B Gao

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Cytokines, STATs and liver disease
    Bin Gao
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Mol Immunol 2:92-100. 2005
  2. pmc Interferon-gamma inhibits interferon-alpha signalling in hepatic cells: evidence for the involvement of STAT1 induction and hyperexpression of STAT1 in chronic hepatitis C
    Svetlana Radaeva
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 12420 Parklawn Drive, MSC 8115, Bethesda, MD 20892, USA
    Biochem J 379:199-208. 2004
  3. ncbi request reprint RSA 2004: combined basic research satellite symposium - session four: hepatitis virus and alcohol interactions in immunity and liver disease
    Gyongyi Szabo
    University of Massachusetts Medical Center, Department of Medicine, Worcester, MA 01605 2324, USA
    Alcohol Clin Exp Res 29:1753-7. 2005
  4. pmc Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury
    Norio Horiguchi
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland
    Gastroenterology 134:1148-58. 2008
  5. pmc Natural killer and natural killer T cells in liver fibrosis
    Bin Gao
    Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Biochim Biophys Acta 1832:1061-9. 2013
  6. pmc STAT proteins - key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver
    Bin Gao
    Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    J Hepatol 57:430-41. 2012
  7. pmc Hepatoprotective and anti-inflammatory cytokines in alcoholic liver disease
    Bin Gao
    Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Gastroenterol Hepatol 27:89-93. 2012
  8. ncbi request reprint Interaction of alcohol and hepatitis viral proteins: implication in synergistic effect of alcohol drinking and viral hepatitis on liver injury
    Bin Gao
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Park Building Room 120, 12420 Parklawn Drive, MSC 8115, Bethesda, MD 20892, USA
    Alcohol 27:69-72. 2002
  9. ncbi request reprint Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells
    B Gao
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
    FEBS Lett 488:179-84. 2001
  10. doi request reprint Activation of natural killer cells inhibits liver fibrosis: a novel strategy to treat liver fibrosis
    Bin Gao
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 2S 33, Bethesda, MD 20892 8115, USA
    Expert Rev Gastroenterol Hepatol 1:173-80. 2007

Collaborators

Detail Information

Publications97

  1. ncbi request reprint Cytokines, STATs and liver disease
    Bin Gao
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Mol Immunol 2:92-100. 2005
    ..This article reviews the biological significance of STAT1, 2, 3, 4, 5, 6 in hepatic functions and diseases...
  2. pmc Interferon-gamma inhibits interferon-alpha signalling in hepatic cells: evidence for the involvement of STAT1 induction and hyperexpression of STAT1 in chronic hepatitis C
    Svetlana Radaeva
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 12420 Parklawn Drive, MSC 8115, Bethesda, MD 20892, USA
    Biochem J 379:199-208. 2004
    ....
  3. ncbi request reprint RSA 2004: combined basic research satellite symposium - session four: hepatitis virus and alcohol interactions in immunity and liver disease
    Gyongyi Szabo
    University of Massachusetts Medical Center, Department of Medicine, Worcester, MA 01605 2324, USA
    Alcohol Clin Exp Res 29:1753-7. 2005
    ....
  4. pmc Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury
    Norio Horiguchi
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland
    Gastroenterology 134:1148-58. 2008
    ..Signal transducer and activator of transcription 3 (STAT3) is known to be activated in human alcoholic liver disease, but its role in the pathogenesis of alcoholic liver injury remains obscure...
  5. pmc Natural killer and natural killer T cells in liver fibrosis
    Bin Gao
    Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Biochim Biophys Acta 1832:1061-9. 2013
    ..Finally, the potential for NK and NKT cells to be used as therapeutic targets for anti-fibrotic therapy is discussed. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease...
  6. pmc STAT proteins - key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver
    Bin Gao
    Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    J Hepatol 57:430-41. 2012
    ..The identification of functions for these STAT proteins has increased our understanding of liver disease pathophysiology and treatments, while also suggesting new therapeutic modalities for managing liver disease...
