C S Fox

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Overweight, obesity, and the development of stage 3 CKD: the Framingham Heart Study
    Meredith C Foster
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Am J Kidney Dis 52:39-48. 2008
  2. pmc Abdominal subcutaneous adipose tissue: a protective fat depot?
    Stacy A Porter
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes Care 32:1068-75. 2009
  3. pmc Cross-sectional associations between abdominal and thoracic adipose tissue compartments and adiponectin and resistin in the Framingham Heart Study
    Shilpa H Jain
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:903-8. 2009
  4. pmc Thoracic periaortic and visceral adipose tissue and their cross-sectional associations with measures of vascular function
    Kathryn A Britton
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Obesity (Silver Spring) 21:1496-503. 2013
  5. pmc Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations
    Conall M O'Seaghdha
    National Heart, Lung, and Blood Institute s Framingham Heart Study and Center for Population Studies, Framingham, Massachusetts, United States of America Renal Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 9:e1003796. 2013
  6. pmc Genetic association for renal traits among participants of African ancestry reveals new loci for renal function
    Ching Ti Liu
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002264. 2011
  7. pmc Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD
    Carsten A Böger
    Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
    PLoS Genet 7:e1002292. 2011
  8. pmc Genome-wide association and functional follow-up reveals new loci for kidney function
    Cristian Pattaro
    Institute of Genetic Medicine, European Academy of Bozen Bolzano EURAC and Affiliated Institute of the University of Lübeck, Bolzano, Italy
    PLoS Genet 8:e1002584. 2012
  9. pmc Association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants identified by UMOD gene region sequencing
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 7:e38311. 2012
  10. pmc NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium
    Nancy L Heard-Costa
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000539. 2009

Detail Information

Publications128 found, 100 shown here

  1. pmc Overweight, obesity, and the development of stage 3 CKD: the Framingham Heart Study
    Meredith C Foster
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Am J Kidney Dis 52:39-48. 2008
    ..Prior research yielded conflicting results about the magnitude of the association between body mass index (BMI) and chronic kidney disease (CKD)...
  2. pmc Abdominal subcutaneous adipose tissue: a protective fat depot?
    Stacy A Porter
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes Care 32:1068-75. 2009
    ..Obesity is associated with increased metabolic and cardiovascular risk. The ectopic fat hypothesis suggests that subcutaneous fat may be protective, but this theory has yet to be fully explored...
  3. pmc Cross-sectional associations between abdominal and thoracic adipose tissue compartments and adiponectin and resistin in the Framingham Heart Study
    Shilpa H Jain
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:903-8. 2009
    ....
  4. pmc Thoracic periaortic and visceral adipose tissue and their cross-sectional associations with measures of vascular function
    Kathryn A Britton
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Obesity (Silver Spring) 21:1496-503. 2013
    ..Perivascular fat may have a local adverse effect on the vasculature. We evaluated whether thoracic periaortic adipose tissue (TAT), a type of perivascular fat, and visceral adipose tissue (VAT) were associated with vascular function...
  5. pmc Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations
    Conall M O'Seaghdha
    National Heart, Lung, and Blood Institute s Framingham Heart Study and Center for Population Studies, Framingham, Massachusetts, United States of America Renal Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 9:e1003796. 2013
    ..We characterized the expression of these genes in gut, kidney, and bone, and demonstrate modulation of gene expression in bone in response to dietary calcium in mice. Our results shed new light on the genetics of calcium homeostasis...
  6. pmc Genetic association for renal traits among participants of African ancestry reveals new loci for renal function
    Ching Ti Liu
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002264. 2011
    ..We identified several SNPs in association with eGFR in African Ancestry individuals, as well as 3 suggestive loci for UACR and eGFR. Functional genetic studies support a role for kcnq1 in glomerular development in zebrafish...
  7. pmc Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD
    Carsten A Böger
    Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
    PLoS Genet 7:e1002292. 2011
    ..Additional work is required to characterize the association of genetic determinants of CKD and ESRD at different stages of disease progression...
  8. pmc Genome-wide association and functional follow-up reveals new loci for kidney function
    Cristian Pattaro
    Institute of Genetic Medicine, European Academy of Bozen Bolzano EURAC and Affiliated Institute of the University of Lübeck, Bolzano, Italy
    PLoS Genet 8:e1002584. 2012
    ..By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD...
