A F Freeman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Kawasaki disease: summary of the American Heart Association guidelines
    Alexandra F Freeman
    National Institutes of Health, Bethesda, Maryland, USA
    Am Fam Physician 74:1141-8. 2006
  2. ncbi request reprint Coronary artery aneurysms in patients with hyper IgE recurrent infection syndrome
    Jennifer C Ling
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Immunol 122:255-8. 2007
  3. ncbi request reprint Hyper IgE syndrome: review and future directions
    Alexandra F Freeman
    National Institute of Allergy and Infectious Disease, National Institutes of Health, Building 10, CRC B3 4141, MSC 1684, Bethesda, MD 20892 1684, USA
    Expert Rev Clin Immunol 1:645-51. 2005
  4. doi request reprint Lung parenchyma surgery in autosomal dominant hyper-IgE syndrome
    Alexandra F Freeman
    Laboratory of Clinical Infectious Diseases, NIAID, NIH, NIH Building 10 Room 11 N234, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Clin Immunol 33:896-902. 2013
  5. pmc Intrathoracic nontuberculous mycobacterial infections in otherwise healthy children
    Alexandra F Freeman
    SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 27102, USA
    Pediatr Pulmonol 44:1051-6. 2009
  6. ncbi request reprint Pneumocystis jiroveci infection in patients with hyper-immunoglobulin E syndrome
    Alexandra F Freeman
    National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Pediatrics 118:e1271-5. 2006
  7. ncbi request reprint Angiogenesis in fatal acute Kawasaki disease coronary artery and myocardium
    A F Freeman
    Department of Pediatrics, Feinberg School of Medicine, Northwestern University, W140, Ward 12 204, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Pediatr Cardiol 26:578-84. 2005
  8. doi request reprint Antimicrobial prophylaxis for primary immunodeficiencies
    Alexandra F Freeman
    Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
    Curr Opin Allergy Clin Immunol 9:525-30. 2009
  9. pmc Clinical manifestations of hyper IgE syndromes
    Alexandra F Freeman
    Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, MD, USA
    Dis Markers 29:123-30. 2010
  10. doi request reprint Coronary artery abnormalities in Hyper-IgE syndrome
    Alexandra F Freeman
    Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases NIAID, 10 Center Drive, Bethesda, MD 20892 1899, USA
    J Clin Immunol 31:338-45. 2011

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Kawasaki disease: summary of the American Heart Association guidelines
    Alexandra F Freeman
    National Institutes of Health, Bethesda, Maryland, USA
    Am Fam Physician 74:1141-8. 2006
    ..Kawasaki disease is the leading cause of acquired heart disease among children in developed countries. This article provides a summary of the diagnostic and treatment guidelines published by the American Heart Association...
  2. ncbi request reprint Coronary artery aneurysms in patients with hyper IgE recurrent infection syndrome
    Jennifer C Ling
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Immunol 122:255-8. 2007
    ..Further studies are necessary to determine the incidence, pathogenesis, and optimal therapy of these arterial abnormalities in HIES...
  3. ncbi request reprint Hyper IgE syndrome: review and future directions
    Alexandra F Freeman
    National Institute of Allergy and Infectious Disease, National Institutes of Health, Building 10, CRC B3 4141, MSC 1684, Bethesda, MD 20892 1684, USA
    Expert Rev Clin Immunol 1:645-51. 2005
    ..Identification of the genetic etiology or etiologies of this syndrome will allow for targeted therapies as well as great advances in understanding the connections between immunologic function and connective tissue...
  4. doi request reprint Lung parenchyma surgery in autosomal dominant hyper-IgE syndrome
    Alexandra F Freeman
    Laboratory of Clinical Infectious Diseases, NIAID, NIH, NIH Building 10 Room 11 N234, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Clin Immunol 33:896-902. 2013
    ..Healing of pneumonias is often abnormal with formation of pneumatoceles and bronchiectasis. We aimed to explore whether healing after lung surgery is also aberrant...
  5. pmc Intrathoracic nontuberculous mycobacterial infections in otherwise healthy children
    Alexandra F Freeman
    SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 27102, USA
    Pediatr Pulmonol 44:1051-6. 2009
    ..It does not appear to be associated with recognized underlying immune deficiency or CFTR mutations...
  6. ncbi request reprint Pneumocystis jiroveci infection in patients with hyper-immunoglobulin E syndrome
    Alexandra F Freeman
    National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Pediatrics 118:e1271-5. 2006
    ..Our experience suggests that P. jiroveci can cause pneumonia in patients with hyper-immunoglobulin E syndrome both with and without chronic lung disease...