  7. pmc Hepatoprotective and anti-inflammatory cytokines in alcoholic liver disease
    Bin Gao
    Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Gastroenterol Hepatol 27:89-93. 2012
    ....
  8. ncbi request reprint Interaction of alcohol and hepatitis viral proteins: implication in synergistic effect of alcohol drinking and viral hepatitis on liver injury
    Bin Gao
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Park Building Room 120, 12420 Parklawn Drive, MSC 8115, Bethesda, MD 20892, USA
    Alcohol 27:69-72. 2002
    ....
  9. ncbi request reprint Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells
    B Gao
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
    FEBS Lett 488:179-84. 2001
    ....
  10. doi request reprint Activation of natural killer cells inhibits liver fibrosis: a novel strategy to treat liver fibrosis
    Bin Gao
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 2S 33, Bethesda, MD 20892 8115, USA
    Expert Rev Gastroenterol Hepatol 1:173-80. 2007
    ..Clinical studies will be required to confirm whether stimulating NK cell activity is effective and safe in treating human liver fibrosis...
  11. pmc Innate immunity in alcoholic liver disease
    Bin Gao
    Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol Gastrointest Liver Physiol 300:G516-25. 2011
    ..Understanding of the role of innate immunity in the pathogenesis of alcoholic liver disease may help us identify novel therapeutic targets to treat this disease...
  12. ncbi request reprint Therapeutic potential of interleukin-6 in preventing obesity- and alcohol-associated fatty liver transplant failure
    Bin Gao
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Park Building Room 120, 12420 Parklawn Drive, MSC 8115, Bethesda, MD 20892, USA
    Alcohol 34:59-65. 2004
    ..Higher concentrations of IL-6 may be required to protect against alcoholic fatty liver isograft injury because alcohol inhibits IL-6 signaling in the liver...
  13. pmc Tissue inhibitor of metalloproteinase 1 (TIMP-1) deficiency exacerbates carbon tetrachloride-induced liver injury and fibrosis in mice: involvement of hepatocyte STAT3 in TIMP-1 production
    Hua Wang
    Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Biosci 1:14. 2011
    ..abstract:..
  14. ncbi request reprint Host factors and failure of interferon-alpha treatment in hepatitis C virus
    Bin Gao
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Hepatology 39:880-90. 2004
    ..We discuss possible underlying mechanisms responsible for these effects. Potential therapeutic strategies to enhance the effectiveness of IFN-alpha therapy for HCV are also proposed...
  15. pmc Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases
    Bin Gao
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Leukoc Biol 86:513-28. 2009
    ..Understanding the role of NK and NKT cells in the pathogenesis of chronic liver disease may help us design better therapies to treat patients with this disease...
  16. pmc Alcoholic liver disease: pathogenesis and new therapeutic targets
    Bin Gao
    Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 141:1572-85. 2011
    ..There is an urgent need to develop new pathophysiology-oriented therapies. Recent translational studies of human samples and animal models have identified promising therapeutic targets...
  17. doi request reprint Liver: An organ with predominant innate immunity
    Bin Gao
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 47:729-36. 2008
    ..In addition, the liver also plays an important role in controlling systemic innate immunity through the biosynthesis of numerous soluble pathogen-recognition receptors and complement components...
  18. pmc Transcriptional regulation of alpha(1b) adrenergic receptors (alpha(1b)AR) by nuclear factor 1 (NF1): a decline in the concentration of NF1 correlates with the downregulation of alpha(1b)AR gene expression in regenerating liver
    B Gao
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
    Mol Cell Biol 16:5997-6008. 1996
    ....
  19. ncbi request reprint IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3
    X Shen
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
    FEBS Lett 480:132-6. 2000
    ....
  20. doi request reprint Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver
    Won Il Jeong
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 7:227-35. 2008
    ..We conclude that paracrine activation of hepatic CB1 receptors by stellate cell-derived 2-AG mediates ethanol-induced steatosis through increasing lipogenesis and decreasing fatty acid oxidation...
