Research Topics
Species | Jay N GieddSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Review: magnetic resonance imaging of male/female differences in human adolescent brain anatomyJay N Giedd
Child Psychiatry Branch, Brain Imaging Unit, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, MSC 1367, Building 10, Room 4 C110, Bethesda, MD, 20892, USA
Biol Sex Differ 3:19. 2012..White matter volumes increase throughout childhood and adolescence in both sexes but more rapidly in adolescent males resulting in an expanding magnitude of sex differences from childhood to adulthood...
Structural brain magnetic resonance imaging of pediatric twinsJay N Giedd
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Hum Brain Mapp 28:474-81. 2007..Understanding of influences on trajectories of brain development may shed light on the emergence of psychopathology during childhood and adolescence and ultimately may guide therapeutic interventions...- Structural magnetic resonance imaging of the adolescent brainJay N Giedd
National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Room 4C110, 10 Center Dr MSC 1367, Bethesda, MD 20892 1367, USA
Ann N Y Acad Sci 1021:77-85. 2004..The details of the relationships between anatomical changes and behavioral changes, and the forces that influence brain development, have not been well established and remain a prominent goal of ongoing investigations... 
The teen brain: insights from neuroimagingJay N Giedd
Brain Imaging Unit, Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Adolesc Health 42:335-43. 2008....- Anatomic magnetic resonance imaging of the developing child and adolescent brain and effects of genetic variationJay N Giedd
Child Psychiatry Branch, National Institutes of Mental Health, Bethesda, MD, USA
Neuropsychol Rev 20:349-61. 2010.... - Puberty-related influences on brain developmentJay N Giedd
Child Psychiatry Branch, National Institute of Mental Health, Building 10, Room 4C110, 10 Center Drive, MSC 1367, Bethesda, MD 20892, United States
Mol Cell Endocrinol 254:154-62. 2006..Subjects with XXY have gray matter reductions in the insula, temporal gyri, amygdala, hippocampus, and cingulate-areas consistent with the language-based learning difficulties common in this group... - XXY (Klinefelter syndrome): a pediatric quantitative brain magnetic resonance imaging case-control studyJay N Giedd
Child Psychiatry Branch NIMH, National Institutes of Health, Building 10, Room 4C110, 10 Center Dr, MSC 1367, Bethesda, MD 20892, USA
Pediatrics 119:e232-40. 2007..The objective of this study was to examine possible neuroanatomical substrates of these cognitive and behavioral features during childhood and adolescence... - Structural MRI of pediatric brain development: what have we learned and where are we going?Jay N Giedd
Child Psychiatry Branch NIMH, Bethesda, MD 20892, USA
Neuron 67:728-34. 2010..In this review we summarize general contributions of structural MRI to our understanding of neurodevelopment in health and illness... - Dynamic mapping of hippocampal development in childhood onset schizophreniaTom F Nugent
Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
Schizophr Res 90:62-70. 2007.... - Sexual dimorphism of brain developmental trajectories during childhood and adolescenceRhoshel K Lenroot
Child Psychiatry Branch of the National Institute of Mental Health, NIMH CHP 10 Center Drive, Bethesda, MD 20814 9692, USA
Neuroimage 36:1065-73. 2007..These sexually dimorphic trajectories confirm the importance of longitudinal data in studies of brain development and underline the need to consider sex matching in studies of brain development... - Differences in genetic and environmental influences on the human cerebral cortex associated with development during childhood and adolescenceRhoshel K Lenroot
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 9692, USA
Hum Brain Mapp 30:163-74. 2009..These results suggest that both the specific cortical region and the age of the population should be taken into account when using cortical thickness as an intermediate phenotype to link genes, environment, and behavior... - Delayed white matter growth trajectory in young nonpsychotic siblings of patients with childhood-onset schizophreniaNitin Gogtay
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Arch Gen Psychiatry 69:875-84. 2012..As reported before for gray matter, WM growth may also be an age-specific endophenotype that shows compensatory normalization with age... - Progressive brain volume loss during adolescence in childhood-onset schizophreniaAlexandra L Sporn
Child Psychiatry Branch, NIMH, Bldg 10, Rm 3N202, Bethesda, MD 20892, USA
