Research Topics
Genomes and Genes | Stavros GarantziotisSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Ecogenomics of respiratory diseases of public health significanceStavros Garantziotis
Clinical Research Program and Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Annu Rev Public Health 31:37-51 1 p following 51. 2010....
Genetics and genomics in human lung transplantationStavros Garantziotis
Duke University Medical Center, Duke Lung and Heart Lung Transplant Center, Division of Pulmonary, Allergy and Critical Care Medicine, Durham, NC 27710, USA
Expert Rev Respir Med 1:271-8. 2007....- Serum inter-alpha-trypsin inhibitor and matrix hyaluronan promote angiogenesis in fibrotic lung injuryStavros Garantziotis
Clinical Research Unit, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Am J Respir Crit Care Med 178:939-47. 2008..Inter-alpha-trypsin inhibitor (IaI) is a serum protein that can bind to hyaluronan (HA) and may contribute to the angiogenic response to tissue injury... - Hyaluronan mediates ozone-induced airway hyperresponsiveness in miceStavros Garantziotis
NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 284:11309-17. 2009..These data support the conclusion that pulmonary matrix can contribute to the development of airway hyperresponsiveness... - TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalationStavros Garantziotis
National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina, USA
Am J Respir Crit Care Med 181:666-75. 2010..However, the relation between TLR4 and hyaluronan in the airway response to ozone remains unexplored... - CD14 is an essential mediator of LPS-induced airway diseaseDavid M Brass
National Institute of Environmental Health Sciences, Rall Bldg, Rm C224, PO Box 12233 MD C2 15, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
Am J Physiol Lung Cell Mol Physiol 293:L77-83. 2007.... - The role of the extracellular matrix protein mindin in airway response to environmental airways injurySarah Frush
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, North Carolina, USA
Environ Health Perspect 119:1403-8. 2011..Our previous work demonstrated that the extracellular matrix protein mindin contributes to allergic airways disease. However, the role of mindin in nonallergic airways disease has not previously been explored... - The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspaceZhuowei Li
Department of Immunology, Duke University Medical Center, Box 103004, Durham, NC 27710, USA
J Leukoc Biol 85:124-31. 2009..In conclusion, these data suggest that mindin participates in integrin-dependent trafficking of eosinophils and can contribute to the severity of allergic airways disease... - Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharideStavros Garantziotis
Department of Medicine, Duke University Medical Center, Durham, NC 27709, USA
Transplantation 84:1012-9. 2007..We have developed and pursued the hypothesis that local activation of pulmonary innate immunity through toll-like receptor (TLR)-4 is critical to the development of posttransplant alloimmune lung injury... - Evaluating genome-wide DNA methylation changes in mice by Methylation Specific Digital KaryotypingKathy Boon
National Heart Lung and Blood Institute National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
BMC Genomics 9:598. 2008..The method generates 21 base pairs long sequence tags derived from specific locations in the genome. The resulting tag frequencies determine in a quantitative manner the methylation level of the corresponding loci... - Ambient ozone primes pulmonary innate immunity in miceJohn W Hollingsworth
Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Box 3136, Durham, NC 27710, USA
J Immunol 179:4367-75. 2007..These observations indicate that ozone exposure increases both the pulmonary and the systemic biologic response to inhaled LPS by priming the innate immune system... - In utero supplementation with methyl donors enhances allergic airway disease in miceJohn W Hollingsworth
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Clin Invest 118:3462-9. 2008..Our findings indicate that dietary factors can modify the heritable risk of allergic airway disease through epigenetic mechanisms during a vulnerable period of fetal development in mice... - Inter-alpha-trypsin inhibitor promotes bronchial epithelial repair after injury through vitronectin bindingJennifer E Adair
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 284:16922-30. 2009..We conclude that IaI interacts not only with hyaluronan, as previously reported, but also other ECM components like vitronectin and is an important regulator of cellular repair after injury... - CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway diseaseJohn W Hollingsworth
Division of Pulmonary, Allergy, and Critical Care Medicine, DUMC 3136, Duke University Medical Center, Durham, NC 27710, USA
Am J Respir Cell Mol Biol 37:248-53. 2007..In addition, CD44-deficient animals had 150% fewer neutrophils at 24 h and 50% greater neutrophils 48 h after LPS exposure. These results support the role of CD44 in modulating the biologic response to inhaled LPS... - Inter-alpha-trypsin inhibitor attenuates complement activation and complement-induced lung injuryStavros Garantziotis
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 179:4187-92. 2007..This novel function of IaI provides a mechanistic explanation for its observed salutary effects in sepsis and opens new possibilities for its use as a treatment agent in inflammatory diseases... - Innate immune activation potentiates alloimmune lung disease independent of chemokine (C-X-C motif) receptor 3Tereza Martinu