  21. ncbi request reprint Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease
    Feng Hong
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 40:933-41. 2004
    ..In conclusion, long-term IL-6 administration ameliorates fatty livers and protects against warm ischemia/reperfusion fatty liver injury, suggesting the therapeutic potential of IL-6 in treating human fatty liver disease...
  22. ncbi request reprint Ethanol inhibits the JAK-STAT signaling pathway in freshly isolated rat hepatocytes but not in cultured hepatocytes or HepG2 cells: evidence for a lack of involvement of ethanol metabolism
    J Chen
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Clin Biochem 34:203-9. 2001
    ....
  23. ncbi request reprint Additive activation of hepatic NF-kappaB by ethanol and hepatitis B protein X (HBX) or HCV core protein: involvement of TNF-alpha receptor 1-independent and -dependent mechanisms
    W H Kim
    Section on Liver Biology, Laboratory of Physiologic Studies, NIAAA, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 15:2551-3. 2001
    ..With the essential role of TNFR1 in alcoholic liver injury, targeting TNFR1 by hepatitis viral proteins could contribute to cooperative effects of alcohol consumption and viral hepatitis on liver disease...
  24. ncbi request reprint Chronic alcohol consumption accelerates liver injury in T cell-mediated hepatitis: alcohol disregulation of NF-kappaB and STAT3 signaling pathways
    Barbara Jaruga
    Section on Liver Biology, NIAAA NIH, Park Bldg Rm 120, 12420 Parklawn Dr, MSC 8115, Bethesda, MD 20892, USA
    Am J Physiol Gastrointest Liver Physiol 287:G471-9. 2004
    ..Downregulation of the antiapoptotic STAT3 signal may also contribute to alcohol potentiation of T cell hepatitis...
  25. ncbi request reprint Cell type-specific transcriptional activation and suppression of the alpha1B adrenergic receptor gene middle promoter by nuclear factor 1
    B Gao
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 273:31784-7. 1998
    ..This may be one of the mechanisms whereby NF1 can activate or suppress the expression of different genes, and it may also underlie the tissue-specific regulation of the alpha1B AR gene...
  26. ncbi request reprint Alpha-adrenergic inhibition of proliferation in HepG2 cells stably transfected with the alpha1B-adrenergic receptor through a p42MAPkinase/p21Cip1/WAF1-dependent pathway
    K L Auer
    Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
    FEBS Lett 436:131-8. 1998
    ..Activation of this inhibitory pathway via alpha1B(AR) appears to be p42MAPkinase and p21Cip1/WAF1 dependent...
  27. ncbi request reprint Both the cyclic AMP response element and the activator protein 2 binding site mediate basal and cyclic AMP-induced transcription from the dominant promoter of the rat alpha 1B-adrenergic receptor gene in DDT1MF-2 cells
    B Gao
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
    Mol Pharmacol 52:1019-26. 1997
    ..These data indicate that both the CRE and the AP2 element in the P2 promoter contribute to basal as well as cAMP-induced transcription of the alpha 1B-AR gene in DDT1MF-2 cells...
  28. pmc Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury
    Sandor Batkai
    Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
    FASEB J 21:1788-800. 2007
    ..We also demonstrate that CB2-/- mice have a normal hemodynamic profile...
  29. ncbi request reprint Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes
    Barbara Jaruga
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 171:3233-44. 2003
    ....
  30. pmc Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3
    Sung Hwan Ki
    Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Hepatology 52:1291-300. 2010
    ..Finally, expression of IL-22 receptor 1 is up-regulated whereas IL-22 is undetectable in the livers from mice with chronic-binge ethanol feeding or patients with alcoholic hepatitis...
  31. ncbi request reprint Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells
    M Spector
    Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298, USA
    Exp Cell Res 258:109-20. 2000
    ..Cell spreading has been reported to play important roles in wound repair, tumor invasion, and metastasis. Therefore, catecholamines acting via the (alpha1)AR may modulate these physiological and pathological processes...
