Hon-Chung Fung

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD
    Parastoo Momeni
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, MD, USA
    BMC Neurol 6:44. 2006
  2. pmc A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan
    Hon Chung Fung
    Department of Neurology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, 199 Tung Hwa North Road, Taipei, 10591, Taiwan
    BMC Neurol 6:47. 2006
  3. ncbi request reprint The architecture of the tau haplotype block in different ethnicities
    Hon Chung Fung
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Building 35, Room 1A1008, MSC 3707, Bethesda, MD 20892, USA
    Neurosci Lett 377:81-4. 2005
  4. pmc A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release
    Mar Matarin
    Molecular Genetics Unit, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet Neurol 6:414-20. 2007
  5. ncbi request reprint Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease
    Hon Chung Fung
    Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA
    Mov Disord 21:880-1. 2006
  6. ncbi request reprint Interleukin-1alpha and -1beta promoter polymorphisms in Taiwanese patients with dementia
    Hsiu Kuan Wang
    Department of Life Science, National Taiwan Normal University, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan, ROC
    Dement Geriatr Cogn Disord 24:104-10. 2007
  7. ncbi request reprint Analysis of the PINK1 gene in a cohort of patients with sporadic early-onset parkinsonism in Taiwan
    Hon Chung Fung
    Department of Neurology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, 199 Tun Hwa North Road, Taipei 10591, Taiwan
    Neurosci Lett 394:33-6. 2006
  8. ncbi request reprint Genomewide SNP assay reveals mutations underlying Parkinson disease
    Javier Simon-Sanchez
    Molecular Genetics Unit, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hum Mutat 29:315-22. 2008
  9. ncbi request reprint Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data
    Jennifer C Schymick
    Laboratory of Neurogenetics, National Institute on Aging, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Lancet Neurol 6:322-8. 2007
  10. ncbi request reprint Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson's disease
    Yih Ru Wu
    Second Department of Neurology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taipei, Taiwan
    Hum Genet 114:236-41. 2004

