E L Gardner

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint A slow-onset, long-duration indanamine monoamine reuptake inhibitor as a potential maintenance pharmacotherapy for psychostimulant abuse: effects in laboratory rat models relating to addiction
    Eliot L Gardner
    Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Building C Room 393, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropharmacology 51:993-1003. 2006
  2. ncbi request reprint Critical assessment of how to study addiction and its treatment: human and non-human animal models
    CHARLES P O'BRIEN
    Philadelphia VA Medical Center, Mental Illness Research and Education Center, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Pharmacol Ther 108:18-58. 2005
  3. pmc The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity
    Panayotis K Thanos
    Behavioral Neuropharmacology and Neuroimaging Lab, Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Pharmacol Biochem Behav 89:499-507. 2008
  4. ncbi request reprint What we have learned about addiction from animal models of drug self-administration
    E L Gardner
    Intramural Research Program, National Institute on Drug Abuse, Building C Room 272, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
    Am J Addict 9:285-313. 2000
  5. ncbi request reprint Endocannabinoid signaling system and brain reward: emphasis on dopamine
    Eliot L Gardner
    Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Building C Room 393, Baltimore, MD 21224, USA
    Pharmacol Biochem Behav 81:263-84. 2005
  6. pmc Use of animal models to develop antiaddiction medications
    Eliot L Gardner
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Curr Psychiatry Rep 10:377-84. 2008
  7. ncbi request reprint Addictive potential of cannabinoids: the underlying neurobiology
    Eliot L Gardner
    National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Building C, Room 272, 5500 Nathan Shock Drive, Baltimore, MD 20850, USA
    Chem Phys Lipids 121:267-90. 2002
  8. doi request reprint Addiction and brain reward and antireward pathways
    Eliot L Gardner
    Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Adv Psychosom Med 30:22-60. 2011
  9. ncbi request reprint Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats
    Stanislav R Vorel
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Neurosci 22:9595-603. 2002
  10. pmc Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors
    Jeremy G Gilbert
    Neuropsychopharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, Maryland 21224, USA
    Synapse 57:17-28. 2005

Collaborators

Detail Information

Publications45

  1. ncbi request reprint A slow-onset, long-duration indanamine monoamine reuptake inhibitor as a potential maintenance pharmacotherapy for psychostimulant abuse: effects in laboratory rat models relating to addiction
    Eliot L Gardner
    Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Building C Room 393, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropharmacology 51:993-1003. 2006
    ..We conclude that the prodrug strategy employed in the design of 30,640 achieved its goal. We suggest that such compounds may be useful as maintenance pharmacotherapies for psychostimulant addiction...
  2. ncbi request reprint Critical assessment of how to study addiction and its treatment: human and non-human animal models
    CHARLES P O'BRIEN
    Philadelphia VA Medical Center, Mental Illness Research and Education Center, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Pharmacol Ther 108:18-58. 2005
    ..This review examines in detail some animal and human models that have led not only to important theories of addiction mechanisms but also to medications shown to be effective in the clinic...
  3. pmc The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity
    Panayotis K Thanos
    Behavioral Neuropharmacology and Neuroimaging Lab, Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Pharmacol Biochem Behav 89:499-507. 2008
    ..These results suggest that along with its involvement in seeking behavior for drugs of abuse, the D(3) dopamine receptor may also be involved in seeking behavior for natural reinforcers such as food...
  4. ncbi request reprint What we have learned about addiction from animal models of drug self-administration
    E L Gardner
    Intramural Research Program, National Institute on Drug Abuse, Building C Room 272, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
    Am J Addict 9:285-313. 2000
    ....
  5. ncbi request reprint Endocannabinoid signaling system and brain reward: emphasis on dopamine
    Eliot L Gardner
    Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Building C Room 393, Baltimore, MD 21224, USA
    Pharmacol Biochem Behav 81:263-84. 2005
    ....
  6. pmc Use of animal models to develop antiaddiction medications
    Eliot L Gardner
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Curr Psychiatry Rep 10:377-84. 2008
    ..I conclude by noting some of the new and novel medications that have been developed preclinically using such models and the hope for further developments along such lines...
