Kai Ge

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms
    Elisabetta Mueller
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:41925-30. 2002
  2. pmc PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex
    Young Wook Cho
    Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 282:20395-406. 2007
  3. pmc Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis
    Young Wook Cho
    Nuclear Receptor Biology Section, CEB, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 10:27-39. 2009
  4. pmc Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis
    LiFeng Wang
    Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:7317-22. 2010
  5. pmc Epigenetic regulation of adipogenesis by histone methylation
    Kai Ge
    Adipocyte Biology and Gene Regulation Section, Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1819:727-32. 2012
  6. pmc Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression
    Kai Ge
    Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 28:1081-91. 2008
  7. pmc Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis
    LiFeng Wang
    Adipocyte Biology and Gene Regulation Section, Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 32:45-59. 2013
  8. pmc UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity
    Chaochen Wang
    Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:15324-9. 2012
  9. pmc The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis
    A Hongjun Wang
    Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 32:1075-86. 2013
  10. pmc Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation
    QiHuang Jin
    Nuclear Receptor Biology Section, CEB, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    EMBO J 30:249-62. 2011

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms
    Elisabetta Mueller
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:41925-30. 2002
    ..Analyses involving coactivator binding and transcriptional assays indicate that PPARgamma2 has an enhanced ability to bind components of the DRIP/TRAP complex, coactivators required for fat differentiation...
  2. pmc PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex
    Young Wook Cho
    Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 282:20395-406. 2007
    ..As histone H3 K4 methylation associates with active genes, our study suggests a potential role of PTIP in the regulation of gene expression...
  3. pmc Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis
    Young Wook Cho
    Nuclear Receptor Biology Section, CEB, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 10:27-39. 2009
    ..Finally, deletion of PTIP in brown adipose tissue significantly reduces tissue weight. Thus, by regulating PPARgamma and C/EBPalpha expression, PTIP plays a critical role in adipogenesis...
  4. pmc Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis
    LiFeng Wang
    Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:7317-22. 2010
    ..These results indicate that H3K27 methyltransferase Ezh2 directly represses Wnt genes to facilitate adipogenesis and suggest that acetylation and trimethylation on H3K27 play opposing roles in regulating Wnt expression...
  5. pmc Epigenetic regulation of adipogenesis by histone methylation
    Kai Ge
    Adipocyte Biology and Gene Regulation Section, Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1819:727-32. 2012
    ..This article is part of a Special Issue entitled: Chromatin in time and space...
  6. pmc Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression
    Kai Ge
    Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 28:1081-91. 2008
    ....
  7. pmc Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis
    LiFeng Wang
    Adipocyte Biology and Gene Regulation Section, Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 32:45-59. 2013
    ..Finally, deletion of G9a in mouse adipose tissues increases adipogenic gene expression and tissue weight. Thus, by inhibiting PPARγ expression and facilitating Wnt10a expression, G9a represses adipogenesis...
  8. pmc UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity
    Chaochen Wang
    Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:15324-9. 2012
    ....
  9. pmc The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis
    A Hongjun Wang
    Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 32:1075-86. 2013
    ..Our data indicate that, through cooperation with PolII and KDM6A, Spt6 orchestrates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation...
  10. pmc Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation
    QiHuang Jin
    Nuclear Receptor Biology Section, CEB, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    EMBO J 30:249-62. 2011
    ....
  11. pmc A multifunctional protein, EWS, is essential for early brown fat lineage determination
    Jun Hong Park
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Dev Cell 26:393-404. 2013
    ..Remarkably, Ews null BATs and brown preadipocytes ectopically express myogenic genes. These results demonstrate that EWS is essential for early brown fat lineage determination. ..
  12. pmc Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases
    SunHwa Hong
    Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:18439-44. 2007
    ....
  13. pmc 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions
    Elsa Callen
    Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Cell 153:1266-80. 2013
    ..We conclude that 53BP1 promotes productive CSR and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 and PTIP...
  14. pmc H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation
    Gangqing Hu
    Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Stem Cell 12:180-92. 2013
    ..We propose that H2A.Z mediates such contrasting activities by acting as a general facilitator that generates access for a variety of complexes, both activating and repressive...