  7. ncbi request reprint Angiogenesis in fatal acute Kawasaki disease coronary artery and myocardium
    A F Freeman
    Department of Pediatrics, Feinberg School of Medicine, Northwestern University, W140, Ward 12 204, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Pediatr Cardiol 26:578-84. 2005
    ....
  8. doi request reprint Antimicrobial prophylaxis for primary immunodeficiencies
    Alexandra F Freeman
    Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
    Curr Opin Allergy Clin Immunol 9:525-30. 2009
    ..Antibiotic prophylaxis is one of the mainstays of therapy of primary immunodeficiencies. We aim to summarize what is known about antibiotic prophylaxis for select primary immunodeficiencies...
  9. pmc Clinical manifestations of hyper IgE syndromes
    Alexandra F Freeman
    Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, MD, USA
    Dis Markers 29:123-30. 2010
    ..The identification of these genetic etiologies is leading to advances in understanding the pathogenesis of these syndromes with the goal of improving treatment...
  10. doi request reprint Coronary artery abnormalities in Hyper-IgE syndrome
    Alexandra F Freeman
    Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases NIAID, 10 Center Drive, Bethesda, MD 20892 1899, USA
    J Clin Immunol 31:338-45. 2011
    ..Coronary artery abnormalities have been reported infrequently. We aimed to determine the frequency and characteristics of coronary artery abnormalities...
  11. doi request reprint Hyper IgE (Job's) syndrome: a primary immune deficiency with oral manifestations
    A F Freeman
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Oral Dis 15:2-7. 2009
    ..In this review, we discuss the clinical phenotype of HIES including immunologic and non-immunologic features, the genetics of HIES, and treatment...
  12. pmc Acupuncture for symptom management in patients with hyper-IgE (Job's) syndrome
    Adeline X Y Ge
    National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892, USA
    J Altern Complement Med 17:71-6. 2011
    ..The objective of this study was to investigate the effects of acupuncture treatment for symptom management in patients with hyper-immunoglobulin E (IgE) syndrome (HIES)...
  13. doi request reprint Coronary abnormalities in hyper-IgE recurrent infection syndrome: depiction at coronary MDCT angiography
    Ahmed M Gharib
    Department of Radiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Clinical Research Center, Bethesda, MD 20892, USA
    AJR Am J Roentgenol 193:W478-81. 2009
    ..The purpose of this study is to describe the coronary abnormalities in genetically confirmed HIES patients as depicted by coronary MDCT angiography (MDCTA)...
  14. ncbi request reprint STAT3 mutations in the hyper-IgE syndrome
    Steven M Holland
    National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    N Engl J Med 357:1608-19. 2007
    ..Inheritance is autosomal dominant; sporadic cases are also found...
  15. ncbi request reprint Recent developments in Kawasaki disease
    A F Freeman
    Department of Pediatrics, The Children s Memorial Hospital, Northwestern University Medical School, Chicago, Illinois 60614 3363, USA
    Curr Opin Infect Dis 14:357-61. 2001
    ..The recent advances in Kawasaki disease are helping to provide some clues in the etiology, pathogenesis and therapy for Kawasaki disease...
  16. doi request reprint Novel intraoral phenotypes in hyperimmunoglobulin-E syndrome
    D L Domingo
    National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    Oral Dis 14:73-81. 2008
    ..This study aims to characterize intraoral soft tissue findings in HIES patients...
  17. ncbi request reprint Streptococcus pneumoniae empyema necessitatis
    Alexandra F Freeman
    Department of Pediatrics, The Feinberg School of Medicine, Northwestern University, Children s Memorial Hospital, Chicago, IL, USA
    Pediatr Infect Dis J 23:177-9. 2004
    ..The most common etiologies are tuberculosis and actinomycosis. We describe a 1-year-old boy with Streptococcus pneumoniae empyema necessitatis and review previously reported cases...
  18. doi request reprint Hyper IgE syndrome: an update on clinical aspects and the role of signal transducer and activator of transcription 3
    Michelle L Paulson
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA
    Curr Opin Allergy Clin Immunol 8:527-33. 2008
    ..We present newly recognized aspects of the clinical phenotype and discuss recent genetic and immunologic findings...
  19. pmc Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia
    Donald C Vinh
    Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 115:1519-29. 2010
    ..This novel clinical syndrome links susceptibility to mycobacterial, viral, and fungal infections with malignancy and can be transmitted in an autosomal dominant pattern...
