Stavros Garantziotis

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Ecogenomics of respiratory diseases of public health significance
    Stavros Garantziotis
    Clinical Research Program and Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Annu Rev Public Health 31:37-51 1 p following 51. 2010
  2. ncbi request reprint Genetics and genomics in human lung transplantation
    Stavros Garantziotis
    Duke University Medical Center, Duke Lung and Heart Lung Transplant Center, Division of Pulmonary, Allergy and Critical Care Medicine, Durham, NC 27710, USA
    Expert Rev Respir Med 1:271-8. 2007
  3. pmc Serum inter-alpha-trypsin inhibitor and matrix hyaluronan promote angiogenesis in fibrotic lung injury
    Stavros Garantziotis
    Clinical Research Unit, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 178:939-47. 2008
  4. pmc Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice
    Stavros Garantziotis
    NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 284:11309-17. 2009
  5. pmc TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation
    Stavros Garantziotis
    National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina, USA
    Am J Respir Crit Care Med 181:666-75. 2010
  6. ncbi request reprint CD14 is an essential mediator of LPS-induced airway disease
    David M Brass
    National Institute of Environmental Health Sciences, Rall Bldg, Rm C224, PO Box 12233 MD C2 15, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
    Am J Physiol Lung Cell Mol Physiol 293:L77-83. 2007
  7. pmc Sulfite-mediated oxidation of myeloperoxidase to a free radical: immuno-spin trapping detection in human neutrophils
    Kalina Ranguelova
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 60:98-106. 2013
  8. pmc The role of the extracellular matrix protein mindin in airway response to environmental airways injury
    Sarah Frush
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, North Carolina, USA
    Environ Health Perspect 119:1403-8. 2011
  9. pmc The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace
    Zhuowei Li
    Department of Immunology, Duke University Medical Center, Box 103004, Durham, NC 27710, USA
    J Leukoc Biol 85:124-31. 2009
  10. ncbi request reprint Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide
    Stavros Garantziotis
    Department of Medicine, Duke University Medical Center, Durham, NC 27709, USA
    Transplantation 84:1012-9. 2007

Detail Information

Publications36

  1. pmc Ecogenomics of respiratory diseases of public health significance
    Stavros Garantziotis
    Clinical Research Program and Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Annu Rev Public Health 31:37-51 1 p following 51. 2010
    ....
  2. ncbi request reprint Genetics and genomics in human lung transplantation
    Stavros Garantziotis
    Duke University Medical Center, Duke Lung and Heart Lung Transplant Center, Division of Pulmonary, Allergy and Critical Care Medicine, Durham, NC 27710, USA
    Expert Rev Respir Med 1:271-8. 2007
    ....
  3. pmc Serum inter-alpha-trypsin inhibitor and matrix hyaluronan promote angiogenesis in fibrotic lung injury
    Stavros Garantziotis
    Clinical Research Unit, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 178:939-47. 2008
    ..Inter-alpha-trypsin inhibitor (IaI) is a serum protein that can bind to hyaluronan (HA) and may contribute to the angiogenic response to tissue injury...
  4. pmc Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice
    Stavros Garantziotis
    NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 284:11309-17. 2009
    ..These data support the conclusion that pulmonary matrix can contribute to the development of airway hyperresponsiveness...
  5. pmc TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation
    Stavros Garantziotis
    National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina, USA
    Am J Respir Crit Care Med 181:666-75. 2010
    ..However, the relation between TLR4 and hyaluronan in the airway response to ozone remains unexplored...
  6. ncbi request reprint CD14 is an essential mediator of LPS-induced airway disease
    David M Brass
    National Institute of Environmental Health Sciences, Rall Bldg, Rm C224, PO Box 12233 MD C2 15, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
    Am J Physiol Lung Cell Mol Physiol 293:L77-83. 2007
    ....
  7. pmc Sulfite-mediated oxidation of myeloperoxidase to a free radical: immuno-spin trapping detection in human neutrophils
    Kalina Ranguelova
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 60:98-106. 2013
    ..Our present study demonstrates that myeloperoxidase initiates (bi)sulfite oxidation leading to MPO radical damage, possibly leading to (bi)sulfite-exacerbated allergic reactions...
  8. pmc The role of the extracellular matrix protein mindin in airway response to environmental airways injury
    Sarah Frush
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, North Carolina, USA
    Environ Health Perspect 119:1403-8. 2011
    ..Our previous work demonstrated that the extracellular matrix protein mindin contributes to allergic airways disease. However, the role of mindin in nonallergic airways disease has not previously been explored...