  7. ncbi request reprint Addictive potential of cannabinoids: the underlying neurobiology
    Eliot L Gardner
    National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Building C, Room 272, 5500 Nathan Shock Drive, Baltimore, MD 20850, USA
    Chem Phys Lipids 121:267-90. 2002
    ..This paper reviews those data, and concludes that cannabinoids act on brain reward processes and reward-related behaviors in strikingly similar fashion to other addictive drugs...
  8. doi request reprint Addiction and brain reward and antireward pathways
    Eliot L Gardner
    Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Adv Psychosom Med 30:22-60. 2011
    ....
  9. ncbi request reprint Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats
    Stanislav R Vorel
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Neurosci 22:9595-603. 2002
    ....
  10. pmc Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors
    Jeremy G Gilbert
    Neuropsychopharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, Maryland 21224, USA
    Synapse 57:17-28. 2005
    ....
  11. pmc The selective dopamine D3 receptor antagonist SB-277011A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions
    Arlene C Pak
    Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Int J Neuropsychopharmacol 9:585-602. 2006
    ..The results suggest that selective D3 receptor antagonism constitutes a new and promising pharmacotherapeutic approach to the treatment of nicotine dependence...
  12. pmc Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism
    Xia Li
    Neuropsychopharmacology Section, Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Neuropsychopharmacology 34:1783-96. 2009
    ....
  13. pmc Selective dopamine D3 receptor antagonism by SB-277011A attenuates cocaine reinforcement as assessed by progressive-ratio and variable-cost-variable-payoff fixed-ratio cocaine self-administration in rats
    Zheng Xiong Xi
    Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 21:3427-38. 2005
    ..If these results extrapolate to humans, SB-277011A or similar selective DA D(3) receptor antagonists may be useful in the treatment of cocaine addiction...
  14. pmc The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in rats
    Xiao Qing Peng
    National Institute on Drug Abuse, Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Neuropharmacology 56:752-60. 2009
    ....
  15. pmc Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats
    Xiao Qing Peng
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Eur J Pharmacol 627:156-61. 2010
    ..These data suggest that orally effective NAAG peptidase inhibitors deserve further study as potential agents for the treatment of cocaine addiction...
  16. pmc The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats
    Krista Spiller
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA
    Psychopharmacology (Berl) 196:533-42. 2008
    ..We have previously reported that selective antagonism of brain D3 receptors by SB-277011A or NGB 2904 significantly attenuates cocaine- or nicotine-enhanced brain stimulation reward (BSR)...
  17. pmc The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats
    Xia Li
    Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropharmacology 54:542-51. 2008
    ..In contrast to its modulatory effect on GABA and glutamate, the mGluR7 receptor does not appear to modulate NAc DA release...
  18. pmc Gamma-vinyl GABA inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats by a non-dopaminergic mechanism
    Xiao Qing Peng
    Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD 21224, United States
    Drug Alcohol Depend 97:216-25. 2008
    ....
  19. pmc Effects of gabapentin on cocaine self-administration, cocaine-triggered relapse and cocaine-enhanced nucleus accumbens dopamine in rats
    Xiao Qing Peng
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, United States
    Drug Alcohol Depend 97:207-15. 2008
    ..This is in striking contrast to positive findings in the same animal models shown by another GABAmimetic--gamma-vinyl GABA (see companion piece to present article)...
  20. pmc Varenicline attenuates nicotine-enhanced brain-stimulation reward by activation of alpha4beta2 nicotinic receptors in rats
    Krista Spiller
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropharmacology 57:60-6. 2009
    ....
  21. pmc Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in rats
    Xia Li
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, Maryland 21224, USA
    J Neurochem 114:1368-80. 2010
    ..The present findings support the potential use of mGluR7 agonists for the treatment of cocaine addiction...