  9. pmc Association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants identified by UMOD gene region sequencing
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 7:e38311. 2012
    ..To identify novel rare variants as well as common variants that may account for this GWAS signal, the exons and 4 kb upstream region of UMOD were sequenced...
  10. pmc NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium
    Nancy L Heard-Costa
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000539. 2009
    ..Our findings establish that common variants in NRXN3 are associated with WC, BMI, and obesity...
  11. pmc Prevalence, distribution, and risk factor correlates of high thoracic periaortic fat in the Framingham Heart Study
    Kathryn A Britton
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Am Heart Assoc 1:e004200. 2012
    ..We sought to determine the prevalence, distribution, and risk factor correlates of high TAT...
  12. pmc Periaortic adipose tissue and aortic dimensions in the Framingham Heart Study
    George Thanassoulis
    NIH NHLBI Framingham Heart Study, Framingham, MA, USA
    J Am Heart Assoc 1:e000885. 2012
    ..Periaortic fat, because of its contiguity with the aorta, may promote vascular remodeling and aortic dilatation. However, the relations between perioartic fat depots and aortic dimensions have not been previously described...
  13. pmc Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Framingham Heart Study
    Dhayana Dallmeier
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Heart Study, Framingham, USA
    Diabetol Metab Syndr 4:28. 2012
    ..abstract:..
  14. pmc Intramuscular fat and associations with metabolic risk factors in the Framingham Heart Study
    Kate E Therkelsen
    Boston University School of Medicine, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 33:863-70. 2013
    ..Intramuscular fat accumulates between muscle fibers or within muscle cells. We investigated the association of intramuscular fat with other ectopic fat deposits and metabolic risk factors...
  15. pmc Association of female reproductive factors with body composition: the Framingham Heart Study
    Subbulaxmi Trikudanathan
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 98:236-44. 2013
    ..The association of female reproductive factors with measures of regional body fat distribution has not been comprehensively studied...
  16. pmc Aminotransferase levels are associated with cardiometabolic risk above and beyond visceral fat and insulin resistance: the Framingham Heart Study
    Stacy A Porter
    Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Arterioscler Thromb Vasc Biol 33:139-46. 2013
    ..We sought to characterize associations between aminotransferase levels and cardiometabolic risk after accounting for visceral adipose tissue and insulin resistance...
  17. pmc Genome-wide association of pericardial fat identifies a unique locus for ectopic fat
    Caroline S Fox
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America
    PLoS Genet 8:e1002705. 2012
    ..rs10198628 near TRIB2 is associated with pericardial fat but not measures of generalized or visceral adiposity, reinforcing the concept that there are unique genetic underpinnings to ectopic fat distribution...
  18. pmc Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women
    Caroline S Fox
    Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts, United States of America
    PLoS Genet 8:e1002695. 2012
    ..More refined phenotypes for body composition and fat distribution can detect new loci not previously uncovered in large-scale GWAS of anthropometric traits...
  19. pmc Correlation of renin angiotensin and aldosterone system activity with subcutaneous and visceral adiposity: the framingham heart study
    Conall M O'Seaghdha
    National Heart, Lung and Blood Institute s Framingham Heart Study, 73 Mt, Wayte Avenue Suite 2, Framingham, MA, USA
    BMC Endocr Disord 12:3. 2012
    ..abstract:..
  20. pmc Relation of vascular growth factors with CT-derived measures of body fat distribution: the Framingham Heart Study
    Bernhard M Kaess
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA
    J Clin Endocrinol Metab 97:987-94. 2012
    ....
  21. pmc Development and reproducibility of a computed tomography-based measurement of renal sinus fat
    Meredith C Foster
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt, Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA
    BMC Nephrol 12:52. 2011
    ..We sought to develop a protocol to quantify renal sinus fat accumulation using multi-detector computed tomography (MDCT)...
  22. pmc Uromodulin concentrations are not associated with incident CKD among persons with coronary artery disease
    Michael G Shlipak
    San Francisco VA Medical Center, CA, USA
    BMC Nephrol 12:2. 2011
    ..This study within persons with known coronary artery disease (CAD) evaluated whether uromodulin concentrations could distinguish CKD risk...
  23. pmc Age-related associations of hypertension and diabetes mellitus with chronic kidney disease
    Tareq M Islam
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Louisiana, USA
    BMC Nephrol 10:17. 2009
    ..The association of diabetes mellitus and hypertension with CKD across the adult lifespan is not well established...
