Lita Freeman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Lipolytic and ligand-binding functions of hepatic lipase protect against atherosclerosis in LDL receptor-deficient mice
    Lita Freeman
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 48:104-13. 2007
  2. ncbi The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter
    Lita A Freeman
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 45:1197-206. 2004
  3. ncbi Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice
    Justina E Wu
    Molecular Disease Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:22913-25. 2004
  4. ncbi Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice
    Zengxuan Nong
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 112:367-78. 2003
  5. ncbi Study of ABCA1 function in transgenic mice
    Charles Joyce
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Arterioscler Thromb Vasc Biol 23:965-71. 2003
  6. ncbi Hepatic lipase, lipoprotein metabolism, and atherogenesis
    Silvia Santamarina-Fojo
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Arterioscler Thromb Vasc Biol 24:1750-4. 2004
  7. ncbi Identification of mouse and human macrophages as a site of synthesis of hepatic lipase
    Herminia Gonzalez-Navarro
    Molecular Disease Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 43:671-5. 2002
  8. ncbi Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations
    Federica Basso
    Molecular Disease Branch, NHLBI, National Institutes of Health, Bethesda, MD 20862, USA
    J Lipid Res 44:296-302. 2003
  9. ncbi Lipid levels in sickle-cell disease associated with haemolytic severity, vascular dysfunction and pulmonary hypertension
    Suzana Zorca
    Pulmonary and Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Br J Haematol 149:436-45. 2010
  10. ncbi Histone tail-independent chromatin binding activity of recombinant cohesin holocomplex
    Alexander Kagansky
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:3382-8. 2004

Collaborators

Detail Information

Publications13

  1. ncbi Lipolytic and ligand-binding functions of hepatic lipase protect against atherosclerosis in LDL receptor-deficient mice
    Lita Freeman
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 48:104-13. 2007
    ..These changes, evident even in the presence of apoE, establish an antiatherogenic role of the ligand-binding function of HL in LDLr-deficient mice...
  2. ncbi The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter
    Lita A Freeman
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 45:1197-206. 2004
    ....
  3. ncbi Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice
    Justina E Wu
    Molecular Disease Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:22913-25. 2004
    ..These findings demonstrate that overexpression of ABCG5/G8 in the liver profoundly alters hepatic but not intestinal sterol transport, identifying distinct roles for liver and intestinal ABCG5/G8 in modulating sterol metabolism...
  4. ncbi Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice
    Zengxuan Nong
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 112:367-78. 2003
    ....
  5. ncbi Study of ABCA1 function in transgenic mice
    Charles Joyce
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Arterioscler Thromb Vasc Biol 23:965-71. 2003
    ..The present review summarizes the most recent studies and discusses insights provided by these transgenic mouse models...
  6. ncbi Hepatic lipase, lipoprotein metabolism, and atherogenesis
    Silvia Santamarina-Fojo
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Arterioscler Thromb Vasc Biol 24:1750-4. 2004
    ....
  7. ncbi Identification of mouse and human macrophages as a site of synthesis of hepatic lipase
    Herminia Gonzalez-Navarro
    Molecular Disease Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 43:671-5. 2002
    ..These combined findings establish that HL is synthesized de novo by macrophages as well as liver, and raises the possibility that HL may have a direct role in the pathogenesis of atherosclerosis...
  8. ncbi Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations
    Federica Basso
    Molecular Disease Branch, NHLBI, National Institutes of Health, Bethesda, MD 20862, USA
    J Lipid Res 44:296-302. 2003
    ..These combined results demonstrate that ABCA1 plays a key role in hepatic cholesterol efflux, inducing pathways that modulate cholesterol homeostasis in the liver, and establish the liver as a major source of plasma HDL-C...
  9. ncbi Lipid levels in sickle-cell disease associated with haemolytic severity, vascular dysfunction and pulmonary hypertension
    Suzana Zorca
    Pulmonary and Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Br J Haematol 149:436-45. 2010
    ..05). These results characterize elevated plasma triglyceride levels as a potential risk factor for PH in SCD...
  10. ncbi Histone tail-independent chromatin binding activity of recombinant cohesin holocomplex
    Alexander Kagansky
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:3382-8. 2004
    ..Histone tails and ATP are dispensable for cohesin binding to chromatin in this reaction. A model for cohesin association with chromatin is proposed...
  11. ncbi Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster
    Alan T Remaley
    National Heart, Lung and Blood Institute, National Institutes of Health, Bldg 10 2C 433, 10 Center Drive, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 295:276-82. 2002
    ..In summary, several potential regulatory elements were found for the ABCG5 and ABCG8 genes, and the intergenic region was found to act as a bidirectional promoter...
  12. ncbi Apolipoprotein A-I and serum amyloid A plasma levels are biomarkers of acute painful episodes in patients with sickle cell disease
    Ashaunta Tumblin
    Pulmonary Brance, National Heart, Lung and Blood Institute, Bethesda, MD, USA
    Haematologica 95:1467-72. 2010
    ..Acute painful episodes are the clinical hallmark of sickle cell disease and have been linked to morbidity and mortality in the sickle cell population...
  13. ncbi High-density lipoprotein cholesterol efflux, nitration of apolipoprotein A-I, and endothelial function in obese women
    Edward Vazquez
    Cardiovascular Pulmonary Branch, Proteomics Core Facility and Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Cardiol 109:527-32. 2012
    ..This finding suggests that the functional measures of HDL might be better markers for cardiovascular risk than the HDL cholesterol levels in this population...