Am J Psychiatry 160:2181-9. 2003..This study examined the rate of loss in cortical gray matter volume in relation to age and clinical status in adolescent patients over a follow-up period of 2-6 years... - Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controlsArmin Raznahan
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MA 20892, USA
Neuroimage 57:1517-23. 2011..These findings suggest that cortical abnormalities in pedigrees affected by schizophrenia may be contributed to by a disruption of dopaminergic infleunces on cortical maturation... - Allelic variation within the putative autism spectrum disorder risk gene homeobox A1 and cerebellar maturation in typically developing children and adolescentsArmin Raznahan
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Autism Res 5:93-100. 2012..002). Our results suggest that common genetic variation within this putative ASD risk gene has the capacity to modify the development of cerebellar systems implicated in ASD neurobiology... - Distinct cortical correlates of autistic versus antisocial traits in a longitudinal sample of typically developing youthGregory L Wallace
Laboratory of Brain and Cognition, National Institute of Mental Health, NIH, Bethesda, Maryland 20892 1366, USA
J Neurosci 32:4856-60. 2012..These results support the dimensional view of psychopathology and provide neural signatures that can serve as informative endophenotypes for future genetic studies... - Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychosesNitin Gogtay
Child Psychiatry Branch, National Institute of Mental Health NIH, Building 10, Room 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892 1600, USA
Arch Gen Psychiatry 61:17-22. 2004..We hypothesized that cortical GM loss would occur in patients with COS but not in adolescents with atypical psychoses... - How does your cortex grow?Armin Raznahan
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 31:7174-7. 2011..Knowing of these developmental dissociations, and further specifying their timing and sex-biases, provides potent new research targets for basic and clinical neuroscience... - Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorderPhilip Shaw
Child Psychiatry Branch, Room 3N202, Bldg 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 64:921-31. 2007..Attention-deficit/hyperactivity disorder (ADHD) is one of the most heritable neuropsychiatric disorders, and a polymorphism within the dopamine D4 receptor (DRD4) gene has been frequently implicated in its pathogenesis... - Patterns of coordinated anatomical change in human cortical development: a longitudinal neuroimaging study of maturational couplingArmin Raznahan
Child Psychiatry Branch, National Institute of Health, National Institutes of Mental Health, Bethesda, MD 20892, USA
Neuron 72:873-84. 2011.... - Dynamic mapping of cortical development before and after the onset of pediatric bipolar illnessNitin Gogtay
Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
J Child Psychol Psychiatry 48:852-62. 2007..We report the first prospective study of cortical brain development in pediatric bipolar illness for 9 male children, visualized before and after illness onset... - Neurodevelopmental trajectories of the human cerebral cortexPhilip Shaw
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 28:3586-94. 2008.... - A pediatric twin study of brain morphometryGregory L Wallace
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
J Child Psychol Psychiatry 47:987-93. 2006..CONCLUSION: Understanding the relative contributions of genetic and nongenetic factors on developmental brain trajectories may have implications for better understanding brain-based disorders and typical cognitive development... - Longitudinally mapping the influence of sex and androgen signaling on the dynamics of human cortical maturation in adolescenceArmin Raznahan
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 107:16988-93. 2010.... - Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational studyPhilip Shaw
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
Lancet Neurol 6:494-500. 2007.... - Trajectories of anatomic brain development as a phenotypeJay N Giedd
Brain Imaging Unit, Child Psychiatry Branch NIMH, 10 Center Drive, MSC 1367 Bethesda, MD 20892, USA
Novartis Found Symp 289:101-12; discussion 112-8, 193-5. 2008.... - Dynamic mapping of normal human hippocampal developmentNitin Gogtay
Child Psychiatry Branch, NIMH, Bethesda, Maryland 20892, USA
Hippocampus 16:664-72. 2006..These distinct developmental trajectories of hippocampal subregions may parallel differences in their functional development... - Corpus callosum development in childhood-onset schizophreniaAudrey Keller
Child Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3N 202, 10 Center Drive MSC 1600, Bethesda, MD 20892-1600, USA
