Odile Gabay

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Sirt1-deficient mice exhibit an altered cartilage phenotype
    Odile Gabay
    Cartilage Biology and Orthopedic Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD, USA Electronic address
    Joint Bone Spine 80:613-20. 2013
  2. doi request reprint Epigenetics, sirtuins and osteoarthritis
    Odile Gabay
    Cartilage Biology and Orthopedics Branch, National Institute of Arthritis, Musculoskeletal and Skin Disease NIH, Bethesda, MD 20892, USA
    Joint Bone Spine 79:570-3. 2012
  3. doi request reprint Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model
    Odile Gabay
    Cartilage Biology and Orthopedic Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 65:159-66. 2013
  4. pmc Osteoarthritis and obesity: experimental models
    Odile Gabay
    Cartilage Biology and Orthopaedic Branch, Cartilage Molecular Genetic Group, 50 South Drive, Bldg 50, Room 1314, NIAMS, National Institute of Health, Bethesda, MD 20892, USA
    Joint Bone Spine 75:675-9. 2008
  5. pmc Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice
    Odile Gabay
    Cartilage Molecular Genetics Group, Cartilage Biology and Orthopedics Branch, National Institute of Arthritis, Musculoskeletal and Skin Disease, Bethesda, Maryland, USA
    Ann Rheum Dis 71:613-6. 2012
  6. pmc Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes
    Mona Dvir-Ginzberg
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA
    Arthritis Rheum 63:2363-73. 2011
  7. pmc SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway
    Viktoria Gagarina
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 62:1383-92. 2010
  8. doi request reprint Hand osteoarthritis: new insights
    Odile Gabay
    Cartilage Biology and Orthopedic Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda Maryland 20892, USA
    Joint Bone Spine 80:130-4. 2013

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Sirt1-deficient mice exhibit an altered cartilage phenotype
    Odile Gabay
    Cartilage Biology and Orthopedic Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD, USA Electronic address
    Joint Bone Spine 80:613-20. 2013
    ..We previously demonstrated that Sirt1 regulates apoptosis in cartilage in vitro. Here we attempt to examine in vivo cartilage homeostasis, using Sirt1 total body knockout (KO) mice...
  2. doi request reprint Epigenetics, sirtuins and osteoarthritis
    Odile Gabay
    Cartilage Biology and Orthopedics Branch, National Institute of Arthritis, Musculoskeletal and Skin Disease NIH, Bethesda, MD 20892, USA
    Joint Bone Spine 79:570-3. 2012
    ..Moreover, we discuss the possible therapeutic target of such a protein, reviewing the potential inhibitors/activators of this enzyme and their properties...
  3. doi request reprint Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model
    Odile Gabay
    Cartilage Biology and Orthopedic Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 65:159-66. 2013
    ..This study was undertaken to determine if SIRT-1 enzymatic activity plays a protective role in cartilage homeostasis in vivo, by investigating mice with SIRT-1 mutations to characterize their cartilage...
  4. pmc Osteoarthritis and obesity: experimental models
    Odile Gabay
    Cartilage Biology and Orthopaedic Branch, Cartilage Molecular Genetic Group, 50 South Drive, Bldg 50, Room 1314, NIAMS, National Institute of Health, Bethesda, MD 20892, USA
    Joint Bone Spine 75:675-9. 2008
    ..The link between OA and obesity may not simply be due to high mechanical stresses applied on the tissues, but soluble mediators may play an important role in the onset of OA in obese patients...
  5. pmc Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice
    Odile Gabay
    Cartilage Molecular Genetics Group, Cartilage Biology and Orthopedics Branch, National Institute of Arthritis, Musculoskeletal and Skin Disease, Bethesda, Maryland, USA
    Ann Rheum Dis 71:613-6. 2012
    ..A growing body of evidence indicates that the protein deacetylase, SirT1, affects chondrocyte biology and survival. This report aims to evaluate in vivo attributes of SirT1 in cartilage biology of 129/J murine strains...
  6. pmc Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes
    Mona Dvir-Ginzberg
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA
    Arthritis Rheum 63:2363-73. 2011
    ..This study was undertaken to test the hypothesis that SirT1 is adversely affected by TNFα, resulting in altered gene expression...
  7. pmc SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway
    Viktoria Gagarina
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 62:1383-92. 2010
    ..We undertook the present study to assess the role of SirT1 in the survival of osteoarthritic (OA) chondrocytes in humans...
  8. doi request reprint Hand osteoarthritis: new insights
    Odile Gabay
    Cartilage Biology and Orthopedic Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda Maryland 20892, USA
    Joint Bone Spine 80:130-4. 2013
    ..Finally, we also reviewed the different treatments currently available as well as potential future therapies...