Kamran Ghoreschi

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550)
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 186:4234-43. 2011
  2. ncbi Janus kinases in immune cell signaling
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Rev 228:273-87. 2009
  3. ncbi Selectivity and therapeutic inhibition of kinases: to be or not to be?
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 10:356-60. 2009
  4. ncbi Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 467:967-71. 2010
  5. ncbi Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1
    Kiyoshi Hirahara
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 36:1017-30. 2012
  6. ncbi T helper 17 cell heterogeneity and pathogenicity in autoimmune disease
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Trends Immunol 32:395-401. 2011
  7. ncbi Helper T-cell differentiation and plasticity: insights from epigenetics
    Kiyoshi Hirahara
    Department of Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1930, USA
    Immunology 134:235-45. 2011
  8. ncbi Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
    Xiang Ping Yang
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:247-54. 2011
  9. ncbi Signal transduction pathways and transcriptional regulation in Th17 cell differentiation
    Kiyoshi Hirahara
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cytokine Growth Factor Rev 21:425-34. 2010
  10. ncbi Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)
    Jian Kang Jiang
    NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA
    J Med Chem 51:8012-8. 2008

Collaborators

Detail Information

Publications10

  1. ncbi Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550)
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 186:4234-43. 2011
    ..Thus, CP-690,550 may improve autoimmune diseases and prevent transplant rejection by suppressing the differentiation of pathogenic Th1 and Th17 cells as well as innate immune cell signaling...
  2. ncbi Janus kinases in immune cell signaling
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Rev 228:273-87. 2009
    ..Despite the fact that Jaks were discovered only a little more than a decade ago, at the time of writing there are 20 clinical trials underway testing the safety and efficacy of Jak inhibitors...
  3. ncbi Selectivity and therapeutic inhibition of kinases: to be or not to be?
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 10:356-60. 2009
    ..In this Perspective, we discuss the present status of Janus kinase inhibitors-a new class of immunosuppressive drugs-and the advantages and disadvantages of selectively inhibiting this class of kinase...
  4. ncbi Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 467:967-71. 2010
    ..These data indicate an alternative mode for T(H)17 differentiation. Consistent with genetic data linking IL23R with autoimmunity, our findings re-emphasize the importance of IL-23 and therefore may have therapeutic implications...
  5. ncbi Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1
    Kiyoshi Hirahara
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 36:1017-30. 2012
    ..Thus, these data identify a suppressive activity of IL-27, by which CD4(+) T cells can restrict differentiation of Th17 cells in trans...
  6. ncbi T helper 17 cell heterogeneity and pathogenicity in autoimmune disease
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Trends Immunol 32:395-401. 2011
    ..Ideally, better understanding of expression and action of key transcription factors and the epigenetic landscape of Th17 can help explain the flexibility and diversity of interleukin-17-producing cells...
  7. ncbi Helper T-cell differentiation and plasticity: insights from epigenetics
    Kiyoshi Hirahara
    Department of Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1930, USA
    Immunology 134:235-45. 2011
    ..In this review, we will discuss recent progress in the understanding of how cytokines influence gene expression and epigenetic modifications, and the impact of these findings on our views of helper cell lineage commitment and plasticity...
  8. ncbi Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
    Xiang Ping Yang
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:247-54. 2011
    ..Thus, the balance rather than the absolute magnitude of these signals determined the propensity of cells to make a key inflammatory cytokine...
  9. ncbi Signal transduction pathways and transcriptional regulation in Th17 cell differentiation
    Kiyoshi Hirahara
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cytokine Growth Factor Rev 21:425-34. 2010
    ..In this review, we will discuss the current understanding of the signaling pathways, molecular interactions, and transcriptional and epigenetic events that contribute to Th17 differentiation and acquisition of effector functions...
  10. ncbi Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)
    Jian Kang Jiang
    NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA
    J Med Chem 51:8012-8. 2008
    ..Finally, an appraisal of the minimum energy conformation of each stereoisomer and molecular docking at Jak3 was performed in an effort to better understand each compounds selectivity and potency profiles...