Genoveffa Franchini

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc International Retrovirology Association brings together scientists and clinicians to bridge discoveries about human T-lymphotropic viruses from the laboratory to clinical trials
    Edward Murphy
    Laboratory Medicine and Epidemiology Biostatistics, University of California at San Francisco and Blood Systems Research Institute, San Francisco, California, USA
    Retrovirology 2:22. 2005
  2. pmc CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques
    Anna Hryniewicz
    NCI, Bldg 41 Rm D 804, Bethesda, MD 20892 5065, USA
    Blood 108:3834-42. 2006
  3. ncbi request reprint Immune intervention strategies for HIV-1 infection of humans in the SIV macaque model
    Genoveffa Franchini
    National Cancer Institute, Basic Research Laboratory, 41 D804, Bethesda, MD 20892 5055, USA
    Vaccine 20:A52-60. 2002
  4. ncbi request reprint Poxvirus-based vaccine candidates for HIV: two decades of experience with special emphasis on canarypox vectors
    Genoveffa Franchini
    Animal Models Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892 5065, USA
    Expert Rev Vaccines 3:S75-88. 2004
  5. ncbi request reprint T-cell control by human T-cell leukemia/lymphoma virus type 1
    Genoveffa Franchini
    Basic Research Laboratory, National Cancer Institute, Bethesda, Maryland 20892 5055, USA
    Int J Hematol 78:280-96. 2003
  6. ncbi request reprint Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques
    Anna Hryniewicz
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Building 41, Bethesda, MD 20892, USA
    J Immunol 178:3492-504. 2007
  7. ncbi request reprint Avipox-based simian immunodeficiency virus (SIV) vaccines elicit a high frequency of SIV-specific CD4+ and CD8+ T-cell responses in vaccinia-experienced SIVmac251-infected macaques
    Janos Nacsa
    Basic Research Laboratory, National Cancer Institute, 41 D804 Bethesda, MD 20892 5055, USA
    Vaccine 22:597-606. 2004
  8. ncbi request reprint Contrasting effects of low-dose IL-2 on vaccine-boosted simian immunodeficiency virus (SIV)-specific CD4+ and CD8+ T cells in macaques chronically infected with SIVmac251
    Janos Nacsa
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 174:1913-21. 2005
  9. pmc Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbits
    Valerio W Valeri
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892 5065, USA
    Blood 116:3809-17. 2010
  10. pmc Reduced protection from simian immunodeficiency virus SIVmac251 infection afforded by memory CD8+ T cells induced by vaccination during CD4+ T-cell deficiency
    Monica Vaccari
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bldg 41, Room D804, Bethesda, MD 20892, USA
    J Virol 82:9629-38. 2008

Detail Information

Publications83

  1. pmc International Retrovirology Association brings together scientists and clinicians to bridge discoveries about human T-lymphotropic viruses from the laboratory to clinical trials
    Edward Murphy
    Laboratory Medicine and Epidemiology Biostatistics, University of California at San Francisco and Blood Systems Research Institute, San Francisco, California, USA
    Retrovirology 2:22. 2005
    ....
  2. pmc CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques
    Anna Hryniewicz
    NCI, Bldg 41 Rm D 804, Bethesda, MD 20892 5065, USA
    Blood 108:3834-42. 2006
    ..Therefore, blunting T(reg) function in macaques infected with SIV did not have detrimental virologic effects and may provide a valuable approach to complement ART and therapeutic vaccination in the treatment of HIV-1 infection...
  3. ncbi request reprint Immune intervention strategies for HIV-1 infection of humans in the SIV macaque model
    Genoveffa Franchini
    National Cancer Institute, Basic Research Laboratory, 41 D804, Bethesda, MD 20892 5055, USA
    Vaccine 20:A52-60. 2002
    ..Here, we will review the relative effect of ART and vaccination during primary SIVmac infection of macaques...
  4. ncbi request reprint Poxvirus-based vaccine candidates for HIV: two decades of experience with special emphasis on canarypox vectors
    Genoveffa Franchini
    Animal Models Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892 5065, USA
    Expert Rev Vaccines 3:S75-88. 2004
    ....
