Research Topics
Species | Masahiro FujitaSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [123I]epidepride SPETMasahiro Fujita
Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, CT, USA
Eur J Nucl Med Mol Imaging 31:644-54. 2004..It is concluded that SC is required for accurate quantification of distribution volumes of receptor ligands in SPET studies...
Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammationMasahiro Fujita
Molecular Imaging Branch, National Institute of Mental Health, 31 Center Drive, MSC 2035, Bethesda, MD 20892 2035, USA
Neuroimage 40:43-52. 2008..In conclusion, with the exception of those subjects who appeared to have no PBR binding, [(11)C]PBR28 is a promising ligand to quantify PBRs and localize inflammation associated with increased densities of PBRs...- Quantification of brain phosphodiesterase 4 in rat with (R)-[11C]Rolipram-PETMasahiro Fujita
Molecular Imaging Branch, National Institute of Mental Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
Neuroimage 26:1201-10. 2005..Phosphodiesterase 4 (PDE4) catabolizes the second messenger 3', 5'-cyclic adenosine monophosphate and may play a critical role in brain diseases. Our aim was to quantify PDE4 in rats with positron emission tomography (PET)... - Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPETMasahiro Fujita
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 0135, USA
Eur J Nucl Med Mol Imaging 30:1620-9. 2003..These results demonstrate the feasibility of quantifying high-affinity type nAChRs using [123I]5-I-A-85380 in humans and support the use of VT' measured by bolus studies... - Influence of acetylcholine levels on the binding of a SPECT nicotinic acetylcholine receptor ligand [123I]5-I-A-85380Masahiro Fujita
Department of Psychiatry, Yale University and VA Connecticut HCS, West Haven, Connecticut, USA
Synapse 48:116-22. 2003..However, decreased thalamic activities could have been caused by other mechanisms, including internalization of the receptor with an associated decreased affinity for radioligand... - Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivoEmmanuelle Briard
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Med Chem 51:17-30. 2008..11)C] 3 and [ (11)C] 10 are effective for imaging PBR in monkey brain. [ (11)C] 10 especially warrants further evaluation in human subjects... - Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptorsMasao Imaizumi
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bldg 31, Rm B2B37, 31 Center Drive, MSC 2035, Bethesda, MD 20892 2035, USA
Neuroimage 39:1289-98. 2008..The objectives of the current study were to evaluate kinetics of brain uptake, and the influence of the peripheral binding on the arterial input function in rhesus monkey... 
Pre- and post-synaptic dopamine imaging and its relation with frontostriatal cognitive function in Parkinson disease: PET studies with [11C]NNC 112 and [18F]FDOPAVanessa L Cropley
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 0135, USA
Psychiatry Res 163:171-82. 2008..These results suggest that striatal dopamine denervation may contribute to some frontostriatal cognitive impairment in moderate stage PD...- Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammationAmira K Brown
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 2035, USA
J Nucl Med 48:2072-9. 2007..The aim of this study was to estimate the human radiation doses of (11)C-PBR28 based on biodistribution data in monkeys and humans. In addition, we scanned 1 human subject who fortuitously behaved as if he lacked the PBR binding protein... - Whole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [(11)C](R)-rolipram: comparison of two-dimensional planar, bisected and quadrisected image analysesDavid R Sprague
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 2035, USA
Nucl Med Biol 35:493-500. 2008..The aim of this study was to estimate the human radiation absorbed dose of the radioligand based on its biodistribution in both monkeys and humans... - Chemical fate of the nicotinic acetylcholinergic radiotracer [123I]5-IA-85380 in baboon brain and plasmaRonald M Baldwin
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
Nucl Med Biol 33:549-54. 2006.... - Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarkerWilliam C Kreisl
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
Neuroimage 49:2924-32. 2010..Non-binding may be differentially expressed in organs of the body. The relatively low in vivo specific binding of [(11)C]-(R)-PK 11195 may have obscured its detection of non-binding in peripheral organs... - Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PETEmmanuelle Briard
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Med Chem 52:688-99. 2009..In rat, a low level radiometabolite of intermediate lipophilicity was identified as [18F]2-fluoro-N-(2-phenoxyphenyl)acetamide ([18F]11). [18F]9 is a promising radioligand for future imaging of PBR in living human brain... - Biodistribution and radiation dosimetry of a positron emission tomographic ligand, 18F-SP203, to image metabotropic glutamate subtype 5 receptors in humansYasuyuki Kimura
Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bethesda, MD 20892 1026, USA
Eur J Nucl Med Mol Imaging 37:1943-9. 2010.... - Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D1 receptor radioligand 11C-NNC 112 in humansVanessa L Cropley