  15. pmc EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR
    Chunxi Wang
    Cell and Molecular Biology Section, National Cancer Institute, NIH, Bethesda, Bethesda, MD 20892, USA
    Cancer Res 72:315-24. 2012
    ..Together, our findings establish that aberrant upregulation of EZH2 in NB cells silences several tumor suppressors, which contribute to the genesis and maintenance of the undifferentiated phenotype of NB tumors...
  16. pmc PTIP promotes chromatin changes critical for immunoglobulin class switch recombination
    Jeremy A Daniel
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Science 329:917-23. 2010
    ..These results demonstrate that PTIP promotes specific chromatin changes that control the accessibility of the Igh locus to CSR and suggest a nonredundant role for the MLL3-MLL4 complex in altering antibody effector function...
  17. pmc Adipogenesis is differentially impaired by thyroid hormone receptor mutant isoforms
    Alok Mishra
    Laboratory of Molecular Biology, Center for Cancer Research, NCI Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 37, Convent Drive, Room No 5128, Bethesda, Maryland 20892 4264, USA
    J Mol Endocrinol 44:247-55. 2010
    ..The finding that induction of adipogenesis is differentially regulated by TR isoforms suggests that TR isoform-specific ligands could be designed for therapeutic intervention for lipid abnormalities...
  18. pmc Affinity purification of MLL3/MLL4 histone H3K4 methyltransferase complex
    Young Wook Cho
    Nuclear Receptor Biology Section, NIDDK, NIH, Bethesda, MD, USA
    Methods Mol Biol 809:465-72. 2012
    ..In this chapter, we provide a one-step affinity purification protocol on isolation of the MLL3/MLL4 histone H3K4 methyltransferase complex using FLAG-tagged PA1, a unique subunit of the MLL3/MLL4 complex...
  19. ncbi request reprint Thyroid hormone-induced juxtaposition of regulatory elements/factors and chromatin remodeling of Crabp1 dependent on MED1/TRAP220
    Sung Wook Park
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Cell 19:643-53. 2005
    ..This indicates new TRAP/Mediator functions in facilitating ultimate recruitment and function of RNA polymerase II and the general transcription machinery...
  20. ncbi request reprint Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis
    Kai Ge
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 417:563-7. 2002
    ..These data indicate that TRAP220 acts, via the TRAP complex, as a PPAR gamma(2)-selective coactivator and, accordingly, that it is specific for one fibroblast differentiation pathway (adipogenesis) relative to another (myogenesis)...
  21. pmc Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation
    Alexander J Muller
    DuPont Pharmaceuticals Company, Wilmington, Delaware, USA
    Mol Cell Biol 23:4295-306. 2003
    ..Ultrastructurally, myofibrils in ventricular cardiomyocytes of Bin1 null embryos were severely disorganized. These results define a developmentally critical role for the Bin1 gene in cardiac muscle development...
  22. pmc Heterogeneous expression and functions of androgen receptor co-factors in primary prostate cancer
    Peng Li
    Department of Pathology, New York University Medical Center, New York, New York, USA
    Am J Pathol 161:1467-74. 2002
    ..Together, these findings indicate that changes in levels of expression of AR co-factors may play important, yet different, roles in prostate tumorigenesis...
  23. ncbi request reprint The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis
    Mohamed Guermah
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, 10021, New York, NY, USA
    Mol Cell 12:991-1001. 2003
    ..Furthermore TAF8 acts as a positive regulator of adipogenesis and reverses the inhibitory effect of its histone fold. These data suggest a selective role for TAF8 in a specific cell differentiation process(es)...
  24. ncbi request reprint Role of mediator in transcriptional activation by the aryl hydrocarbon receptor
    Song Wang
    Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    J Biol Chem 279:13593-600. 2004
    ..Our findings demonstrate a novel role for Med220 in AHR-regulated transcription that differs mechanistically from its role in transcriptional regulation by other previously studied transcription factors...
  25. pmc Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity
    Yuzhi Jia
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 102:12531-6. 2005
    ..We conclude that transcription coactivator PBP/TRAP220/MED1 is involved in the regulation of hepatic CAR function and that PBP deficiency in liver abrogates acetaminophen hepatotoxicity...