Meredith A Fox

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems
    Dennis L Murphy
    Laboratory of Clinical Science, NIMH Intramural Research Program, NIH, Building 10, Room 3D41, 10 Center Drive, MSC 1264, Bethesda, MD 20892, USA
    Neuropharmacology 55:932-60. 2008
  2. ncbi Naloxone, not proglumide or MK-801, alters effects of morphine preexposure on morphine-induced taste aversions
    Meredith A Fox
    Laboratory of Clinical Science, Building 10, Room 3D41 National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Pharmacol Biochem Behav 84:169-77. 2006
  3. ncbi A pharmacological analysis of mice with a targeted disruption of the serotonin transporter
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Building 10, Room 3D41, Bethesda, MD 20892, USA
    Psychopharmacology (Berl) 195:147-66. 2007
  4. ncbi Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropharmacology 53:643-56. 2007
  5. ncbi Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice
    Meredith A Fox
    Laboratory of Clinical Science LCS, National Institute of Mental Health NIMH, National Institutes of Health NIH, 10 Center Drive, Building 10 3D41, MSC 1264, Bethesda, MD 20892 1264, USA
    Psychopharmacology (Berl) 201:203-18. 2008
  6. ncbi Functional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT)
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1264, USA
    Br J Pharmacol 159:879-87. 2010
  7. ncbi The serotonin 5-HT(2A) receptor agonist TCB-2: a behavioral and neurophysiological analysis
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1264, USA
    Psychopharmacology (Berl) 212:13-23. 2010
  8. ncbi Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1264, USA
    Int J Neuropsychopharmacol 12:1055-65. 2009
  9. ncbi Imaging elevated brain arachidonic acid signaling in unanesthetized serotonin transporter (5-HTT)-deficient mice
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Neuropsychopharmacology 34:1695-709. 2009
  10. ncbi Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice
    Pablo R Moya
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    BMC Pharmacol 11:3. 2011

Detail Information

Publications11

  1. ncbi How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems
    Dennis L Murphy
    Laboratory of Clinical Science, NIMH Intramural Research Program, NIH, Building 10, Room 3D41, 10 Center Drive, MSC 1264, Bethesda, MD 20892, USA
    Neuropharmacology 55:932-60. 2008
    ..We provide in-depth examples of gene-based discoveries primarily related to SLC6A4 that have clarified serotonin's many important homeostatic functions in humans, non-human primates, mice and other species...
  2. ncbi Naloxone, not proglumide or MK-801, alters effects of morphine preexposure on morphine-induced taste aversions
    Meredith A Fox
    Laboratory of Clinical Science, Building 10, Room 3D41 National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Pharmacol Biochem Behav 84:169-77. 2006
    ....
  3. ncbi A pharmacological analysis of mice with a targeted disruption of the serotonin transporter
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Building 10, Room 3D41, Bethesda, MD 20892, USA
    Psychopharmacology (Berl) 195:147-66. 2007
    ..Partial or complete ablation of serotonin transporter (SERT) expression in mice leads to altered responses to serotonin receptor agonists and other classes of drugs...
  4. ncbi Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropharmacology 53:643-56. 2007
    ..These studies also show that the exaggerated behavioral responses observed in SERT +/- and -/- mice are mediated by postsynaptic Htr1a receptors, and suggest intact postsynaptic Htr1a function in SERT -/- mice...
  5. ncbi Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice
    Meredith A Fox
    Laboratory of Clinical Science LCS, National Institute of Mental Health NIMH, National Institutes of Health NIH, 10 Center Drive, Building 10 3D41, MSC 1264, Bethesda, MD 20892 1264, USA
    Psychopharmacology (Berl) 201:203-18. 2008
    ..Serotonin transporter (SERT) knockout (-/-) mice have an altered phenotype in adulthood, including high baseline anxiety and depressive-like behaviors, associated with increased baseline extracellular serotonin levels throughout life...
  6. ncbi Functional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT)
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1264, USA
    Br J Pharmacol 159:879-87. 2010
    ..Our findings strongly support the correlation of WAY 100635 induced head twitches with increased 5-HT availability, induced genetically or pharmacologically...
  7. ncbi The serotonin 5-HT(2A) receptor agonist TCB-2: a behavioral and neurophysiological analysis
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1264, USA
    Psychopharmacology (Berl) 212:13-23. 2010
    ..There are few reports on the high-affinity 5-HT(2A) agonist (4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide (TCB-2)...
  8. ncbi Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1264, USA
    Int J Neuropsychopharmacol 12:1055-65. 2009
    ..These findings suggest that it is conceivable that there might be increased vulnerability in individuals with SERT polymorphisms that may reduce SERT by more than 50%, the level in SERT+/- mice...
  9. ncbi Imaging elevated brain arachidonic acid signaling in unanesthetized serotonin transporter (5-HTT)-deficient mice
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Neuropsychopharmacology 34:1695-709. 2009
    ..Increased baseline AA signaling in humans having polymorphisms with reduced 5-HTT function might be identified using positron emission tomography...
  10. ncbi Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice
    Pablo R Moya
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    BMC Pharmacol 11:3. 2011
    ..In this study, we determined the responsiveness of 5-HT2CR in serotonin transporter (SERT) knockout (-/-) mice, a model characterized by increased anxiety-like and stress-responsive behaviors...
  11. ncbi Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity
    Dennis L Murphy
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Philos Trans R Soc Lond B Biol Sci 368:20120435. 2013
    ..OCD resembles disorders such as depression, in which gene × gene interactions, gene × environment interactions and stress elements coalesce to yield OC symptoms and, in some individuals, full-blown OCD with multiple comorbid disorders...