  24. pmc The relation of C--reactive protein to chronic kidney disease in African Americans: the Jackson Heart Study
    Ervin R Fox
    Department of Medicine, University of Mississippi School of Medicine, Jackson, MS, USA
    BMC Nephrol 11:1. 2010
    ..73 m2) than their counterparts of European-descent. Inflammation has been related to renal disease in non-Hispanic whites, but there are limited data on the role of inflammation in renal dysfunction in African Americans in the community...
  25. pmc Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study
    Meredith C Foster
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt, Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA
    BMC Med Genet 12:148. 2011
    ..Ectopic fat accumulation in the renal sinus is associated with chronic kidney disease and hypertension. The genetic contributions to renal sinus fat accumulation in humans have not been well characterized...
  26. pmc Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study
    Christopher J O'Donnell
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S4. 2007
    ..We conducted a genome-wide association study (GWAS) for SCA measurements in the community-based Framingham Heart Study...
  27. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  28. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
    ..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes...
  29. pmc A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study
    Shih Jen Hwang
    National Heart Lung and Blood Institutes, Bethesda, MD, USA
    BMC Med Genet 8:S10. 2007
    ..Many endocrine conditions have strong familial components. We tested for association between the Affymetrix GeneChip Human Mapping 100K single nucleotide polymorphism (SNP) set and measures of kidney function and endocrine traits...
  30. pmc Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies
    Anna Kottgen
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
    BMC Med Genet 9:49. 2008
    ..The study of 70,987 single nucleotide polymorphisms (SNPs) in 1,010 FHS participants provides a list of SNPs showing the strongest associations with renal traits which need to be verified in independent study samples...
  31. pmc Genome-wide association with diabetes-related traits in the Framingham Heart Study
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 8:S16. 2007
    ..Susceptibility to type 2 diabetes may be conferred by genetic variants having modest effects on risk. Genome-wide fixed marker arrays offer a novel approach to detect these variants...
  32. pmc A three-stage approach for genome-wide association studies with family data for quantitative traits
    Ming Huei Chen
    Department of Neurology and Framingham Heart Study, Boston University School of Medicine, MA, USA
    BMC Genet 11:40. 2010
    ..We also apply the three-stage approach to the GWA analyses of uric acid in Framingham Heart Study's SNP Health Association Resource (SHARe) project...
  33. pmc Periaortic fat deposition is associated with peripheral arterial disease: the Framingham heart study
    Caroline S Fox
    National Heart, Lung, and Blood Institute Framingham Heart Study, Bethesda, MD, USA
    Circ Cardiovasc Imaging 3:515-9. 2010
    ..We hypothesized that persons with greater amounts of periaortic fat are more likely to have clinical PAD and a low ankle-brachial index...
  34. ncbi request reprint Glycemic status and development of kidney disease: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave Suite 2, Framingham, Massachusetts 01702, USA
    Diabetes Care 28:2436-40. 2005
    ..Diabetes is a major risk factor for the development of kidney disease and is the leading cause of end-stage renal disease in the U.S. Whether pre-diabetes is associated with the development of kidney disease is unclear...
  35. ncbi request reprint Cross-sectional association of kidney function with valvular and annular calcification: the Framingham heart study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Framingham, MA 01702, USA
    J Am Soc Nephrol 17:521-7. 2006
    ..Further research is warranted to understand whether traditional and novel vascular risk factor burden, as well as metabolic derangements found in early kidney disease, can account for the CKD-MAC association...
  36. pmc Relation of subcutaneous and visceral adipose tissue to coronary and abdominal aortic calcium (from the Framingham Heart Study)
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 104:543-7. 2009
    ..However, these cross-sectional associations are attenuated by cardiovascular disease risk factors, possibly because they mediate the association between adiposity measures and subclinical cardiovascular disease...
  37. pmc Use of evidence-based therapies in short-term outcomes of ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction in patients with chronic kidney disease: a report from the National Cardiovascular Data Acute Coronary
    Caroline S Fox
    National Heart, Lung, and Blood Institutes s Framingham Heart Study, Framingham, Mass, USA
    Circulation 121:357-65. 2010
    ..Our goal was to characterize the association between CKD severity and short-term outcomes and the use of in-hospital evidence-based therapies among patients with ST-segment elevation MI (STEMI) and non-ST-segment elevation MI (NSTEMI)...