  5. ncbi request reprint T-cell control by human T-cell leukemia/lymphoma virus type 1
    Genoveffa Franchini
    Basic Research Laboratory, National Cancer Institute, Bethesda, Maryland 20892 5055, USA
    Int J Hematol 78:280-96. 2003
    ..The relevance of these laboratory findings is related to clonal T-cell proliferation and adult T-cell leukemia/lymphoma development in vivo...
  6. ncbi request reprint Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques
    Anna Hryniewicz
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Building 41, Bethesda, MD 20892, USA
    J Immunol 178:3492-504. 2007
    ..These results underscore the importance of testing immunomodulatory approaches in vivo to assess potential risks and benefits for HIV-1-infected individuals...
  7. ncbi request reprint Avipox-based simian immunodeficiency virus (SIV) vaccines elicit a high frequency of SIV-specific CD4+ and CD8+ T-cell responses in vaccinia-experienced SIVmac251-infected macaques
    Janos Nacsa
    Basic Research Laboratory, National Cancer Institute, 41 D804 Bethesda, MD 20892 5055, USA
    Vaccine 22:597-606. 2004
    ....
  8. ncbi request reprint Contrasting effects of low-dose IL-2 on vaccine-boosted simian immunodeficiency virus (SIV)-specific CD4+ and CD8+ T cells in macaques chronically infected with SIVmac251
    Janos Nacsa
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 174:1913-21. 2005
    ..Thus, we conclude that the decrease in virus-specific CD4+ T cell response may be due to IL-2-promoted redistribution of cells from the circulation, or due to Ag-induced cell death, rather than suppression by a T regulatory population...
  9. pmc Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbits
    Valerio W Valeri
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892 5065, USA
    Blood 116:3809-17. 2010
    ..These data suggest that infection of dendritic cells may be required for the establishment and maintenance of HTLV-1 infection in primate species...
  10. pmc Reduced protection from simian immunodeficiency virus SIVmac251 infection afforded by memory CD8+ T cells induced by vaccination during CD4+ T-cell deficiency
    Monica Vaccari
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bldg 41, Room D804, Bethesda, MD 20892, USA
    J Virol 82:9629-38. 2008
    ....
  11. ncbi request reprint Modeling a safer smallpox vaccination regimen, for human immunodeficiency virus type 1-infected patients, in immunocompromised macaques
    Yvette Edghill-Smith
    Laboratory of Receptor Biology and Gene Expression, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 5055, USA
    J Infect Dis 188:1181-91. 2003
    ....
  12. pmc Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection
    Valentina Cecchinato
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892 5065, USA
    J Immunol 180:5439-47. 2008
    ..These data provide the first direct evidence that immune activation drives viral replication, and suggest caution in the use of therapeutic approaches for HIV infection in vivo that increase CD4(+) T cell proliferation...
  13. ncbi request reprint Functional simian immunodeficiency virus Gag-specific CD8+ intraepithelial lymphocytes in the mucosae of SIVmac251- or simian-human immunodeficiency virus KU2-infected macaques
    Liljana Stevceva
    Basic Research Laboratory, National Cancer Institute, 41 D804, Bethesda, MD 20892 5055, USA
    Virology 319:190-200. 2004
    ..Direct staining of tetramers also revealed their presence in intact tissue. These Gag-specific IELs expressed the activation marker CD69 and produced IFN-gamma, suggesting an active immune response in this locale...
  14. ncbi request reprint Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques
    Adriano Boasso
    Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:4313-20. 2009
    ..Further studies are required to elucidate the immunologic or virologic mechanism by which d-1mT inhibited SIV replication in vivo...
  15. pmc Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Virol 81:11593-603. 2007
    ..Increased T(reg) and IDO in LT of SIV-infected macaques may be the consequence of increased tissue inflammation and/or may favor virus replication during the chronic phase of SIV infection...
  16. ncbi request reprint Correlation between viral RNA levels but not immune responses in plasma and tissues of macaques with long-standing SIVmac251 infection
    Marcin Moniuszko
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, 41 D804, Bethesda, MD 20892, USA
    Virology 333:159-68. 2005
    ..These results may imply that there are differences in the immunological pressure exerted by cytotoxic T lymphocytes (CTLs) in tissue compartments of SIVmac251-infected macaques...
