Dori R Germolec

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Biokinetics and subchronic toxic effects of oral arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid in v-Ha-ras transgenic (Tg.AC) mice
    Yaxiong Xie
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 112:1255-63. 2004
  2. pmc Lack of evidence for contact sensitization by Pfiesteria extract
    Rachel M Patterson
    Toxicology Operations Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 115:1023-8. 2007
  3. ncbi request reprint Arsenic induces overexpression of growth factors in human keratinocytes
    D R Germolec
    Environmental Immunology and Neurobiology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 141:308-18. 1996
  4. pmc Key issues for the assessment of the allergenic potential of genetically modified foods: breakout group reports
    Dori R Germolec
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:1131-9. 2003
  5. ncbi request reprint Extended histopathology in immunotoxicity testing: interlaboratory validation studies
    D R Germolec
    Laboratory of Molecular Toxicology National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 78:107-15. 2004
  6. ncbi request reprint Sensitivity and predictivity in immunotoxicity testing: immune endpoints and disease resistance
    D R Germolec
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, 111 Alexander Drive, P O Box 12233, Research Triangle Park, NC 27709, USA
    Toxicol Lett 149:109-14. 2004
  7. ncbi request reprint The accuracy of extended histopathology to detect immunotoxic chemicals
    D R Germolec
    Laboratory of Molecular Toxicology National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 82:504-14. 2004
  8. pmc Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors
    D R Germolec
    Environmental Immunology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Pathol 153:1775-85. 1998
  9. ncbi request reprint Arsenic can mediate skin neoplasia by chronic stimulation of keratinocyte-derived growth factors
    D R Germolec
    Environmental Immunology and Neurobiology Section, NIH, Research Triangle Park, NC 27709, USA
    Mutat Res 386:209-18. 1997
  10. pmc Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice
    Eda Yildirim
    Intramural Research Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Am J Physiol Lung Cell Mol Physiol 303:L539-49. 2012