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
J Nucl Med 47:100-4. 2006.... - Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brainMasao Imaizumi
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2035, USA
Synapse 61:595-605. 2007..A critical factor for human use will be whether the tracer has adequately fast wash out from brain relative to the half-life of the radionuclide to obtain stable values of distribution volume... - Quantification of metabotropic glutamate subtype 5 receptors in the brain by an equilibrium method using 18F-SP203Yasuyuki Kimura
Molecular Imaging Branch, 10 Center Drive, MSC 1026, Bldg 10, National Institute of Mental Health, Bethesda, MD 20892, USA
Neuroimage 59:2124-30. 2012..In addition, when using 18F-SP203, the equilibrium method is more efficient because it requires much less data... - Image-derived input function for human brain using high resolution PET imaging with [C](R)-rolipram and [C]PBR28Paolo Zanotti-Fregonara
Molecular Imaging Branch, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bethesda, Maryland, United States of America
PLoS ONE 6:e17056. 2011..Three of the methods required arterial blood samples to scale the image-input, and four were blood-free methods... - PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurementsSami S Zoghbi
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
J Nucl Med 47:520-7. 2006.... - Brain and whole-body imaging of nociceptin/orphanin FQ peptide receptor in humans using the PET ligand 11C-NOP-1ATalakad G Lohith
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1026, USA
J Nucl Med 53:385-92. 2012..Here, we assessed the ability of (11)C-NOP-1A to quantify NOP receptors in human brain and estimated its radiation safety profile... - Small effect of dopamine release and no effect of dopamine depletion on [18F]fallypride binding in healthy humansVanessa L Cropley
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
Synapse 62:399-408. 2008..These findings indicate that [18F]fallypride is useful for measuring amphetamine-induced dopamine release, but may be unreliable for estimating tonic dopamine levels, in striatum and extrastriatal regions of healthy humans... - PET measurement of the in vivo affinity of 11C-(R)-rolipram and the density of its target, phosphodiesterase-4, in the brains of conscious and anesthetized ratsTetsuji Itoh
National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
J Nucl Med 50:749-56. 2009..We also studied 2 critical factors in small-animal PET scans: the influence of anesthesia and the difference in binding under in vivo and in vitro conditions... - Brain and whole-body imaging in rhesus monkeys of 11C-NOP-1A, a promising PET radioligand for nociceptin/orphanin FQ peptide receptorsYasuyuki Kimura
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1026, USA
J Nucl Med 52:1638-45. 2011..4) for PET brain imaging. Here, we assessed the utility of (11)C-NOP-1A for quantifying NOP receptors in the monkey brain and estimated the radiation safety profile of this radioligand based on its biodistribution in monkeys... - Metabotropic glutamate subtype 5 receptors are quantified in the human brain with a novel radioligand for PETAmira K Brown
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland, USA
J Nucl Med 49:2042-8. 2008.... - Biodistribution and radiation dosimetry in humans of a new PET ligand, (18)F-PBR06, to image translocator protein (18 kDa)Yota Fujimura
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2035, USA
J Nucl Med 51:145-9. 2010..The objective of this study was to estimate the radiation absorbed doses of (18)F-PBR06 based on biodistribution data in humans... - Disulfiram inhibits defluorination of (18)F-FCWAY, reduces bone radioactivity, and enhances visualization of radioligand binding to serotonin 5-HT1A receptors in human brainYong Hoon Ryu
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Nucl Med 48:1154-61. 2007..We previously showed that miconazole, an inhibitor of CYP2E1, blocks defluorination of FCWAY in rats. Here, we used (18)F-FCWAY to test the ability of the less toxic agent disulfiram to inhibit defluorination in humans... - In vivo and in vitro measurement of brain phosphodiesterase 4 in rats after antidepressant administrationMasahiro Fujita
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Synapse 61:78-86. 2007..g., continuous infusion vs. intermittent injection of antidepressant) in large brain areas. However, the results do not deny possibility of changes in discrete areas, which were not studied in the current study applying PET... - Central type benzodiazepine receptors in Gulf War veterans with posttraumatic stress disorderMasahiro Fujita
Department of Psychiatry, Yale University and Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
Biol Psychiatry 56:95-100. 2004..CONCLUSIONS: Less severe symptoms and shorter duration of the illness in the current group than the prior one may be the source of the difference in the results of the two studies... - Widespread decrease of nicotinic acetylcholine receptors in Parkinson's diseaseMasahiro Fujita
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 1, Room B3 10, I Center Drive, MSC 0135, Bethesda, MD, USA
Ann Neurol 59:174-7. 2006..Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects... - Kinetic analysis in human brain of [11C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: a retest study and use of an image-derived input functionPaolo Zanotti-Fregonara