  17. ncbi request reprint Subunit recombinant vaccine protects against monkeypox
    Jean Michel Heraud
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 177:2552-64. 2006
    ..Their identification may guide future efforts to develop simpler, safer, and more effective vaccines for monkeypox and smallpox...
  18. ncbi request reprint Containment of simian immunodeficiency virus infection in vaccinated macaques: correlation with the magnitude of virus-specific pre- and postchallenge CD4+ and CD8+ T cell responses
    Zdenek Hel
    Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:4778-87. 2002
    ..The results presented in this work also further demonstrate the potential of a DNA-prime/attenuated poxvirus-boost vaccine regimen in an animal model that well mirrors human AIDS...
  19. ncbi request reprint Vaccination of macaques with long-standing SIVmac251 infection lowers the viral set point after cessation of antiretroviral therapy
    Elzbieta Tryniszewska
    Basic Research Laboratory, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 169:5347-57. 2002
    ..These data provide the proof of concept that therapeutic vaccination before cessation of ART may be a feasible approach in the clinical management of HIV-1 infection...
  20. pmc Impact of vaccine-induced mucosal high-avidity CD8+ CTLs in delay of AIDS viral dissemination from mucosa
    Igor M Belyakov
    Vaccine Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 107:3258-64. 2006
    ....
  21. ncbi request reprint Decreased number of CD4+ and CD8+ T cells that express the interleukin-7 receptor in blood and tissues of SIV-infected macaques
    Marcin Moniuszko
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, NCI, 41 D804, Bethesda, MD 20892 5065, USA
    Virology 356:188-97. 2006
    ..IL-7R(+) T cells within the SIV-specific CD8(+) T cells varied and were lowest in most tissues of viremic macaques, likely reflecting continuous antigen stimulation of effector cells...
  22. ncbi request reprint Improved vaccine protection from simian AIDS by the addition of nonstructural simian immunodeficiency virus genes
    Zdenek Hel
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 176:85-96. 2006
    ..These data provide the first clear evidence of the importance of nonstructural HIV Ags as components of an HIV-1 vaccine...
  23. doi request reprint HAART reduces death ligand but not death receptors in lymphoid tissue of HIV-infected patients and simian immunodeficiency virus-infected macaques
    Jean Philippe Herbeuval
    Experimental Immunology Branch, CCR, NCI, NIH, Bethesda, Maryland, USA
    AIDS 23:35-40. 2009
    ..To determine how antiretroviral therapy (ART) or HAART affects the expression of apoptotic ligands and their death receptors in the blood and lymphoid tissues of HIV-infected patients and simian immunodeficiency virus-infected macaques...
  24. pmc Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques
    Yongjun Sui
    Vaccine Branch, Biostatistics and Data Management Section, and Laboratory of Experimental Immunology, National Cancer Institute, and Laboratory of Host Defenses and Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:9843-8. 2010
    ..Thus, strategic use of molecular adjuvants can provide better mucosal protection through induction of both innate and adaptive immunity...
  25. pmc Smallpox vaccine safety is dependent on T cells and not B cells
    Shari N Gordon
    Animal Models and Retroviral Vaccines Section, 9000 Rockville Pike NCI, 41 D804, Bethesda, MD 20892 5065, USA
    J Infect Dis 203:1043-53. 2011
    ..As both Dryvax and LC16m8 vaccines protect healthy macaques from a lethal monkeypox intravenous challenge, our data identify LC16m8 as a safer and effective alternative to ACAM2000 and Dryvax vaccines for immunocompromised individuals...
  26. ncbi request reprint Smallpox vaccine does not protect macaques with AIDS from a lethal monkeypox virus challenge
    Yvette Edghill-Smith
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Infect Dis 191:372-81. 2005
    ..Thus, vaccination strategies that bypass CD4(+) cell help are needed to elicit IgG antibodies with high affinity and adequate tissue distribution and to restore protection against smallpox in severely immunocompromised individuals...
