Research Topics
Genomes and Genes
Species | N D FreedmanSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Association of coffee drinking with total and cause-specific mortalityNeal D Freedman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
N Engl J Med 366:1891-904. 2012..Coffee is one of the most widely consumed beverages, but the association between coffee consumption and the risk of death remains unclear...- Alcohol and head and neck cancer risk in a prospective studyN D Freedman
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Executive Plaza North, Suite 3109, 6130 Executive Boulevard, MSC 7361, Bethesda, MD 20892 7361, USA
Br J Cancer 96:1469-74. 2007..7), men (34.4). In summary, drinking >3 alcoholic beverages per day was associated with increased risk in men and women, but consumption of up to one drink per day may be associated with reduced risk relative to non-drinking... - Coffee intake is associated with lower rates of liver disease progression in chronic hepatitis CNeal D Freedman
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
Hepatology 50:1360-9. 2009..Tea intake was not associated with outcomes. CONCLUSION: In a large prospective study of participants with advanced hepatitis C-related liver disease, regular coffee consumption was associated with lower rates of disease progression... - The association of menstrual and reproductive factors with upper gastrointestinal tract cancers in the NIH-AARP cohortNeal D Freedman
Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, 6120 Executive Blvd, EPS 320, MSC 7232, Rockville, MD 20852, USA
Cancer 116:1572-81. 2010..Established risk factors do not appear to explain these differences, suggesting a possible role for sex hormones... - Association of meat and fat intake with liver disease and hepatocellular carcinoma in the NIH-AARP cohortNeal D Freedman
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd, Rockville, MD 20852, USA
J Natl Cancer Inst 102:1354-65. 2010..Several plausible mechanisms, including fat, iron, heterocyclic amines, and N-nitroso compounds, link meat intake with chronic liver disease (CLD) and hepatocellular carcinoma (HCC). Few studies have investigated these associations... - Silymarin use and liver disease progression in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis trialN D Freedman
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
Aliment Pharmacol Ther 33:127-37. 2011..Silymarin is the most commonly used herbal product for chronic liver disease; yet, whether silymarin protects against liver disease progression remains unclear... - Coffee consumption is associated with response to peginterferon and ribavirin therapy in patients with chronic hepatitis CNeal D Freedman
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
Gastroenterology 140:1961-9. 2011..However, its relationship with therapy for hepatitis C virus infection has not been evaluated... - Alcohol intake and risk of oesophageal adenocarcinoma: a pooled analysis from the BEACON ConsortiumNeal D Freedman
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Rockville, MD 20852, USA
Gut 60:1029-37. 2011..Therefore, the association of alcohol intake with OSCC, OA, and OGJA was determined in nine case-control studies and two cohort studies of the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium (BEACON)... - Association between smoking and risk of bladder cancer among men and womenNeal D Freedman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd, EPS 320, MSC 7232, Rockville, MD 20852, USA
JAMA 306:737-45. 2011..2 per 100,000 person-years) and women (32.5 per 100,000 person-years to 33.2 per 100,000 person-years); however, changing smoking prevalence and cigarette composition warrant revisiting risk estimates for smoking and bladder cancer... - Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancerNeal D Freedman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA
Carcinogenesis 30:71-7. 2009..These findings should be interpreted cautiously until replicated in other studies... - Cigarette smoking and subsequent risk of lung cancer in men and women: analysis of a prospective cohort studyNeal D Freedman
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 6120 ExecutiveBoulevard, MSC 7232, Rockville, MD 20852, USA
Lancet Oncol 9:649-56. 2008..To address this question, we aimed to compare incidence rates of lung cancer by stratum of smoking use in men and women of the National Institutes of Health (NIH)-AARP cohort... 
Fruit and vegetable intake and gastric cancer risk in a large United States prospective cohort studyNeal D Freedman
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Cancer Causes Control 19:459-67. 2008..Fruit and vegetable intake may protect against gastric cancer incidence. Results from case-control studies have indicated an inverse association, but results from cohort studies are inconsistent...- Menstrual and reproductive factors and gastric cancer risk in a large prospective study of womenNeal D Freedman
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Gut 56:1671-7. 2007..Gastric cancer incidence rates are consistently lower in women than men in both high and low-risk regions worldwide. Sex hormones, such as progesterone and estrogen, may protect women against gastric cancer... 
