Research Topics
| E L GardnerSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
A slow-onset, long-duration indanamine monoamine reuptake inhibitor as a potential maintenance pharmacotherapy for psychostimulant abuse: effects in laboratory rat models relating to addictionEliot L Gardner
Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Building C Room 393, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Neuropharmacology 51:993-1003. 2006..We conclude that the prodrug strategy employed in the design of 30,640 achieved its goal. We suggest that such compounds may be useful as maintenance pharmacotherapies for psychostimulant addiction...- Critical assessment of how to study addiction and its treatment: human and non-human animal modelsEliot L Gardner
Philadelphia VA Medical Center, Mental Illness Research and Education Center, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Pharmacol Ther 108:18-58. 2005..This review examines in detail some animal and human models that have led not only to important theories of addiction mechanisms but also to medications shown to be effective in the clinic... 
The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesityPanayotis K Thanos
Behavioral Neuropharmacology and Neuroimaging Lab, Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Pharmacol Biochem Behav 89:499-507. 2008..These results suggest that along with its involvement in seeking behavior for drugs of abuse, the D(3) dopamine receptor may also be involved in seeking behavior for natural reinforcers such as food...- What we have learned about addiction from animal models of drug self-administrationE L Gardner
Intramural Research Program, National Institute on Drug Abuse, Building C Room 272, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
Am J Addict 9:285-313. 2000.... - Endocannabinoid signaling system and brain reward: emphasis on dopamineEliot L Gardner
Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Building C Room 393, Baltimore, MD 21224, USA
Pharmacol Biochem Behav 81:263-84. 2005.... - Use of animal models to develop antiaddiction medicationsEliot L Gardner
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA
Curr Psychiatry Rep 10:377-84. 2008..I conclude by noting some of the new and novel medications that have been developed preclinically using such models and the hope for further developments along such lines... - Addictive potential of cannabinoids: the underlying neurobiologyEliot L Gardner
National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Building C, Room 272, 5500 Nathan Shock Drive, Baltimore, MD 20850, USA
Chem Phys Lipids 121:267-90. 2002..This paper reviews those data, and concludes that cannabinoids act on brain reward processes and reward-related behaviors in strikingly similar fashion to other addictive drugs... 
Addiction and brain reward and antireward pathwaysEliot L Gardner
Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Adv Psychosom Med 30:22-60. 2011....- Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in ratsStanislav R Vorel
Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
J Neurosci 22:9595-603. 2002.... - Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptorsJeremy G Gilbert
Neuropsychopharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, Maryland 21224, USA
Synapse 57:17-28. 2005.... - The selective dopamine D3 receptor antagonist SB-277011A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functionsArlene C Pak
Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Int J Neuropsychopharmacol 9:585-602. 2006..The results suggest that selective D3 receptor antagonism constitutes a new and promising pharmacotherapeutic approach to the treatment of nicotine dependence... - Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanismXia Li
Neuropsychopharmacology Section, Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Neuropsychopharmacology 34:1783-96. 2009.... - Selective dopamine D3 receptor antagonism by SB-277011A attenuates cocaine reinforcement as assessed by progressive-ratio and variable-cost-variable-payoff fixed-ratio cocaine self-administration in ratsZheng-Xiong Xi
Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Eur J Neurosci 21:3427-38. 2005..If these results extrapolate to humans, SB-277011A or similar selective DA D(3) receptor antagonists may be useful in the treatment of cocaine addiction... - The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in ratsXiao Qing Peng
National Institute on Drug Abuse, Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA
Neuropharmacology 56:752-60. 2009.... - Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in ratsXiao Qing Peng
Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Eur J Pharmacol 627:156-61. 2010..These data suggest that orally effective NAAG peptidase inhibitors deserve further study as potential agents for the treatment of cocaine addiction... - The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in ratsKrista Spiller
Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA
Psychopharmacology (Berl) 196:533-42. 2008..We have previously reported that selective antagonism of brain D3 receptors by SB-277011A or NGB 2904 significantly attenuates cocaine- or nicotine-enhanced brain stimulation reward (BSR)... - The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in ratsXia Li
Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
Neuropharmacology 54:542-51. 2008..In contrast to its modulatory effect on GABA and glutamate, the mGluR7 receptor does not appear to modulate NAc DA release... - Gamma-vinyl GABA inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats by a non-dopaminergic mechanismXiao Qing Peng
Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD 21224, United States
Drug Alcohol Depend 97:216-25. 2008.... - Effects of gabapentin on cocaine self-administration, cocaine-triggered relapse and cocaine-enhanced nucleus accumbens dopamine in ratsXiao Qing Peng
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, United States
Drug Alcohol Depend 97:207-15. 2008..This is in striking contrast to positive findings in the same animal models shown by another GABAmimetic--gamma-vinyl GABA (see companion piece to present article)... - Varenicline attenuates nicotine-enhanced brain-stimulation reward by activation of alpha4beta2 nicotinic receptors in ratsKrista Spiller
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Neuropharmacology 57:60-6. 2009.... - Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in ratsXia Li
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, Maryland 21224, USA
J Neurochem 114:1368-80. 2010..The present findings support the potential use of mGluR7 agonists for the treatment of cocaine addiction... - Hypothesis-driven medication discovery for the treatment of psychostimulant addictionZheng Xiong Xi
National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
Curr Drug Abuse Rev 1:303-27. 2008..We conclude that hypothesis-based medication development strategies could significantly promote medication discovery for the effective treatment of psychostimulant addiction... - Attenuation of basal and cocaine-enhanced locomotion and nucleus accumbens dopamine in cannabinoid CB1-receptor-knockout miceXia Li
Neuropsychopharmacology Section, Chemical Biology Research Branch, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 204:1-11. 2009..Effect of cannabinoid CB1 receptor deletion on cocaine's actions is controversial. This is partly based on findings in CB1-receptor-knockout (CB1(-/-)) mice with CD1 genetic background... - N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in ratsZheng Xiong Xi
Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Neuropharmacology 58:304-13. 2010..These data suggest a potential utility for 2-PMPA or NAAG in the treatment of cocaine addiction... - Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanismZheng Xiong Xi
Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
J Neurochem 112:564-76. 2010..These findings suggest that 2-PMPA is effective in attenuating cocaine-induced reinstatement of drug-seeking behavior, likely by attenuating cocaine-induced increases in NAc DA and glutamate via pre-synaptic mGluR2/3s... - The basolateral complex of the amygdala mediates the modulation of intracranial self-stimulation threshold by drug-associated cuesRobert J Hayes
Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Dr, Baltimore, Maryland 21224, USA
Eur J Neurosci 20:273-80. 2004..We conclude that the BLC is necessary for cues associated with previous drug exposure to modulate activity within or downstream from the classical reward circuitry of the medial forebrain bundle... - Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in ratsZheng Xiong Xi
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Neuropharmacology 53:771-82. 2007..Together, the present data, combined with previous findings, support the potential use of l-THP for treatment of cocaine addiction... - Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in ratsZheng Xiong Xi
Neuropsychopharmacology Section, Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD 21224, USA
Neuropsychopharmacology 33:1735-45. 2008..Thus, AM 251 or other more potent CB1 receptor antagonists deserve further study as potentially effective anti-cocaine medications... - Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addictionZheng Xiong Xi
Neuropsychopharmacology Section, Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA
CNS Drug Rev 13:240-59. 2007..In addition, NGB 2904 may also act as a useful tool to study the role of D3 receptors in drug addiction... - Agents in development for the management of cocaine abuseDavid A Gorelick
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Drugs 64:1547-73. 2004..A recent phase I trial of a "cocaine vaccine" found it to be well tolerated and producing detectable levels of anti-cocaine antibodies for up to 9 months after immunisation... - Mechanism-based medication development for the treatment of nicotine dependenceZheng Xiong Xi
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Acta Pharmacol Sin 30:723-39. 2009..For drugs in each category, we discuss the mechanistic rationale for their potential anti-nicotine efficacy, major findings in preclinical and clinical studies, and future research directions... - The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in ratsZheng Xiong Xi
Neuropsychopharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD 21224, USA
Neuropsychopharmacology 31:1393-405. 2006..Owing to these properties and to its lack of rewarding effects (as assessed by BSR and by substitution during drug self-administration), NGB 2904 merits further investigation as a potential agent for treatment of cocaine addiction... - Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in ratsZheng Xiong Xi
Neuropsychopharmacology Section, Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 176:57-65. 2004..We have previously shown that selective D3 receptor blockade by the novel D3 antagonist SB-277011A inhibits cocaine's reinforcing action and cocaine-induced reinstatement of cocaine-seeking behavior... - Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbensZheng Xiong Xi
Neuropsychopharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
J Neurosci 26:8531-6. 2006.... - A single high dose of methamphetamine increases cocaine self-administration by depletion of striatal dopamine in ratsZ X Xi
Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, 251 Bayview Boulevard, BRC Room 05A705, Baltimore, MD 21224, USA
Neuroscience 161:392-402. 2009.... - Gamma-vinyl GABA, an irreversible inhibitor of GABA transaminase, alters the acquisition and expression of cocaine-induced sensitization in male ratsEliot L Gardner
Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA
Synapse 46:240-50. 2002.... - Evidence for the role of dopamine D3 receptors in oral operant alcohol self-administration and reinstatement of alcohol-seeking behavior in miceChristian A Heidbreder
Department of Neuropsychopharmacology, Centre of Excellence for Drug Discovery in Psychiatry, Verona, Italy
Addict Biol 12:35-50. 2007..Provided these results can be extrapolated to humans, they suggest that selective DA D(3) receptor antagonists may be useful in the pharmacotherapeutic management of alcohol intake and prevention of relapse to alcohol-seeking behavior... - The selective dopamine D3 receptor antagonist SB-277011-A attenuates ethanol consumption in ethanol preferring (P) and non-preferring (NP) ratsPanayotis K Thanos
Behavioral Neuropharmacology Lab, Medical Department, Building 490, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Pharmacol Biochem Behav 81:190-7. 2005.... - Attenuation of brain response to heroin correlates with the reinstatement of heroin-seeking in rats by fMRIFeng Luo
Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Neuroimage 22:1328-35. 2004.... - The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidenceChristian A Heidbreder
Centre of Excellence for Drug Discovery in Psychiatry, GlaxoSmithKline Pharmaceuticals, 37135 Verona, Italy
Brain Res Brain Res Rev 49:77-105. 2005..Provided these results can be extrapolated to human drug addicts, they suggest that selective DA D3 receptor antagonists may prove effective as potential pharmacotherapeutic agents to manage drug dependence and addiction... - Role of dopamine D3 receptors in the addictive properties of ethanolChristian A Heidbreder
Center of Excellence for Drug Discovery in Psychiatry, GlaxoSmithKline Pharmaceuticals, Via A Fleming 4, 37135 Verona, Italy
Drugs Today (Barc) 40:355-65. 2004..The present review is intended to highlight a new, promising area in alcohol research that focuses on the role of the dopamine D(3) receptor in the addictive properties of ethanol... - Acute administration of the selective D3 receptor antagonist SB-277011A blocks the acquisition and expression of the conditioned place preference response to heroin in male ratsCharles R Ashby
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John's University, Jamaica, New York 11439, USA
Synapse 48:154-6. 2003 - Cocaine treatment increases expression of a 40 kDa catecholamine-regulated protein in discrete brain regionsNiki Sharan
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada
Synapse 47:33-44. 2003..Elevated levels of CRP40 could play a protective role for dopamine neurons in response to increased oxidative stress that has been shown to be induced by cocaine and that can lead to apoptosis and neurodegeneration... - Electrical and chemical stimulation of the basolateral complex of the amygdala reinstates cocaine-seeking behavior in the ratRobert J Hayes
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Psychopharmacology (Berl) 168:75-83. 2003..These results are congruent with the hypothesis that the basolateral complex of the amygdala is part of a neural system mediating drug-seeking behavior... - Systemic administration of 1R,4S-4-amino-cyclopent-2-ene-carboxylic acid, a reversible inhibitor of GABA transaminase, blocks expression of conditioned place preference to cocaine and nicotine in ratsCharles R Ashby
Department of Pharmaceutical Sciences, St John s University, Jamaica, Queens, New York 11439, USA
Synapse 44:61-3. 2002..These results are the first to suggest that reversible inhibition of GABA transaminase may be useful in blocking cue-induced relapse to nicotine and cocaine...