  27. pmc Preexisting infection with human T-cell lymphotropic virus type 2 neither exacerbates nor attenuates simian immunodeficiency virus SIVmac251 infection in macaques
    Shari N Gordon
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    J Virol 84:3043-58. 2010
    ..These data provide the impetus for the development of an attenuated HTLV-2-based vectored vaccine for HIV-1; this approach could elicit persistent mucosal immunity that may prevent HIV-1/SIV(mac251) infection...
  28. ncbi request reprint Vaccine-induced CD8+ central memory T cells in protection from simian AIDS
    Monica Vaccari
    Animal Models and Retroviral Vaccines Section and National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 175:3502-7. 2005
    ..We propose that effective preventive or therapeutic T cell vaccines for HIV-1 should induce long-term protective central memory T cells...
  29. pmc SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, 40 Convent Drive, Bethesda, MD 20892, USA
    Blood 110:928-36. 2007
    ..Manipulation of the interaction of PD-1 with its ligands could thus potentially restore the CD8+ T-cell responses in SIV infection...
  30. ncbi request reprint Prior DNA immunization enhances immune response to dominant and subdominant viral epitopes induced by a fowlpox-based SIVmac vaccine in long-term slow-progressor macaques infected with SIVmac251
    Antonia Radaelli
    National Cancer Institute, Basic Research Laboratory, 41 D804, Bethesda, MD 20892 5055, USA
    Virology 312:181-95. 2003
    ..Hopefully, this modality of vaccine combination may be useful in the clinical management of HIV-1-infected individuals...
  31. pmc Antibodies to gp120 and PD-1 expression on virus-specific CD8+ T cells in protection from simian AIDS
    Monica Vaccari
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA
    J Virol 87:3526-37. 2013
    ....
  32. ncbi request reprint Antiretroviral therapy partly reverses the systemic and mucosal distribution of NK cell subsets that is altered by SIVmac₂₅₁ infection of macaques
    Namal P M Liyanage
    Animal Models and Retroviral Vaccines Section, NCI, NIH, Bethesda, MD 20892, USA
    Virology 450:359-68. 2014
    ..Thus, SIVmac251 infection causes changes in the distribution and function of NK cells and antiretroviral therapy during chronic infection only partially restores NK homeostasis and function...
  33. pmc Fatal pancreatitis in simian immunodeficiency virus SIV(mac251)-infected macaques treated with 2',3'-dideoxyinosine and stavudine following cytotoxic-T-lymphocyte-associated antigen 4 and indoleamine 2,3-dioxygenase blockade
    Monica Vaccari
    Animal Models and Retroviral Vaccines Section, NCI, NIH, Bethesda, Maryland, USA
    J Virol 86:108-13. 2012
    ..Thus, caution should be used when considering approaches aimed at targeting immune activation during ART...
  34. pmc Both mucosal and systemic routes of immunization with the live, attenuated NYVAC/simian immunodeficiency virus SIV(gpe) recombinant vaccine result in gag-specific CD8(+) T-cell responses in mucosal tissues of macaques
    Liljana Stevceva
    Basic Research Laboratory, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Virol 76:11659-76. 2002
    ..We conclude that immunization with a live vector vaccine results in the appearance of CD8(+) T-cell responses at mucosal sites even when the vaccine is delivered by nonmucosal routes...
  35. pmc In vivo genetic mutations define predominant functions of the human T-cell leukemia/lymphoma virus p12I protein
    Risaku Fukumoto
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA
    Blood 113:3726-34. 2009
    ....
  36. ncbi request reprint Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus
    Yvette Edghill-Smith
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, 41 D804, Bethesda, Maryland 20892, USA
    Nat Med 11:740-7. 2005
    ..Thus, vaccines able to induce long-lasting protective antibody responses may constitute realistic alternatives to the currently available smallpox vaccine (Dryvax)...
  37. pmc Recombinant interleukin-7 induces proliferation of naive macaque CD4+ and CD8+ T cells in vivo
    Marcin Moniuszko
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bldg 41, Rm D804, Bethesda, MD 20892 5065, USA
    J Virol 78:9740-9. 2004
    ..Thus, IL-7 may be of benefit in the treatment of iatrogenic or virus-induced T-cell depletion...