  38. pmc Pericardial fat, intrathoracic fat, and measures of left ventricular structure and function: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Circulation 119:1586-91. 2009
    ..Whether the associations of pericardial fat and measures of cardiac structure and function are independent of the systemic effects of obesity and visceral adiposity has not been fully explored...
  39. ncbi request reprint Cross-sectional relations of serum aldosterone and urine sodium excretion to urinary albumin excretion in a community-based sample
    C S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
    Kidney Int 69:2064-9. 2006
    ..Our cross-sectional observations raise the possibility that dietary salt intake may be associated with early renovascular damage...
  40. ncbi request reprint Relations of inflammation and novel risk factors to valvular calcification
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 97:1502-5. 2006
    ..In conclusion, inflammatory markers were elevated in patients with valvular calcium. Our findings suggest that much of the observed association between systemic inflammatory markers and valvular calcium may be due to shared risk factors...
  41. pmc Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the Framingham heart study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes Care 31:1582-4. 2008
    ..We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes...
  42. pmc A multi-marker approach to predict incident CKD and microalbuminuria
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702, USA
    J Am Soc Nephrol 21:2143-9. 2010
    ..In conclusion, circulating homocysteine, aldosterone, and BNP provide incremental information regarding risk for incident CKD and MA beyond traditional risk factors...
  43. pmc Cardiovascular disease risk factors, type 2 diabetes mellitus, and the Framingham Heart Study
    Caroline S Fox
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Division of Endocrinology, Metabolism, and Diabetes, Framingham, MA 01702, USA
    Trends Cardiovasc Med 20:90-5. 2010
    ..This review will focus on the contemporary contributions of the Framingham Heart Study to the field of diabetes epidemiology, including data on diabetes trends, genetics, and future advances in population-based studies...
  44. ncbi request reprint Increasing cardiovascular disease burden due to diabetes mellitus: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702 5827, USA
    Circulation 115:1544-50. 2007
    ..We tested the hypothesis that the relative burden of CVD attributable to diabetes mellitus (DM) has increased over the past 5 decades...
  45. ncbi request reprint Genome-wide linkage to chromosome 6 for waist circumference in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Bethesda, Maryland, USA
    Diabetes 53:1399-402. 2004
    ..Substantial evidence exists for linkage to waist circumference, a measure of central adiposity. Potential candidate genes include ESR1, OPRM1, and NMBR. Further research is necessary to understand the genes involved in central adiposity...
  46. ncbi request reprint Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring
    Caroline S Fox
    National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, Mass 01702 5827, USA
    JAMA 291:2851-5. 2004
    ..Atrial fibrillation (AF) is the most common cardiac dysrhythmia in the United States. Whereas rare cases of familial AF have been reported, it is unknown if AF among unselected individuals is a heritable condition...
  47. ncbi request reprint Temporal trends in coronary heart disease mortality and sudden cardiac death from 1950 to 1999: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Circulation 110:522-7. 2004
    ..Although declines in coronary heart disease (CHD) mortality have been noted, there is still uncertainty about the magnitude of the decline and whether the trend is similar for sudden cardiac death (SCD)...
  48. ncbi request reprint Genomewide linkage analysis to serum creatinine, GFR, and creatinine clearance in a community-based population: the Framingham Heart Study
    Caroline S Fox
    NHLBI, NIH, Framingham Heart Study, Framingham, MA 01702, USA
    J Am Soc Nephrol 15:2457-61. 2004
    ..Further research is necessary to identify the genes involved in the development of kidney disease and to understand their roles in this complex process...
  49. ncbi request reprint Kidney function is inversely associated with coronary artery calcification in men and women free of cardiovascular disease: the Framingham Heart Study
    Caroline S Fox
    NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
    Kidney Int 66:2017-21. 2004
    ..Because the risk of coronary heart disease is increased even at moderate declines in kidney function, we sought to test whether high CAC scores are seen among those with mild reductions in kidney function...
  50. ncbi request reprint Trends in cardiovascular complications of diabetes
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702 5827, USA
    JAMA 292:2495-9. 2004
    ..Despite reductions in cardiovascular disease (CVD) mortality over the past few decades, it is unclear whether adults with and without diabetes have experienced similar declines in CVD risk...
  51. pmc Short-term outcomes of acute myocardial infarction in patients with acute kidney injury: a report from the national cardiovascular data registry
    Caroline S Fox
    NHLBI s Framingham Heart Study, Division of Intramural Research, NHLBI, 73 Mt Wayte Ave, Ste 2, Framingham, MA 01702, USA
    Circulation 125:497-504. 2012
    ..However, the relationship between severity of AKI and in-hospital outcomes in the setting of acute myocardial infarction has not been well documented...