Schizophr Res 62:105-14. 2003..If replicated, this may reflect anticipated late occipital and extrastriate changes in brain regions... - Effects of hormones and sex chromosomes on stress-influenced regions of the developing pediatric brainA Blythe Rose
National Institute of Mental Health, National Institutes of Health, Bldg. 10, Rm 4C110, 10 Center Drive, Bethesda, MD 20892, USA
Ann N Y Acad Sci 1032:231-3. 2004..Future studies that examine longitudinal data and/or other diagnostic groups, however, may help to better elucidate specific hormone and sex chromosome effects upon stress-related structures in the brain... - A bivariate twin study of regional brain volumes and verbal and nonverbal intellectual skills during childhood and adolescenceGregory L Wallace
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892 1600, USA
Behav Genet 40:125-34. 2010..These results suggest that distinct mechanisms contribute to the small phenotypic relationships between brain volumes and verbal versus nonverbal intelligence... - The changing impact of genes and environment on brain development during childhood and adolescence: initial findings from a neuroimaging study of pediatric twinsRhoshel K Lenroot
National Institutes of Mental Health, Bethesda, MD 20892 1600, USA
Dev Psychopathol 20:1161-75. 2008..Areas associated with more complex reasoning abilities become increasingly heritable with maturation. The potential mechanisms by which gene-environment interactions may affect heritability values during development is discussed... - Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometryNitin Gogtay
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 105:15979-84. 2008..Growth rates were correlated with functional prognosis and were visualized as detailed 3D maps. Finally, these findings also confirm that the progressive GM deficits seen in schizophrenia are not the result of WM overgrowth... - Dosage effects of X and Y chromosomes on language and social functioning in children with supernumerary sex chromosome aneuploidies: implications for idiopathic language impairment and autism spectrum disordersNancy Raitano Lee
Child Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
J Child Psychol Psychiatry 53:1072-81. 2012..The current research sought to fill this gap in the literature and to examine dosage effects of X and Y chromosomes on language and social functioning... - Age-related temporal and parietal cortical thinning in autism spectrum disordersGregory L Wallace
Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 20892 1366, USA
Brain 133:3745-54. 2010..e. greater thinning) may be characteristic of these disorders... - Children experience cognitive decline despite reversal of brain atrophy one year after resolution of Cushing syndromeDeborah P Merke
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1932, USA
J Clin Endocrinol Metab 90:2531-6. 2005..Despite rapid reversibility of cerebral atrophy, children experience a significant decline in cognitive function 1 yr after correction of hypercortisolism... - Cerebellum development during childhood and adolescence: a longitudinal morphometric MRI studyHenning Tiemeier
Child Psychiatry Branch, National Institute of Mental Health NIH, Bethesda, MD 20892, USA
Neuroimage 49:63-70. 2010.... - Dynamic mapping of human cortical development during childhood through early adulthoodNitin Gogtay
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:8174-9. 2004..Direct comparison with normal cortical development may help understanding of some neurodevelopmental disorders such as childhood-onset schizophrenia or autism... - Structural brain MRI abnormalities in healthy siblings of patients with childhood-onset schizophreniaNitin Gogtay
Child Psychiatry Branch, National Institute of Mental Health, NationalInstitutes of Health, Bethesda, MD 20892 1600, USA
Am J Psychiatry 160:569-71. 2003.... - Autism risk gene MET variation and cortical thickness in typically developing children and adolescentsAlexis Hedrick
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20814, USA
Autism Res 5:434-9. 2012..Our results suggest that genetic differences in the MET gene may influence the development of cortical systems implicated in the neurobiology of ASD... - A magnetization transfer imaging study of corpus callosum myelination in young children with autismMarta Gozzi
Pediatrics and Developmental Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1255, USA
Biol Psychiatry 72:215-20. 2012..Here, we used magnetization transfer imaging to provide insight into the myelination of the corpus callosum in children with autism... - Prenatal growth in humans and postnatal brain maturation into late adolescenceArmin Raznahan