  32. pmc Endocannabinoids and liver disease. III. Endocannabinoid effects on immune cells: implications for inflammatory liver diseases
    Pal Pacher
    Laboratory of Physiological Studies, National Institutes of Health NIAAA, 5625 Fishers Lane, MSC 9413, Bethesda, Maryland 20892 9413, USA
    Am J Physiol Gastrointest Liver Physiol 294:G850-4. 2008
    ..which play pivotal role in the early development and progression of inflammatory and other liver diseases...
  33. ncbi request reprint IL-6-deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver
    Osama El-Assal
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Mol Immunol 1:205-11. 2004
    ....
  34. pmc Molecular mechanisms of alcoholic fatty liver
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Bethesda, MD 20892, USA
    Alcohol Clin Exp Res 33:191-205. 2009
    ..Furthermore, oxidative modifications and inactivation of the enzymes involved in the mitochondrial and/or peroxisomal beta-oxidation of fatty acids could contribute to fat accumulation in the liver...
  35. pmc Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma
    Bani Mukhopadhyay
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
    J Biol Chem 285:19002-11. 2010
    ..We conclude that RARgamma regulates CB(1)R expression and is thus involved in the control of hepatic fat metabolism by endocannabinoids...
  36. ncbi request reprint Chronic ethanol consumption inhibits hepatic natural killer cell activity and accelerates murine cytomegalovirus-induced hepatitis
    Hong Na Pan
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Alcohol Clin Exp Res 30:1615-23. 2006
    ..Chronic alcohol drinking accelerates the progression of liver disease in patients with hepatitis viral infection; however, the underlying mechanisms are not fully understood...
  37. pmc Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis
    Mohanraj Rajesh
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
    J Leukoc Biol 82:1382-9. 2007
    ..These findings suggest that selective CB(2) receptor agonists may represent a novel, protective strategy against I/R injury by attenuating oxidative stress, inflammatory response, and apoptosis...
  38. ncbi request reprint Retinoic acid signaling sensitizes hepatic stellate cells to NK cell killing via upregulation of NK cell activating ligand RAE1
    Svetlana Radaeva
    Section on Liver Biology, NIAAA NIH, 5625 Fishers Lane, Rm 2S 33, Bethesda, MD 20892, USA
    Am J Physiol Gastrointest Liver Physiol 293:G809-16. 2007
    ..In contrast, fully activated HSCs become resistant to NK cell killing because of lack of RAE1 expression, leading to chronic liver fibrosis and disease...
  39. ncbi request reprint Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-x(L) proteins
    Feng Hong
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, MD 20892, USA
    Oncogene 21:32-43. 2002
    ..These findings suggest that elevated serum IL-6 levels in ALD may overcome the inhibitory effect of ethanol on IL-6-mediated anti-apoptotic signals and prevent alcohol-induced hepatic apoptosis by induction of Bcl-2 and Bcl-x(L)...
  40. ncbi request reprint Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-gamma)
    Rui Sun
    NIAAA, NIH, Bethesda, MD 20892, USA
    Gastroenterology 127:1525-39. 2004
    ..This report analyzes the effects of activation of innate immunity by viral infection or the toll-like receptor 3 (TLR3) ligand on liver regeneration...
  41. ncbi request reprint IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1
    Barbara Jaruga
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1044-52. 2004
    ....
  42. doi request reprint Successful transplantation of reduced-sized rat alcoholic fatty livers made possible by mobilization of host stem cells
    M Hisada
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Transplant 12:3246-56. 2012
    ..Thus chemokine insufficiency was associated with transplant failure of whole grafts, which was overcome by the increased regenerative requirements promoted by the small grafts and mediated by SDF-1 resulting in stem cell influx...
  43. pmc Myeloid STAT3 inhibits T cell-mediated hepatitis by regulating T helper 1 cytokine and interleukin-17 production
    Fouad Lafdil
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland
    Gastroenterology 137:2125-35.e1-2. 2009
    ..The aim of this study was to investigate the immune cell-signaling pathways involved-specifically the role of signal transducer and activator of transcription 3 (STAT3)-in T cell-mediated hepatitis in mice...
