Terry J Fry

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution
    Terry J Fry
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 104:2794-800. 2004
  2. pmc Antigen loading of DCs with irradiated apoptotic tumor cells induces improved anti-tumor immunity compared to other approaches
    Terry J Fry
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Immunol Immunother 58:1257-64. 2009
  3. doi request reprint Expanding options to improve outcomes following hematopoietic stem cell transplantation
    Terry J Fry
    Division of Blood and Marrow Transplantation, Children s National Medical Center, Washington, District of Columbia, USA
    Pediatr Blood Cancer 55:1043-4. 2010
  4. ncbi request reprint The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance
    Terry J Fry
    Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:6571-6. 2005
  5. pmc Graft-versus-host disease impairs vaccine responses through decreased CD4+ and CD8+ T cell proliferation and increased perforin-mediated CD8+ T cell apoptosis
    Christian M Capitini
    Blood and Marrow Transplant Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 190:1351-9. 2013
  6. ncbi request reprint Cytokine signals in T-cell homeostasis
    Martin Guimond
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 1104, USA
    J Immunother 28:289-94. 2005
  7. pmc Extracorporeal photopheresis attenuates murine graft-versus-host disease via bone marrow-derived interleukin-10 and preserves responses to dendritic cell vaccination
    Christian M Capitini
    Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biol Blood Marrow Transplant 17:790-9. 2011
  8. pmc Val-boroPro accelerates T cell priming via modulation of dendritic cell trafficking resulting in complete regression of established murine tumors
    Meghaan P Walsh
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 8:e58860. 2013
  9. pmc Reduced-intensity allogeneic stem cell transplantation in children and young adults with ultrahigh-risk pediatric sarcomas
    Kristin Baird
    Pediatric Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Blood Marrow Transplant 18:698-707. 2012
  10. pmc Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool
    Fraia Melchionda
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Clin Invest 115:1177-87. 2005

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution
    Terry J Fry
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 104:2794-800. 2004
    ..Therefore, flt3L is a potent immunorestorative agent that enhances both thymic-dependent and thymic-independent pathways of T-cell regeneration...
  2. pmc Antigen loading of DCs with irradiated apoptotic tumor cells induces improved anti-tumor immunity compared to other approaches
    Terry J Fry
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Immunol Immunother 58:1257-64. 2009
    ..We conclude that signals provided to the DCs by apoptotic cells substantially augment the potency of DC vaccines...
  3. doi request reprint Expanding options to improve outcomes following hematopoietic stem cell transplantation
    Terry J Fry
    Division of Blood and Marrow Transplantation, Children s National Medical Center, Washington, District of Columbia, USA
    Pediatr Blood Cancer 55:1043-4. 2010
    ..However, the risk of treatment-related mortality remains approximately 5-10%, in part due to complications such as veno-occlusive disease (VOD) for which there has been less progress...
  4. ncbi request reprint The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance
    Terry J Fry
    Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:6571-6. 2005
    ..Thus, IL-7 plays critical and nonredundant roles in both T cell lymphopoiesis and in maintaining and restoring peripheral T cell homeostasis...
  5. pmc Graft-versus-host disease impairs vaccine responses through decreased CD4+ and CD8+ T cell proliferation and increased perforin-mediated CD8+ T cell apoptosis
    Christian M Capitini
    Blood and Marrow Transplant Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 190:1351-9. 2013
    ..These results provide important insights toward optimizing vaccine responses after allogeneic BMT...
  6. ncbi request reprint Cytokine signals in T-cell homeostasis
    Martin Guimond
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 1104, USA
    J Immunother 28:289-94. 2005
    ....
  7. pmc Extracorporeal photopheresis attenuates murine graft-versus-host disease via bone marrow-derived interleukin-10 and preserves responses to dendritic cell vaccination
    Christian M Capitini
    Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biol Blood Marrow Transplant 17:790-9. 2011
    ..Importantly, the attenuation of GVHD by ECP-treated splenocytes permits donor lymphocyte infusion-dependent responses to DC vaccines after allo-BMT...
  8. pmc Val-boroPro accelerates T cell priming via modulation of dendritic cell trafficking resulting in complete regression of established murine tumors
    Meghaan P Walsh
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 8:e58860. 2013
    ..Finally, we show that Val-boroPro has potent adjuvant properties resulting in an effective therapeutic vaccine...
