Gretchen L Gierach

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Relationship between mammographic density and breast cancer death in the Breast Cancer Surveillance Consortium
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    J Natl Cancer Inst 104:1218-27. 2012
  2. pmc Coffee intake and breast cancer risk in the NIH-AARP diet and health study cohort
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Suite 550, Rockville, MD, USA
    Int J Cancer 131:452-60. 2012
  3. pmc Mammographic density does not differ between unaffected BRCA1/2 mutation carriers and women at low-to-average risk of breast cancer
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Office of Preventive Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res Treat 123:245-55. 2010
  4. pmc Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health-AARP Diet and Health Study
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Suite 550, Rockville, MD 20852 7234, USA
    Breast Cancer Res 10:R38. 2008
  5. pmc Physical activity, sedentary behavior, and endometrial cancer risk in the NIH-AARP Diet and Health Study
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7234, USA
    Int J Cancer 124:2139-47. 2009
  6. pmc Prediagnosis body mass index, physical activity, and mortality in endometrial cancer patients
    Hannah Arem
    MHS, 6120 Executive Blvd, EPS 3029, Rockville, MD 20852, USA
    J Natl Cancer Inst 105:342-9. 2013
  7. pmc Risk factors for specific histopathological types of postmenopausal breast cancer in the NIH-AARP Diet and Health Study
    Sarah J Nyante
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Room 7 E236, MSC 9774, Bethesda, MD 20892 9774, USA
    Am J Epidemiol 178:359-71. 2013
  8. pmc Intensity and timing of physical activity in relation to postmenopausal breast cancer risk: the prospective NIH-AARP diet and health study
    Tricia M Peters
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, Bethesda, MD, USA
    BMC Cancer 9:349. 2009
  9. pmc Physical activity and postmenopausal breast cancer risk in the NIH-AARP diet and health study
    Tricia M Peters
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, MSC 7232, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 18:289-96. 2009
  10. pmc Endometrial cancer risk factors by 2 main histologic subtypes: the NIH-AARP Diet and Health Study
    Hannah P Yang
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, NIH, Department of Human Services, Bethesda, USA
    Am J Epidemiol 177:142-51. 2013

Detail Information

Publications34

  1. pmc Relationship between mammographic density and breast cancer death in the Breast Cancer Surveillance Consortium
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    J Natl Cancer Inst 104:1218-27. 2012
    ..Women with elevated mammographic density have an increased risk of developing breast cancer. However, among women diagnosed with breast cancer, it is unclear whether higher density portends reduced survival, independent of other factors...
  2. pmc Coffee intake and breast cancer risk in the NIH-AARP diet and health study cohort
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Suite 550, Rockville, MD, USA
    Int J Cancer 131:452-60. 2012
    ..Null findings persisted for risk of both HR-positive and -negative breast cancers. These findings from a large prospective cohort do not support a role of coffee intake in breast carcinogenesis...
  3. pmc Mammographic density does not differ between unaffected BRCA1/2 mutation carriers and women at low-to-average risk of breast cancer
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Office of Preventive Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res Treat 123:245-55. 2010
    ..Taking these factors into account did not significantly alter the results of the age/body mass index-adjusted analysis. Our results do not provide support for an independent effect of BRCA1/2 mutation status on mammographic density...
  4. pmc Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health-AARP Diet and Health Study
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Suite 550, Rockville, MD 20852 7234, USA
    Breast Cancer Res 10:R38. 2008
    ..Epidemiologic evidence for a protective role of NSAIDs in breast cancer, however, is equivocal...
  5. pmc Physical activity, sedentary behavior, and endometrial cancer risk in the NIH-AARP Diet and Health Study
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7234, USA
    Int J Cancer 124:2139-47. 2009
    ..02). Associations with vigorous activities, which may interact with body mass index, suggest directions for future research to clarify underlying biologic mechanisms, including those relating to hormonal alterations...
  6. pmc Prediagnosis body mass index, physical activity, and mortality in endometrial cancer patients
    Hannah Arem
    MHS, 6120 Executive Blvd, EPS 3029, Rockville, MD 20852, USA
    J Natl Cancer Inst 105:342-9. 2013
    ..Intervention studies of the effect of these modifiable lifestyle factors on mortality are needed...
  7. pmc Risk factors for specific histopathological types of postmenopausal breast cancer in the NIH-AARP Diet and Health Study
    Sarah J Nyante
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Room 7 E236, MSC 9774, Bethesda, MD 20892 9774, USA
    Am J Epidemiol 178:359-71. 2013
    ..82, 95% CI: 1.39, 2.37) and mixed ductal-lobular (HR = 1.87, 95% CI: 1.39, 2.51) tumors. Differing associations for hormonal factors and mucinous and tubular cancers suggest etiologies distinct from those of common breast cancers. ..