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 2035, USA
Neuroimage 54:1903-9. 2011..The aims of this study were to perform kinetic modeling of [(11)C](R)-rolipram in healthy humans using an arterial input function and to replace this arterial input in humans with an image-derived input function... - Whole-body biodistribution and radiation dosimetry estimates for the PET dopamine transporter probe 18F-FECNT in non-human primatesDnyanesh N Tipre
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bldg 1 Rm B3 10, 1 Center Drive, Bethesda, MD 20892 0135, USA
Nucl Med Commun 25:737-42. 2004..The aim of the current study was to quantify the distribution of radioactivity in three rhesus monkeys after the injection of approximately 185 MBq (5 mCi) of 18F-FECNT... - In vivo binding of protoporphyrin IX to rat translocator protein imaged with positron emission tomographyHarushige Ozaki
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Synapse 64:649-53. 2010..Although PPIX at physiological concentrations would likely occupy an insignificant percentage of TSPOs, it does reach high-enough concentrations in porphyria to occupy and have pharmacological effects via this target... - Effects of cAMP-dependent protein kinase activator and inhibitor on in vivo rolipram binding to phosphodiesterase 4 in conscious ratsTetsuji Itoh
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Synapse 64:172-6. 2010..These results support the value of measuring in vivo [(11)C](R)-rolipram binding in brain to assess responses to physiological or pharmacological challenges to the cAMP second messenger system... - Quantification of translocator protein (18 kDa) in the human brain with PET and a novel radioligand, (18)F-PBR06Yota Fujimura
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2035, USA
J Nucl Med 50:1047-53. 2009.... - Human biodistribution and radiation dosimetry of the tachykinin NK1 antagonist radioligand [18F]SPA-RQ: comparison of thin-slice, bisected, and 2-dimensional planar image analysisDavid R Sprague
Molecular Imaging Branch, NIMH, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
J Nucl Med 48:100-7. 2007..The aims of this study were to estimate the radiation safety profile and relative risks of [(18)F]SPA-RQ with 3 different methods of image analysis... - Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123i]5-i-A-85380 in healthy human subjectsMasahiro Fujita
Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, VA Connecticut 116A2, West Haven 06516, USA
Eur J Nucl Med Mol Imaging 29:183-90. 2002..These results suggest that [123I]5-I-A-85380 is a promising SPET agent to image alpha4beta2 nAChRs in humans, with acceptable dosimetry and high brain uptake... - Image-derived input function in PET brain studies: blood-based methods are resistant to motion artifactsPaolo Zanotti-Fregonara
Molecular Imaging Branch, National Institute of Mental Health, NIH, Bethesda, Maryland 20892 2035, USA
Nucl Med Commun 33:982-9. 2012..The present study used both simulated and clinical [11C](R)-rolipram data to assess the robustness of a blood-based IDIF method (a method that is ultimately normalized with blood samples) with regard to motion artifacts... - PET [11C]DASB imaging of serotonin transporters in patients with alcoholismAmira K Brown
Molecular Imaging Branch, National Institute of Mental Health, One Center Drive, Bethesda, MD 20892, USA
Alcohol Clin Exp Res 31:28-32. 2007..We measured densities of the serotonin transporter (SERT) in a moderate-sized sample of alcoholic patients who were assessed for aggressive characteristics... - PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in ratMasao Imaizumi
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
Neurosci Lett 411:200-5. 2007..In this first study to demonstrate neuroinflammation in vivo with small animal PET, [11C]PBR28 had adequate sensitivity to localize and quantify the associated increase in PBRs... - Comparison of 18F- and 11C-labeled aryloxyanilide analogs to measure translocator protein in human brain using positron emission tomographyLeah P Dickstein
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1026, USA
Eur J Nucl Med Mol Imaging 38:352-7. 2011.... - Population-based input function and image-derived input function for [(11)C](R)-rolipram PET imaging: Methodology, validation and application to the study of major depressive disorderPaolo Zanotti-Fregonara
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Neuroimage 63:1532-41. 2012.... - Increased in vivo expression of an inflammatory marker in temporal lobe epilepsyJussi Hirvonen
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1026, USA
J Nucl Med 53:234-40. 2012..In this study, we sought to determine whether in vivo expression of TSPO is increased ipsilateral to the seizure focus in patients with temporal lobe epilepsy... - Translocator protein PET imaging for glial activation in multiple sclerosisUnsong Oh
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bldg 10 Rm 5C103, Bethesda, MD 20892, USA
J Neuroimmune Pharmacol 6:354-61. 2011..Global [(11)C]PBR28 binding showed correlation with disease duration (p = 0.041), but not with measures of clinical disability. These results further define TSPO as an informative marker of glial activation in MS... - Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligandsVictor W Pike