  9. pmc The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace
    Zhuowei Li
    Department of Immunology, Duke University Medical Center, Box 103004, Durham, NC 27710, USA
    J Leukoc Biol 85:124-31. 2009
    ..In conclusion, these data suggest that mindin participates in integrin-dependent trafficking of eosinophils and can contribute to the severity of allergic airways disease...
  10. ncbi request reprint Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide
    Stavros Garantziotis
    Department of Medicine, Duke University Medical Center, Durham, NC 27709, USA
    Transplantation 84:1012-9. 2007
    ..We have developed and pursued the hypothesis that local activation of pulmonary innate immunity through toll-like receptor (TLR)-4 is critical to the development of posttransplant alloimmune lung injury...
  11. pmc Evaluating genome-wide DNA methylation changes in mice by Methylation Specific Digital Karyotyping
    Kathy Boon
    National Heart Lung and Blood Institute National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    BMC Genomics 9:598. 2008
    ..The method generates 21 base pairs long sequence tags derived from specific locations in the genome. The resulting tag frequencies determine in a quantitative manner the methylation level of the corresponding loci...
  12. pmc Inter-alpha-trypsin inhibitor promotes bronchial epithelial repair after injury through vitronectin binding
    Jennifer E Adair
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 284:16922-30. 2009
    ..We conclude that IaI interacts not only with hyaluronan, as previously reported, but also other ECM components like vitronectin and is an important regulator of cellular repair after injury...
  13. pmc CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway disease
    John W Hollingsworth
    Division of Pulmonary, Allergy, and Critical Care Medicine, DUMC 3136, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 37:248-53. 2007
    ..In addition, CD44-deficient animals had 150% fewer neutrophils at 24 h and 50% greater neutrophils 48 h after LPS exposure. These results support the role of CD44 in modulating the biologic response to inhaled LPS...
  14. pmc In utero supplementation with methyl donors enhances allergic airway disease in mice
    John W Hollingsworth
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 118:3462-9. 2008
    ..Our findings indicate that dietary factors can modify the heritable risk of allergic airway disease through epigenetic mechanisms during a vulnerable period of fetal development in mice...
  15. ncbi request reprint Ambient ozone primes pulmonary innate immunity in mice
    John W Hollingsworth
    Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Box 3136, Durham, NC 27710, USA
    J Immunol 179:4367-75. 2007
    ..These observations indicate that ozone exposure increases both the pulmonary and the systemic biologic response to inhaled LPS by priming the innate immune system...
  16. ncbi request reprint Inter-alpha-trypsin inhibitor attenuates complement activation and complement-induced lung injury
    Stavros Garantziotis
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 179:4187-92. 2007
    ..This novel function of IaI provides a mechanistic explanation for its observed salutary effects in sepsis and opens new possibilities for its use as a treatment agent in inflammatory diseases...
  17. pmc Innate immune activation potentiates alloimmune lung disease independent of chemokine (C-X-C motif) receptor 3
    Tereza Martinu
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Heart Lung Transplant 30:717-25. 2011
    ..We hypothesized that the chemokine (C-X-C motif) receptor 3 (CXCR3) receptor is necessary for the development of LPS-induced pulmonary GVHD...
  18. pmc Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease
    Tereza Martinu
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 9:e97951. 2014
    ....
  19. pmc Cerium dioxide nanoparticles do not modulate the lipopolysaccharide-induced inflammatory response in human monocytes
    Salik Hussain
    Clinical Research Unit, National Institute of Environmental Health Sciences National Institute of Health, Research Triangle Park, Durham, NC 27709, USA
    Int J Nanomedicine 7:1387-97. 2012
    ..We investigated the inflammation-modulating effects of CeO(2) nanoparticles at noncytotoxic concentrations in human peripheral blood monocytes...
  20. pmc Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity
    Rebecca L Heise
    Laboratory of Respiratory Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 286:17435-44. 2011
    ..In conclusion, we show for the first time that innate immunity transduces mechanical stress responses through the matrix component hyaluronan, and activation of the Wnt/β-catenin pathway...
  21. pmc Leukocyte-derived IL-10 reduces subepithelial fibrosis associated with chronically inhaled endotoxin
    Stavros Garantziotis
    Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Box 3683, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 35:662-7. 2006
    ..The role of IL-10 on airway hyperreactivity is complex: IL-10 deficiency protects against LPS-induced hyperreactivity, and is associated with higher eNOS, iNOS, and airway nitrate levels...
  22. pmc Bronchial epithelial injury in the context of alloimmunity promotes lymphocytic bronchiolitis through hyaluronan expression
    Vandy P Stober
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
    Am J Physiol Lung Cell Mol Physiol 306:L1045-55. 2014
    ..We conclude that sterile bronchial epithelial injury in the context of alloimmunity can lead to sustained ER stress and promote allograft rejection through hyaluronan expression. ..