Collaborators

Detail Information

Publications20

  1. pmc Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD
    Parastoo Momeni
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, MD, USA
    BMC Neurol 6:44. 2006
    ..A new locus for amyotrophic lateral sclerosis--frontotemporal dementia (ALS-FTD) has recently been ascribed to chromosome 9p...
  2. pmc A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan
    Hon Chung Fung
    Department of Neurology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, 199 Tung Hwa North Road, Taipei, 10591, Taiwan
    BMC Neurol 6:47. 2006
    ..Recently, a common LRRK2 variant Gly2385Arg was reported in ethnic Chinese PD population in Taiwan. We analyzed the frequency of this variant in our independent PD case-control population of Han Chinese from Taiwan...
  3. ncbi request reprint The architecture of the tau haplotype block in different ethnicities
    Hon Chung Fung
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Building 35, Room 1A1008, MSC 3707, Bethesda, MD 20892, USA
    Neurosci Lett 377:81-4. 2005
    ..We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans...
  4. pmc A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release
    Mar Matarin
    Molecular Genetics Unit, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet Neurol 6:414-20. 2007
    ..We aimed to identify any common genetic variability exerting a moderate to large effect on risk of ischaemic stroke, and to generate publicly available genome-wide genotype data to facilitate others doing the same...
  5. ncbi request reprint Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease
    Hon Chung Fung
    Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA
    Mov Disord 21:880-1. 2006
    ..The extreme rarity of the G2019S mutation in our population suggests the occurrence of this mutation resulted from a common European founder...
  6. ncbi request reprint Interleukin-1alpha and -1beta promoter polymorphisms in Taiwanese patients with dementia
    Hsiu Kuan Wang
    Department of Life Science, National Taiwan Normal University, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan, ROC
    Dement Geriatr Cogn Disord 24:104-10. 2007
    ..We investigated whether IL-1alpha -889 C/T and IL-1beta -511 C/T promoter polymorphisms are associated with the risk of Alzheimer's disease (AD) and vascular dementia (VaD)...
  7. ncbi request reprint Analysis of the PINK1 gene in a cohort of patients with sporadic early-onset parkinsonism in Taiwan
    Hon Chung Fung
    Department of Neurology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, 199 Tun Hwa North Road, Taipei 10591, Taiwan
    Neurosci Lett 394:33-6. 2006
    ..Overall, these data indicate that PINK1 mutations are rare in our population. Based on our results, unless common mutational hotspots are identified, routine testing for this mutation at least in our population may not be cost-effective...
  8. ncbi request reprint Genomewide SNP assay reveals mutations underlying Parkinson disease
    Javier Simon-Sanchez
    Molecular Genetics Unit, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hum Mutat 29:315-22. 2008
    ..All mutations were confirmed by independent gene dosage experiments. These data demonstrate the utility of this approach in the direct detection of mutations that underlie disease...
  9. ncbi request reprint Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data
    Jennifer C Schymick
    Laboratory of Neurogenetics, National Institute on Aging, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Lancet Neurol 6:322-8. 2007
    ..We sought to identify genetic variants associated with an increased or decreased risk for developing ALS in a cohort of American sporadic cases...
  10. ncbi request reprint Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson's disease
    Yih Ru Wu
    Second Department of Neurology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taipei, Taiwan
    Hum Genet 114:236-41. 2004
    ..Therefore, -110 A/C may be a functional polymorphism in the 5' promoter region of HSP70-1 and may affect susceptibility to PD...
  11. ncbi request reprint Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data
    Hon Chung Fung
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet Neurol 5:911-6. 2006
    ....
  12. ncbi request reprint The tau H2 haplotype is almost exclusively Caucasian in origin
    Whitney Evans
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurosci Lett 369:183-5. 2004
    ..We discuss this observation in terms of the origin of the H2 haplotype and the epidemiology of the tauopathies...
  13. ncbi request reprint Tangle diseases and the tau haplotypes
    John Hardy
    Laboratory of Neurogenetics, National Institutes on Aging and of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20852, USA
    Alzheimer Dis Assoc Disord 20:60-2. 2006
    ..We discuss the reason for this disequilibrium, its evolutionary history, and the role of genetic variability at MAPT in the etiology of tauopathies...
  14. doi request reprint SCA17 repeat expansion: mildly expanded CAG/CAA repeat alleles in neurological disorders and the functional implications
    Chiung Mei Chen
    Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei, Taiwan
    Clin Chim Acta 411:375-80. 2010
    ..The spectrum of SCA17 clinical presentation is broad...
  15. doi request reprint SCA8 repeat expansion: large CTA/CTG repeat alleles in neurological disorders and functional implications
    Yih Ru Wu
    Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, 10507, Taiwan
    Hum Genet 125:437-44. 2009
    ..Therefore, our preliminary results suggest that ATXN8 gene -62 G/A polymorphism may be functional in modulating ATXN8 expression...
  16. doi request reprint PPP2R2B CAG repeat length in the Han Chinese in Taiwan: Association analyses in neurological and psychiatric disorders and potential functional implications
    Chiung Mei Chen
    Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Am J Med Genet B Neuropsychiatr Genet 150:124-9. 2009
    ..Therefore, our preliminary results suggest that the PPP2R2B gene CAG repeat polymorphism may be functional and may, in part, play a role in conferring susceptibility to AD and ET in Taiwan...
  17. pmc Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans
    Joyce van de Leemput
    Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 3:e108. 2007
    ..We show here that heterozygous deletion of the 5' part of the ITPR1 gene, encompassing exons 1-10, 1-40, and 1-44 in three studied families, underlies SCA15 in humans...
  18. doi request reprint Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese
    Yih Ru Wu
    Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Clin Chim Acta 411:955-8. 2010
    ..Impaired ubiquitin-proteasome system function may contribute to the pathogenesis of Parkinson's disease (PD)...
  19. ncbi request reprint Risk factors for vascular dementia: a hospital-based study in Taiwan
    Jun Cheng Lin
    Department of Neurology, Chang Gung University and Chang Gung Memorial Hospital, Taipei, Taiwan
    Acta Neurol Taiwan 16:22-6. 2007
    ..In Taiwan, next to Alsheimer's, vascular dementia (VD) is the second leading cause of dementia in the elderly. Few studies have examined cardiovascular risk factors and their association with VD in Taiwan...
  20. pmc Structural genomic variation in ischemic stroke
    Mar Matarin
    Molecular Genetics Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurogenetics 9:101-8. 2008
    ..The application of genome-wide SNP arrays now facilitates the evaluation of structural changes through the entire genome as part of a genome-wide genetic association study...