Research Topics
Genomes and Genes
Species | Montserrat Garcia-ClosasSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analysesMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 7076, Rockville, MD 20952 7234, USA
Hum Genet 119:376-88. 2006..Evaluation of potential underlying gene-gene interactions or associations in population subgroups will require even larger sample sizes...
Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control studyMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20952 7234, USA
BMC Cancer 7:60. 2007..We evaluated whether common genetic variation in SHBG and its 3' neighbor ATP1B2, in linkage disequilibrium, is associated with the risk of epithelial ovarian cancer...- Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer riskMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland, United States of America
PLoS Genet 3:e29. 2007..In conclusion, this large-scale evaluation of candidate cancer genes has identified common genetic variants in the regulatory regions of VEGF that could be associated with bladder cancer risk... - Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristicsMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
PLoS Genet 4:e1000054. 2008..Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment... - Common genetic variation in GATA-binding protein 3 and differential susceptibility to breast cancer by estrogen receptor alpha tumor statusMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, Room 7076, MSC 7234, Rockville, MD 20852 7234, USA
Cancer Epidemiol Biomarkers Prev 16:2269-75. 2007..These differential associations are consistent with markedly different levels of GATA3 protein by ER status. Additional epidemiologic studies are needed to clarify these intriguing relationships... - Genetic susceptibility loci for breast cancer by estrogen receptor statusMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
Clin Cancer Res 14:8000-9. 2008.... - Established breast cancer risk factors by clinically important tumour characteristicsM Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Rockville, MD 20852 7234, USA
Br J Cancer 95:123-9. 2006..In conclusion, these data support distinctive risk factor relationships by tumour characteristics of prognostic relevance. These findings might be useful in developing targeted prevention efforts... - Genetic variation in the nucleotide excision repair pathway and bladder cancer riskMontserrat Garcia-Closas
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Room 7076, 6120 Executive Boulevard, MSC 7234, Rockville, MD 20852 7234, USA
Cancer Epidemiol Biomarkers Prev 15:536-42. 2006..A detailed characterization of genetic variation in key NER genes is warranted and might ultimately help identify multiple susceptibility variants that could be responsible for substantial joint increases in risk... - NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analysesMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20852 7234, USA
Lancet 366:649-59. 2005..Associations between polymorphisms in other NAT and GST genes and bladder-cancer risk have been inconsistent... - Relationship between serum hormone concentrations, reproductive history, alcohol consumption and genetic polymorphisms in pre-menopausal womenMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, 6120 Executive Boulevard, Bethesda, MD 20852 7234, USA
Int J Cancer 102:172-8. 2002.... - Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancerYawei Zhang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA
Cancer Epidemiol Biomarkers Prev 15:353-8. 2006..6; 95% CI, 1.1-2.4; P = 0.02). In conclusion, our results do not support that the polymorphisms evaluated in six BER pathway genes play a major role in breast carcinogenesis, particularly in Caucasian populations... - Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancerMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
Int J Cancer 121:2532-8. 2007..However, data suggested that common variation in TP53 or WDR79 could be associated with ER negative breast cancers... - Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish womenMia M Gaudet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland 20852, USA
Pharmacogenet Genomics 16:547-53. 2006..The present study provides strong evidence against the existence of a substantial overall association between common genetic variation in CYP1B1 and breast cancer risk... - Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer riskJonine D Figueroa
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
Carcinogenesis 28:1788-93. 2007..17 (1.00-1.36). Results from this study provide evidence for associations between variants in genes in the DSBR pathway and bladder cancers risk that warrant replication in other study populations... - Performance of common genetic variants in breast-cancer risk modelsSholom Wacholder
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 5050, MSC 7244, Bethesda, MD 20892, USA
N Engl J Med 362:986-93. 2010..Genomewide association studies have identified multiple genetic variants associated with breast cancer. The extent to which these variants add to existing risk-assessment models is unknown... - Variation in breast cancer hormone receptor and HER2 levels by etiologic factors: a population-based analysisMark E Sherman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
Int J Cancer 121:1079-85. 2007..07) for low PR and HER2 expression vs. OR = 1.78 (95% CI = 1.25-2.55) for high expression (p-heterogeneity = 0.001). PR and HER2 levels in breast cancer vary by BMI, suggesting a heterogeneous etiology for tumors related to these markers... - Evidence for an intensity-dependent interaction of NAT2 acetylation genotype and cigarette smoking in the Spanish Bladder Cancer StudyJay H Lubin
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
Int J Epidemiol 36:236-41. 2007..9 in never-smokers and 1.6 in ever-smokers, a 1.8-fold enhancement in smokers. Evidence indicates that acetylation is an exposure-dependent process, and thus the magnitude of the interaction may also depend on exposure level... - Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genesHannah P Yang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
Carcinogenesis 31:827-33. 2010..Associations with variants in other genes have been suggested, but findings have been inconsistent... - Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer riskMia M Gaudet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Hum Genet 121:483-90. 2007..Additional studies are required to replicate these findings and to determine whether rs361525 is a causative SNP or is a marker of a causative SNP... 
