T P Garrington

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi Organization and regulation of mitogen-activated protein kinase signaling pathways
    T P Garrington
    Program in Molecular Signal Transduction, Division of Basic Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Opin Cell Biol 11:211-8. 1999
  2. ncbi Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells
    K Chayama
    Division of Basic Sciences, Department of Pediatrics, and the Program in Molecular Signal Transduction, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 98:4599-604. 2001
  3. ncbi Reovirus-induced apoptosis is mediated by TRAIL
    P Clarke
    Departments of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Virol 74:8135-9. 2000
  4. ncbi MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway
    W Sun
    Department of Pharmacology, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Denver, CO 80262, USA
    J Biol Chem 276:5093-100. 2001
  5. ncbi MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells
    T P Garrington
    Department of Pharmacology and University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    EMBO J 19:5387-95. 2000
  6. ncbi MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src
    Weiyong Sun
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Mol Cell Biol 23:2298-308. 2003

Research Grants

  1. MEKK2 KO DEFINES HEMATOPOIETIC CELL SIGNAL FUNCTION
    Timothy Garrington; Fiscal Year: 2004

Collaborators

Detail Information

Publications6

  1. ncbi Organization and regulation of mitogen-activated protein kinase signaling pathways
    T P Garrington
    Program in Molecular Signal Transduction, Division of Basic Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Opin Cell Biol 11:211-8. 1999
    ..As new MAPK members are defined, determining their organization in kinase modules will be critical in understanding their select role in cellular regulation...
  2. ncbi Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells
    K Chayama
    Division of Basic Sciences, Department of Pediatrics, and the Program in Molecular Signal Transduction, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 98:4599-604. 2001
    ..These findings suggest that JNK activation by antigen cross-linking is dependent on the MEKK2-MKK7 pathway, and cytokine production in mast cells is regulated in part by the signaling complex MEKK2-MEK5-ERK5...
  3. ncbi Reovirus-induced apoptosis is mediated by TRAIL
    P Clarke
    Departments of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Virol 74:8135-9. 2000
    ..We propose that reovirus infection promotes apoptosis via the expression of DR5 and the release of TRAIL from infected cells. Virus-induced regulation of the TRAIL apoptotic pathway defines a novel mechanism for virus-induced apoptosis...
  4. ncbi MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway
    W Sun
    Department of Pharmacology, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Denver, CO 80262, USA
    J Biol Chem 276:5093-100. 2001
    ..MEKK2 and MEKK3 are differentially associated with signaling from specific upstream receptor systems, whereas both activate the MEK5-BMK1/ERK5 pathway...
  5. ncbi MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells
    T P Garrington
    Department of Pharmacology and University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    EMBO J 19:5387-95. 2000
    ..MEKK2 is the first MAP3K shown to be required for mast cell tyrosine kinase receptor signaling controlling cytokine gene expression...
  6. ncbi MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src
    Weiyong Sun
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Mol Cell Biol 23:2298-308. 2003
    ....

Research Grants1

  1. MEKK2 KO DEFINES HEMATOPOIETIC CELL SIGNAL FUNCTION
    Timothy Garrington; Fiscal Year: 2004
    ..Gary Johnson's lab is an ideal environment in which to learn these skills. ..