid tumors...
  10. ncbi request reprint Novel mutations in collagen VI genes: expansion of the Bethlem myopathy phenotype
    P C Scacheri
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurology 58:593-602. 2002
    ..To investigate the molecular basis of autosomal dominant limb-girdle muscular dystrophy (AD-LGMD) in three large new families...

Research Grants1