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Genomes and Genes | Terry J FrySummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitutionTerry J Fry
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Blood 104:2794-800. 2004..Therefore, flt3L is a potent immunorestorative agent that enhances both thymic-dependent and thymic-independent pathways of T-cell regeneration...- The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenanceTerry J Fry
Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 174:6571-6. 2005..Thus, IL-7 plays critical and nonredundant roles in both T cell lymphopoiesis and in maintaining and restoring peripheral T cell homeostasis... 
Expanding options to improve outcomes following hematopoietic stem cell transplantationTerry J Fry
Division of Blood and Marrow Transplantation, Children s National Medical Center, Washington, District of Columbia, USA
Pediatr Blood Cancer 55:1043-4. 2010..However, the risk of treatment-related mortality remains approximately 5-10%, in part due to complications such as veno-occlusive disease (VOD) for which there has been less progress...
Antigen loading of DCs with irradiated apoptotic tumor cells induces improved anti-tumor immunity compared to other approachesTerry J Fry
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute National Institutes of Health, Bethesda, MD 20892, USA
Cancer Immunol Immunother 58:1257-64. 2009..We conclude that signals provided to the DCs by apoptotic cells substantially augment the potency of DC vaccines...- Extracorporeal photopheresis attenuates murine graft-versus-host disease via bone marrow-derived interleukin-10 and preserves responses to dendritic cell vaccinationChristian M Capitini
Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Biol Blood Marrow Transplant 17:790-9. 2011..Importantly, the attenuation of GVHD by ECP-treated splenocytes permits donor lymphocyte infusion-dependent responses to DC vaccines after allo-BMT... - Cytokine signals in T-cell homeostasisMartin Guimond
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-1104, USA
J Immunother (1997) 28:289-94. 2005.... - Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsetsClaude Sportes
Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
J Exp Med 205:1701-14. 2008.... - Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell poolFraia Melchionda
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
J Clin Invest 115:1177-87. 2005.... - Harnessing the biology of IL-7 for therapeutic applicationCrystal L Mackall
Immunology Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
Nat Rev Immunol 11:330-42. 2011..This Review summarizes the biology of IL-7 and the results of its clinical use that are available so far to provide a perspective on the opportunities for clinical application of this cytokine... - Autoimmunity during lymphopenia: a two-hit modelTom Krupica
Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
Clin Immunol 120:121-8. 2006.... - Bone marrow deficient in IFN-{gamma} signaling selectively reverses GVHD-associated immunosuppression and enhances a tumor-specific GVT effectChristian M Capitini
Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 113:5002-9. 2009.... - Escape from immune surveillance does not result in tolerance to tumor-associated antigensFraia Melchionda
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
J Immunother (1997) 27:329-38. 2004.... - Bax deficiency partially corrects interleukin-7 receptor alpha deficiencyAnnette R Khaled
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, MD 21702, USA
Immunity 17:561-73. 2002..The BH3 only proteins, Bad and Bim, were also part of the death pathway repressed by IL-7. Thus, in young mice, Bax emerges as an essential protein in the death pathway induced by IL-7 deficiency... - IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cellsSteven A Rosenberg
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1201, USA
J Immunother 29:313-9. 2006..These studies suggest an important role for interleukin-7 in the treatment of patients with lymphopenia... - IL-7 in allogeneic transplant: clinical promise and potential pitfallsKristen M Snyder
Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, NCI, NIH, Bethseda, MD 20892, USA
Leuk Lymphoma 47:1222-8. 2006..Thus, careful consideration of how best to incorporate IL-7 into allogeneic trials will be needed if the full potential of this agent is to be realized... - Cancer immunotherapy: will expanding knowledge lead to success in pediatric oncology?Terry J Fry
Division, Blood Marrow Transplantation and Immunology, Center for Cancer and Blood Disorders, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 10010, USA
Hematol Oncol Clin North Am 24:109-27. 2010..In this article, we briefly provide a general overview of our current understanding of the immune system, with a focus on concepts in tumor immunology, followed by a discussion of how these concepts are being used in the clinic... - IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primatesTerry J Fry
