Maciej Gasior

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Neuroprotective and disease-modifying effects of the ketogenic diet
    Maciej Gasior
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3702, USA
    Behav Pharmacol 17:431-9. 2006
  2. ncbi request reprint Pharmacological modulation of GABA(B) receptors affects cocaine-induced seizures in mice
    Maciej Gasior
    Drug Development Group, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 174:211-9. 2004
  3. ncbi request reprint Chlormethiazole potentiates the discriminative stimulus effects of methamphetamine in rats
    Maciej Gasior
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, MSC 1408, Building 10, Room 5N250, Bethesda, MD 20892 1408, USA
    Eur J Pharmacol 494:183-9. 2004
  4. doi request reprint Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose
    Maciej Gasior
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Epilepsia 51:1385-94. 2010
  5. ncbi request reprint Attenuation of the stimulant and convulsant effects of cocaine by 17-substituted-3-hydroxy and 3-alkoxy derivatives of dextromethorphan
    Agustin Zapata
    Drug Development Group, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Pharmacol Biochem Behav 74:313-23. 2003
  6. pmc Effects of cocaine-kindling on the expression of NMDA receptors and glutamate levels in mouse brain
    Rafal M Kaminski
    Drug Development Group, Behavioral Neuroscience Branch, National Institute on Drug Abuse, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurochem Res 36:146-52. 2011
  7. pmc Efficacy of the ketogenic diet in the 6-Hz seizure test
    Adam L Hartman
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Epilepsia 49:334-9. 2008
  8. ncbi request reprint The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid
    Maciej Gasior
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3702, USA
    Epilepsia 48:793-800. 2007
  9. ncbi request reprint Caffeine potentiates the discriminative-stimulus effects of nicotine in rats
    Maciej Gasior
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 162:385-95. 2002
  10. ncbi request reprint NAALADase (GCP II) inhibition prevents cocaine-kindled seizures
    Jeffrey M Witkin
    Drug Development Group, Addiction Research Center, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Neuropharmacology 43:348-56. 2002

