Research Topics
Genomes and Genes
Species | Mia M GaudetSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New YorkMia M Gaudet
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hil, NC 27516, USA
Breast Cancer Res Treat 99:235-40. 2006....- Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish womenMia M Gaudet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland 20852, USA
Pharmacogenet Genomics 16:547-53. 2006..The present study provides strong evidence against the existence of a substantial overall association between common genetic variation in CYP1B1 and breast cancer risk... - Comprehensive assessment of genetic variation of catechol-O-methyltransferase and breast cancer riskMia M Gaudet
Division of Cancer Epidemiology, National Cancer Institute, 6120 Executive Boulevard, EPS 7055, Rockville, MD 20852, USA
Cancer Res 66:9781-5. 2006..The suggestion of increased risk associated with a haplotype in the 3' UTR of COMT needs to be confirmed in independent study populations... - Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer riskMia M Gaudet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Hum Genet 121:483-90. 2007..Additional studies are required to replicate these findings and to determine whether rs361525 is a causative SNP or is a marker of a causative SNP... - Genetic variation of TP53, polycyclic aromatic hydrocarbon-related exposures, and breast cancer risk among women on Long Island, New YorkMia M Gaudet
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Breast Cancer Res Treat 108:93-9. 2008..p53 participates in cell cycle control, programmed cell death/apoptosis, and DNA repair, all pathways involved in carcinogenesis. TP53 variants may influence p53 function... 
Genetic variation in CYP17 and endometrial cancer riskMia M Gaudet
National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Hum Genet 123:155-62. 2008..Further evaluation in consortia is necessary to confirm potential weak associations between common variation in CYP17 and endometrial cancer risk and to address the concern of publication bias...
Polycyclic aromatic hydrocarbon-DNA adducts and survival among women with breast cancerSharon K Sagiv
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Environ Res 109:287-91. 2009..Results from this large population-based study do not provide strong support for an association between detectable PAH-DNA adducts and survival among women with breast cancer, except perhaps among those receiving radiation treatment...- Associations between breast cancer risk and the catalase genotype, fruit and vegetable consumption, and supplement useJiyoung Ahn
Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Am J Epidemiol 162:943-52. 2005..CC genotypes were prevalent in approximately 64% of controls; thus, the preventive potential for fruit consumption has widespread implications... - MnSOD Val-9Ala genotype, pro- and anti-oxidant environmental modifiers, and breast cancer among women on Long Island, New YorkMia M Gaudet
Department of Epidemiology, School of Public Health, University of North Carolina, CB 7435, Chapel Hill, NC 27599 7435, USA
Cancer Causes Control 16:1225-34. 2005..This study provides little evidence that variation in Val-9Ala polymorphism of MnSOD alone or through substantial interaction with key exposures believed to be pro- or anti-oxidant properties influences breast cancer risk... - Active and passive cigarette smoke and breast cancer survivalSharon K Sagiv
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Ann Epidemiol 17:385-93. 2007..The association between active and passive cigarette smoking before breast cancer diagnosis and survival was investigated among a cohort of invasive breast cancer cases (n = 1273) participating in a population-based case-control study... - Effects of glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer riskJiyoung Ahn
Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Carcinogenesis 27:1876-82. 2006..These data indicate that GSTA1 genotypes related to reduced GSTA1 expression are associated with increased breast cancer primarily among women with lower consumption of cruciferous vegetables and among current smokers... - Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survivalRebecca J Cleveland
Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7461, USA
Breast Cancer Res Treat 120:745-52. 2010..In summary, our results show that a common variant in LEP may be associated with the risk of developing breast cancer supporting the hypothesis that leptin is involved in breast carcinogenesis... - HSD17B1 genetic variants and hormone receptor-defined breast cancerMia M Gaudet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 17:2766-72. 2008..Associations between HSD17B1 genotypes and risk for ER- breast cancer were inconsistent across studies and should be studied further... - Polycyclic aromatic hydrocarbon-DNA adducts and breast cancer: a pooled analysisMarilie D Gammon
Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
Arch Environ Health 59:640-9. 2004..These data provide only modest support for an association between PAH-DNA adducts and breast cancer development... - Dietary flavonoid intake and breast cancer survival among women on Long IslandBrian N Fink
