Jonathan Freedman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Effects of genetic mutations and chemical exposures on Caenorhabditis elegans feeding: evaluation of a novel, high-throughput screening assay
    Windy A Boyd
    Laboratory of Molecular Toxicology, National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 2:e1259. 2007
  2. pmc Global transcriptome and deletome profiles of yeast exposed to transition metals
    Yong Hwan Jin
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina, United States of America
    PLoS Genet 4:e1000053. 2008
  3. pmc Application of a mathematical model to describe the effects of chlorpyrifos on Caenorhabditis elegans development
    Windy A Boyd
    Biomoleclular Screening Branch, National Toxicology Program, Research Triangle Park, North Carolina, USA
    PLoS ONE 4:e7024. 2009
  4. pmc A discrete time model for the analysis of medium-throughput C. elegans growth data
    Marjolein V Smith
    SRA International, Durham, North Carolina, USA
    PLoS ONE 4:e7018. 2009
  5. pmc Cadmium induces transcription independently of intracellular calcium mobilization
    Brooke E Tvermoes
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e20542. 2011
  6. pmc Comparative toxicogenomic responses of mercuric and methyl-mercury
    Matthew K McElwee
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, 111 T, W Alexander Drive, Research Triangle Park, P, O, Box 12233, 27709 Durham, NC, USA
    BMC Genomics 14:698. 2013
  7. pmc Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity
    Yuxia Cui
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, NC 27708, USA
    Genome Biol 8:R122. 2007

Research Grants

  1. REGULATION OF CADMIUM INDUCIBLE GENE EXPRESSION
    Jonathan Freedman; Fiscal Year: 1999
  2. REGULATION OF CADMIUM INDUCIBLE GENE EXPRESSION
    Jonathan Freedman; Fiscal Year: 2003

Collaborators

  • Grace E Kissling
  • Jeff W Chou
  • Scott Alper
  • Windy A Boyd
  • Marjolein V Smith
  • Sandra J McBride
  • Matthew K McElwee
  • Brooke E Tvermoes
  • Christopher J Portier
  • Daniel W Snyder
  • Julie R Rice
  • Yong Hwan Jin
  • Yuxia Cui
  • Lindsey A Ho
  • Gary S Bird
  • Paul E Dunlap
  • Hanan Al-Refai
  • Pierre R Bushel

Detail Information

Publications7

  1. pmc Effects of genetic mutations and chemical exposures on Caenorhabditis elegans feeding: evaluation of a novel, high-throughput screening assay
    Windy A Boyd
    Laboratory of Molecular Toxicology, National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 2:e1259. 2007
    ..elegans pharynx is a favorable model for studying neuromuscular function, and the effects of chemicals on neuromuscular activity, i.e., feeding. Current feeding methodologies, however, are labor intensive and only semi-quantitative...
  2. pmc Global transcriptome and deletome profiles of yeast exposed to transition metals
    Yong Hwan Jin
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina, United States of America
    PLoS Genet 4:e1000053. 2008
    ....
  3. pmc Application of a mathematical model to describe the effects of chlorpyrifos on Caenorhabditis elegans development
    Windy A Boyd
    Biomoleclular Screening Branch, National Toxicology Program, Research Triangle Park, North Carolina, USA
    PLoS ONE 4:e7024. 2009
    ..Chlorpyrifos, an organophosphate pesticide known to cause developmental delays and malformations in mammals, was used as a model toxicant to test the applicability of the growth model for in vivo toxicological testing...
  4. pmc A discrete time model for the analysis of medium-throughput C. elegans growth data
    Marjolein V Smith
    SRA International, Durham, North Carolina, USA
    PLoS ONE 4:e7018. 2009
    ..The use of this technology requires the development of mathematical and statistical tools to properly analyze the large volumes of biological data...
  5. pmc Cadmium induces transcription independently of intracellular calcium mobilization
    Brooke E Tvermoes
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e20542. 2011
    ..This hypothesis is based on several studies that may be technically problematic; including the use of BAPTA chelators, BAPTA-based fluorescent sensors, and cytotoxic concentrations of metal...
  6. pmc Comparative toxicogenomic responses of mercuric and methyl-mercury
    Matthew K McElwee
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, 111 T, W Alexander Drive, Research Triangle Park, P, O, Box 12233, 27709 Durham, NC, USA
    BMC Genomics 14:698. 2013
    ..Mercury is a ubiquitous environmental toxicant that exists in multiple chemical forms. A paucity of information exists regarding the differences or similarities by which different mercurials act at the molecular level...
  7. pmc Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity
    Yuxia Cui
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, NC 27708, USA
    Genome Biol 8:R122. 2007
    ..Exposure to cadmium is associated with a variety of human diseases. At low concentrations, cadmium activates the transcription of stress-responsive genes, which can prevent or repair the adverse effects caused by this metal...

Research Grants5

  1. REGULATION OF CADMIUM INDUCIBLE GENE EXPRESSION
    Jonathan Freedman; Fiscal Year: 1999
    ..elegans studies will be applicable to understanding how cadmium influences human health because of the evolutionarily conserved nature of signal transduction pathways and regulatory mechanisms controlling gene transcription. ..
  2. REGULATION OF CADMIUM INDUCIBLE GENE EXPRESSION
    Jonathan Freedman; Fiscal Year: 2003
    ..elegans studies will be applicable to understanding how cadmium influences human health because of the evolutionarily conserved nature of signal transduction pathways and regulatory mechanisms controlling gene transcription. ..