I J Fuss

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Nodular regenerative hyperplasia in common variable immunodeficiency
    Ivan J Fuss
    Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Clin Immunol 33:748-58. 2013
  2. pmc The role of IL-13 and NK T cells in experimental and human ulcerative colitis
    I J Fuss
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institutes of Health, Bethesda, Maryland, USA
    Mucosal Immunol 1:S31-3. 2008
  3. ncbi request reprint Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
    Ivan J Fuss
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Inflamm Bowel Dis 12:9-15. 2006
  4. pmc Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
    Ivan J Fuss
    Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda Maryland 20892, USA
    J Clin Invest 113:1490-7. 2004
  5. ncbi request reprint Cytokine network in inflammatory bowel disease
    Ivan J Fuss
    Mucosal Immunity Section, National Institutes of Health, 10 Center Dr, Build 10 Rm 11N238, Bethesda, MD 20892, USA
    Curr Drug Targets Inflamm Allergy 2:101-12. 2003
  6. ncbi request reprint Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    I J Fuss
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 157:1261-70. 1996
  7. pmc Successful granulocyte-colony stimulating factor treatment of Crohn's disease is associated with the appearance of circulating interleukin-10-producing T cells and increased lamina propria plasmacytoid dendritic cells
    P J Mannon
    Mucosal Immunity Section, Laboratory of Host Defense, NIAID, NIH, Bethesda, MD, USA
    Clin Exp Immunol 155:447-56. 2009
  8. ncbi request reprint The signaling function of the IL-13Ralpha2 receptor in the development of gastrointestinal fibrosis and cancer surveillance
    Warren Strober
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Mol Med 9:740-50. 2009
  9. ncbi request reprint Recent advances in the understanding of the induction and regulation of mucosal inflammation
    Warren Strober
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Gastroenterol 38:55-8. 2003
  10. ncbi request reprint The interrelated roles of TGF-beta and IL-10 in the regulation of experimental colitis
    Ivan J Fuss
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:900-8. 2002