A prospective study of tobacco, alcohol, and the risk of esophageal and gastric cancer subtypesNeal D Freedman
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Am J Epidemiol 165:1424-33. 2007..93, 95% CI: 2.69, 9.03) but not risk for esophageal, gastric cardia, or gastric noncardia adenocarcinoma...- Male predominance of upper gastrointestinal adenocarcinoma cannot be explained by differences in tobacco smoking in men versus womenN D Freedman
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA
Eur J Cancer 46:2473-8. 2010..As smoking is a well-established risk factor, we investigated the role of tobacco smoking in the male predominance of UGI adenocarcinomas in the United States NIH-AARP Diet and Health Study... - Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysisC C Abnet
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
Br J Cancer 100:551-7. 2009..64 (0.52-0.80), 0.82 (0.65-1.04), and 0.64 (0.52-0.79), respectively. The corresponding numbers for other NSAIDs were 0.68 (0.57-0.81), 0.80 (0.67-0.95), and 0.65 (0.50-0.85), respectively... - Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort studyNeal D Freedman
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Int J Cancer 122:2330-6. 2008..Results from this large prospective observational study are consistent with previous case-control studies and support the hypothesis that total fruit and vegetable intake is associated with reduced risk of head and neck cancer... - Fruit and vegetable intake and esophageal cancer in a large prospective cohort studyNeal D Freedman
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Int J Cancer 121:2753-60. 2007..A significant inverse association between EAC and Chenopodiaceae (spinach) intake was observed. Results from our study suggest that the relation of fruit and vegetable intake and esophageal cancer risk may vary by histologic type... - Tea, coffee, carbonated soft drinks and upper gastrointestinal tract cancer risk in a large United States prospective cohort studyJ S Ren
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States
Eur J Cancer 46:1873-81. 2010..In summary, hot tea intake was inversely associated with pharyngeal cancer, and coffee was directly associated with gastric cardia cancer, but was inversely associated with EADC during some follow-up periods... - Prospective investigation of the cigarette smoking-head and neck cancer association by sexNeal D Freedman
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Rockville, Maryland 20852, USA
Cancer 110:1593-601. 2007..Very few prospective studies have examined the association between cigarette smoking and cancers of the head and neck in women, even though the rates of smoking in women are increasing rapidly worldwide... - Physical activity and esophageal and gastric carcinoma in a large prospective studyMichael F Leitzmann
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Am J Prev Med 36:112-9. 2009..Few studies have investigated the relationship of physical activity to esophageal and gastric carcinoma according to histology and anatomic site... - Alcohol and risk of breast cancer by histologic type and hormone receptor status in postmenopausal women: the NIH-AARP Diet and Health StudyJasmine Q Lew
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Rockville, MD 20852, USA
Am J Epidemiol 170:308-17. 2009..13 (95% CI: 0.73, 1.77) for >20 g versus 0 g/day, and 1.21 (95% CI: 0.79, 1.84) for >20 g versus 0 g/day, respectively. Moderate consumption of alcohol was associated with breast cancer, specifically hormone receptor-positive tumors... - Prospective study of physical activity and lung cancer by histologic type in current, former, and never smokersMichael F Leitzmann
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
Am J Epidemiol 169:542-53. 2009..The inverse findings among former and current smokers in combination with the null results for physical activity among never smokers may point toward residual confounding by cigarette smoking as an explanation for the relations observed... - A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinomaChristian C Abnet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Nat Genet 42:764-7. 2010..19 x 10(-15); OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China... - Prospective study of self-reported diabetes and risk of upper gastrointestinal cancersShih Wen Lin
Cancer Prevention Fellowship Program, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 20:954-61. 2011..Obesity increases the risks of GCA and EADC, and the associations may be partially mediated by insulin resistance. A few case-control studies have shown an association between diabetes and an increased risk of EADC... - Cigarette smoking and adenocarcinomas of the esophagus and esophagogastric junction: a pooled analysis from the international BEACON consortiumMichael B Cook
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Blvd, Bethesda, MD 20852 7234, USA
J Natl Cancer Inst 102:1344-53. 2010.... - Vitamin E intake and risk of esophageal and gastric cancers in the NIH-AARP Diet and Health StudySarah Carman
NEB DCEG, National Cancer Institute, Bethesda, MD 20892 7232, USA
Int J Cancer 125:165-70. 2009..An increase of 71 mg/day (half the interquartile range) in supplemental vitamin E had an hazard ratio (95% confidence interval) of 0.92 (0.85-1.00) and the p value for trend in the quartile analysis was 0.015... - A prospective study of BMI and risk of oesophageal and gastric adenocarcinomaChristian C Abnet
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, United States
Eur J Cancer 44:465-71. 2008..84 (0.50-1.42). Using non-linear models, we found that higher BMI was associated with increased risk of EADC even within the normal BMI. Increased adiposity was associated with higher risk of EADC even within the normal weight range... - Sex disparities in cancer incidence by period and ageMichael B Cook
National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20852 7234, USA
Cancer Epidemiol Biomarkers Prev 18:1174-82. 2009..Cancer epidemiology articles often point out that cancer rates tend to be higher among males than females yet rarely is this theme the subject of investigation... - Vitamin D-related genes, serum vitamin D concentrations and prostate cancer riskJiyoung Ahn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Carcinogenesis 30:769-76. 2009..Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status... - Physical activity and head and neck cancer riskMichael F Leitzmann
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cancer Causes Control 19:1391-9. 2008..To investigate the relation of physical activity to head and neck cancer... - Neighborhood socioeconomic deprivation and mortality: NIH-AARP diet and health studyJacqueline M Major
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
PLoS ONE 5:e15538. 2010.... - Meat consumption and risk of esophageal and gastric cancer in a large prospective studyAmanda J Cross
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
Am J Gastroenterol 106:432-42. 2011..Although there have been multiple studies of meat and colorectal cancer, other gastrointestinal malignancies are understudied... - Intakes of fruit, vegetables, and specific botanical groups in relation to lung cancer risk in the NIH-AARP Diet and Health StudyMargaret E Wright
Department of Pathology MC 847, College of Medicine, University of Illinois at Chicago, 840 South Wood Street, Room 130, Chicago, IL 60612, USA
Am J Epidemiol 168:1024-34. 2008..06). These results provide support for a protective role of specific botanical subgroups of fruits and vegetables in lung cancer prevention in men, although the findings could also be due to residual confounding by smoking or chance...