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Heart Lung Transplant 30:717-25. 2011..We hypothesized that the chemokine (C-X-C motif) receptor 3 (CXCR3) receptor is necessary for the development of LPS-induced pulmonary GVHD... - Cerium dioxide nanoparticles do not modulate the lipopolysaccharide-induced inflammatory response in human monocytesSalik Hussain
Clinical Research Unit, National Institute of Environmental Health Sciences National Institute of Health, Research Triangle Park, Durham, NC 27709, USA
Int J Nanomedicine 7:1387-97. 2012..We investigated the inflammation-modulating effects of CeO(2) nanoparticles at noncytotoxic concentrations in human peripheral blood monocytes... - Leukocyte-derived IL-10 reduces subepithelial fibrosis associated with chronically inhaled endotoxinStavros Garantziotis
Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Box 3683, Durham, NC 27710, USA
Am J Respir Cell Mol Biol 35:662-7. 2006..The role of IL-10 on airway hyperreactivity is complex: IL-10 deficiency protects against LPS-induced hyperreactivity, and is associated with higher eNOS, iNOS, and airway nitrate levels... - Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunityRebecca L Heise
Laboratory of Respiratory Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 286:17435-44. 2011..In conclusion, we show for the first time that innate immunity transduces mechanical stress responses through the matrix component hyaluronan, and activation of the Wnt/β-catenin pathway... - The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergensRhonda H Wilson
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health, Research Triangle Park, NC, USA
Nat Med 18:1705-10. 2012..Together, these findings suggest that household FLA promotes the development of allergic asthma by TLR5-dependent priming of allergic responses to indoor allergens... - Pulmonary fibrosis: thinking outside of the lungStavros Garantziotis
Department of Medicine at Duke University Medical Center, Durham, North Carolina 27710, USA
J Clin Invest 114:319-21. 2004..Previous mechanistic research has focused on the local fibroproliferative process in the lung. However, emerging evidence suggests that circulating cells of hematopoietic origin play a crucial role in the pathogenesis of this disease... - The Environmental Polymorphism Registry: a unique resource that facilitates translational research of environmental diseasePatricia C Chulada
Clinical Research Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
Environ Health Perspect 119:1523-7. 2011..Objective: We have developed a resource of subjects and their DNA to use for translational research of environmental disease... - The effect of toll-like receptors and toll-like receptor genetics in human diseaseStavros Garantziotis
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Annu Rev Med 59:343-59. 2008..The genetics of TLRs provides important insights in gene-environment interactions in health and disease, and it may enable scientists to assess patients' susceptibility to diseases or predict their response to treatments... - The Toll-like receptor gene family is integrated into human DNA damage and p53 networksDaniel Menendez
Chromosome Stability Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
PLoS Genet 7:e1001360. 2011.... - Host-environment interactions in pulmonary fibrosisStavros Garantziotis
Division of Allergy, Pulmonary, and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA
Semin Respir Crit Care Med 27:574-80. 2006..We discuss the theoretical framework of this hypothesis and we present data in support of the concept that genetic and nongenetic host susceptibility may interact with repetitive environmental injury to lead to IPF... 
ONE Nano: NIEHS's Strategic Initiative on the Health and Safety Effects of Engineered NanomaterialsThaddeus T Schug
Cellular, Organs and Systems Pathobiology Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina, USA
Environ Health Perspect 121:410-4. 2013....- Interplay between apoptotic and autophagy pathways after exposure to cerium dioxide nanoparticles in human monocytesSalik Hussain
Clinical Research Program, National Institute of Environmental Health Sciences NIEHS, National Institute of Health NIH, Research Triangle Park, NC, USA
Autophagy 9:101-3. 2013..A better understanding of the implication and biological significance of CeO 2 NPs-induced autophagy and apoptosis will help us understand the risks associated with its uses and develop safer nanomedicine... - Formation of reactive sulfite-derived free radicals by the activation of human neutrophils: an ESR studyKalina Ranguelova
Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 52:1264-71. 2012..Therefore, we propose that the potential toxicity of (bi)sulfite during pulmonary inflammation or lung-associated diseases such as asthma may be related to free radical formation... - Fatal re-expansion pulmonary edema associated with increased lung IL-8 levels following high-dose chemotherapy and autologous stem cell transplantStavros Garantziotis
Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
Respiration 69:351-4. 2002..This suggests that patients who have recently undergone HDC/ASCT may be at increased risk for the development of REPE following thoracentesis...