  38. pmc Superior T memory stem cell persistence supports long-lived T cell memory
    Enrico Lugli
    Immunotechnology Section, Vaccine Research Center, NIAID, NIH, 40, Convent Dr, Bethesda, Maryland 20892, USA
    J Clin Invest 123:594-9. 2013
    ..Thus, one mechanism for maintenance of long-term T cell memory derives from the unique homeostatic properties of TSCM cells. Vaccination strategies designed to elicit durable cellular immunity should target the generation of TSCM cells...
  39. pmc Protection afforded by an HIV vaccine candidate in macaques depends on the dose of SIVmac251 at challenge exposure
    Monica Vaccari
    Animal Models and Retroviral Vaccine Section, National Cancer Institute, Bethesda, MD, USA
    J Virol 87:3538-48. 2013
    ..Thus, the choice of the experimental model greatly influences the vaccine efficacy of vaccines for human immunodeficiency virus (HIV)...
  40. pmc TRIM5α does not affect simian immunodeficiency virus SIV(mac251) replication in vaccinated or unvaccinated Indian rhesus macaques following intrarectal challenge exposure
    Claudio Fenizia
    Animal Models and Retroviral Vaccines Section, Vaccine Branch, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 85:12399-409. 2011
    ..Thus, the TRIM5α genotype does not confound results of mucosal infection of rhesus macaques with SIV(mac251)...
  41. pmc Vaccine induced antibodies to the first variable loop of human immunodeficiency virus type 1 gp120, mediate antibody-dependent virus inhibition in macaques
    Izabela Bialuk
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA
    Vaccine 30:78-94. 2011
    ....
  42. pmc Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles
    Vibeke Andresen
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA
    Blood 118:1549-59. 2011
    ..Further, these results highlight the importance of studying the function of the HTLV-1 viral proteins, not only in isolation, but also in the context of full viral replication...
  43. ncbi request reprint HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication
    Christophe Nicot
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, National Institutes of Health, 41 D804, Bethesda, Maryland 20892, USA
    Nat Med 10:197-201. 2004
    ..Because Tex and Rex are positive regulators of viral gene expression, their inhibition by p30(II) reduces virion production. p30(II) inhibits virus expression by reducing Tax and Rex protein expression...
  44. pmc High frequency of virus-specific CD8+ T cells in the central nervous system of macaques chronically infected with simian immunodeficiency virus SIVmac251
    Marcin Moniuszko
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, Maryland 20892 5055, USA
    J Virol 77:12346-51. 2003
    ..These data suggest that this Gag-specific response may contribute to the containment of viral replication in this locale...
  45. pmc Palmitoylation and p8-mediated human T-cell leukemia virus type 1 transmission
    Dustin Edwards
    Animal Models and Retroviral Vaccines Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 88:2319-22. 2014
    ..However, the ability of p8 to localize to the cell surface and to increase cell adhesion and viral transmission was not affected by the C39A mutation. ..
  46. pmc Antibodies with high avidity to the gp120 envelope protein in protection from simian immunodeficiency virus SIV(mac251) acquisition in an immunization regimen that mimics the RV-144 Thai trial
    Poonam Pegu
    Animal Models and Retroviral Vaccine Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 87:1708-19. 2013
    ..The current results emphasize the utility of determining the titer of repeated mucosal challenge in the preclinical evaluation of HIV vaccines...
  47. ncbi request reprint A novel chimeric Rev, Tat, and Nef (Retanef) antigen as a component of an SIV/HIV vaccine
    Zdenek Hel
    Basic Research Laboratory, National Cancer Institute, 41 D804, Bethesda, MD 20892, USA
    Vaccine 20:3171-86. 2002
    ..No adverse effects were observed in either naive or SIV-infected rhesus macaques. Thus, an analogous HIV-1-based chimeric vaccine may represent useful component of an HIV-1 vaccine...
  48. pmc Human T-cell leukemia/lymphoma virus type 1 p30, but not p12/p8, counteracts toll-like receptor 3 (TLR3) and TLR4 signaling in human monocytes and dendritic cells
    Claudio Fenizia
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, NIH, Bethesda, Maryland, USA
    J Virol 88:393-402. 2014
    ....