  9. pmc Reduced-intensity allogeneic stem cell transplantation in children and young adults with ultrahigh-risk pediatric sarcomas
    Kristin Baird
    Pediatric Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Blood Marrow Transplant 18:698-707. 2012
    ..Enhanced chemo- and radiosensitivity of tumors and normal tissues was observed posttransplantation...
  10. pmc Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool
    Fraia Melchionda
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Clin Invest 115:1177-87. 2005
    ....
  11. pmc Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets
    Claude Sportes
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Exp Med 205:1701-14. 2008
    ....
  12. doi request reprint Harnessing the biology of IL-7 for therapeutic application
    Crystal L Mackall
    Immunology Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Nat Rev Immunol 11:330-42. 2011
    ..This Review summarizes the biology of IL-7 and the results of its clinical use that are available so far to provide a perspective on the opportunities for clinical application of this cytokine...
  13. ncbi request reprint Escape from immune surveillance does not result in tolerance to tumor-associated antigens
    Fraia Melchionda
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    J Immunother 27:329-38. 2004
    ....
  14. pmc Bone marrow deficient in IFN-{gamma} signaling selectively reverses GVHD-associated immunosuppression and enhances a tumor-specific GVT effect
    Christian M Capitini
    Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 113:5002-9. 2009
    ....
  15. ncbi request reprint Bax deficiency partially corrects interleukin-7 receptor alpha deficiency
    Annette R Khaled
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, MD 21702, USA
    Immunity 17:561-73. 2002
    ..The BH3 only proteins, Bad and Bim, were also part of the death pathway repressed by IL-7. Thus, in young mice, Bax emerges as an essential protein in the death pathway induced by IL-7 deficiency...
  16. ncbi request reprint Autoimmunity during lymphopenia: a two-hit model
    Tom Krupica
    Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Clin Immunol 120:121-8. 2006
    ....
  17. ncbi request reprint IL-7 in allogeneic transplant: clinical promise and potential pitfalls
    Kristen M Snyder
    Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, NCI, NIH, Bethseda, MD 20892, USA
    Leuk Lymphoma 47:1222-8. 2006
    ..Thus, careful consideration of how best to incorporate IL-7 into allogeneic trials will be needed if the full potential of this agent is to be realized...
  18. pmc IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells
    Steven A Rosenberg
    Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1201, USA
    J Immunother 29:313-9. 2006
    ..These studies suggest an important role for interleukin-7 in the treatment of patients with lymphopenia...
  19. ncbi request reprint IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primates
    Terry J Fry
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 101:2294-9. 2003
    ..These results also raise the possibility that IL-7 therapy could be used to temporarily modulate T-cell cycling in vivo in the context of immunotherapies such as vaccination...
  20. doi request reprint Cancer immunotherapy: will expanding knowledge lead to success in pediatric oncology?
    Terry J Fry
    Division, Blood Marrow Transplantation and Immunology, Center for Cancer and Blood Disorders, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 10010, USA
    Hematol Oncol Clin North Am 24:109-27. 2010
    ..In this article, we briefly provide a general overview of our current understanding of the immune system, with a focus on concepts in tumor immunology, followed by a discussion of how these concepts are being used in the clinic...
  21. doi request reprint Analysis of pediatric autologous PBSC apheresis and transplant: age is a major factor affecting post-transplant toxicity
    Leonid Dubrovsky
    Pediatric Residency Program, Children s National Medical Center, Washington, District of Columbia, USA
    Pediatr Blood Cancer 59:301-5. 2012
    ..HCT can be curative, but is associated with significant toxicity...
  22. pmc Dose-adjusted EPOCH-rituximab combined with fludarabine provides an effective bridge to reduced-intensity allogeneic hematopoietic stem-cell transplantation in patients with lymphoid malignancies
    Rachel B Salit
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Clin Oncol 30:830-6. 2012
    ..To this end, we developed a novel regimen by adding fludarabine to dose-adjusted continuous-infusion etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin plus with or without rituximab (DA-EPOCH-F/R)...
  23. ncbi request reprint Interleukin-7 and immunorestoration in HIV: beyond the thymus
    Terry J Fry
    Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892 1928, USA
    J Hematother Stem Cell Res 11:803-7. 2002
    ....
  24. doi request reprint Cancer immunotherapy: will expanding knowledge lead to success in pediatric oncology?
