R N Germain

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc A decade of imaging cellular motility and interaction dynamics in the immune system
    Ronald N Germain
    Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 336:1676-81. 2012
  2. pmc Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node
    Clemens Scheinecker
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 196:1079-90. 2002
  3. pmc Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
    Marcello Chieppa
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:2841-52. 2006
  4. pmc Maintaining system homeostasis: the third law of Newtonian immunology
    Ronald N Germain
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 13:902-6. 2012
  5. ncbi request reprint Dynamic imaging of the immune system: progress, pitfalls and promise
    Ronald N Germain
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 6:497-507. 2006
  6. ncbi request reprint T-cell development and the CD4-CD8 lineage decision
    Ronald N Germain
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    Nat Rev Immunol 2:309-22. 2002
  7. ncbi request reprint T-cell activation: the power of one
    Ronald N Germain
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Rm 11N311, 10 Center Drive MSC 1892, Bethesda, MD 20892 1892, USA
    Curr Biol 13:R137-9. 2003
  8. pmc An extended vision for dynamic high-resolution intravital immune imaging
    Ronald N Germain
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Bldg 10 Rm 11N311, 10 Center Dr MSC 1892 Bethesda, MD 20892, USA
    Semin Immunol 17:431-41. 2005
  9. ncbi request reprint An innately interesting decade of research in immunology
    Ronald N Germain
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 10:1307-20. 2004
  10. ncbi request reprint Ligand-dependent regulation of T cell development and activation
    Ronald N Germain
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Immunol Res 27:277-86. 2003

Collaborators

Detail Information

Publications67

  1. pmc A decade of imaging cellular motility and interaction dynamics in the immune system
    Ronald N Germain
    Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 336:1676-81. 2012
    ..Here, we review themes emerging from such studies and speculate on the future of immunoimaging...
  2. pmc Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node
    Clemens Scheinecker
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 196:1079-90. 2002
    ....
  3. pmc Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
    Marcello Chieppa
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:2841-52. 2006
    ..Collectively, these findings support a model in which epithelial cell TLR signaling upon exposure to microbial stimuli induces active DC sampling of the gut lumen at sites distant from organized lymphoid tissues...
  4. pmc Maintaining system homeostasis: the third law of Newtonian immunology
    Ronald N Germain
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 13:902-6. 2012
    ....
  5. ncbi request reprint Dynamic imaging of the immune system: progress, pitfalls and promise
    Ronald N Germain
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 6:497-507. 2006
    ..In this article, we review the basic techniques and the tools used for in situ imaging, as well as the limitations and potential artefacts of these methods...
  6. ncbi request reprint T-cell development and the CD4-CD8 lineage decision
    Ronald N Germain
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    Nat Rev Immunol 2:309-22. 2002
    ..Aspects of both models now appear to be correct; mistake-prone instruction of lineage choice precedes a subsequent selection step that filters out most incorrect decisions...
  7. ncbi request reprint T-cell activation: the power of one
    Ronald N Germain
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Rm 11N311, 10 Center Drive MSC 1892, Bethesda, MD 20892 1892, USA
    Curr Biol 13:R137-9. 2003
    ..On the basis of this and other recent findings, a 'pseudodimer' with one foreign- and one self-antigen-engaged receptor linked via a CD4 molecule has been proposed as the fundamental unit of effective T-cell signaling...
  8. pmc An extended vision for dynamic high-resolution intravital immune imaging
    Ronald N Germain
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Bldg 10 Rm 11N311, 10 Center Dr MSC 1892 Bethesda, MD 20892, USA
    Semin Immunol 17:431-41. 2005
    ..The end result will be a new level of understanding of how orchestrated cell movement and interaction contribute to the physiological and pathological activities of the immune system...
  9. ncbi request reprint An innately interesting decade of research in immunology
    Ronald N Germain
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 10:1307-20. 2004
    ..But biological systems are just that-systems-and the parts need to work together. And so we arrive, a century later, at an appreciation for just how intimately related these two seemingly disparate aspects of host defense really are...
  10. ncbi request reprint Ligand-dependent regulation of T cell development and activation
    Ronald N Germain
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Immunol Res 27:277-86. 2003
    ....
  11. ncbi request reprint The art of the probable: system control in the adaptive immune system
    R N Germain
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Science 293:240-5. 2001
    ....
  12. pmc Special regulatory T-cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm
    Ronald N Germain
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunology 123:20-7. 2008
    ....
  13. doi request reprint Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging
    Ronald N Germain
    Laboratory of Immunology, Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Immunol Rev 221:163-81. 2008
    ..We also describe how the methods we have developed for imaging within lymphoid sites are being applied to other tissues and organs, revealing dynamic details of host-pathogen interactions previously inaccessible to direct observation...