  44. pmc Anti-inflammatory and anti-apoptotic roles of endothelial cell STAT3 in alcoholic liver injury
    Andrew M Miller
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Alcohol Clin Exp Res 34:719-25. 2010
    ..We have previously shown that IL-6 also activates STAT3 in sinusoidal endothelial cells (SECs). Thus, the purpose of this study was to investigate whether STAT3 in endothelial cells also plays a protective role in alcoholic liver injury...
  45. ncbi request reprint Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
    Svetlana Radaeva
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 39:1332-42. 2004
    ....
  46. ncbi request reprint IL-6 prevents T cell-mediated hepatitis via inhibition of NKT cells in CD4+ T cell- and STAT3-dependent manners
    Rui Sun
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:5648-55. 2004
    ..Taken together, these findings suggest that in addition to its antiapoptotic abilities, as previously well documented, IL-6/STAT3 inhibits NKT cells via targeting CD4(+) T cells and consequently prevents T cell-mediated hepatitis...
  47. ncbi request reprint Interferon-alpha activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes
    Svetlana Radaeva
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 122:1020-34. 2002
    ..Primary mouse and rat hepatocytes respond poorly to IFN-alpha stimulation. Thus, it is very important to examine the IFN-alpha signal pathway in primary human hepatocytes...
  48. pmc Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS
    Feng Hong
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 110:1503-13. 2002
    ..STAT1 and STAT3 in hepatocytes also negatively regulate one another through the induction of SOCS...
  49. ncbi request reprint Differential STAT5 activation and phenotypic marker expression by immune cells following low levels of ethanol consumption in mice
    Tai L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0613, USA
    Immunopharmacol Immunotoxicol 24:121-38. 2002
    ..Taken together, these findings suggest that low levels of ethanol consumption can differentially modulate immune cells in thymus, spleen, bone marrow and liver, which may be due to differential regulation of STAT5 activation by ethanol...
  50. ncbi request reprint STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity
    Won Il Jeong
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 44:1441-51. 2006
    ..STAT1 could be a new therapeutic target for treating liver fibrosis...
  51. pmc Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis
    Won Il Jeong
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Gastroenterology 134:248-58. 2008
    ..Here, we identified a novel mechanism by which alcohol accelerates liver fibrosis: inhibition of the antifibrotic effects of natural killer (NK) cells and interferon-gamma (IFN-gamma)...
  52. ncbi request reprint Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration
    Yongzhi Cui
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892 0822, USA
    Hepatology 46:504-13. 2007
    ..CONCLUSION: Aberrant cytokine-Stat5 signaling in hepatocytes alters their physiology through increased activity of Stat1 and Stat3. Such cross-talk between different pathways could add to the complexity of syndromes observed in disease...
  53. pmc Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride
    Ogyi Park
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 49:1683-94. 2009
    ..During chronic liver injury, hepatic iNKT cells are depleted and play a role in inhibiting liver fibrosis in the early stage but not the late stage of fibrosis...
  54. ncbi request reprint STAT1 plays an essential role in LPS/D-galactosamine-induced liver apoptosis and injury
    Won Ho Kim
    Section on Liver Biology, National Institute on Alcohol Abuse and Alcoholism National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Gastrointest Liver Physiol 285:G761-8. 2003
    ..Taken together, these findings suggest that STAT1 plays an essential role in LPS/D-galactosamine-induced liver apoptosis and injury...
  55. pmc Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis
    Hyun Seok Kim
    Genetics of Development and Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 12:224-36. 2010
    ..Thus, SIRT6 plays a critical role in fat metabolism and may serve as a therapeutic target for treating fatty liver disease, the most common cause of liver dysfunction in humans...
  56. ncbi request reprint Hepatitis B virus X protein sensitizes primary mouse hepatocytes to ethanol- and TNF-alpha-induced apoptosis by a caspase-3-dependent mechanism
    Won Ho Kim
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Mol Immunol 2:40-8. 2005
    ....
  57. ncbi request reprint Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3
    Hongna Pan
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Mol Immunol 1:43-9. 2004
    ..In conclusion, hydrodynamic gene delivery of IL-22 protects against liver injury induced by a variety of toxins, suggesting the therapeutic potential of IL-22 in treating human liver disease...