Sex steroid hormone levels in breast adipose tissue and serum in postmenopausal womenRoni T Falk
Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA
Breast Cancer Res Treat 131:287-94. 2012..Measurement of sex hormones in serum and in the microenvironment may help in understanding the hormonal etiology of breast cancer, suggest methods for prevention, and have value in gauging treatment response and prognosis...- Genetic variation in the base excision repair pathway and bladder cancer riskJonine D Figueroa
Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA
Hum Genet 121:233-42. 2007..24 (1.02-1.51) and 1.30 (1.04-1.62), respectively. In summary, data from this large case-control study suggested bladder cancer risk associations with selected BER SNPs, which need to be confirmed in other study populations... - Comprehensive assessment of genetic variation of catechol-O-methyltransferase and breast cancer riskMia M Gaudet
Division of Cancer Epidemiology, National Cancer Institute, 6120 Executive Boulevard, EPS 7055, Rockville, MD 20852, USA
Cancer Res 66:9781-5. 2006..The suggestion of increased risk associated with a haplotype in the 3' UTR of COMT needs to be confirmed in independent study populations... - A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility lociNathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Nat Genet 42:978-84. 2010..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis... - Smoking and bladder cancer in Spain: effects of tobacco type, timing, environmental tobacco smoke, and genderClaudine Samanic
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 15:1348-54. 2006..2 to 1.7, suggesting that nearly the entire male excess of bladder cancer observed in Spain is explained by cigarette smoking rather than occupational/environmental exposures to other bladder carcinogens... - HSD17B1 genetic variants and hormone receptor-defined breast cancerMia M Gaudet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 17:2766-72. 2008..Associations between HSD17B1 genotypes and risk for ER- breast cancer were inconsistent across studies and should be studied further... - Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control studyLee E Moore
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD, USA
Lancet Oncol 9:359-66. 2008..DNA hypomethylation has been suggested to cause genomic instability and increase cancer risk. We aimed to test the hypothesis that DNA hypomethylation is associated with increased risk of bladder cancer... - Differences in risk factors for breast cancer molecular subtypes in a population-based studyXiaohong R Yang
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7014, 6120 Executive Boulevard, Bethesda, MD 20892 7236, USA
Cancer Epidemiol Biomarkers Prev 16:439-43. 2007..Results from this study have shown that breast cancer risk factors may vary by molecular subtypes identified in expression studies, suggesting etiologic, in addition to clinical, heterogeneity of breast cancer... - Genetic variation in CYP17 and endometrial cancer riskMia M Gaudet
National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Hum Genet 123:155-62. 2008..Further evaluation in consortia is necessary to confirm potential weak associations between common variation in CYP17 and endometrial cancer risk and to address the concern of publication bias... - Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genesJonine D Figueroa
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
Carcinogenesis 29:1955-62. 2008..These results indicate that genetic variation in carcinogen-metabolizing genes, particularly AKR1C3, could be associated with bladder cancer risk... - Active and passive cigarette smoking and the risk of endometrial cancer in PolandHannah P Yang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd, Suite 520, Rockville, MD 20852, USA
Eur J Cancer 46:690-6. 2010..However, dose-response relationships with quantitative measures of active smoking or passive smoking remain less clear... - Estimating age-specific breast cancer risks: a descriptive tool to identify age interactionsWilliam F Anderson
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Executive Plaza South 8070, 6120 Executive Plaza Blvd, Rockville, MD 20892 7242, USA
Cancer Causes Control 18:439-47. 2007..Clarifying age-specific female breast cancer risks and interactions may provide important etiologic clues... - Common genetic variants in the PSCA gene influence gene expression and bladder cancer riskYi Ping Fu
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 109:4974-9. 2012.... - Assessment of automated image analysis of breast cancer tissue microarrays for epidemiologic studiesKelly L Bolton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 19:992-9. 2010..We assessed agreement between automated and pathologist scores of a diverse set of immunohistochemical assays done on breast cancer tissue microarrays (TMA)... - Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE reviewLawrence S Engel
Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
Am J Epidemiol 156:95-109. 2002..45, 95% CI: -0.03, 0.93). These results indicate that, among populations studied to date, GSTM1 null status is associated with a modest increase in the risk of bladder cancer... - Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancerWei Tang
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Hum Mol Genet 21:1918-30. 2012..1 protein. Our study shows an example of genetic and functional role of an uncommon protective genetic variant in a complex human disease, such as bladder cancer... - Intrauterine environment and breast cancer risk in a population-based case-control study in PolandSue Kyung Park
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Int J Cancer 119:2136-41. 2006..Our results add support to the growing evidence that some perinatal exposures may relate to breast cancer risk. Additional studies are needed to confirm associations and clarify the biologic mechanisms underlying these associations... - Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in PolandSarah J Nyante
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
Breast Cancer Res 13:R42. 2011..Thus, we examined the relationship between single nucleotide polymorphisms (SNPs) in PRL and PRLR, serum prolactin levels and breast cancer risk in a population-based case-control study... - Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European backgroundIdan Menashe
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 7:e29396. 2012..Identification of the aromatic amine metabolism pathway provides support for the ability of this approach to identify pathways with established relevance to bladder carcinogenesis... - Fine mapping of 14q24.1 breast cancer susceptibility locusPhoebe Lee
Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Hum Genet 131:479-90. 2012..Therefore, we conclude that rs999737 is an optimal tag SNP for common variants in the 14q24.1 region and thus narrow the candidate variants that should be investigated in follow-up laboratory evaluation... - Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancerLee E Moore
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Int J Cancer 120:2452-8. 2007..Additional work is needed to comprehensively evaluate genomic variation in CTH and related genes in the trans-sulfuration pathway and bladder cancer risk... - The ATM missense mutation p.Ser49Cys (c.146C>G) and the risk of breast cancerDenise L Stredrick
Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5060, USA
Hum Mutat 27:538-44. 2006..S49C, may be breast cancer susceptibility alleles. Because of their low frequency, even larger sample sizes are required to more firmly establish these associations... - Construction and validation of tissue microarrays of ductal carcinoma in situ and terminal duct lobular units associated with invasive breast carcinomaXiaohong Rose Yang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20852, USA
Diagn Mol Pathol 15:157-61. 2006..Additional exploration of this approach is needed... - Effects of electron-beam irradiation on buccal-cell DNAPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Am J Hum Genet 73:646-51. 2003.... - A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European backgroundMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
Pharmacogenet Genomics 21:231-6. 2011..Further studies are required to determine the functional implications of rs1495741 and the structure and evolution of the haplotype on which it resides... - Estrogen receptor and progesterone receptor expression in normal terminal duct lobular units surrounding invasive breast cancerXiaohong R Yang
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Blvd, Bethesda, MD USA
Breast Cancer Res Treat 137:837-47. 2013..Analyses of mapped TDLUs may provide information about the sequence of molecular changes occurring in breast carcinogenesis... - Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association ConsortiumJonine D Figueroa
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Hum Mol Genet 20:4693-706. 2011..Our results underscore the need for large pooling efforts with tumor pathology data to help refine risk estimates for SNP associations with susceptibility to different subtypes of breast cancer... - Hormonal markers in breast cancer: coexpression, relationship with pathologic characteristics, and risk factor associations in a population-based studyXiaohong R Yang
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
Cancer Res 67:10608-17. 2007.... - Endometrial cancer and genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2 within a population-based case-control studyJames V Lacey