  14. pmc Systems biology in immunology: a computational modeling perspective
    Ronald N Germain
    Program in Systems Immunology and Infectious Disease Modeling, National Institute of Allergy and Infectious Disease, Laboratory of Immunology, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 29:527-85. 2011
    ....
  15. doi request reprint Vaccines and the future of human immunology
    Ronald N Germain
    Lymphocyte Biology Section and Program in Systems Immunology and Infectious Disease Modeling, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Immunity 33:441-50. 2010
    ....
  16. pmc Computational analysis of T cell receptor signaling and ligand discrimination--past, present, and future
    Ronald N Germain
    Lymphocyte Biology Section, Laboratory of Immunology, Trans NIH Center for Human Immunology CHI, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    FEBS Lett 584:4814-22. 2010
    ..We end by pointing to future, more biologically accurate models that incorporate spatial aspects of molecular organization in antigen-engaged T lymphocytes with this underlying biochemistry...
  17. ncbi request reprint TCR signaling for initiation and completion of thymocyte positive selection has distinct requirements for ligand quality and presenting cell type
    K Yasutomo
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 165:3015-22. 2000
    ....
  18. ncbi request reprint The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation
    R N Germain
    Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 17:467-522. 1999
    ..The principles of signal spreading and stochastic resonance incorporated into this model reveal a striking similarity in mechanisms of decision-making among T cells, neurons, and bacteria...
  19. pmc In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas
    C Reis e Sousa
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    J Exp Med 186:1819-29. 1997
    ..This model avoids the need to invoke a three-cell interaction for Th1 differentiation and points to the DC as both a sentinel for innate recognition and the dictator of class selection in the subsequent adaptive response...
  20. ncbi request reprint Development of mature CD8+ thymocytes: selection rather than instruction?
    J P van Meerwijk
    Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Science 261:911-5. 1993
    ....
  21. pmc Modeling T cell antigen discrimination based on feedback control of digital ERK responses
    Gregoire Altan-Bonnet
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Biol 3:e356. 2005
    ..The organization of the signaling network that we model here may be a prototypic solution to the problem of achieving ligand selectivity, low noise, and high sensitivity in biological responses...
  22. ncbi request reprint Comparison of thymocyte development in normal and invariant chain-deficient mice provides evidence that maturation-related changes in TCR and co-receptor levels play a critical role in cell fate
    L Y Huang
    Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Int Immunol 8:1429-40. 1996
    ....
  23. ncbi request reprint Dynamic imaging of T cell-dendritic cell interactions in lymph nodes
    Sabine Stoll
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 296:1873-6. 2002
    ..This high-resolution spatiotemporal analysis provides insight into the nature of cell interactions critical to early immune responses within lymphoid structures...
  24. pmc The in situ dynamics of dendritic cell interactions
    Wolfgang Kastenmuller
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Eur J Immunol 40:2103-6. 2010
    ..In this Viewpoint, we discuss the insights generated by direct visualization of DC-T-cell interactions and the controversies/unanswered questions that need to be addressed in future work...
  25. ncbi request reprint Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes
    J P van Meerwijk
    Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 154:6314-23. 1995
    ....
  26. ncbi request reprint Peptide and beta 2-microglobulin regulation of cell surface MHC class I conformation and expression
    G R Otten
    Lymphocyte Biology Section, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892
    J Immunol 148:3723-32. 1992
    ..The study of H chain-peptide-beta 2m interaction on the cell surface may be relevant to understanding intracellular peptide loading events...
  27. ncbi request reprint Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin
    J Delon
    Laboratory of Immunology, Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 15:691-701. 2001
    ....
  28. ncbi request reprint Binding domain regulation of MHC class II molecule assembly, trafficking, fate, and function
    R N Germain
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Semin Immunol 7:361-72. 1995
    ....
  29. pmc Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method
    Martin Meier-Schellersheim
    Lymphocyte Biology Section and Program in Systems Immunology and Infectious Disease Modeling, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Comput Biol 2:e82. 2006
    ..These features of Simmune were critical to the model development and analysis presented here and are likely to be useful in the computational investigation of many aspects of cell biology...
  30. ncbi request reprint T cell heterogeneity: firmly fixed, predominantly plastic or merely malleable?
    JOHN J O'SHEA
    National Institutes of Health, Bethesda, Maryland 20852 1820, USA
    Nat Immunol 9:450-3. 2008
  31. pmc Computational reconstruction of cell and tissue surfaces for modeling and data analysis
    Frederick Klauschen
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Protoc 4:1006-12. 2009
    ..Processing time is of the order of minutes depending on data features and reconstruction parameters...
  32. pmc Life and death as a T lymphocyte: from immune protection to HIV pathogenesis
    Nienke Vrisekoop
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol 8:91. 2009
    ..In a paper just published in Journal of Biology, Marques et al. suggest that a mouse model with its activated CD4(+) T cells are deleted has relevance for HIV infection...