  8. pmc Intensity and timing of physical activity in relation to postmenopausal breast cancer risk: the prospective NIH-AARP diet and health study
    Tricia M Peters
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, Bethesda, MD, USA
    BMC Cancer 9:349. 2009
    ..Despite strong evidence of an inverse association of physical activity with postmenopausal breast cancer risk, whether a certain intensity or time of life of physical activity is most effective for lowering breast cancer risk is not known...
  9. pmc Physical activity and postmenopausal breast cancer risk in the NIH-AARP diet and health study
    Tricia M Peters
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, MSC 7232, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 18:289-96. 2009
    ..Although physical activity has been associated with reduced breast cancer risk, whether this association varies across breast cancer subtypes or is modified by reproductive and lifestyle factors is unclear...
  10. pmc Endometrial cancer risk factors by 2 main histologic subtypes: the NIH-AARP Diet and Health Study
    Hannah P Yang
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, NIH, Department of Human Services, Bethesda, USA
    Am J Epidemiol 177:142-51. 2013
    ..Because of the limited number of Type II cancers, additional evaluation of risk factors will benefit from consortial efforts...
  11. pmc Body mass index and risk of lung cancer among never, former, and current smokers
    Llewellyn Smith
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 104:778-89. 2012
    ..These studies are difficult to interpret because of potential confounding by cigarette smoking, a major risk factor for lung cancer that is associated with lower BMI...
  12. pmc Anthropometric measures and physical activity and the risk of lung cancer in never-smokers: a prospective cohort study
    Tram Kim Lam
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 8:e70672. 2013
    ..If anything, we observed some evidence for positive associations with a larger BMI or waist circumference...
  13. pmc Ovarian cancer incidence trends in relation to changing patterns of menopausal hormone therapy use in the United States
    Hannah P Yang
    National Cancer Institute, Bethesda, MD, MD 20852, USA
    J Clin Oncol 31:2146-51. 2013
    ..Given that MHT use is also associated with increased ovarian cancer risk, we tested whether ovarian cancer incidence rates changed after 2002...
  14. pmc Unopposed estrogen and estrogen plus progestin menopausal hormone therapy and lung cancer risk in the NIH-AARP Diet and Health Study Cohort
    Louise A Brinton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Cancer Causes Control 23:487-96. 2012
    ..Previous studies have reported that lung cancer risk may be decreased, increased, or unaffected by prior use of menopausal hormone therapy (MHT)...
  15. pmc Menopausal hormone therapy and breast cancer risk in the NIH-AARP Diet and Health Study Cohort
    Louise A Brinton
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, USA
    Cancer Epidemiol Biomarkers Prev 17:3150-60. 2008
    ..Results from the Women's Health Initiative trial raise new questions regarding the effects of estrogen therapy (ET) and estrogen plus progestin therapy (EPT) on breast cancer risk...
  16. pmc Alcohol and endometrial cancer risk in the NIH-AARP diet and health study
    Hannah P Yang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Int J Cancer 128:2953-61. 2011
    ..Our results do not support that alcohol is a strong contributor to endometrial cancer risk, but slight risk increases may prevail among some users or for selected tumor characteristics...
  17. ncbi request reprint Breast cancer risk in older women: results from the NIH-AARP Diet and Health Study
    Louise A Brinton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
    Cancer Causes Control 25:843-57. 2014
    ..Divergent risk factors exist for premenopausal and postmenopausal breast cancers, but it is unclear whether differences by age exist among postmenopausal women...
  18. pmc Nonsteroidal anti-inflammatory drug use and endometrial cancer risk in the NIH-AARP Diet and Health Study
    Kim N Danforth
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Cancer Prev Res (Phila) 2:466-72. 2009
    ..Overall, our data do not support an association between aspirin or NA-NSAID use and endometrial cancer risk...
  19. pmc Reproductive and hormonal factors and lung cancer risk in the NIH-AARP Diet and Health Study cohort
    Louise A Brinton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 20:900-11. 2011
    ..Inconsistent findings about hormonal factors on risk may reflect incomplete control for confounding, misclassification of exposures, or insufficient attention to variation by histology...
  20. pmc Prospective evaluation of risk factors for male breast cancer
    Louise A Brinton
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 100:1477-81. 2008
    ..Differences in risk factors may reflect unique mechanisms associated with androgens and their ratio to bioavailable estrogens...
  21. pmc Estrogen metabolism and mammographic density in postmenopausal women: a cross-sectional study
    Barbara J Fuhrman
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 21:1582-91. 2012
    ..We investigated the cross-sectional associations of urinary estrogens, and their 2-, 4-, and 16-hydroxylated metabolites with MD...
  22. pmc Epithelial ovarian cancer and exposure to dietary nitrate and nitrite in the NIH-AARP Diet and Health Study
    Briseis Aschebrook-Kilfoy
    Occupational and Environmental Epidemiology Branch, DCEG, NCI, NIH, Rockville, Maryland 20852, USA
    Eur J Cancer Prev 21:65-72. 2012
    ..There were no clear differences in risk by histologic subtype of ovarian cancer. Our findings suggest that a role of dietary nitrate and nitrite in ovarian cancer risk should be followed in other large cohort studies...