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Gynecol Oncol 120:167-73. 2011..We assessed whether common genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2-genes that reportedly are frequently altered in endometrial cancer-was associated with risk of endometrial cancer... - A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)Gilles Thomas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Nat Genet 41:579-84. 2009..1 (rs999737; P = 1.74 x 10(-7)) localizes to RAD51L1, a gene in the homologous recombination DNA repair pathway. We also confirmed associations with loci on chromosomes 2q35, 5p12, 5q11.2, 8q24, 10q26 and 16q12.1... - Genetic variation in the androgen receptor gene and endometrial cancer riskHannah P Yang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
Cancer Epidemiol Biomarkers Prev 18:585-9. 2009..Results from our study, taken together with previously published studies, provide little evidence of a consistent association between common genetic variation in AR and endometrial cancer risk... - Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosisMia M Gaudet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Int J Cancer 124:1716-20. 2009..02, 0.88-1.17; 0.90, 0.72-1.11; 1.04, 0.90-1.21, respectively). Our results do not support a relationship between SIPA1 polymorphisms and breast cancer risk or subsequent survival... - Urinary pH, cigarette smoking and bladder cancer riskJuan Alguacil
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
Carcinogenesis 32:843-7. 2011..024). These results suggest that urine pH, which is determined primarily by diet and body surface area, may be an important modifier of smoking and risk of bladder cancer... - Assessing the probability that a positive report is false: an approach for molecular epidemiology studiesSholom Wacholder
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7244, USA
J Natl Cancer Inst 96:434-42. 2004..An FPRP-based criterion for deciding whether to call a finding noteworthy formalizes the process already used informally by investigators--that is, tempering enthusiasm for remarkable study findings with considerations of plausibility... - Analysis of terminal duct lobular unit involution in luminal A and basal breast cancersXiaohong R Yang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Breast Cancer Res 14:R64. 2012..Accordingly, we performed a masked microscopic assessment of TDLU involution in benign tissues associated with luminal A and CBP breast cancers diagnosed among women less than age 55 years... - Ovarian volumes among women with endometrial carcinoma: associations with risk factors and serum hormonesMark E Sherman
National Cancer Institute, Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
Gynecol Oncol 107:431-5. 2007..Accordingly, we assessed ovarian volumes in relation to serum sex hormone levels among post-menopausal women with endometrial carcinoma who participated in a multi-center case-control study... - Etiology of hormone receptor-defined breast cancer: a systematic review of the literatureMichelle D Althuis
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7084, 6120 Executive Boulevard, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 13:1558-68. 2004..Large population-based studies of determinants of hormone receptor-defined breast cancers defined using state-of-the-art quantitative immunostaining methods are needed to clarify the role of ER/PR expression in breast cancer etiology... - Effects of electron-beam irradiation on whole genome amplificationAndrew W Bergen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20892 7236, USA
Cancer Epidemiol Biomarkers Prev 14:1016-9. 2005..Multiple Displacement Amplification wgaDNA derived from E-beam-irradiated gDNA is not suitable for genotyping analysis... - Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristicsJonine D Figueroa
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Breast Cancer Res Treat 121:727-35. 2010..These results warrant analysis in studies of clinical outcomes accounting for age, ER status and treatment... - Detectable clonal mosaicism and its relationship to aging and cancerKevin B Jacobs
Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
Nat Genet 44:651-8. 2012..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases... - A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3Montserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Hum Mol Genet 20:4282-9. 2011..Our findings suggest that genetic variation in SLC14A1 could provide new etiological insights into bladder carcinogenesis... - Cigarette smoking and cancer risk: modeling total exposure and intensityJay H Lubin
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Am J Epidemiol 166:479-89. 2007..The intensity effects were statistically homogeneous, indicating that after accounting for risk from total pack-years, intensity patterns were comparable across the diverse cancer sites... - Molecular pathology in epidemiologic studies: a primer on key considerationsMark E Sherman
National Cancer Institute, Division of Cancer Epidemiology and Genetics, Rockville, MD, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