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
Cancer Epidemiol Biomarkers Prev 16:2285-92. 2007..However, the effects of flavonoids on survival are not known. In a population-based cohort of breast cancer patients, we investigated whether dietary flavonoid intake before diagnosis is associated with subsequent survival... - Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer riskJiyoung Ahn
Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York, USA
Cancer Res 64:7634-9. 2004.... - Genetic variation in the androgen receptor gene and endometrial cancer riskHannah P Yang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
Cancer Epidemiol Biomarkers Prev 18:585-9. 2009..Results from our study, taken together with previously published studies, provide little evidence of a consistent association between common genetic variation in AR and endometrial cancer risk... - An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studiesJay H Lubin
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
Cancer Causes Control 22:1217-31. 2011.... - Cooked meat and risk of breast cancer--lifetime versus recent dietary intakeSusan E Steck
Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Epidemiology 18:373-82. 2007..Polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines (HCAs) are carcinogens formed in or on the surface of well-done meat, cooked at high temperature... - Five polymorphisms and breast cancer risk: results from the Breast Cancer Association ConsortiumMia M Gaudet
Department of Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cancer Epidemiol Biomarkers Prev 18:1610-6. 2009.... - Fruits, vegetables, and micronutrient intake in relation to breast cancer survivalBrian N Fink
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Breast Cancer Res Treat 98:199-208. 2006..To determine whether fruit, vegetable, and micronutrient intake 1 year prior to breast cancer diagnosis is associated with a reduction in the subsequent risk of all-cause or breast cancer-specific mortality... - No association between glutathione peroxidase Pro198Leu polymorphism and breast cancer riskJiyoung Ahn
Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Cancer Epidemiol Biomarkers Prev 14:2459-61. 2005 - Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosisMia M Gaudet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Int J Cancer 124:1716-20. 2009..02, 0.88-1.17; 0.90, 0.72-1.11; 1.04, 0.90-1.21, respectively). Our results do not support a relationship between SIPA1 polymorphisms and breast cancer risk or subsequent survival... - Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor statusMia M Gaudet
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
Cancer Epidemiol Biomarkers Prev 13:1485-94. 2004..Our results support an inverse association for fruit and vegetable intake among postmenopausal but not premenopausal breast cancer, which may be more pronounced among women with ER+ tumors... - Prevalence and predictors of antioxidant supplement use during breast cancer treatment: the Long Island Breast Cancer Study ProjectHeather Greenlee
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
Cancer 115:3271-82. 2009..The authors of this report analyzed the prevalence of and factors associated with antioxidant supplement use during breast cancer (BC) treatment among women who participated in the Long Island Breast Cancer Study Project... - Residential environmental exposures and other characteristics associated with detectable PAH-DNA adducts in peripheral mononuclear cells in a population-based sample of adult femalesSumitra Shantakumar
Department of Epidemiology, CB 7435 McGavran Greenberg Hall, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
J Expo Anal Environ Epidemiol 15:482-90. 2005..These data suggest that PAH-DNA adducts detected in a population-based sample of adult women with ambient exposure levels reflect some key residential PAH exposure sources assessed in this study, such as cigarette smoking... - Endometrial cancer and genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2 within a population-based case-control studyJames V Lacey
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Gynecol Oncol 120:167-73. 2011..We assessed whether common genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2-genes that reportedly are frequently altered in endometrial cancer-was associated with risk of endometrial cancer... - Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genesHannah P Yang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
Carcinogenesis 31:827-33. 2010..Associations with variants in other genes have been suggested, but findings have been inconsistent... - Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in PolandSarah J Nyante
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
Breast Cancer Res 13:R42. 2011..Thus, we examined the relationship between single nucleotide polymorphisms (SNPs) in PRL and PRLR, serum prolactin levels and breast cancer risk in a population-based case-control study... - Associations between polycyclic aromatic hydrocarbon-related exposures and p53 mutations in breast tumorsIrina Mordukhovich