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Blood 101:2294-9. 2003..These results also raise the possibility that IL-7 therapy could be used to temporarily modulate T-cell cycling in vivo in the context of immunotherapies such as vaccination... - Analysis of pediatric autologous PBSC apheresis and transplant: age is a major factor affecting post-transplant toxicityLeonid Dubrovsky
Pediatric Residency Program, Children s National Medical Center, Washington, District of Columbia, USA
Pediatr Blood Cancer 59:301-5. 2012..HCT can be curative, but is associated with significant toxicity... - Dose-adjusted EPOCH-rituximab combined with fludarabine provides an effective bridge to reduced-intensity allogeneic hematopoietic stem-cell transplantation in patients with lymphoid malignanciesRachel B Salit
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
J Clin Oncol 30:830-6. 2012..To this end, we developed a novel regimen by adding fludarabine to dose-adjusted continuous-infusion etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin plus with or without rituximab (DA-EPOCH-F/R)... - Cancer immunotherapy: will expanding knowledge lead to success in pediatric oncology?Terry J Fry
Division, Blood Marrow Transplantation and Immunology, Center for Cancer and Blood Disorders, Children s National Medical Center, Washington, DC 10010, USA
Pediatr Clin North Am 55:147-67, xi. 2008..In this article, we briefly provide a general overview of our current understanding of the immune system, with a focus on concepts in tumor immunology, followed by a discussion of how these concepts are being used in the clinic... - Interleukin-7 and immunorestoration in HIV: beyond the thymusTerry J Fry
Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892 1928, USA
J Hematother Stem Cell Res 11:803-7. 2002.... - Reduced-intensity allogeneic stem cell transplantation in children and young adults with ultrahigh-risk pediatric sarcomasKristin Baird
Pediatric Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Blood Marrow Transplant 18:698-707. 2012..Enhanced chemo- and radiosensitivity of tumors and normal tissues was observed posttransplantation... - Radiofrequency ablation induces antigen-presenting cell infiltration and amplification of weak tumor-induced immunitySergio A Dromi
Diagnostic Radiology Department, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Radiology 251:58-66. 2009..To evaluate the influence of subtotal radiofrequency (RF) ablation on a tumor-specific immune response in a murine tumor model and to explore the role of intratumoral dendritic cells (ITDCs) in mediating this effect... - Unusual sites of extraskeletal metastases of Ewing sarcoma after allogeneic hematopoietic stem cell transplantationChristian M Capitini
Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Pediatr Hematol Oncol 31:142-4. 2009..Further clinical trials are needed to evaluate the role for allogeneic SCT for this disease... - Extending the horizon for cell-based immunotherapy by understanding the mechanisms of action of photopheresisChing Y Voss
Center for Cancer and Blood Disorders, Children s National Medical Center, Washington, DC 20010, USA
Transfus Med Rev 24:22-32. 2010..Such immunotherapy interventions could bring significant clinical benefit to patients undergoing transplant rejection or autoimmune-related disorders and deserve further investigation as well as validation studies... - The graft-versus-tumor effect in pediatric malignancyTerry J Fry
Division of Blood and Marrow Transplantation Immunology, Center for Cancer and Blood Disorders, Children s National Medical Center, 1 West Wing, 111 Michigan Avenue, NW, Washington, DC 20010, USA
Pediatr Clin North Am 57:67-81. 2010.... - Interleukin 7 worsens graft-versus-host diseaseManoj L Sinha
Pediatric Oncology Branch, Experimental Transplantation and Immunology Branch, National Cancer Institute, and Veterinary Resources Program, National Institutes of Health, Bethesda, MD 20892, USA
Blood 100:2642-9. 2002..These results suggest that use of IL-7 should be limited to the setting of TCD BMT to obtain the greatest benefit on immune competence with the least toxicity... - Interleukin-7: from bench to clinicTerry J Fry
Immunology Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1928, USA
Blood 99:3892-904. 2002 - Current concepts of thymic agingTerry J Fry
Pediatric Oncology Branch, National Cancer Institute, Bldg. 10, Rm. 13N240, 10 Center Dr. MSC 1928, Bethesda, MD 20892-1928, USA
Springer Semin Immunopathol 24:7-22. 2002 - Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infectionCaroline Fluur
Department of Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
J Immunol 178:5340-50. 2007..Elevated IL-7 levels associated with lymphopenic conditions, including HIV-infection, might participate in the increased sensitivity of T cells for activation-induced apoptosis...