Collaborators

Detail Information

Publications36

  1. pmc Biokinetics and subchronic toxic effects of oral arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid in v-Ha-ras transgenic (Tg.AC) mice
    Yaxiong Xie
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 112:1255-63. 2004
    ..These effects may play a role in arsenic-induced hepatotoxicity and carcinogenesis and may be of particular toxicologic relevance...
  2. pmc Lack of evidence for contact sensitization by Pfiesteria extract
    Rachel M Patterson
    Toxicology Operations Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 115:1023-8. 2007
    ..Although the toxin has not been isolated and purified, the original data suggested both hydrophilic and hydrophobic toxic components. Some investigators propose that dermonecrotic properties are associated with a hydrophobic fraction...
  3. ncbi request reprint Arsenic induces overexpression of growth factors in human keratinocytes
    D R Germolec
    Environmental Immunology and Neurobiology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 141:308-18. 1996
    ..The present studies demonstrate that growth-promoting cytokines and growth factors are induced in keratinocytes following treatment with arsenic and could play a significant role in arsenic-induced skin cancer...
  4. pmc Key issues for the assessment of the allergenic potential of genetically modified foods: breakout group reports
    Dori R Germolec
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:1131-9. 2003
    ..This article is a brief summary of the discussions of each of the six breakout groups regarding our current state of knowledge and what information is needed to advance the field...
  5. ncbi request reprint Extended histopathology in immunotoxicity testing: interlaboratory validation studies
    D R Germolec
    Laboratory of Molecular Toxicology National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 78:107-15. 2004
    ....
  6. ncbi request reprint Sensitivity and predictivity in immunotoxicity testing: immune endpoints and disease resistance
    D R Germolec
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, 111 Alexander Drive, P O Box 12233, Research Triangle Park, NC 27709, USA
    Toxicol Lett 149:109-14. 2004
    ....
  7. ncbi request reprint The accuracy of extended histopathology to detect immunotoxic chemicals
    D R Germolec
    Laboratory of Molecular Toxicology National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 82:504-14. 2004
    ....
  8. pmc Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors
    D R Germolec
    Environmental Immunology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Pathol 153:1775-85. 1998
    ....
  9. ncbi request reprint Arsenic can mediate skin neoplasia by chronic stimulation of keratinocyte-derived growth factors
    D R Germolec
    Environmental Immunology and Neurobiology Section, NIH, Research Triangle Park, NC 27709, USA
    Mutat Res 386:209-18. 1997
    ..These studies suggest that in vitro studies with human keratinocyte cultures examined in conjunction with TG.AC transgenic mice can provide a useful model for examining the tumor enhancing properties of environmental chemicals...
  10. pmc Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice
    Eda Yildirim
    Intramural Research Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Am J Physiol Lung Cell Mol Physiol 303:L539-49. 2012
    ..Thus we propose that TRPC1 signaling is necessary in lymphocyte biology and in regulation of allergen-induced lung hyperresponsiveness, making TRPC1 a potential target for treatment of immune diseases and asthma...
  11. pmc It's all about sex: gender, lung development and lung disease
    Michelle A Carey
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Trends Endocrinol Metab 18:308-13. 2007
    ..In this review, the influence of gender and sex hormones on lung development and pathology will be discussed, with specific emphasis on pulmonary fibrosis, asthma and cancer...
  12. ncbi request reprint Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection
    Michelle A Carey
    Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Research Triangle Park, NC 27709, USA
    J Immunol 175:6878-84. 2005
    ..COX-1 deficiency is detrimental whereas COX-2 deficiency is beneficial to the host during influenza viral infection...
  13. pmc Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice
    Michelle A Carey
    Division of Intramural Research, NIH NIEHS, Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 175:126-35. 2007
    ..Airway hyperresponsiveness is a critical feature of asthma. Substantial epidemiologic evidence supports a role for female sex hormones in modulating lung function and airway hyperresponsiveness in humans...
  14. pmc Assessment of allergenic potential of genetically modified foods: an agenda for future research
    MaryJane K Selgrade
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:1140-1. 2003
    ..These groups agreed that research should progress quickly in the area of hazard identification and that a need exists for more basic research to understand the mechanisms underlying food allergy. A list of research needs was developed...
  15. ncbi request reprint The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies
    Michelle A Carey
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Physiol Lung Cell Mol Physiol 293:L272-8. 2007
    ..Specific emphasis will be placed on fibrosis, allergic airway disease, acute lung injury models, respiratory infection, and lung toxicology studies...
  16. pmc Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, North Carolina27709, USA
    Cancer Res 68:8278-85. 2008
    ....
  17. ncbi request reprint Cyclooxygenase enzymes in allergic inflammation and asthma
    Michelle A Carey
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive Mail Drop D2 02, Research Triangle Park, NC 27709, USA
    Prostaglandins Leukot Essent Fatty Acids 69:157-62. 2003
    ....
  18. pmc Pharmacologic inhibition of COX-1 and COX-2 in influenza A viral infection in mice
    Michelle A Carey
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 5:e11610. 2010
    ..We previously demonstrated that cyclooxygenase (COX)-1 deficiency results in greater morbidity and inflammation, whereas COX-2 deficiency leads to reduced morbidity, inflammation and mortality in influenza infected mice...
  19. pmc Sodium arsenite-induced stress-related gene expression in normal human epidermal, HaCaT, and HEL30 keratinocytes
    Kevin J Trouba
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 110:761-6. 2002
    ..They also suggest that arsenite modulates gene expression in NHEK involved in cellular signaling and other aspects of intermediary metabolism that may contribute to the carcinogenic process...
  20. pmc Immunotoxicogenomics: the potential of genomics technology in the immunotoxicity risk assessment process
    Robert W Luebke