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, United States
J Med Chem 54:366-73. 2011..31 showed high affinity for HABs, MABs, and LABs. In conclusion, [(11)C]31 represents a promising new chemotype for developing novel TSPO radioligands as biomarkers of neuroinflammation... - Downregulation of brain phosphodiesterase type IV measured with 11C-(R)-rolipram positron emission tomography in major depressive disorderMasahiro Fujita
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1026, USA
Biol Psychiatry 72:548-54. 2012..This study sought to quantify the binding of 11C-(R)-rolipram, a PDE4 inhibitor, as an indirect measure of this enzyme's activity in the brain of individuals with major depressive disorder (MDD) compared with healthy control subjects... - Cerebral benzodiazepine receptors in depressed patients measured with [123I]iomazenil SPECTAkira Kugaya
Department of Psychiatry, Yale University, New Haven, CT, USA
Biol Psychiatry 54:792-9. 2003..CONCLUSIONS: GABA(A) receptor binding measured in vivo with BZ radioligand binding are not altered in patients with depression... - Increased peripheral benzodiazepine receptors in arterial plaque of patients with atherosclerosis: an autoradiographic study with [(3)H]PK 11195Yota Fujimura
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
Atherosclerosis 201:108-11. 2008..In conclusion, this study demonstrated that macrophage and inflammatory activity in atherosclerotic plaque can be imaged specifically by the binding of PBR indicating future application of PET imaging for PBR... - Synthesis and evaluation of radioligands for imaging brain nociceptin/orphanin FQ peptide (NOP) receptors with positron emission tomographyVictor W Pike
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, United States
J Med Chem 54:2687-700. 2011..Overall, [(11)C](S)-10c showed the most favorable receptor-specific signal and kinetics and is now selected for evaluation in human subjects... - Propofol Decreases In Vivo Binding of 11C-PBR28 to Translocator Protein (18 kDa) in the Human BrainChristina S Hines
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland
J Nucl Med 54:64-9. 2013..The purpose of this study was to determine whether the anesthetic propofol alters brain uptake of (11)C-PBR28 in healthy subjects... - Consensus nomenclature for in vivo imaging of reversibly binding radioligandsRobert B Innis
National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
J Cereb Blood Flow Metab 27:1533-9. 2007..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands... - Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transportersSubroto Ghose
Molecular Imaging Branch, NIMH, NIH, Bethesda, Maryland 20892, USA
Synapse 56:100-4. 2005..3H]MeNER displayed much higher affinity for NET than for SERT or DAT in homogenate binding studies. Each of these features supports the binding specificity of this candidate in vivo NET ligand... - Molecular imaging of the dopaminergic system and its association with human cognitive functionVanessa L Cropley
Department of Physiology, Behavioural Neuroscience Laboratory, Monash Centre for Brain and Behaviour, Monash University, Victoria, Australia
Biol Psychiatry 59:898-907. 2006.... - Image-derived input function for brain PET studies: many challenges and few opportunitiesPaolo Zanotti-Fregonara
Molecular Imaging Branch, NIMH, NIH, Bethesda, Maryland 20892 2035, USA
J Cereb Blood Flow Metab 31:1986-98. 2011..Even in those cases, it only rarely translates into a less-invasive procedure for the patient. Finally, we discuss some possible alternative methods for obtaining less-invasive input function... - Increase in prefrontal cortex serotonin 2A receptors following estrogen treatment in postmenopausal womenAkira Kugaya
Department of Psychiatry, Yale University, New Haven, Conn 06516, USA
Am J Psychiatry 160:1522-4. 2003..This study investigated the effect of estrogen on brain serotonin 2A (5-HT(2A)) receptors in postmenopausal women and whether there was any correlation of receptor changes with cognition and mood... - Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activitiesKyeong Min Kim
Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita City, Osaka 565-8565, Japan
J Nucl Med 44:512-9. 2003..This scatter correction method was approximately equally useful with data from the 6 different collimators and is recommended for more accurate quantitation of nonuniformly distributed brain activities... - Nanoparticles of amorphous ruthenium sulfide easily obtainable from a TiO2-supported hexanuclear cluster complex [Ru6C(CO)16]2-: a highly active catalyst for the reduction of SO2 with H2Atsushi Ishiguro
RIKEN, The Institute of Physical and Chemical Research, Hirosawa 2-1, Wako-shi, Saitama 351-0198, Japan
Chemistry 8:3260-8. 2002..Amorphous ruthenium sulfide maintains its nano-sized scale (approximately 14 A) regardless of the reaction temperature, while RuS(2) crystallite aggregates to form larger nonuniform particles... - Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cellsAyumi Satoh
First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
Oncogene 23:8876-86. 2004..It thus appears that CIITA methylation is a key mechanism that enables some gastrointestinal cancer cells to escape immune surveillance...