  22. pmc Hypothesis-driven medication discovery for the treatment of psychostimulant addiction
    Zheng Xiong Xi
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Curr Drug Abuse Rev 1:303-27. 2008
    ..We conclude that hypothesis-based medication development strategies could significantly promote medication discovery for the effective treatment of psychostimulant addiction...
  23. pmc Attenuation of basal and cocaine-enhanced locomotion and nucleus accumbens dopamine in cannabinoid CB1-receptor-knockout mice
    Xia Li
    Neuropsychopharmacology Section, Chemical Biology Research Branch, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 204:1-11. 2009
    ..Effect of cannabinoid CB1 receptor deletion on cocaine's actions is controversial. This is partly based on findings in CB1-receptor-knockout (CB1(-/-)) mice with CD1 genetic background...
  24. pmc N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats
    Zheng Xiong Xi
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Neuropharmacology 58:304-13. 2010
    ..These data suggest a potential utility for 2-PMPA or NAAG in the treatment of cocaine addiction...
  25. pmc Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism
    Zheng Xiong Xi
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Neurochem 112:564-76. 2010
    ..These findings suggest that 2-PMPA is effective in attenuating cocaine-induced reinstatement of drug-seeking behavior, likely by attenuating cocaine-induced increases in NAc DA and glutamate via pre-synaptic mGluR2/3s...
  26. ncbi request reprint The basolateral complex of the amygdala mediates the modulation of intracranial self-stimulation threshold by drug-associated cues
    Robert J Hayes
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Dr, Baltimore, Maryland 21224, USA
    Eur J Neurosci 20:273-80. 2004
    ..We conclude that the BLC is necessary for cues associated with previous drug exposure to modulate activity within or downstream from the classical reward circuitry of the medial forebrain bundle...
  27. pmc Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats
    Zheng Xiong Xi
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropharmacology 53:771-82. 2007
    ..Together, the present data, combined with previous findings, support the potential use of l-THP for treatment of cocaine addiction...
  28. ncbi request reprint Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats
    Zheng Xiong Xi
    Neuropsychopharmacology Section, Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 33:1735-45. 2008
    ..Thus, AM 251 or other more potent CB1 receptor antagonists deserve further study as potentially effective anti-cocaine medications...
  29. pmc Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addiction
    Zheng Xiong Xi
    Neuropsychopharmacology Section, Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA
    CNS Drug Rev 13:240-59. 2007
    ..In addition, NGB 2904 may also act as a useful tool to study the role of D3 receptors in drug addiction...
  30. ncbi request reprint Agents in development for the management of cocaine abuse
    David A Gorelick
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drugs 64:1547-73. 2004
    ..A recent phase I trial of a "cocaine vaccine" found it to be well tolerated and producing detectable levels of anti-cocaine antibodies for up to 9 months after immunisation...
  31. pmc Mechanism-based medication development for the treatment of nicotine dependence
    Zheng Xiong Xi
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Acta Pharmacol Sin 30:723-39. 2009
    ..For drugs in each category, we discuss the mechanistic rationale for their potential anti-nicotine efficacy, major findings in preclinical and clinical studies, and future research directions...
  32. ncbi request reprint The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats
    Zheng Xiong Xi
    Neuropsychopharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:1393-405. 2006
    ..Owing to these properties and to its lack of rewarding effects (as assessed by BSR and by substitution during drug self-administration), NGB 2904 merits further investigation as a potential agent for treatment of cocaine addiction...
  33. pmc Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats
    Zheng Xiong Xi
    Neuropsychopharmacology Section, Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 176:57-65. 2004
    ..We have previously shown that selective D3 receptor blockade by the novel D3 antagonist SB-277011A inhibits cocaine's reinforcing action and cocaine-induced reinstatement of cocaine-seeking behavior...
  34. ncbi request reprint Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens
    Zheng Xiong Xi
    Neuropsychopharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 26:8531-6. 2006
    ....
  35. pmc A single high dose of methamphetamine increases cocaine self-administration by depletion of striatal dopamine in rats
    Z X Xi
    Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, 251 Bayview Boulevard, BRC Room 05A705, Baltimore, MD 21224, USA
    Neuroscience 161:392-402. 2009
    ....