  58. ncbi request reprint IL-6 modulates hepatocyte proliferation via induction of HGF/p21cip1: regulation by SOCS3
    Rui Sun
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 338:1943-9. 2005
    ..SOCS3 negatively regulates liver regeneration...
  59. ncbi request reprint Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners
    Svetlana Radaeva
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 130:435-52. 2006
    ..Viral hepatitis infection, which is a major cause of liver fibrosis, is associated with activation of innate immunity. However, the role of innate immunity in liver fibrosis remains obscure...
  60. pmc Proteomic analysis of nuclei dissected from fixed rat brain tissue using expression microdissection
    A R Blackler
    National Cancer Institute, NIH, Bethesda, Maryland 20892, United States
    Anal Chem 85:7139-45. 2013
    ..These data demonstrate that the flashcube-xMD technology is applicable to the proteomic study of a broad range of targets in molecular pathology. ..
  61. ncbi request reprint Personality profiles and the prediction of categorical personality disorders
    R R McCrae
    Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224 6825, USA
    J Pers 69:155-74. 2001
    ..Together with other literature, these data suggest that the current categorical system should be replaced by a more comprehensive system of personality traits and personality-related problems...
  62. ncbi request reprint Hsc70 chaperones clathrin and primes it to interact with vesicle membranes
    R Jiang
    Laboratory of Cell Biology, Section on Cell Physiology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:8439-47. 2000
    ..We propose that Hsc70 not only uncoats clathrin but also chaperones it to prevent it from inappropriately polymerizing in the cell cytosol and primes it to reform clathrin-coated pits...
  63. pmc Dissociation between liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell-specific signal transducer and activator of transcription 3 gene knockout mice
    Norio Horiguchi
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 51:1724-34. 2010
    ..An additional deletion of STAT3 in hepatocytes in myeloid-specific STAT3 knockout mice restored hepatic necrosis but decreased liver inflammation...
  64. pmc Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
    Hai Song
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:1431-6. 2010
    ....
  65. pmc Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity
    Hua Wang
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 51:1354-62. 2010
    ..Conclusion: An interplay of myeloid and hepatic STAT3 signaling is essential to prevent liver failure during liver regeneration through tempering a strong innate inflammatory response mediated by STAT1 signaling...
  66. pmc CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model
    Partha Mukhopadhyay
    Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9413, USA
    Br J Pharmacol 160:657-68. 2010
    ....
  67. ncbi request reprint Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor
    Jie Liu
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892, USA
    J Biol Chem 278:45034-9. 2003
    ..We conclude that AEA and 2-AG synthesis are differentially regulated in macrophages, and AEA rather than 2-AG is a major contributor to LPS-induced hypotension...
  68. ncbi request reprint STAT1 contributes to dsRNA inhibition of liver regeneration after partial hepatectomy in mice
    Rui Sun
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 44:955-66. 2006
    ....
  69. pmc Liver regeneration is suppressed in alcoholic cirrhosis: correlation with decreased STAT3 activation
    Norio Horiguchi
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Rm 2S 33, Bethesda, MD 20892, USA
    Alcohol 41:271-80. 2007
    ..In conclusion: liver regeneration is suppressed in alcoholic cirrhotic livers, which may be partly due to decreased STAT3 activation...
  70. ncbi request reprint Dose-dependent activation of antiapoptotic and proapoptotic pathways by ethanol treatment in human vascular endothelial cells: differential involvement of adenosine
    Jie Liu
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892, USA
    J Biol Chem 277:20927-33. 2002
    ....
  71. pmc Th17 cells and their associated cytokines in liver diseases
    Fouad Lafdil
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Cell Mol Immunol 7:250-4. 2010
    ....
  72. ncbi request reprint Expression of interferon alfa signaling components in human alcoholic liver disease
    Van Anh Nguyen
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 35:425-32. 2002
    ....