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
Environ Health Perspect 118:511-8. 2010..Objectives: We hypothesized that associations of PAH-related exposures with breast cancer would differ according to tumor p53 mutation status, effect, type, and number... - Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control dataJay H Lubin
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
Am J Epidemiol 171:1250-61. 2010.... - Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriersKate M Im
Center for Cancer Research, Cancer Inflammation Program, Human Genetics Section, National Cancer Institute, Frederick, MD, USA
Hum Genet 130:685-99. 2011.... - The epidemiology of gastric cancerMary Beth Terry
Columbia University Mailman School of Public Health, Department of Epidemiology, New York, NY 10032, USA
Semin Radiat Oncol 12:111-27. 2002..Future epidemiologic studies that include information on site of origin as well as molecular markers promise to yield more homogeneous classification of case groups, which will enhance identification of underlying disease processes... - Detectable clonal mosaicism and its relationship to aging and cancerKevin B Jacobs
Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
Nat Genet 44:651-8. 2012..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases... - Calcium intake and colorectal adenoma in a US colorectal cancer early detection programUlrike Peters
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Am J Clin Nutr 80:1358-65. 2004..Calcium can reduce the risk of colorectal tumors by binding secondary bile and fatty acids, which leads to antiproliferative effects in the bowel, or by acting directly on the colonic epithelium, which affects differentiation and apoptosis... - Ethnic differences in the nutrient intake adequacy of premenopausal US women: results from the Third National Health Examination SurveyLenore Arab
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Am Diet Assoc 103:1008-14. 2003..To examine the adequacy of dietary intake of calcium; folate; and vitamins C, D, E, B-6, and B-12 in premenopausal US women of differing ethnicity... - MGMT genotype modulates the associations between cigarette smoking, dietary antioxidants and breast cancer riskJing Shen
Department of Environmental Health Sciences, Columbia University, New York, NY 10032, USA
Carcinogenesis 26:2131-7. 2005.... - Polymorphisms in XRCC1 modify the association between polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, dietary antioxidants, and breast cancer riskJing Shen
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 14:336-42. 2005..Further understanding of the biological function of XRCC1 variants and their interactions with PAH-DNA adducts, antioxidants, and other genes in the pathway are needed... - OGG1 polymorphisms and breast cancer riskPavel Rossner
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
Cancer Epidemiol Biomarkers Prev 15:811-5. 2006..In addition, data on functionality of these polymorphisms are crucial to understand if these modest differences are important... - IGHMBP2 Thr671Ala polymorphism might be a modifier for the effects of cigarette smoking and PAH-DNA adducts to breast cancer riskJing Shen
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
Breast Cancer Res Treat 99:1-7. 2006..Additional studies focused on the biological function of the variant-G allele and interactions with other genetic polymorphisms are necessary to confirm our findings... - Genetic polymorphisms in the one-carbon metabolism pathway and breast cancer risk: a population-based case-control study and meta-analysesJolanta Lissowska
Department of Cancer Epidemiology and Prevention, Cancer Center and M Sklodowska Curie Institute of Oncology, Warsaw, Poland
Int J Cancer 120:2696-703. 2007..In conclusion, this report does not support a substantial overall association between the evaluated polymorphisms in the one-carbon metabolism pathway and breast cancer risk... - A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin usersXinran Xu
Departments of Community and Preventive Medicine and Epidemiology and Medicine, Columbia University, New York, NY, USA
Am J Clin Nutr 85:1098-102. 2007..Folic acid from multivitamins needs to be reduced by DHFR before it participates in cellular reactions... - Relationship between urinary 15-F2t-isoprostane and 8-oxodeoxyguanosine levels and breast cancer riskPavel Rossner
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 15:639-44. 2006..In summary, our results suggest that urinary markers of lipid peroxidation and oxidative DNA damage may be associated with breast cancer risk... - Plasma protein carbonyl levels and breast cancer riskPavel Rossner
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
J Cell Mol Med 11:1138-48. 2007..8, 95% CI = 1.2-2.6) compared to women with levels below the median for both markers of oxidative stress. In summary, our results suggest that increased plasma protein carbonyl levels may be associated with breast cancer risk...