    Terry J Fry
    Division, Blood Marrow Transplantation and Immunology, Center for Cancer and Blood Disorders, Children s National Medical Center, Washington, DC 10010, USA
    Pediatr Clin North Am 55:147-67, xi. 2008
    ..In this article, we briefly provide a general overview of our current understanding of the immune system, with a focus on concepts in tumor immunology, followed by a discussion of how these concepts are being used in the clinic...
  25. doi request reprint Extending the horizon for cell-based immunotherapy by understanding the mechanisms of action of photopheresis
    Ching Y Voss
    Center for Cancer and Blood Disorders, Children s National Medical Center, Washington, DC 20010, USA
    Transfus Med Rev 24:22-32. 2010
    ..Such immunotherapy interventions could bring significant clinical benefit to patients undergoing transplant rejection or autoimmune-related disorders and deserve further investigation as well as validation studies...
  26. doi request reprint The graft-versus-tumor effect in pediatric malignancy
    Terry J Fry
    Division of Blood and Marrow Transplantation Immunology, Center for Cancer and Blood Disorders, Children s National Medical Center, 1 West Wing, 111 Michigan Avenue, NW, Washington, DC 20010, USA
    Pediatr Clin North Am 57:67-81. 2010
    ....
  27. pmc Radiofrequency ablation induces antigen-presenting cell infiltration and amplification of weak tumor-induced immunity
    Sergio A Dromi
    Diagnostic Radiology Department, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Radiology 251:58-66. 2009
    ..To evaluate the influence of subtotal radiofrequency (RF) ablation on a tumor-specific immune response in a murine tumor model and to explore the role of intratumoral dendritic cells (ITDCs) in mediating this effect...
  28. pmc Unusual sites of extraskeletal metastases of Ewing sarcoma after allogeneic hematopoietic stem cell transplantation
    Christian M Capitini
    Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Pediatr Hematol Oncol 31:142-4. 2009
    ..Further clinical trials are needed to evaluate the role for allogeneic SCT for this disease...
  29. ncbi request reprint Interleukin 7 worsens graft-versus-host disease
    Manoj L Sinha
    Pediatric Oncology Branch, Experimental Transplantation and Immunology Branch, National Cancer Institute, and Veterinary Resources Program, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 100:2642-9. 2002
    ..These results suggest that use of IL-7 should be limited to the setting of TCD BMT to obtain the greatest benefit on immune competence with the least toxicity...
  30. doi request reprint Minor Antigen Distribution Predicts Site-Specific Graft-versus-Tumor Activity of Adoptively Transferred, Minor Antigen-Specific CD8 T Cells
    Jessica C Shand
    Blood and Marrow Transplant Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Electronic address
    Biol Blood Marrow Transplant 20:26-36. 2014
    ..We concluded that targetĀ alloantigen expression in the same compartment of tumor growth impairs CD8 responses to both solid and hematologic tumors. ..
  31. ncbi request reprint Interleukin-7: from bench to clinic
    Terry J Fry
    Immunology Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1928, USA
    Blood 99:3892-904. 2002
  32. ncbi request reprint Current concepts of thymic aging
    Terry J Fry
    Pediatric Oncology Branch, National Cancer Institute, Bldg 10, Rm 13N240, 10 Center Dr MSC 1928, Bethesda, MD 20892 1928, USA
    Springer Semin Immunopathol 24:7-22. 2002
  33. doi request reprint T-cell adoptive immunotherapy for acute lymphoblastic leukemia
    Terry J Fry
    1Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD
    Hematology Am Soc Hematol Educ Program 2013:348-53. 2013
    ....
  34. pmc A pan-inhibitor of DASH family enzymes induces immune-mediated regression of murine sarcoma and is a potent adjuvant to dendritic cell vaccination and adoptive T-cell therapy
    Brynn B Duncan
    Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD Department of Pediatrics, Division of Pediatric Hematology Oncology, Medstar Georgetown University Hospital, Washington, DC Department of Biochemistry, Tufts University School of Medicine, Boston, MA
    J Immunother 36:400-11. 2013
    ..These studies warrant the clinical investigation of ARI-4175 for treatment of sarcomas and other malignancies, particularly as an adjuvant to tumor vaccines and ACT. ..
  35. ncbi request reprint Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection
    Caroline Fluur
    Department of Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    J Immunol 178:5340-50. 2007
    ..Elevated IL-7 levels associated with lymphopenic conditions, including HIV-infection, might participate in the increased sensitivity of T cells for activation-induced apoptosis...