  73. ncbi request reprint Effect of constitutive 70-kDa heat shock protein polymerization on its interaction with protein substrate
    B Gao
    Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:16792-7. 1996
    ....
  74. pmc Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy
    Partha Mukhopadhyay
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 48:457-67. 2010
    ....
  75. pmc Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice
    Xiaoling Xu
    Genetics of Development and Disease Branch, NIDDK, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:1843-52. 2006
    ..These findings elucidate the relationship between SMAD4 and PTEN and extend our understanding of CC formation...
  76. ncbi request reprint Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism
    Jing Wang
    School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    J Hepatol 44:446-54. 2006
    ..Here we examined the effect of the activation of NK cells induced by toll-like receptor 3 (TLR3) ligand, polyinosinic-polycytidylic acid (poly I:C), on concanavalin A (Con A)-induced T cell-mediated liver injury...
  77. ncbi request reprint In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats
    Zhaoli Sun
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 125:202-15. 2003
    ..This is further complicated by the prevalence of steatosis in about 13%-50% of donor livers, which is associated with a high risk of dysfunction and primary nonfunction...
  78. ncbi request reprint Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery
    Akira Moh
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA
    Lab Invest 87:1018-28. 2007
    ..However, the hepatocytic STAT3 may have limited role in liver mass recovery although DNA synthesis may be impaired...
  79. pmc Activation of innate immunity (NK/IFN-gamma) in rat allogeneic liver transplantation: contribution to liver injury and suppression of hepatocyte proliferation
    Kezhen Shen
    Department of Hepatobiliary Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
    Am J Physiol Gastrointest Liver Physiol 294:G1070-7. 2008
    ..These findings suggest that, compared with syngeneic transplantation, innate immunity (NK/IFN-gamma) is activated after allogeneic transplantation, which likely contributes to liver injury and inhibits hepatocyte proliferation...
  80. doi request reprint Endocannabinoids, CB1 receptors, and liver disease: hitting more than one bird with the same stone
    George Kunos
    Gastroenterology 134:622-5. 2008
  81. ncbi request reprint Involvement of natural killer cells in PolyI:C-induced liver injury
    Zhongjun Dong
    School of Life Sciences, University of Science and Technology of China, 443 Huangshan Road, Hefei, Anhui 230027, China
    J Hepatol 41:966-73. 2004
    ..However, the roles of natural killer (NK) cells in liver injury remain obscure. Here we examined the effect of Polyinosinic: polycytidylic acid (PolyI:C)-activated NK cells on liver injury...
  82. ncbi request reprint Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway
    Won Ho Kim
    Division of Metabolic Disease, Department of Biomedical Science, National Institutes of Health, 5 Nokbun dong, Eunpyung Gu, Seoul 122 701, South Korea
    Cell Signal 17:1516-32. 2005
    ..Collectively, these data demonstrate that TNF-alpha/IFN-gamma synergistically activates JNK/SAPK, playing an important role in promoting apoptosis of pancreatic beta-cell via activation of p53 pathway together with ROS...
  83. ncbi request reprint Isolation of murine hepatic lymphocytes using mechanical dissection for phenotypic and functional analysis of NK1.1+ cells
    Zhong Jun Dong
    Institution of Immunology, University of Science and Technology of China, 443 Huangshan Road, Hefei 230027, Anhui Province, China
    World J Gastroenterol 10:1928-33. 2004
    ..To choose an appropriate methods for the isolation of hepatic lymphocytes between the mechanical dissection and the enzymatic digestion and investigate the effects of two methods on phenotype and function of hepatic lymphocytes...
  84. ncbi request reprint Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation
    Zhigang Tian
    School of Life Sciences, University of Science and Technology of China, 443 Huangshan Road, Hefei City, Anhui 230027, China
    Biochem Biophys Res Commun 298:297-302. 2002
    ..Taken together, these findings suggest that leptin plays an important role in NK cell development and activation...
  85. ncbi request reprint Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin
    Weiguo Hu
    Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    Nat Med 14:98-103. 2008
    ....