  20. pmc Diverticulitis in a young man with hyper-IgE syndrome
    Daniel G Stover
    Department of Medicine and Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    South Med J 103:1261-3. 2010
    ..Although the majority of complications are sinopulmonary and skin infections, diverticulitis should be considered in the differential of intra-abdominal processes in HIES...
  21. pmc Combined immunodeficiency associated with DOCK8 mutations
    Qian Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 361:2046-55. 2009
    ..Recurrent sinopulmonary and cutaneous viral infections with elevated serum levels of IgE are features of some variants of combined immunodeficiency. The genetic causes of these variants are unknown...
  22. pmc Chronic invasive aspergillosis caused by Aspergillus viridinutans
    Donald C Vinh
    National Institutes of Health, Bethesda, Maryland 20892 1684, USA
    Emerg Infect Dis 15:1292-4. 2009
    ..Disease was distinct from typical aspergillosis, being chronic and spreading in a contiguous manner across anatomical planes. We emphasize the recognition of fumigati-mimetic molds as agents of chronic or refractory aspergillosis...
  23. ncbi request reprint Macrolide resistance in group A Streptococcus
    Alexandra F Freeman
    Feinburg School of Medicine, Northwestern University, Chicago, IL, USA
    Pediatr Infect Dis J 21:1158-60. 2002
  24. ncbi request reprint Refractory Kawasaki disease
    Alexandra F Freeman
    Children s Memorial Hospital, Feinberg School of Medicine of Northwestern University, Chicago, IL, USA
    Pediatr Infect Dis J 23:463-4. 2004
  25. ncbi request reprint A new complication of stem cell transplantation: measles inclusion body encephalitis
    Alexandra F Freeman
    Division of Infectious Disease, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital, 2300 Children s Plaza, Chicago, IL 60614, USA
    Pediatrics 114:e657-60. 2004
    ..In addition, this case demonstrates the utility of brain biopsy in the diagnosis of encephalitis of unknown cause in the immunocompromised host...
  26. ncbi request reprint Linezolid-resistant Staphylococcus aureus in two pediatric patients receiving low-dose linezolid therapy
    Susanne M Roberts
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892, USA
    Pediatr Infect Dis J 25:562-4. 2006
    ..LZD-susceptible S. aureus was isolated 2 months after LZD discontinuation. LZD-resistant S. aureus remains rare but may occur while receiving suppressive therapy...
  27. ncbi request reprint Persistent bacterial infections and primary immune disorders
    Alexandra F Freeman
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1684, USA
    Curr Opin Microbiol 10:70-5. 2007
    ..Exploration of these particular infections in their specific immune defects sheds light on both host and bacterial mechanisms that have implications for pathogenesis and therapy...
  28. pmc The hyper-IgE syndromes
    Alexandra F Freeman
    Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Disease, Building 10, CRC B3 4141, MSC 1684, 9000 Rockville Pike, Bethesda, MD 20892 1684, USA
    Immunol Allergy Clin North Am 28:277-91, viii. 2008
    ..The new and evolving genetic and immunologic understandings of this previously elusive set of diseases should lead to more effective disease-specific therapies...
  29. doi request reprint Invasive aspergillosis due to Neosartorya udagawae
    Donald C Vinh
    Sections of Immunopathogenesis, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD 20892 1684, USA
    Clin Infect Dis 49:102-11. 2009
    ..However, genetic-based methods indicate that organisms phenotypically identified as A. fumigatus actually constitute a mold complex, designated Aspergillus section fumigati subgenus fumigati...
  30. ncbi request reprint Is noma neonatorum a presentation of ecthyma gangrenosum in the newborn?
    Alexandra F Freeman
    Pediatric Infectious Disease Division, Children s Memorial Hospital, Northwestern University Medical School, Chicago, IL, USA
    Pediatr Infect Dis J 21:83-5. 2002
    ..Our case is consistent with previous descriptions of noma neonatorum; however, we question the distinction between noma neonatorum and a neonatal presentation of ecthyma gangrenosum...
  31. ncbi request reprint Inflammatory pulmonary nodules in Kawasaki disease
    Alexandra F Freeman
    Department of Pediatrics, Feinberg School of Medicine, Chicago, Illinois, USA
    Pediatr Pulmonol 36:102-6. 2003
    ..Recognition of this pulmonary complication of KD may enable cautious observation of such lesions for spontaneous resolution...