  36. ncbi request reprint Gamma-vinyl GABA, an irreversible inhibitor of GABA transaminase, alters the acquisition and expression of cocaine-induced sensitization in male rats
    Eliot L Gardner
    Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA
    Synapse 46:240-50. 2002
    ....
  37. ncbi request reprint Evidence for the role of dopamine D3 receptors in oral operant alcohol self-administration and reinstatement of alcohol-seeking behavior in mice
    Christian A Heidbreder
    Department of Neuropsychopharmacology, Centre of Excellence for Drug Discovery in Psychiatry, Verona, Italy
    Addict Biol 12:35-50. 2007
    ..Provided these results can be extrapolated to humans, they suggest that selective DA D(3) receptor antagonists may be useful in the pharmacotherapeutic management of alcohol intake and prevention of relapse to alcohol-seeking behavior...
  38. ncbi request reprint The selective dopamine D3 receptor antagonist SB-277011-A attenuates ethanol consumption in ethanol preferring (P) and non-preferring (NP) rats
    Panayotis K Thanos
    Behavioral Neuropharmacology Lab, Medical Department, Building 490, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Pharmacol Biochem Behav 81:190-7. 2005
    ....
  39. ncbi request reprint Attenuation of brain response to heroin correlates with the reinstatement of heroin-seeking in rats by fMRI
    Feng Luo
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neuroimage 22:1328-35. 2004
    ....
  40. pmc The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence
    Christian A Heidbreder
    Centre of Excellence for Drug Discovery in Psychiatry, GlaxoSmithKline Pharmaceuticals, 37135 Verona, Italy
    Brain Res Brain Res Rev 49:77-105. 2005
    ..Provided these results can be extrapolated to human drug addicts, they suggest that selective DA D3 receptor antagonists may prove effective as potential pharmacotherapeutic agents to manage drug dependence and addiction...
  41. ncbi request reprint Role of dopamine D3 receptors in the addictive properties of ethanol
    Christian A Heidbreder
    Center of Excellence for Drug Discovery in Psychiatry, GlaxoSmithKline Pharmaceuticals, Via A Fleming 4, 37135 Verona, Italy
    Drugs Today (Barc) 40:355-65. 2004
    ..The present review is intended to highlight a new, promising area in alcohol research that focuses on the role of the dopamine D(3) receptor in the addictive properties of ethanol...
  42. ncbi request reprint Acute administration of the selective D3 receptor antagonist SB-277011A blocks the acquisition and expression of the conditioned place preference response to heroin in male rats
    Charles R Ashby
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Saint John s University, Jamaica, New York 11439, USA
    Synapse 48:154-6. 2003
  43. ncbi request reprint Cocaine treatment increases expression of a 40 kDa catecholamine-regulated protein in discrete brain regions
    Niki Sharan
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada
    Synapse 47:33-44. 2003
    ..Elevated levels of CRP40 could play a protective role for dopamine neurons in response to increased oxidative stress that has been shown to be induced by cocaine and that can lead to apoptosis and neurodegeneration...
  44. ncbi request reprint Electrical and chemical stimulation of the basolateral complex of the amygdala reinstates cocaine-seeking behavior in the rat
    Robert J Hayes
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Psychopharmacology (Berl) 168:75-83. 2003
    ..In animals, the BLC is necessary for cocaine-seeking behavior elicited by cocaine-associated cues. It has not been determined whether BLC activation is sufficient to reinstate cocaine seeking...
  45. ncbi request reprint Systemic administration of 1R,4S-4-amino-cyclopent-2-ene-carboxylic acid, a reversible inhibitor of GABA transaminase, blocks expression of conditioned place preference to cocaine and nicotine in rats
    Charles R Ashby
    Department of Pharmaceutical Sciences, St John s University, Jamaica, Queens, New York 11439, USA
    Synapse 44:61-3. 2002
    ..These results are the first to suggest that reversible inhibition of GABA transaminase may be useful in blocking cue-induced relapse to nicotine and cocaine...