  33. ncbi request reprint Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells
    Hai Qi
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Science 312:1672-6. 2006
    ..These findings suggest a possible role for antigen-specific B-DC interactions in promoting T cell-dependent antibody responses in vivo...
  34. ncbi request reprint Imaging of T-cell interactions with antigen presenting cells in culture and in intact lymphoid tissue
    Jerome Delon
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Immunol Rev 189:51-63. 2002
    ....
  35. ncbi request reprint Illuminating the landscape of in vivo immunity: insights from dynamic in situ imaging of secondary lymphoid tissues
    Alex Y C Huang
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 21:331-9. 2004
    ..We highlight controversies, point out key unanswered questions, and briefly outline what we believe are some of the near-term directions that in situ microscopic analysis of the immune system will take...
  36. pmc Quantifying cellular interaction dynamics in 3D fluorescence microscopy data
    Frederick Klauschen
    Program in Systems Immunology and Infectious Disease Modeling, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    Nat Protoc 4:1305-11. 2009
    ....
  37. ncbi request reprint Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes
    Irena Stefanova
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 420:429-34. 2002
    ....
  38. ncbi request reprint In vivo antigen presentation
    Ronald N Germain
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, MSC 1892, Bethesda, MD 20892 1892, USA
    Curr Opin Immunol 16:120-5. 2004
    ....
  39. ncbi request reprint The transmembrane segment of invariant chain mediates binding to MHC class II molecules in a CLIP-independent manner
    F Castellino
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA
    Eur J Immunol 31:841-50. 2001
    ....
  40. ncbi request reprint MHC-dependent survival of naïve T cells? A complicated answer to a simple question
    Jeffrey R Dorfman
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bldg 10 Rm 11N311, 10 Center Dr MSC 1892, National Institutes of Health, Bethesda, MD 20892, USA
    Microbes Infect 4:547-54. 2002
    ..Overall, our analysis of the available data suggests that most or all mature CD4(+) (and perhaps also many CD8(+)) T lymphocytes do not depend on self-recognition for their viability in the periphery...
  41. ncbi request reprint Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction
    Flora Castellino
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 440:890-5. 2006
    ....
  42. ncbi request reprint Chemokine-guided CD4+ T cell help enhances generation of IL-6RalphahighIL-7Ralpha high prememory CD8+ T cells
    Flora Castellino
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 178:778-87. 2007
    ..They also reveal that elevated IL-6Ralpha expression by a subset of CD8(+) T cells represents an early imprint of CD4(+) T cell helper function that actively contributes to the survival of activated CD8(+) T cells...
  43. ncbi request reprint Cooperation between CD4+ and CD8+ T cells: when, where, and how
    Flora Castellino
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 24:519-40. 2006
    ..We propose a model based on these new findings that may serve as a general paradigm for cellular interactions that occur in an inflamed lymph node during the initiation of immune responses...
  44. ncbi request reprint On the role of self-recognition in T cell responses to foreign antigen
    Irena Stefanova
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Immunol Rev 191:97-106. 2003
    ....
  45. pmc Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 32:253-65. 2010
    ..Our results reveal insight into the dynamic regulation of T cell:B cell interactions and identify SLAM family members as critical components of sustained T cell:B cell adhesion required for productive humoral immunity...
  46. ncbi request reprint TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
    Irena Stefanova
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, MSC 1892, Bethesda, Maryland 20892 1892, USA
    Nat Immunol 4:248-54. 2003
    ..The characteristics of these pathways suggest that they constitute an important part of the mechanism allowing T cells to discriminate between self and foreign ligands...
  47. pmc In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies
    Nathan C Peters
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Science 321:970-4. 2008
    ..Thus, L.m. appears to have evolved to both evade and exploit the innate host response to sand fly bite in order to establish and promote disease...
  48. pmc Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis
    Masaru Ishii
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    Nature 458:524-8. 2009
    ....
  49. ncbi request reprint Seeing is believing: a focus on the contribution of microscopic imaging to our understanding of immune system function
    Marc Bajenoff
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Eur J Immunol 37:S18-33. 2007
    ..We conclude with some speculations about the opportunities for further advances using ever more powerful imaging methods...
  50. pmc SAP-controlled T-B cell interactions underlie germinal centre formation
    Hai Qi
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 455:764-9. 2008
    ..These results offer an explanation for the germinal centre defect due to SAP deficiency and provide new insights into the bi-directional communication between cognate T and B cells in vivo...
  51. ncbi request reprint Self-recognition and the regulation of CD4+ T cell survival
    Ronald N Germain
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Adv Exp Med Biol 512:97-105. 2002
    ....