  49. pmc TLR agonists and/or IL-15 adjuvanted mucosal SIV vaccine reduced gut CD4⁺ memory T cell loss in SIVmac251-challenged rhesus macaques
    Yongjun Sui
    Vaccine Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, United States
    Vaccine 30:59-68. 2011
    ..Overall, these data highlight one unrecognized role of adjuvant in HIV vaccine development, and show that vaccines can produce a surprising discordance between CD4(+) T cell levels and SIV viral load...
  50. pmc Targeting the vaginal mucosa with human papillomavirus pseudovirion vaccines delivering simian immunodeficiency virus DNA
    Shari N Gordon
    Animal Models and Retroviral Vaccines Section, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:714-23. 2012
    ....
  51. pmc Cervicovaginal lamina propria lymphocytes: phenotypic characterization and their importance in cytotoxic T-lymphocyte responses to simian immunodeficiency virus SIVmac251
    Liljana Stevceva
    Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 76:9-18. 2002
    ..Information on the quality and quantity of local immune responses may help in the design of vaccine strategies aimed at containing viral replication at the site of viral encounter...
  52. ncbi request reprint Emergence of cytotoxic T lymphocyte escape mutants following antiretroviral treatment suspension in rhesus macaques infected with SIVmac251
    Janos Nacsa
    National Cancer Institute, Basic Research Laboratory, 41 D804, Bethesda, Maryland 20892, USA
    Virology 305:210-8. 2003
    ..In addition, these data also suggest that interruption of therapy may be less effective in chronic infection because of preexisting immune escape and that immune escape is a risk of interruption of therapy...
  53. ncbi request reprint T cell receptor recognition motifs govern immune escape patterns in acute SIV infection
    David A Price
    Human Immunology Section, Vaccine Research Center, NIAID NIH, Bethesda, MD 20892, USA
    Immunity 21:793-803. 2004
    ..These findings have profound implications for the development of vaccines that elicit T cell immunity to combat pathogens with unstable genomes...
  54. pmc Hijacking the T-cell communication network by the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) p12 and p8 proteins
    Nancy Van Prooyen
    Animal Models and Retroviral Vaccine Section, Vaccine Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892 5065, USA
    Mol Aspects Med 31:333-43. 2010
    ..Altogether the current knowledge demonstrates that the concerted activity of p8 and p12 is essential for the persistence of virus infected cells in the host...
  55. pmc Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques
    Monica Vaccari
    1 Animal Models and Retroviral Vaccines Section, NCI, NIH, Bethesda, Maryland
    AIDS Res Hum Retroviruses 30:355-62. 2014
    ..Our findings confirm recent results observed in asymptomatic HIV-infected patients and suggest that CQ does not provide an obvious benefit in the absence of antiretroviral therapy...
  56. doi request reprint Phase III HIV vaccine trial in Thailand: a step toward a protective vaccine for HIV
    Monica Vaccari
    Animal Models and Retroviral Vaccine Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Expert Rev Vaccines 9:997-1005. 2010
    ....
  57. ncbi request reprint Retroviral proteins that target the major histocompatibility complex class I
    Julie M Johnson
    National Cancer Institute, Basic Research Laboratory, 41 D804, Bethesda, MD 20892 5055, USA
    Virus Res 88:119-27. 2002
    ....
  58. pmc Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence
    Dustin Edwards
    Animal Models and Retroviral Vaccines Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, MD 20892, USA
    Viruses 3:861-85. 2011
    ..Though these proteins are not essential for virus replication in vitro, p8, p12, p13, and p30 have an important role in the establishment and maintenance of HTLV-1 infection in vivo...
  59. ncbi request reprint Memory T cells in Rhesus macaques
    Monica Vaccari
    Animal Models and Retroviral Vaccine Section, NCI, NIH, Building 41, Room D804, Bethesda, Maryland 20892, USA
    Adv Exp Med Biol 684:126-44. 2010
    ..Emphasis is placed on studies of memory cells in macaques infected with SIV because many studies are available. Lastly, we highlight the usefulness of the Rhesus macaque model in studies related to the aging of the immune system...