  23. ncbi request reprint Long-term overall and disease-specific mortality associated with benign gynecologic surgery performed at different ages
    Gretchen L Gierach
    From the 1Hormonal and Reproductive Epidemiology Branch, 2Biostatistics Branch, and 3Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD and 4John P Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, MD
    Menopause 21:592-601. 2014
    ..As bilateral salpingo-oophorectomy is frequently performed with hysterectomy for nonmalignant conditions, defining health outcomes associated with benign bilateral salpingo-oophorectomy performed at different ages is critical...
  24. doi request reprint Cigarette smoking and endometrial carcinoma risk: the role of effect modification and tumor heterogeneity
    Ashley S Felix
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD, 20892 9774, USA
    Cancer Causes Control 25:479-89. 2014
    ..We examined effect modification of this relationship and associations with tumor characteristics in the National Institutes of Health-AARP Diet and Health Study...
  25. pmc Circulating estrogens and estrogens within the breast among postmenopausal BRCA1/2 mutation carriers
    Jennifer T Loud
    Clinical Genetics Branch CGB, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 9609 Medical Center Drive, Room 6E536, Bethesda, MD, 20850 9772, USA
    Breast Cancer Res Treat 143:517-29. 2014
    ..If confirmed, future etiologic studies could utilize the more readily obtainable serum hormone levels as a reliable surrogate measure of exposure at the tissue level...
  26. pmc Etiologic factors for male breast cancer in the U.S. Veterans Affairs medical care system database
    Louise A Brinton
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 5018, Rockville, MD 20852, USA
    Breast Cancer Res Treat 119:185-92. 2010
    ..21-8.03), obesity (1.91, 1.50-2.44), and orchitis/epididymitis (1.80, 1.08-3.01). These results support previous speculations that male breast cancer is influenced not only by tissue at risk, but also by hormonal and inflammatory factors...
  27. pmc Accelerometer-based measures of active and sedentary behavior in relation to breast cancer risk
    Cher M Dallal
    Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res Treat 134:1279-90. 2012
    ..Our findings support an inverse association between accelerometer-based measures of moderate-to-vigorous physical activity and breast cancer while also suggesting potential increases in risk with sedentary time...
  28. pmc Relationship of mammographic density and gene expression: analysis of normal breast tissue surrounding breast cancer
    Xuezheng Sun
    Authors Affiliations Department of Epidemiology Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland Department of Biology, Trinity University, San Antonio, Texas Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    Clin Cancer Res 19:4972-82. 2013
    ..To evaluate how mammographic density and breast tissue composition relate to extratumoral microenvironment gene expression, we used data on 121 patients with breast cancer from the population-based Polish Women's Breast Cancer Study...
  29. doi request reprint Epidemiology of triple negative breast cancers
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, DHHS NIH NCI Division of Cancer Epidemiology and Genetics, Bethesda, MD 20892 7244, USA
    Breast Dis 32:5-24. 2010
    ..Information sources for this review included the National Cancer Institute's Surveillance, Epidemiology, and End Results 13 Registries Public-Use Database [5], CANCERLIT, Index Medicus, and PubMed...
  30. ncbi request reprint Opportunities for molecular epidemiological research on ductal carcinoma in-situ and breast carcinogenesis: Interdisciplinary approaches
    Mark E Sherman
    National Cancer Institute, Division of Cancer Prevention, Bethesda, MD, USA
    Breast Dis 34:105-16. 2014
    ..Accordingly, methods are needed to both specifically detect and identify DCIS lesions with potential to progress to invasive cancer and to discover techniques to triage and conservatively manage indolent cases of DCIS. ..
  31. doi request reprint Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res Treat 121:727-35. 2010
    ..These results warrant analysis in studies of clinical outcomes accounting for age, ER status and treatment...
  32. ncbi request reprint Recreational physical activity and mammographic breast density characteristics
    Katherine W Reeves
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Suite 510, 3520 Fifth Avenue, Pittsburgh, PA 15213, USA
    Cancer Epidemiol Biomarkers Prev 16:934-42. 2007
    ..These results suggest that the mechanism by which physical activity reduces breast cancer risk may not involve breast density...
  33. doi request reprint Nonsteroidal anti-inflammatory drug use and serum total estradiol in postmenopausal women
    Alana G Hudson
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Cancer Epidemiol Biomarkers Prev 17:680-7. 2008
    ..These cross-sectional findings suggest that NSAID use may be associated with lower circulating estradiol levels, potentially representing one mechanism through which NSAIDs exert protective effects on breast cancer...
  34. ncbi request reprint Hostility scores are associated with increased risk of cardiovascular events in women undergoing coronary angiography: a report from the NHLBI-Sponsored WISE Study
    Marian B Olson
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Psychosom Med 67:546-52. 2005
    ..To evaluate hostility-related personality traits assessed by the Cook Medley Hostility Inventory and to relate these to the occurrence of adverse cardiac events in women with suspected myocardial ischemia...