  52. pmc The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy
    P Romagnoli
    Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
    J Exp Med 180:1107-13. 1994
    ....
  53. ncbi request reprint A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gp160
    H Takahashi
    Metabolism Branch, National Cancer Institute, Bethesda, MD 20892
    Science 246:118-21. 1989
    ..These data indicate the importance of single residues in defining peptide epitopic specificity and have implications for both the effect of immune pressure on selection of viral mutants and the design of effective vaccines...
  54. pmc Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes
    Marc Bajenoff
    Lymphocyte Biology Section, Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 25:989-1001. 2006
    ..These results highlight the central role of stromal microanatomy in orchestrating cell migration within the LN...
  55. pmc Serum angiotensin-1 converting enzyme activity processes a human immunodeficiency virus 1 gp160 peptide for presentation by major histocompatibility complex class I molecules
    S Kozlowski
    Molecular Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
    J Exp Med 175:1417-22. 1992
    ..The ability of naturally occurring extracellular proteases to convert inactive peptides to T cell antigens has important implications for understanding cytotoxic T lymphocyte responses in vivo, and for rational peptide vaccine design...
  56. ncbi request reprint Distinct contributions of different CD40 TRAF binding sites to CD154-induced dendritic cell maturation and IL-12 secretion
    Matthew F Mackey
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive MSC 1892, Bethesda, MD 20892 1892, USA
    Eur J Immunol 33:779-89. 2003
    ....
  57. pmc Fibroblastic reticular cells guide T lymphocyte entry into and migration within the splenic T cell zone
    Marc Bajenoff
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:3947-54. 2008
    ..These data reveal that FRCs form a substrate for T cells in the spleen, guiding these lymphocytes from their site of entry in the MZ into the PALS, within which they continue to move on the same network...
  58. ncbi request reprint Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node
    Marc Bajenoff
    Lymphocyte Biology Section, Laboratory of Immunology, NIAID, NIH, Bethesda, MD 20892, USA
    Trends Immunol 28:346-52. 2007
    ....
  59. pmc Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas
    Jackson G Egen
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 28:271-84. 2008
    ..By characterizing the migration of both innate and adaptive immune cells throughout the process of granuloma development, these studies provide a new perspective on the cellular events involved in mycobacterial containment and escape...
  60. pmc Natural killer cell behavior in lymph nodes revealed by static and real-time imaging
    Marc Bajenoff
    Institut National de la Sante et de la Recherche Medicale, Universite de Nice Sophia Antipolis, E03 44, 06560 Valbonne, France
    J Exp Med 203:619-31. 2006
    ..Therefore, NK cells form a reactive but low mobile network in a strategic area of the LN where they can receive inflammatory signals, interact with DCs, and regulate colocalized T cell responses...
  61. pmc Quantitative challenges in understanding ligand discrimination by alphabeta T cells
    Ofer Feinerman
    ImmunoDynamics Group, Program in Computational Biology and Immunology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Mol Immunol 45:619-31. 2008
  62. ncbi request reprint Obituary: Charles A. Janeway Jr (1943-2003)
    William E Paul
    Nature 423:237. 2003
  63. pmc Variability and robustness in T cell activation from regulated heterogeneity in protein levels
    Ofer Feinerman
    ImmunoDynamics Group, Program in Computational Biology and Immunology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 460, New York, NY 10065, USA
    Science 321:1081-4. 2008
    ..These findings reveal how eukaryotic cells can draw on regulated variation in gene expression to achieve phenotypic variability in a controlled manner...
  64. ncbi request reprint ERM proteins regulate cytoskeleton relaxation promoting T cell-APC conjugation
    Sophie Faure
    Institut Cochin, Departement de Biologie Cellulaire, Institut National de la Santé et de la Recherche Médicale U567 Centre National de la Recherche Scientifique UMR 8104, Universite Rene Descartes, 22 rue Mechain, 75014 Paris, France
    Nat Immunol 5:272-9. 2004
    ..These findings identify an antigen-dependent molecular pathway that favors immunological synapse formation and the subsequent development of an effective immune response...
  65. ncbi request reprint L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells
    Greta Guarda
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:743-52. 2007
    ..The inducible recruitment of blood-borne effector and memory T cells to lymph nodes may represent a mechanism for terminating primary and limiting secondary immune responses...
  66. ncbi request reprint Imaging dynamic interactions in immune responses
    Ronald N Germain
    Semin Immunol 17:385-6. 2005
  67. ncbi request reprint A plaidoyer for 'systems immunology'
    Christophe Benoist
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Immunol Rev 210:229-34. 2006
    ..We propose that distinct standards are needed for validation, evaluation, and visualization of global analyses, such that in-depth descriptions of cellular responses may complement the gene/factor-centric approaches currently in favor...