Cancer Epidemiol Biomarkers Prev 19:966-72. 2010..Concurrently, methodologic research to extend the range of assays that can be done on fixed tissues is expanding possibilities for molecular pathologic studies in epidemiologic research... - Detection of somatic mutations by high-resolution DNA melting (HRM) analysis in multiple cancersJesus Gonzalez-Bosquet
Laboratory of Translational Genomics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 6:e14522. 2011..Although the overall accuracy appears to be better in frozen specimens, somatic alterations were detected in DNA extracted from paraffin-embedded samples... - Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studiesXiaohong R Yang
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Sciences, Rockville, MD 20852, USA
J Natl Cancer Inst 103:250-63. 2011..Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors... - Loss of antigenicity in stored sections of breast cancer tissue microarraysJennifer H Fergenbaum
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health/DHHS, 6120 Executive Boulevard, Executive Plaza South, Room 7080, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 13:667-72. 2004..Improved methods for sectioning TMAs and storing tissue sections aimed at reducing loss of immunoreactivity are critical for the use of TMAs in epidemiological studies... - Leukocyte telomere length in a population-based case-control study of ovarian cancer: a pilot studyLisa Mirabello
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA
Cancer Causes Control 21:77-82. 2010..Ovarian cancer tissues also have shortened telomeres and increased telomerase activity, suggesting that telomere abnormalities may be related to ovarian cancer... - Does increased urination frequency protect against bladder cancer?Debra T Silverman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
Int J Cancer 123:1644-8. 2008..Increased urination frequency, coupled with possible dilution of the urine from increased water intake, may diminish the effect of urinary carcinogens on bladder cancer risk... - Test-retest reliability of self-reported reproductive and lifestyle data in the context of a German case-control study on breast cancer and postmenopausal hormone therapyTracy Slanger
German Cancer Research Center, Department of Clinical Epidemiology, Heidelberg, Germany
Ann Epidemiol 17:993-8. 2007.... - Association of a common AKAP9 variant with breast cancer risk: a collaborative analysisBernd Frank
Helmholtz University Group Molecular Epidemiology, Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
J Natl Cancer Inst 100:437-42. 2008..10 (95% CI = 1.04 to 1.17, P = .001). Among the combined subset of 2795 familial breast cancer patients, the respective ORs were 1.27 (95% CI = 1.12 to 1.45, P = .0003) and 1.16 (95% CI = 1.06 to 1.27, P = .001)... - Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer riskSascha Abbas
Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld, 69120 Heidelberg, Germany
Breast Cancer Res 10:R31. 2008..Effect modification by serum 25-hydroxyvitamin D (25 [OH]D), the biomarker for vitamin D status in humans, has rarely been examined... - The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D statusSascha Abbas
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
Cancer Epidemiol Biomarkers Prev 17:1339-43. 2008..Our results provide evidence for a serum 25(OH)D-independent effect of Gc2 allele carrier status in postmenopausal breast cancer... - Risk of different histological types of postmenopausal breast cancer by type and regimen of menopausal hormone therapyDieter Flesch-Janys
Department of Medical Biometry and Epidemiology, Center for Experimental Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Int J Cancer 123:933-41. 2008..These data suggest that the risks associated with menopausal HT differ by type and regimen of HT and histological type of breast cancer and may vary by progestagenic component, depending on the effective dose... - Evaluation of a short retrospective questionnaire for physical activity in womenMartina E Schmidt
Unit of Environmental Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Eur J Epidemiol 21:575-85. 2006..The median interviewing time was 10 min. Overall, this short questionnaire appears to be a useful and valid tool to distinguish between high and low levels of women's physical activity in the distant past... - The role of HIV-related knowledge and ethnicity in determining HIV risk perception and willingness to undergo HIV testing among rural women in Burkina FasoMalabika Sarker
Department of Tropical Hygiene and Public Health, University of Heidelberg, Germany
AIDS Behav 9:243-9. 2005..The dissemination of information on the asymptomatic nature of HIV infection could potentially be very important in forming risk perception, awareness, and their willingness to participate in HIV interventions... - Serum 25-hydroxyvitamin D and risk of post-menopausal breast cancer--results of a large case-control studySascha Abbas
Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
Carcinogenesis 29:93-9. 2008....