Collaborators

Detail Information

Publications25

  1. pmc Nodular regenerative hyperplasia in common variable immunodeficiency
    Ivan J Fuss
    Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Clin Immunol 33:748-58. 2013
    ..The purpose of this study was to define the characteristics and course of this complication of CVID...
  2. pmc The role of IL-13 and NK T cells in experimental and human ulcerative colitis
    I J Fuss
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institutes of Health, Bethesda, Maryland, USA
    Mucosal Immunol 1:S31-3. 2008
    ..In the following review the insights gained from both animal models and human studies as to the function that IL-13 and NK T cells have in the pathogenesis of UC will be discussed...
  3. ncbi request reprint Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
    Ivan J Fuss
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Inflamm Bowel Dis 12:9-15. 2006
    ..These molecules contain an identical p40 chain that is bound to a p35 chain in IL-12 and a p19 chain in IL-23, making both potentially susceptible to modulation by an anti-IL-12p40 monoclonal antibody (mAb)...
  4. pmc Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
    Ivan J Fuss
    Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda Maryland 20892, USA
    J Clin Invest 113:1490-7. 2004
    ..These studies show that UC is associated with an atypical Th2 response mediated by nonclassical NKT cells producing IL-13 and having cytotoxic potential for epithelial cells...
  5. ncbi request reprint Cytokine network in inflammatory bowel disease
    Ivan J Fuss
    Mucosal Immunity Section, National Institutes of Health, 10 Center Dr, Build 10 Rm 11N238, Bethesda, MD 20892, USA
    Curr Drug Targets Inflamm Allergy 2:101-12. 2003
    ..This review discusses these models and the insights they provide into the pathogenesis and regulation of IBD...
  6. ncbi request reprint Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    I J Fuss
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 157:1261-70. 1996
    ..These different patterns may determine the type of inflammatory process present...
  7. pmc Successful granulocyte-colony stimulating factor treatment of Crohn's disease is associated with the appearance of circulating interleukin-10-producing T cells and increased lamina propria plasmacytoid dendritic cells
    P J Mannon
    Mucosal Immunity Section, Laboratory of Host Defense, NIAID, NIH, Bethesda, MD, USA
    Clin Exp Immunol 155:447-56. 2009
    ....
  8. ncbi request reprint The signaling function of the IL-13Ralpha2 receptor in the development of gastrointestinal fibrosis and cancer surveillance
    Warren Strober
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Mol Med 9:740-50. 2009
    ....
  9. ncbi request reprint Recent advances in the understanding of the induction and regulation of mucosal inflammation
    Warren Strober
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Gastroenterol 38:55-8. 2003
  10. ncbi request reprint The interrelated roles of TGF-beta and IL-10 in the regulation of experimental colitis
    Ivan J Fuss
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:900-8. 2002
    ..Therefore, these studies suggest that TGF-beta production is a primary mechanism of counter-regulation of Th1 T cell-mediated mucosal inflammation, and that IL-10 is necessary as a secondary factor that facilitates TGF-beta production...
  11. doi request reprint Induction of TNBS colitis in mice
    Frank Scheiffele
    National Institute of Allergy and Infectious Disease, NIH, Bethesda, Maryland, USA
    Curr Protoc Immunol . 2002
    ..A support protocol for isolating lamina propria mononuclear cells from mouse colons is also included...
  12. pmc Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis
    Tomohiro Watanabe
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 118:545-59. 2008
    ....
  13. pmc NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction
    Zhiqiong Yang
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    Gastroenterology 133:1510-21. 2007
    ..Mutations in the CARD15 gene encoding NOD2 are susceptibility factors in Crohn's disease. We explored the mechanism of this susceptibility using mice that over express NOD2...
  14. ncbi request reprint Induction of IL-13 triggers TGF-beta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis
    Stefan Fichtner-Feigl
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 178:5859-70. 2007
    ..A similar mechanism may obtain in certain forms of human inflammatory bowel disease...
  15. pmc Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice
    Jun Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:3042-9. 2006
    ..These results suggest that CYLD limits inflammation and tumorigenesis by regulating ubiquitination in vivo...
  16. ncbi request reprint Excess IL-12 but not IL-23 accompanies the inflammatory bowel disease associated with common variable immunodeficiency
    Peter J Mannon
    Mucosal Immunity Section, Laboratory of Host Defense, NIAID, NIH, Bethesda, Maryland 20892, USA
    Gastroenterology 131:748-56. 2006
    ..This study was designed to assess the status of the gastrointestinal tract and to define the mucosal immune abnormalities in patients with and without symptomatic gut inflammatory disease...
  17. ncbi request reprint Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis
    Tomohiro Watanabe
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 CRC, Room 5W3940, 10 Center Drive, Bethesda, Maryland 20892, USA
    Immunity 25:473-85. 2006
    ..Thus, NOD2-deficient mice become susceptible to colitis as a result of increased TLR2 responses when they have the capacity to respond to an antigen expressed by mucosal bacteria...
  18. ncbi request reprint The immunology of mucosal models of inflammation
    Warren Strober
    Mucosal Immunity Section, Laboratory of Clinical Investigation, NIAID, NIH, Bethesda, Maryland 20892 1890, USA
    Annu Rev Immunol 20:495-549. 2002
    ..What emerges is that murine models of mucosal inflammation have given us a road map that allows us to begin to define the immunology of the IBDs in all its complexity and to find unexpected ways to treat these diseases...
  19. ncbi request reprint Regulatory cells induced by feeding TNP-haptenated colonic protein cross-protect mice from colitis induced by an unrelated hapten
    Monica Boirivant
    Department of Infectious, Parasitic and Immune Mediated Diseases Istituto Superiore di Sanità, Roma, Italy
    Inflamm Bowel Dis 11:48-55. 2005
    ....
  20. ncbi request reprint Anti-interleukin-12 antibody for active Crohn's disease
    Peter J Mannon
    Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 351:2069-79. 2004
    ..Crohn's disease is associated with excess cytokine activity mediated by type 1 helper T (Th1) cells. Interleukin-12 is a key cytokine that initiates Th1-mediated inflammatory responses...
  21. ncbi request reprint Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells
    Frank Heller
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 17:629-38. 2002
    ..These data thus describe a cellular mechanism underlying an experimental colitis that may explain the pathogenesis of ulcerative colitis...
  22. ncbi request reprint Treatment of ulcerative colitis with infliximab: are we there yet?
    Ivan J Fuss
    J Pediatr Gastroenterol Nutr 38:247-9. 2004
  23. pmc Specific regulation of T helper cell 1-mediated murine colitis by CEACAM1
    Hideki Iijima
    Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Exp Med 199:471-82. 2004
    ....
  24. pmc Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF-kappa B decoy oligonucleotides
    Stefan Fichtner-Feigl
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 115:3057-71. 2005
    ..In each case, decoy administration led to inflammation-clearing effects, suggesting a therapeutic potency applicable to human IBD...
  25. ncbi request reprint An enteric helminth infection protects against an allergic response to dietary antigen
    Mohamed Elfatih H Bashir
    Mucosal Immunology Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 169:3284-92. 2002
    ..Taken together, these results suggest that helminth-dependent protection against allergic disease involves immunoregulatory mechanisms that block production of allergen-specific IgE...