  60. pmc Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission
    Nancy Van Prooyen
    Animal Models Retroviral Vaccine Section, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:20738-43. 2010
    ..This work identifies p8 as a viral target for the development of therapeutic strategies that may limit the expansion of infected cells in HTLV-1 carriers and decrease HTLV-1-associated morbidity...
  61. pmc Inhibition of T-cell receptor signal transduction and viral expression by the linker for activation of T cells-interacting p12(I) protein of human T-cell leukemia/lymphoma virus type 1
    Risaku Fukumoto
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, NIH, Bethesda, MD 20892 5065, USA
    J Virol 81:9088-99. 2007
    ....
  62. ncbi request reprint Do regulatory T-cells play a role in AIDS pathogenesis?
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    AIDS Rev 8:141-7. 2006
    ....
  63. pmc Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses
    Igor M Belyakov
    Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:9458-63. 2003
    ..These properties, shared with the existing smallpox vaccine, provide a basis for further evaluation of these replication-deficient vaccinia viruses as safer vaccines against smallpox or against complications from vaccinia virus...
  64. ncbi request reprint Seizing of T cells by human T-cell leukemia/lymphoma virus type 1
    Genoveffa Franchini
    National Cancer Institute, Basic Research Laboratory, Bethesda, Maryland 20892, USA
    Adv Cancer Res 89:69-132. 2003
    ..The relevance of these laboratory findings will be related to clonal T-cell proliferation and adult T-cell leukemia/lymphoma development in vivo...
  65. ncbi request reprint Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology
    Richard F Little
    Center for Cancer Research CCR, National Cancer Institute NCI, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:4653-9. 2003
    ..These results suggest that tumor pathogenesis is responsible for the improved outcome of ARLs in the era of HAART...
  66. ncbi request reprint IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primates
    Terry J Fry
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 101:2294-9. 2003
    ..These results also raise the possibility that IL-7 therapy could be used to temporarily modulate T-cell cycling in vivo in the context of immunotherapies such as vaccination...
  67. ncbi request reprint Species-specific transformation of T cells by HV(MNE)
    Maria Grazia Ferrari
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, 41 D804, Bethesda, MD 20892 5055, USA
    Virology 317:299-307. 2003
    ..Thus, this EBV-like virus from M. nemestrina differs from the other EBV-like viruses found in nonhuman primates inasmuch as it appears to preferentially transform T cells...
  68. ncbi request reprint Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV
    Koen K A Van Rompay
    California National Primate Research Center, University of California at Davis, Davis, CA 95616, USA
    J Acquir Immune Defic Syndr 38:124-34. 2005
    ..The results of these investigations suggest that immunization of human infants with poxvirus-based HIV vaccine candidates may offer protection against early and late HIV infection through breastfeeding...
  69. ncbi request reprint Support for the RV144 HIV vaccine trial
    Robert Belshe
    Science 305:177-80; author reply 177-80. 2004
  70. pmc Repression of human T-cell leukemia virus type 1 and type 2 replication by a viral mRNA-encoded posttranscriptional regulator
    Ihab Younis
    Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Rd, Columbus, OH 43210, USA
    J Virol 78:11077-83. 2004
    ..These data are consistent with the critical role of these proteins in viral persistence and pathogenesis in animal models of HTLV-1 and HTLV-2 infection...
  71. ncbi request reprint Human T-cell leukemia/lymphoma virus type 1 nonstructural genes and their functions
    Christophe Nicot
    Department of Microbiology, University of Kansas Medical Center, Molecular Genetics, and Immunology, 3025 Wahl Hall West, 3901 Rainbow Boulevard, Kansas City, KS 66160 7420, USA
    Oncogene 24:6026-34. 2005
    ..Here, we will review current knowledge of the functions of three additional proteins encoded in the pX region, p12I, p13II, and p30II...
  72. ncbi request reprint Human T-cell leukemia virus type I p30 nuclear/nucleolar retention is mediated through interactions with RNA and a constituent of the 60 S ribosomal subunit
    Sofiane Ghorbel
    Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas 66160 7420, USA
    J Biol Chem 281:37150-8. 2006
    ..We further demonstrate that p30 nuclear/nucleolar retention is dependent upon de novo RNA transcripts and interactions with components of the ribosomal machinery...
