S C Garman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms
    S C Garman
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, 12441 Parklawn Drive, Rockville, MD 20852, USA
    J Mol Biol 311:1049-62. 2001
  2. ncbi request reprint The 1.9 A structure of alpha-N-acetylgalactosaminidase: molecular basis of glycosidase deficiency diseases
    Scott C Garman
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Structure 10:425-34. 2002
  3. ncbi request reprint Structure of the C-terminal domains of merozoite surface protein-1 from Plasmodium knowlesi reveals a novel histidine binding site
    Scott C Garman
    Structural Biology Section, Laboratory of Immunogenetics and Malaria Vaccine Development Unit, Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 278:7264-9. 2003
  4. ncbi request reprint Pediatric Fabry disease
    Markus Ries
    Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 3D03, Bethesda, MD 20892 1260, USA
    Pediatrics 115:e344-55. 2005
  5. ncbi request reprint The molecular defect leading to Fabry disease: structure of human alpha-galactosidase
    Scott C Garman
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, 12441 Parklawn Drive, Rockville, MD 20852, USA
    J Mol Biol 337:319-35. 2004
  6. ncbi request reprint Structural basis of Fabry disease
    Scott C Garman
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, 12441 Parklawn Drive, Rockville, MD 20852
    Mol Genet Metab 77:3-11. 2002
  7. pmc The 1.51-Angstrom structure of the poxvirus L1 protein, a target of potent neutralizing antibodies
    Hua Poo Su
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 102:4240-5. 2005
  8. pmc Structure-function relationships in alpha-galactosidase A
    Scott C Garman
    Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA
    Acta Paediatr Suppl 96:6-16. 2007
  9. pmc Mutant alpha-galactosidase A enzymes identified in Fabry disease patients with residual enzyme activity: biochemical characterization and restoration of normal intracellular processing by 1-deoxygalactonojirimycin
    Satoshi Ishii
    Department of Human Genetics, Mount Sinai School of Medicine, Fifth Avenue at 100th Street, New York, NY 10029, U S A
    Biochem J 406:285-95. 2007
  10. ncbi request reprint The glycan code of the endoplasmic reticulum: asparagine-linked carbohydrates as protein maturation and quality-control tags
    Daniel N Hebert
    Department of Biochemistry and Molecular Biology, Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA
    Trends Cell Biol 15:364-70. 2005

Collaborators

Detail Information

Publications10

  1. ncbi request reprint The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms
    S C Garman
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, 12441 Parklawn Drive, Rockville, MD 20852, USA
    J Mol Biol 311:1049-62. 2001
    ..The results of this study point to new directions for the design of molecules to inhibit the interaction of Fc epsilon RI alpha with its natural ligand and thus to prevent a primary step in the allergic response...
  2. ncbi request reprint The 1.9 A structure of alpha-N-acetylgalactosaminidase: molecular basis of glycosidase deficiency diseases
    Scott C Garman
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Structure 10:425-34. 2002
    ..As alpha-NAGAL and alpha-GAL produce type O "universal donor" blood from type A and type B blood, the alpha-NAGAL structure will aid in the engineering of improved enzymes for blood conversion...
  3. ncbi request reprint Structure of the C-terminal domains of merozoite surface protein-1 from Plasmodium knowlesi reveals a novel histidine binding site
    Scott C Garman
    Structural Biology Section, Laboratory of Immunogenetics and Malaria Vaccine Development Unit, Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 278:7264-9. 2003
    ..We propose the histidine binding site in domain 1 as a target for inhibitors of protein binding to MSP-1, which might prevent invasion of the merozoite into red blood cells...
  4. ncbi request reprint Pediatric Fabry disease
    Markus Ries
    Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 3D03, Bethesda, MD 20892 1260, USA
    Pediatrics 115:e344-55. 2005
    ..Fabry disease is an underdiagnosed, treatable, X-linked, multisystem disorder...
  5. ncbi request reprint The molecular defect leading to Fabry disease: structure of human alpha-galactosidase
    Scott C Garman
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, 12441 Parklawn Drive, Rockville, MD 20852, USA
    J Mol Biol 337:319-35. 2004
    ..The structure of human alpha-GAL brings Fabry disease into the realm of molecular diseases, where insights into the structural basis of the disease phenotypes might help guide the clinical treatment of patients...
  6. ncbi request reprint Structural basis of Fabry disease
    Scott C Garman
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, 12441 Parklawn Drive, Rockville, MD 20852
    Mol Genet Metab 77:3-11. 2002
    ..This study furthers our understanding of the structural basis for mutations leading to Fabry disease, from which new avenues for the treatment of lysosomal storage diseases may be developed...
  7. pmc The 1.51-Angstrom structure of the poxvirus L1 protein, a target of potent neutralizing antibodies
    Hua Poo Su
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 102:4240-5. 2005
    ..The structure of L1 is a step in the elucidation of molecular mechanisms common to all poxviruses that may stimulate the design of safer vaccines and new antipoxvirus drugs...
  8. pmc Structure-function relationships in alpha-galactosidase A
    Scott C Garman
    Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA
    Acta Paediatr Suppl 96:6-16. 2007
    ..We present the analysis of 331 different defects in the GLA gene leading to non-native proteins in patients with Fabry disease. These mutations include 278 missense mutations, 49 nonsense mutations, and four single amino acid deletions...
  9. pmc Mutant alpha-galactosidase A enzymes identified in Fabry disease patients with residual enzyme activity: biochemical characterization and restoration of normal intracellular processing by 1-deoxygalactonojirimycin
    Satoshi Ishii
    Department of Human Genetics, Mount Sinai School of Medicine, Fifth Avenue at 100th Street, New York, NY 10029, U S A
    Biochem J 406:285-95. 2007
    ..Excessive degradation in the ER could be responsible for the deficiency of enzyme activity in vivo, and the DGJ approach may be broadly applicable to Fabry disease patients with missense mutations...
  10. ncbi request reprint The glycan code of the endoplasmic reticulum: asparagine-linked carbohydrates as protein maturation and quality-control tags
    Daniel N Hebert
    Department of Biochemistry and Molecular Biology, Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA
    Trends Cell Biol 15:364-70. 2005
    ..These glycosidases and transferases work in concert with resident secretory pathway carbohydrate-binding proteins to form a network that assists in the maturation and trafficking of both native and aberrant glycoproteins within the cell...