  86. ncbi request reprint Cannabinoids hurt, heal in cirrhosis
    George Kunos
    Nat Med 12:608-10. 2006
  87. ncbi request reprint Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis
    Ya Hui Chuang
    Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis, CA 95616, USA
    Hepatology 47:571-80. 2008
    ....
  88. ncbi request reprint Generation of functional ion-channel tools by E3 targeting
    Shang Zhong Xu
    Membrane and Systems Biology Research Institute, University of Leeds, Leeds, LS2 9JT, UK
    Nat Biotechnol 23:1289-93. 2005
    ....
  89. doi request reprint Investigation of endogenous antigen processing by delivery of an intact protein into cells
    Hongmei Fu
    Rheumatology Unit, Infection and Immunity, Institute of Child Health, University College London, London, UK
    J Immunol Methods 335:90-7. 2008
    ..As expected, delivery of OVA protein into RMA-S, a cell line with a deficiency in MHC class I antigen processing due to a TAP defect, failed to present the SIINFEKL epitope to B3Z...
  90. ncbi request reprint First glimpse of the peptide presentation by rhesus macaque MHC class I: crystal structures of Mamu-A*01 complexed with two immunogenic SIV epitopes and insights into CTL escape
    Fuliang Chu
    Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Sciences, 13 Beiyitiao, Zhongguancun, Beijing 100080, People s Republic of China
    J Immunol 178:944-52. 2007
    ..The results we present in this study are most relevant for the rational design of Mamu-A*01-restricted CTL epitopes with improved binding, as a step toward development of AIDS vaccines...
  91. pmc Role of activating transcription factor 3 on TAp73 stability and apoptosis in paclitaxel-treated cervical cancer cells
    Yeo Kyoung Oh
    Center for Biomedical Sciences, NIH, Seoul 122 701, Korea
    Mol Cancer Res 6:1232-49. 2008
    ..The investigation shows that ATF3 may function as a tumor-inhibiting factor through direct regulatory effects on TAp73beta, suggesting a functional link between ATF3 and TAp73beta...
  92. ncbi request reprint AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis
    Won Ho Kim
    Division of Metabolic Diseases, Center for Biomedical Sciences, National Institutes of Health, 194 Tongillo, Eunpyeong gu, Seoul, South Korea
    Cell Signal 19:791-805. 2007
    ..Collectively, these data demonstrate that AMPK activation potentiates beta-cell apoptosis induced by chronic high glucose through augmented GCK downregulation mediated by enhanced ROS production...
  93. ncbi request reprint The complement system in liver diseases
    Xuebin Qin
    Laboratory for Translational Research, Harvard Medical School, Cambridge, MA 02139, USA
    Cell Mol Immunol 3:333-40. 2006
    ..In this review, we will discuss the potential role of the complement system in the pathogenesis of liver diseases...
  94. ncbi request reprint Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism
    Bofeng Li
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
    Hepatology 43:1211-9. 2006
    ..These findings suggest that IL-15 may be of therapeutic relevance in human autoimmune-related hepatitis...
  95. pmc Complex assembly, crystallization and preliminary X-ray crystallographic studies of rhesus macaque MHC Mamu-A*01 complexed with an immunodominant SIV-Gag nonapeptide
    Fuliang Chu
    Laboratory of Molecular Immunology and Molecular Virology, Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People s Republic of China
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:614-6. 2005
    ..8 A resolution. The structure is being solved by molecular replacement and this is the first attempt to determined the crystal structure of a peptide-nonhuman primate MHC complex...
  96. ncbi request reprint MHC class I antigen presentation--recently trimmed and well presented
    Barry Flutter
    Infection and Immunity, Institute of Child Health, University College London, UK
    Cell Mol Immunol 1:22-30. 2004
    ..Many of the cellular components involved in antigen processing and class I presentation are known and their various functions are now becoming clearer...
  97. doi request reprint Manipulation of MHC-I/TCR interaction for immune therapy
    Qing Jun Liu
    Institute of Biotechnology, Academy of Military Medical Sciences, Beijing, China
    Cell Mol Immunol 5:171-82. 2008
    ....