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 94:22-7. 2006
    ..To help move the science of immunotoxicogenomics forward, a partnership of industry, academia, and government was suggested to address data gaps, validation, quality assurance, and protocol development...
  21. ncbi request reprint Gene expression alterations in immune system pathways following exposure to immunosuppressive chemicals
    Rachel M Patterson
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27719, USA
    Ann N Y Acad Sci 1076:718-27. 2006
    ..The distinct gene profiles may specifically relate to cellular targets and mechanism of action...
  22. doi request reprint Evaluation of nanoparticle immunotoxicity
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, SAIC Frederick Inc, NCI Frederick, Frederick, Maryland 21702, USA
    Nat Nanotechnol 4:411-4. 2009
    ..This article outlines practical strategies for identifying and controlling interferences in common evaluation methods and the implications for regulation...
  23. ncbi request reprint Oxidative stress and its role in skin disease
    Kevin J Trouba
    National Institute of Environmental Health Sciences, Laboratory of Molecular Toxicology, Research Triangle Park, NC 27709, USA
    Antioxid Redox Signal 4:665-73. 2002
    ..This review is intended to give investigators an introduction to ROS, antioxidants, two skin disorders influenced by ROS action (skin cancer and psoriasis), and relevant model systems used to study ROS action...
  24. pmc Induction of asthma and the environment: what we know and need to know
    MaryJane K Selgrade
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 114:615-9. 2006
    ..Research to address these questions could have a significant public health and economic impact that would be well worth the investment...
  25. doi request reprint Immunotoxicology and its application in risk assessment
    Andrew A Rooney
    National Toxicology Program, Office of Health Assessment and Translation, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    EXS 101:251-87. 2012
    ..However, since xenobiotics may have effects on more than one aspect of immune function, immunotoxicity data should be evaluated separately for evidence of suppression, stimulation, hypersensitivity, and autoimmunity...
  26. ncbi request reprint Gadolinium chloride-induced hepatocyte proliferation is prevented by antibodies to tumor necrosis factor alpha
    M L Rose
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina, 27599, USA
    Toxicol Appl Pharmacol 170:39-45. 2001
    ....
  27. ncbi request reprint Micromolar concentrations of sodium arsenite induce cyclooxygenase-2 expression and stimulate p42/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes
    K J Trouba
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 79:248-57. 2004
    ..Compounds that inhibit COX-2 expression and activity may be useful in the scientific study, prevention, and treatment of arsenic skin carcinogenesis and deserve further investigation...
  28. ncbi request reprint Accentuated T helper type 2 airway response after allergen challenge in cyclooxygenase-1-/- but not cyclooxygenase-2-/- mice
    Michelle A Carey
    National Institute of Environmental Health Sciences NIH, 111 TW Alexander Drive, Building 101, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 167:1509-15. 2003
    ..These data suggest that genetic deficiency of COX-1 but not COX-2 modulates T cell recruitment, Th2 cytokine secretion, and lung function in the allergic airway...
  29. ncbi request reprint Antioxidants attenuate anthralin-induced skin inflammation in BALB/c mice: role of specific proinflammatory cytokines
    R W Lange
    Environmental Immunology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    J Leukoc Biol 64:170-6. 1998
    ..Systemic antioxidant administration may provide opportunities for therapeutic intervention against anthralin-associated toxicities...
  30. pmc Stimulation of the immune response in B6C3F1 mice by genistein is affected by exposure duration, gender, and litter order
    Tai L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Nutr 135:2449-56. 2005
    ..Overall, the results demonstrated that GEN could enhance the immune responses in mice from the 1st and 2nd litters; however, the effects varied depending on the exposure duration, gender, and litter order...
  31. ncbi request reprint Thalidomide enhances both primary and secondary host resistances to Listeria monocytogenes infection by a neutrophil-related mechanism in female B6C3F1 mice
    Tai L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, Virginia 23298 6013, USA
    Toxicol Appl Pharmacol 209:244-54. 2005
    ..In conclusion, thalidomide enhanced host resistance to both primary and secondary L. monocytogenes infections by a neutrophil-related mechanism in female B6C3F1 mice...
  32. pmc Chronic arsenic exposure increases TGFalpha concentration in bladder urothelial cells of Mexican populations environmentally exposed to inorganic arsenic
    Olga L Valenzuela
    Sección de Toxicología, CINVESTAV IPN, Av Instituto Politecnico Nacional 2508, Col Zacatenco, CP 07300, Mexico DF, Mexico
    Toxicol Appl Pharmacol 222:264-70. 2007
    ..7 vs. 64.9 pg/mg protein (p=0.003). These results suggest that TGF-alpha in exfoliated BUC may serve as a susceptibility marker of adverse health effects on epithelial tissue in arsenic-endemic areas...
  33. pmc Consensus workshop on methods to evaluate developmental immunotoxicity
    Michael I Luster
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA
    Environ Health Perspect 111:579-83. 2003
    ..This report concludes with the work group's consensus of the most appropriate experimental design and tests to screen for potential developmental immunotoxic agents in experimental models, including potential limitations and data gaps...
  34. pmc A statistical model for assessing genetic susceptibility as a risk factor in multifactorial diseases: lessons from occupational asthma
    Eugene Demchuk
    Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 115:231-4. 2007
    ..The genetic components most responsible for differences in individual disease risk are thought to be DNA variants (polymorphisms) that influence the expression or function of mediators involved in the pathological processes...
  35. ncbi request reprint Maternal treatment with a high dose of CpG ODN during gestation alters fetal craniofacial and distal limb development in C57BL/6 mice
    M Renee Prater
    The Edward Via Virginia College of Osteopathic Medicine, Department of Biomedical Sciences, 2265 Kraft Drive, Blacksburg, VA 24060, USA
    Vaccine 24:263-71. 2006
    ....
  36. ncbi request reprint Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha
    Bin He
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 192:254-61. 2003
    ..The data presented here indicate that D4 has weak estrogenic activity, and that these effects are mediated through estrogen receptor-alpha...