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 109:11366-71. 2012..By mapping the sensitivity of postnatal human brain development to prenatal influences, our findings underline the potency of in utero life in shaping postnatal outcomes of neuroscientific and public health importance... - Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorderF Xavier Castellanos
Child Psychiatry Branch, National Institute of Mental Health NIH, Bethesda, MD, USA
Am J Psychiatry 160:1693-6. 2003..To examine brain-behavior relationships in attention deficit hyperactivity disorder (ADHD), the authors obtained magnetic resonance imaging (MRI) scans of monozygotic twins discordant for ADHD... - Children with classic congenital adrenal hyperplasia have decreased amygdala volume: potential prenatal and postnatal hormonal effectsDeborah P Merke
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, The Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892-1932, USA
J Clin Endocrinol Metab 88:1760-5. 2003.... - Progressive loss of cerebellar volume in childhood-onset schizophreniaAudrey Keller
Child Psychiatry Branch, National Institute of Mental Health, Bldg. 10, Rm. 3N 202, Bethesda, MD 20892-1600, USA
Am J Psychiatry 160:128-33. 2003..At least in these patients with severe early-onset schizophrenia, the loss appears secondary to a generalized process... - Brain development in children and adolescents: insights from anatomical magnetic resonance imagingRhoshel K Lenroot
Child Psychiatry Branch, National Institute of Mental Health, Building 10, Room 4C110, 10 Center Drive, Bethesda, MD 20854, USA
Neurosci Biobehav Rev 30:718-29. 2006..Studies are ongoing to explore the influences of genetic and environmental factors on developmental trajectories... - A case study of a multiply talented savant with an autism spectrum disorder: neuropsychological functioning and brain morphometryGregory L Wallace
Institute of Psychiatry, Social, Genetic, and Developmental Psychiatry Centre, King s College, University of London, London WC2R 2LS, UK
Philos Trans R Soc Lond B Biol Sci 364:1425-32. 2009..g. calendars, art, music) that capitalize upon strengths often associated with ASD, such as detail-focused processing, are probably further enhanced through over-learning and massive exposure, and reflected in atypical brain structure... - Cortical anatomy in human X monosomyArmin Raznahan
Department of Child Psychiatry, Institute of Psychiatry, King s College London, UK
Neuroimage 49:2915-23. 2010..g. cortical folding) and CT (e.g. dendritic arborization/pruning). CT disruptions are maximal within and between cortical regions previously implicated in the TS cognitive phenotype... - Prevalence of and risk factors for depressive symptoms among young adolescentsGitanjali Saluja
National Institute of Child Health and Human Development, Rockville, MD 20892 7510, USA
Arch Pediatr Adolesc Med 158:760-5. 2004..To determine the prevalence, risk factors, and risk behaviors associated with depressive symptoms in a nationally representative, cross-sectional sample of young adolescents... - Quantitative morphology of the corpus callosum in obsessive-compulsive disorderKatherine C Lopez
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room 4C110, 10 Center Drive, MSC 1367, Bethesda, MD, USA
Psychiatry Res 212:1-6. 2013..These findings implicate medio-frontal regions of the cortex in the pathophysiology of OCD... - Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorderF Xavier Castellanos
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
JAMA 288:1740-8. 2002..Various anatomic brain abnormalities have been reported for attention-deficit/hyperactivity disorder (ADHD), with varying methods, small samples, cross-sectional designs, and without accounting for stimulant drug exposure... - The anatomy of mentalization: a view from developmental neuroimagingJay N Giedd
Brain Imaging Unit, Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Rockville, Maryland, USA
Bull Menninger Clin 67:132-42. 2003.... - Imaging structural co-variance between human brain regionsAaron Alexander-Bloch
1 Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA 2 David Geffen School of Medicine at University of California, Los Angeles UCLA, California 90095, USA 3 Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridgeshire, CB2 0SZ, UK
Nat Rev Neurosci 14:322-36. 2013..This Review discusses the state of current research into brain structural co-variance, its underlying mechanisms and its potential value in the understanding of various neurological and psychiatric conditions... - The digital revolution and adolescent brain evolutionJay N Giedd
Brain Imaging Section, Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