Detail Information

Publications21

  1. pmc Neuroprotective and disease-modifying effects of the ketogenic diet
    Maciej Gasior
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3702, USA
    Behav Pharmacol 17:431-9. 2006
    ....
  2. ncbi request reprint Pharmacological modulation of GABA(B) receptors affects cocaine-induced seizures in mice
    Maciej Gasior
    Drug Development Group, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 174:211-9. 2004
    ..Previous data have demonstrated that the convulsant effects of cocaine can be modulated by compounds that increase levels of endogenous gamma-aminobutyric acid (GABA) or that directly stimulate GABA(A) receptors...
  3. ncbi request reprint Chlormethiazole potentiates the discriminative stimulus effects of methamphetamine in rats
    Maciej Gasior
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, MSC 1408, Building 10, Room 5N250, Bethesda, MD 20892 1408, USA
    Eur J Pharmacol 494:183-9. 2004
    ..e., benzodiazepines and barbiturates), suggesting the involvement of non-GABAergic mechanisms in the effects produced by chlormethiazole...
  4. doi request reprint Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose
    Maciej Gasior
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Epilepsia 51:1385-94. 2010
    ..For comparison, we studied 3-methyl-glucose (3-MG), which like 2-DG accumulates in cells and reduces glucose uptake, but does not inhibit glycolysis...
  5. ncbi request reprint Attenuation of the stimulant and convulsant effects of cocaine by 17-substituted-3-hydroxy and 3-alkoxy derivatives of dextromethorphan
    Agustin Zapata
    Drug Development Group, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Pharmacol Biochem Behav 74:313-23. 2003
    ..These findings point to potentially novel pharmacological strategies for blocking cocaine stimulant and toxic effects...
  6. pmc Effects of cocaine-kindling on the expression of NMDA receptors and glutamate levels in mouse brain
    Rafal M Kaminski
    Drug Development Group, Behavioral Neuroscience Branch, National Institute on Drug Abuse, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurochem Res 36:146-52. 2011
    ..These data suggest that enhancement of depolarization stimulated glutamate release may be one of the mechanisms underlying the development of increased seizure susceptibility after cocaine kindling...
  7. pmc Efficacy of the ketogenic diet in the 6-Hz seizure test
    Adam L Hartman
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Epilepsia 49:334-9. 2008
    ....
  8. ncbi request reprint The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid
    Maciej Gasior
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3702, USA
    Epilepsia 48:793-800. 2007
    ..The anticonvulsant mechanism of acetone is unknown, but it is metabolized to several bioactive substances that could play a role...
  9. ncbi request reprint Caffeine potentiates the discriminative-stimulus effects of nicotine in rats
    Maciej Gasior
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 162:385-95. 2002
    ..Caffeine and nicotine are the main psychoactive ingredients of coffee and tobacco, respectively, with a high frequency of concurrent use in humans...
  10. ncbi request reprint NAALADase (GCP II) inhibition prevents cocaine-kindled seizures
    Jeffrey M Witkin
    Drug Development Group, Addiction Research Center, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Neuropharmacology 43:348-56. 2002
    ..Similarly, acutely-administered 2-PMPA did not block cocaine seizures in fully-kindled mice. NAALADase inhibition thus provides a novel means of attenuating the development of cocaine seizure kindling...
  11. ncbi request reprint Protective efficacy of neuroactive steroids against cocaine kindled-seizures in mice
    Rafal M Kaminski
    NIDA Addiction Research Center, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Pharmacol 474:217-22. 2003
    ..These findings demonstrate that some neuroactive steroids attenuate convulsant and sensitizing properties of cocaine and add to a growing literature on their potential use in the modulation of effects of drugs of abuse...
  12. pmc The neuropharmacology of the ketogenic diet
    Adam L Hartman
    John M Freeman Pediatric Epilepsy Center, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Pediatr Neurol 36:281-92. 2007
    ....
  13. pmc Prolonged attenuation of amygdala-kindled seizure measures in rats by convection-enhanced delivery of the N-type calcium channel antagonists omega-conotoxin GVIA and omega-conotoxin MVIIA
    Maciej Gasior
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Pharmacol Exp Ther 323:458-68. 2007
    ....
  14. pmc Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys
    Ingela Danielsson
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, NIH, United States Cyberonics, Houston, TX, USA
    Pharmacol Biochem Behav 85:428-34. 2006
    ..These results suggest that IM administration of SNC80 is less potent in producing convulsant effects than in producing other, potentially useful behavioral effects (e.g. antinociception) in rhesus monkeys...
  15. doi request reprint Long-lasting attenuation of amygdala-kindled seizures after convection-enhanced delivery of botulinum neurotoxins a and B into the amygdala in rats
    Maciej Gasior
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland M G, R T, M A R and Department of Neurology, School of Medicine, University of California, Davis, Sacramento, California M A R
    J Pharmacol Exp Ther 346:528-34. 2013
    ....
  16. ncbi request reprint Influence of some convulsant agents on the protective activity of a novel antiepileptic drug, felbamate, against maximal electroshock in mice
    Mariusz Swiader
    Department of Pharmacology and Toxicology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pol J Pharmacol 55:649-53. 2003
    ..It may be concluded that GABAergic inhibition and strychnine-insensitive glycine receptor-mediated events may contribute to the anticonvulsant activity of felbamate...
  17. ncbi request reprint Variables affecting prepulse inhibition of the startle reflex and the response to antipsychotics in DBA/2NCrl mice
    Dorothy G Flood
    CNS Biology, Worldwide Discovery Research, Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
    Psychopharmacology (Berl) 195:203-11. 2007
    ..Thus, the DBA/2 mouse is increasingly used for testing of novel antipsychotics in PPI; however, the strain has not been fully characterized for relevant variables affecting compound testing...
  18. ncbi request reprint Modification by dopaminergic drugs of choice behavior under concurrent schedules of intravenous saline and food delivery in monkeys
    Maciej Gasior
    Behaviroal Pharmacology Laboratory Alcohol and Drug Abuse Research Center, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Pharmacol Exp Ther 308:249-59. 2004
    ..v. self-administration behavior engendered by priming doses of cocaine may involve actions mediated through both D1 and D2 families of dopamine receptors...
  19. doi request reprint The anticonvulsant activity of acetone does not depend upon its metabolites
    Maciej Gasior
    Epilepsia 49:936-7. 2008
  20. ncbi request reprint Effects of cocaine under concurrent fixed ratio schedules of food and IV drug availability: a novel choice procedure in monkeys
    Carol A Paronis
    Preclinical Pharmacology Laboratory ADARC, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 163:283-91. 2002
    ..The relative reinforcing strength of cocaine can be characterized by the distribution of operant behavior during the availability of other reinforcing stimuli...
  21. ncbi request reprint Evaluation of the reinforcing effects of monoamine reuptake inhibitors under a concurrent schedule of food and i.v. drug delivery in rhesus monkeys
    Maciej Gasior
    McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 30:758-64. 2005
    ..The absence of reinforcing effects of atomoxetine support the view that, like desipramine, it has no evident abuse potential...