Research Topics
Genomes and Genes | Hui Ming GaoSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
NADPH oxidases: novel therapeutic targets for neurodegenerative diseasesHui Ming Gao
Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Trends Pharmacol Sci 33:295-303. 2012..Thus, proper modulation of NADPH oxidase activity might hold therapeutic potential for currently incurable neurodegenerative diseases...- Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidaseQingshan Wang
Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
J Neuroinflammation 9:32. 2012..We hypothesized that NOX2 might be a novel action site of naloxone to mediate its anti-inflammatory actions... - Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activityDan Zhang
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Neuroinflammation 5:21. 2008..Hence, prevention of microglial over-activation has been shown to be a prime target for the development of therapeutic agents for inflammation-mediated neurodegenerative diseases... 
Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progressionHui Ming Gao
Neuropharmacology Section, Laboratory of Pharmacology, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, NC 27709, USA
Trends Immunol 29:357-65. 2008..We further propose that dynamic modulation of this inflammatory reaction by interrupting the vicious cycle might become a disease-modifying therapeutic strategy for neurodegenerative diseases...- Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's diseaseHui Ming Gao
Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 119:807-14. 2011..Mechanisms whereby gene-environment interactions mediate chronic, progressive neurodegenerative processes in Parkinson's disease (PD)-the second most common neurodegenerative disease-remain elusive... - HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegenerationHui Ming Gao
Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Neurosci 31:1081-92. 2011..Our findings indicated that HMGB1-Mac1-NADPH oxidase signaling axis bridged chronic neuroinflammation and progressive dopaminergic neurodegeneration, thus identifying a mechanistic basis for chronic PD progression... - Gene-environment interactions: key to unraveling the mystery of Parkinson's diseaseHui Ming Gao
Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Prog Neurobiol 94:1-19. 2011..We highlight the new converging evidence on gene-environment interplay in the development of PD with an emphasis on newly developed multiple-hit PD models involving both genetic lesions and environmental triggers... - Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actionsFeng Zhang
Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Mol Pharmacol 78:466-77. 2010..These findings suggest that resveratrol exerts neuroprotection against LPS-induced dopaminergic neurodegeneration, and NADPH oxidase may be a major player in resveratrol-mediated neuroprotection... 
Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neuronsHui Ming Gao
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Neurosci 23:6181-7. 2003..This study also suggested that microglial NADPH oxidase may be a promising target for PD treatment...- Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's diseaseHui-Ming Gao
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Neurosci 23:1228-36. 2003..Findings from this study may be highly relevant to the elucidation of the multifactorial etiology of PD and the discovery of effective therapeutic agents for the treatment of the disease... - Synergistic dopaminergic neurotoxicity of MPTP and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's diseaseHui Ming Gao
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
FASEB J 17:1957-9. 2003..This study lends strong support for a multifactorial etiology of PD and provides clues for therapeutic interventions... - Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicityFeng Zhang
Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Pharmacol Exp Ther 333:822-33. 2010..These findings indicate that compound A afforded potent neuroprotection against LPS-induced neurodegeneration through selective inhibition of NF-kappaB activation and may be of potential benefit in the treatment of PD... - 3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicityWei Zhang
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, P O Box 12233, NC, USA
FASEB J 19:395-7. 2005..In view of the well-documented very low toxicity of DM and its analogs, this report may provide an important new direction for the development of therapeutic interventions for inflammation-related diseases such as PD... - Fluoxetine protects neurons against microglial activation-mediated neurotoxicityFeng Zhang
Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Parkinsonism Relat Disord 18:S213-7. 2012..Collectively, fluoxetine exerted neuroprotection against microglia-mediated neurotoxicity. Thus, fluoxetine might hold a potential to retard inflammation-mediated chronic neurodegenerative process of PD... - Role of nitric oxide in inflammation-mediated neurodegenerationBin Liu
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27710, USA
Ann N Y Acad Sci 962:318-31. 2002..Among these agents, the opioid receptor antagonist naloxone, especially its non-opioid enantiomer (+)-naloxone, promises to be of potential therapeutic value for the treatment of inflammation-related diseases... - Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivationXiaoming Hu
Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
J Neuroimmune Pharmacol 7:187-201. 2012.... - Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammationBin Liu
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
Environ Health Perspect 111:1065-73. 2003.... - Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's diseaseHui-Ming Gao
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina, USA
FASEB J 17:1954-6. 2003..This study also suggests that NADPH oxidase may be a promising target for therapeutic interventions in Parkinson's disease... - Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phoxHui Zhou
Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 52:303-13. 2012..In conclusion, rotenone directly interacted with gp91(phox); such an interaction triggered membrane translocation of p67(phox), leading to PHOX activation and superoxide production... - Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's diseaseHui-Ming Gao
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, North Carolina, USA
J Neurochem 81:1285-97. 2002.... - Distinct role for microglia in rotenone-induced degeneration of dopaminergic neuronsHui-Ming Gao
Neuropharmacology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Neurosci 22:782-90. 2002..The results of this study should advance our understanding of the mechanism of action for pesticides in the pathogenesis of Parkinson's disease... - CD11b/CD18 (Mac-1) is a novel surface receptor for extracellular double-stranded RNA to mediate cellular inflammatory responsesHui Zhou
Laboratory of Toxicology and Pharmacology, National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
J Immunol 190:115-25. 2013..This study identifies Mac-1 as a novel surface receptor for extracellular dsRNA and implicates it as a potential therapeutic target for virus-related inflammatory diseases... - Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidaseWei Zhang
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Science, Research Triangle Park, North Carolina, USA
FASEB J 18:589-91. 2004..More importantly, due to its proven safety record of long-term clinical use in humans, DM may be a promising agent for the treatment of degenerative neurological disorders such as PD... - Novel anti-inflammatory therapy for Parkinson's diseaseHui Ming Gao
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, NC 27709, USA
Trends Pharmacol Sci 24:395-401. 2003.... - Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegenerationHui Ming Gao
Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosci 28:7687-98. 2008..This study advances understanding of the role of neuroinflammation and abnormal SYN in the pathogenesis of PD and opens new avenues for the discovery of more effective therapies for PD...