  23. pmc The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens
    Rhonda H Wilson
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health, Research Triangle Park, NC, USA
    Nat Med 18:1705-10. 2012
    ..Together, these findings suggest that household FLA promotes the development of allergic asthma by TLR5-dependent priming of allergic responses to indoor allergens...
  24. pmc Pulmonary fibrosis: thinking outside of the lung
    Stavros Garantziotis
    Department of Medicine at Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 114:319-21. 2004
    ..Previous mechanistic research has focused on the local fibroproliferative process in the lung. However, emerging evidence suggests that circulating cells of hematopoietic origin play a crucial role in the pathogenesis of this disease...
  25. pmc Interplay between apoptotic and autophagy pathways after exposure to cerium dioxide nanoparticles in human monocytes
    Salik Hussain
    Clinical Research Program, National Institute of Environmental Health Sciences NIEHS, National Institute of Health NIH, Research Triangle Park, NC, USA
    Autophagy 9:101-3. 2013
    ..A better understanding of the implication and biological significance of CeO 2 NPs-induced autophagy and apoptosis will help us understand the risks associated with its uses and develop safer nanomedicine...
  26. pmc Cyclooxygenase-2 inhibits T helper cell type 9 differentiation during allergic lung inflammation via down-regulation of IL-17RB
    Hong Li
    Laboratory of Respiratory Biology, Division of Intramural Research, National Institutes of Health National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 187:812-22. 2013
    ..Cyclooxygenase (COX)-1 and COX-2 play important roles in allergic lung inflammation and asthma. It is unknown whether COX-derived eicosanoids regulate Th9 cells during allergic lung inflammation...
  27. pmc The Environmental Polymorphism Registry: a unique resource that facilitates translational research of environmental disease
    Patricia C Chulada
    Clinical Research Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1523-7. 2011
    ..Objective: We have developed a resource of subjects and their DNA to use for translational research of environmental disease...
  28. ncbi request reprint The effect of toll-like receptors and toll-like receptor genetics in human disease
    Stavros Garantziotis
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Med 59:343-59. 2008
    ..The genetics of TLRs provides important insights in gene-environment interactions in health and disease, and it may enable scientists to assess patients' susceptibility to diseases or predict their response to treatments...
  29. pmc Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts
    Salik Hussain
    Clinical Research Unit, National Institute of Environmental Health Sciences NIEHS National Institute of Health NIH, Research Triangle Park, Durham, NC, USA
    Part Fibre Toxicol 11:28. 2014
    ..However, the mechanism leading to remodeling is poorly understood. Particularly, there is limited insight about the role of airway epithelial injury in these changes...
  30. pmc ONE Nano: NIEHS's strategic initiative on the health and safety effects of engineered nanomaterials
    Thaddeus T Schug
    Cellular, Organs and Systems Pathobiology Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27560, USA
    Environ Health Perspect 121:410-4, 414e1-5. 2013
    ..Currently, little is known about the health effects of human exposure to these materials...
  31. pmc The Toll-like receptor gene family is integrated into human DNA damage and p53 networks
    Daniel Menendez
    Chromosome Stability Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS Genet 7:e1001360. 2011
    ....
  32. ncbi request reprint Host-environment interactions in pulmonary fibrosis
    Stavros Garantziotis
    Division of Allergy, Pulmonary, and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Semin Respir Crit Care Med 27:574-80. 2006
    ..We discuss the theoretical framework of this hypothesis and we present data in support of the concept that genetic and nongenetic host susceptibility may interact with repetitive environmental injury to lead to IPF...
  33. ncbi request reprint Intracellular signal modulation by nanomaterials
    Salik Hussain
    Clinical Research Program, National Institute of Environmental Health Sciences NIEHS, National Institute of Health NIH, Research Triangle Park, NC, USA
    Adv Exp Med Biol 811:111-34. 2014
    ..Several biomedical applications based on the different signaling pathways induced by nanomaterials are already proposed and will certainly gain a great deal of attraction in the near future. ..
  34. pmc Formation of reactive sulfite-derived free radicals by the activation of human neutrophils: an ESR study
    Kalina Ranguelova
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:1264-71. 2012
    ..Therefore, we propose that the potential toxicity of (bi)sulfite during pulmonary inflammation or lung-associated diseases such as asthma may be related to free radical formation...
  35. ncbi request reprint Fatal re-expansion pulmonary edema associated with increased lung IL-8 levels following high-dose chemotherapy and autologous stem cell transplant
    Stavros Garantziotis
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Respiration 69:351-4. 2002
    ..This suggests that patients who have recently undergone HDC/ASCT may be at increased risk for the development of REPE following thoracentesis...