  73. pmc Long-lasting decrease in viremia in macaques chronically infected with simian immunodeficiency virus SIVmac251 after therapeutic DNA immunization
    Agneta S von Gegerfelt
    Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles Street, Building 535, Room 210, Frederick, MD 21702 1201, USA
    J Virol 81:1972-9. 2007
    ..Several animals show a long-lasting decrease in viremia, suggesting that therapeutic vaccination may provide an additional benefit to antiretroviral therapy...
  74. ncbi request reprint Human immunodeficiency virus type-1 Tat/co-activator acetyltransferase interactions inhibit p53Lys-320 acetylation and p53-responsive transcription
    Robert Harrod
    Laboratory of Molecular Virology, Department of Biological Sciences, Southern Methodist University, Dallas, Texas 75275 0376, USA
    J Biol Chem 278:12310-8. 2003
    ..Our results allude to a mechanism whereby the human immunodeficiency virus type-1 trans-activator might impair tumor suppressor functions in immune/neuronal-derived cells, thus favoring the establishment of neoplasia during AIDS...
  75. ncbi request reprint Equivalent immunogenicity of the highly attenuated poxvirus-based ALVAC-SIV and NYVAC-SIV vaccine candidates in SIVmac251-infected macaques
    Zdenek Hel
    Aventis Pasteur, Ltd 1755 Steeles Avenue West, Toronto, Ontario, M2R 3T4, Canada
    Virology 304:125-34. 2002
    ..Thus, both these vaccine modalities alone or in combination may be suitable candidate vaccines for immune therapy of HIV-1-infected individuals...
  76. pmc Differential antigen requirements for protection against systemic and intranasal vaccinia virus challenges in mice
    David R Kaufman
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Virol 82:6829-37. 2008
    ..These studies also suggest that rAd vectors warrant further assessment as candidate subunit smallpox vaccines...
  77. pmc Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levels
    Ranajit Pal
    Advanced BioScience Laboratories, Inc, Kensington, Maryland 20895, USA
    J Virol 80:3732-42. 2006
    ..Thus, systemic immunization with ALVAC-HIV-1 vaccine candidates elicits anti-HIV-1 immune responses able to contain virus replication also at mucosal sites in macaques...
  78. ncbi request reprint Recombinant canarypox vaccine-elicited CTL specific for dominant and subdominant simian immunodeficiency virus epitopes in rhesus monkeys
    Sampa Santra
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:1847-53. 2002
    ..The later emerging CTL response specific for the subdominant epitope may contribute to the control of viral replication in the setting of chronic infection...
  79. ncbi request reprint Genetic mutation and early onset of T-cell leukemia in pediatric patients infected at birth with HTLV-I
    Maria S Pombo-de-Oliveira
    Laboratorio de Marcadores Celulares and Hematology Service, Instituto Nacional de Cancer, Praca Cruz Vermelha 23, CEP 20230 130 Rio de Janeiro, Brazil
    Leuk Res 26:155-61. 2002
    ....
  80. pmc Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of viral infection
    Bianca R Mothe
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
    J Virol 76:875-84. 2002
    ..In most of the Mamu-A*01-positive macaques tested, CTL responses against epitopes bound by Mamu-A*01 dominated the CD8(+) cellular immune response...
  81. pmc HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS
    Jakob Nilsson
    Division of Molecular Immunology ML 7021, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 108:3808-17. 2006
    ..Considered together, our findings imply that therapeutic manipulation of Treg-cell number and/or function could improve immune control of HIV infection...
  82. ncbi request reprint T cell memory and protective immunity by vaccination: is more better?
    Maurizio Zanetti
    The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093 0815, USA
    Trends Immunol 27:511-7. 2006
    ..These guiding principles might help to raise improved protective T-cell responses by vaccination in humans...
  83. ncbi request reprint [Detection of human herpesvirus type 8 (HHV-8) in the central nervous system in patients from Poland]
    Elzbieta Tryniszewska
    III Klinika Chorob Dzieci, Akademia Medyczna w Białymstoku
    Przegl Epidemiol 60:166. 2006