Charles R Gerfen

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint D1 dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1/2/MAP kinase
    Charles R Gerfen
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892 4075, USA
    J Neurosci 22:5042-54. 2002
  2. ncbi request reprint Indirect-pathway neurons lose their spines in Parkinson disease
    Charles R Gerfen
    Nat Neurosci 9:157-8. 2006
  3. pmc Differences between dorsal and ventral striatum in Drd1a dopamine receptor coupling of dopamine- and cAMP-regulated phosphoprotein-32 to activation of extracellular signal-regulated kinase
    Charles R Gerfen
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:7113-20. 2008
  4. pmc Plasticity within striatal direct pathway neurons after neonatal dopamine depletion is mediated through a novel functional coupling of serotonin 5-HT2 receptors to the ERK 1/2 map kinase pathway
    Pierre Brown
    Laboratory of Systems Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Comp Neurol 498:415-30. 2006
  5. pmc Modulation of striatal projection systems by dopamine
    Charles R Gerfen
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Annu Rev Neurosci 34:441-66. 2011
  6. pmc GENSAT BAC cre-recombinase driver lines to study the functional organization of cerebral cortical and basal ganglia circuits
    Charles R Gerfen
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA Electronic address
    Neuron 80:1368-83. 2013
  7. ncbi request reprint D1 dopamine receptor supersensitivity in the dopamine-depleted striatum animal model of Parkinson's disease
    Charles R Gerfen
    Section on Neuroanatomy, Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD, USA
    Neuroscientist 9:455-62. 2003
  8. pmc Hypothalamic and other connections with dorsal CA2 area of the mouse hippocampus
    Zhenzhong Cui
    Section on Neural Gene Expression, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Comp Neurol 521:1844-66. 2013
  9. pmc Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation
    Elizabeth B Rex
    Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Mol Pharmacol 78:69-80. 2010
  10. ncbi request reprint Increased vulnerability of nigrostriatal terminals in DJ-1-deficient mice is mediated by the dopamine transporter
    Amy B Manning-Bog
    Department of Basic Research, The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
    Neurobiol Dis 27:141-50. 2007

Collaborators

Detail Information

Publications11

  1. ncbi request reprint D1 dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1/2/MAP kinase
    Charles R Gerfen
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892 4075, USA
    J Neurosci 22:5042-54. 2002
    ..These results demonstrate that dopamine input to the striatum maintains distinct forms of protein kinase-mediated gene regulation in the direct and indirect striatal projection neurons...
  2. ncbi request reprint Indirect-pathway neurons lose their spines in Parkinson disease
    Charles R Gerfen
    Nat Neurosci 9:157-8. 2006
  3. pmc Differences between dorsal and ventral striatum in Drd1a dopamine receptor coupling of dopamine- and cAMP-regulated phosphoprotein-32 to activation of extracellular signal-regulated kinase
    Charles R Gerfen
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:7113-20. 2008
    ..These findings indicate that Drd1a sensitization relevant for PD occurs by a novel mechanism that does not require DARPP-32...
  4. pmc Plasticity within striatal direct pathway neurons after neonatal dopamine depletion is mediated through a novel functional coupling of serotonin 5-HT2 receptors to the ERK 1/2 map kinase pathway
    Pierre Brown
    Laboratory of Systems Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Comp Neurol 498:415-30. 2006
    ....
  5. pmc Modulation of striatal projection systems by dopamine
    Charles R Gerfen
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Annu Rev Neurosci 34:441-66. 2011
    ..The contrast provided by these studies has provided new insights into how the striatum responds to fluctuations in DA signaling and how diseases that alter this signaling change striatal function...
  6. pmc GENSAT BAC cre-recombinase driver lines to study the functional organization of cerebral cortical and basal ganglia circuits
    Charles R Gerfen
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA Electronic address
    Neuron 80:1368-83. 2013
    ..Here we provide characterization of GENSAT BAC-Cre driver lines with expression in specific neuroanatomical pathways within the cerebral cortex and basal ganglia. ..
  7. ncbi request reprint D1 dopamine receptor supersensitivity in the dopamine-depleted striatum animal model of Parkinson's disease
    Charles R Gerfen
    Section on Neuroanatomy, Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD, USA
    Neuroscientist 9:455-62. 2003
    ..This switch in D1-receptor-mediated regulation of protein kinase systems responsible for neuronal plasticity is suggested to underlie dyskinesia produced by L-DOPA treatment of Parkinson's disease...
  8. pmc Hypothalamic and other connections with dorsal CA2 area of the mouse hippocampus
    Zhenzhong Cui
    Section on Neural Gene Expression, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Comp Neurol 521:1844-66. 2013
    ..Novel connections from the PVN and to the SUM suggest important regulatory roles for CA2 in mediating social and emotional input for memory processing...
  9. pmc Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation
    Elizabeth B Rex
    Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Mol Pharmacol 78:69-80. 2010
    ..These data support the idea that RanBP9 and RanBP10 may function as signaling integrators and dictate the efficient regulation of D(1) receptor signaling by PKCdelta and PKCgamma...
  10. ncbi request reprint Increased vulnerability of nigrostriatal terminals in DJ-1-deficient mice is mediated by the dopamine transporter
    Amy B Manning-Bog
    Department of Basic Research, The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
    Neurobiol Dis 27:141-50. 2007
    ..control striatum. Thus, under null DJ-1 conditions, DAT changes likely contribute to altered DA neurotransmission and enhanced sensitivity to toxins that utilize DAT for nigrostriatal entry...
  11. ncbi request reprint Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs
    Shiaoching Gong
    Gene Expression Nervous System Atlas Project, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 27:9817-23. 2007