J Adolesc Health 51:101-5. 2012..The consequences of the brain's adaptation to the demands and opportunities of the digital age have enormous implications for adolescent health professionals... - Effects of sex chromosome aneuploidies on brain development: evidence from neuroimaging studiesRhoshel K Lenroot
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Dev Disabil Res Rev 15:318-27. 2009..The limited data regarding effects of having two Y chromosomes (47,XYY) do not find significant differences in brain volume, although there are some reports of increased head size... - Motion artifact in magnetic resonance imaging: implications for automated analysisJonathan D Blumenthal
Child Psychiatry Branch, NIMH, NIH, Bethesda, Maryland, 20892-1367, USA
Neuroimage 16:89-92. 2002..Greater motion artifact was associated with smaller gray matter volumes. Severity of motion artifact is an important, but often overlooked, consideration in the interpretation of automated MRI measures... - A multivariate analysis of neuroanatomic relationships in a genetically informative pediatric sampleJ Eric Schmitt
Virginia Institute for Psychiatric and Behavioral Genetics and Departments of Psychiatry and Human Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
Neuroimage 35:70-82. 2007..These findings are concordant with prior volumetric twin studies and support radial models of brain evolution... - Corpus callosum morphometrics in young children with autism spectrum disorderInbal Boger-Megiddo
Department of Radiology, 5C-1, Children's Hospital and Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA, 98105, USA
J Autism Dev Disord 36:733-9. 2006..Results could reflect decreased inter-hemispheric connectivity or cerebral enlargement due to increase in tissues less represented in the corpus callosum in ASD... - Individual and population penalized regression splines for accelerated longitudinal designsJaroslaw Harezlak
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Biometrics 61:1037-48. 2005..Potential applications extend beyond growth studies to many other fields in which cost and feasibility constraints impose restrictions on sample size and on the numbers and timings of repeated measurements across subjects... - Dynamically spreading frontal and cingulate deficits mapped in adolescents with schizophreniaChristine N Vidal
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, David Geffen School of Medicine at UCLA, 90095-1769, USA
Arch Gen Psychiatry 63:25-34. 2006..CONCLUSION: Frontal and limbic regions may not be equally vulnerable to gray matter attrition, which is consistent with the cognitive, metabolic, and functional vulnerability of the frontal cortices in schizophrenia... - Mapping cortical change in Alzheimer's disease, brain development, and schizophreniaPaul M Thompson
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
Neuroimage 23:S2-18. 2004..Dynamically spreading waves of gray matter loss are tracked in dementia and schizophrenia, and these sequences are related to normally occurring changes in healthy subjects of various ages... - Deformation-based surface morphometry applied to gray matter deformationMoo K Chung
Department of Statistics, University of Wisconsin, 1210 West Dayton Street, Madison, WI 53706 1685, USA
Neuroimage 18:198-213. 2003.... - Childhood neglect is associated with reduced corpus callosum areaMartin H Teicher
Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 56:80-5. 2004..CONCLUSIONS: These data are consistent with animal research that demonstrated reduced CC size in nursery-reared compared with semi-naturally reared primates. Early experience might also affect the development of the human CC... - Cerebellar development and clinical outcome in attention deficit hyperactivity disorderSusan Mackie
Columbia University School of Medicine, New York, NY, USA
Am J Psychiatry 164:647-55. 2007.... - Structural MRI and brain developmentPaul M Thompson
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, University of California, Los Angeles School of Medicine, Los Angeles, California 90095-1769, USA
Int Rev Neurobiol 67:285-323. 2005 - Review of twin and family studies on neuroanatomic phenotypes and typical neurodevelopmentJ Eric Schmitt
Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
Twin Res Hum Genet 10:683-94. 2007.... - The epigenesis of planum temporale asymmetry in twinsMark A Eckert
Department of Neuroscience, McKnight Brain Institute of the University of Florida, Gainesville, FL 32610, USA
Cereb Cortex 12:749-55. 2002..Birth weight differences were also related to twin differences in total cerebral volume, but not central sulcus asymmetry. These results suggest that exogenous perinatal factors affect the epigenesis of planar asymmetry development...