  52. ncbi request reprint Genome-wide linkage analysis to urinary microalbuminuria in a community-based sample: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Kidney Int 67:70-4. 2005
    ..Microalbuminuria is a powerful risk factor for cardiovascular disease. It is not known whether genetic factors play a role in the expression of microalbuminuria in population-based samples...
  53. ncbi request reprint Genomewide linkage analysis of weight change in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA
    J Clin Endocrinol Metab 90:3197-201. 2005
    ..Weight gain adversely affects blood pressure, lipids, and glycemia. The genetic contribution to weight change is unknown...
  54. ncbi request reprint A comparison of death certificate out-of-hospital coronary heart disease death with physician-adjudicated sudden cardiac death
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 95:856-9. 2005
    ..Out-of-hospital coronary heart disease deaths overestimated sudden cardiac death by 47%, suggesting that out-of-hospital coronary heart disease death rates derived from death certificates should be interpreted with caution...
  55. pmc Fatty kidney, hypertension, and chronic kidney disease: the Framingham Heart Study
    Meredith C Foster
    Framingham Heart Study, Framingham, MA, USA
    Hypertension 58:784-90. 2011
    ..In conclusion, fatty kidney is a common condition that is associated with an increased risk of hypertension and chronic kidney disease. Renal sinus fat may play a role in blood pressure regulation and chronic kidney disease...
  56. ncbi request reprint Sex-specific association between estrogen receptor-alpha gene variation and measures of adiposity: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
    J Clin Endocrinol Metab 90:6257-62. 2005
    ..Polymorphisms in estrogen receptor-alpha (ESR1) may be associated with variation in body mass index and waist circumference. However, most prior studies have been limited by sample size and power...
  57. pmc Trends in diabetes, high cholesterol, and hypertension in chronic kidney disease among U.S. adults: 1988-1994 to 1999-2004
    Caroline S Fox
    Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes Care 31:1337-42. 2008
    ..The prevalence of chronic kidney disease (CKD) increased among U.S. adults from 1988-1994 to 1999-2004. We sought to explore the importance of trends in risk factors for CKD over time..
  58. ncbi request reprint Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:39-48. 2007
    ..The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting...
  59. pmc Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project
    Caroline S Fox
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S18. 2007
    ..We tested for association between SNPs on the Affymetrix 100K SNP GeneChip and measures of adiposity in the Framingham Heart Study...
  60. doi request reprint Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Ste 2, Framingham, MA 01702, USA
    Arch Intern Med 168:587-92. 2008
    ..Overt hypothyroidism and hyperthyroidism may be associated with weight gain and loss. We assessed whether variations in thyroid function within the reference (physiologic) range are associated with body weight...
  61. ncbi request reprint Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Circulation 113:2914-8. 2006
    ..Recent studies indicate that the prevalence of type 2 diabetes mellitus is increasing in the United States; less is known about trends in the incidence of type 2 diabetes mellitus...
  62. pmc Novel measurements of periaortic adipose tissue in comparison to anthropometric measures of obesity, and abdominal adipose tissue
    C L Schlett
    Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Obes (Lond) 33:226-32. 2009
    ....
  63. pmc Association of visceral and subcutaneous adiposity with kidney function
    Jill A Young
    Tufts New England Medical Center, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 3:1786-91. 2008
    ..Visceral (VAT) and subcutaneous adipose tissue (SAT) may confer differential metabolic risk profiles. The relations of VAT and SAT were analyzed with CKD as estimated by creatinine- and cystatin-based estimating equations...
  64. pmc Indexes of kidney function and coronary artery and abdominal aortic calcium (from the Framingham Offspring Study)
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 102:440-3. 2008
    ..Neither cysC nor MA was significantly associated with AAC in age- and gender- or multivariable-adjusted models. In conclusion, CKD, cysC, and MA are not associated with CAC or AAC when accounting for cardiovascular disease risk factors...
  65. pmc Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study
    George Thanassoulis
    Framingham Heart Study, Boston University and the National Institutes of Health National Heart, Lung, and Blood Institute, 73 Mt Wayte Ave No 2, Framingham, MA 01702, USA
    Circ Arrhythm Electrophysiol 3:345-50. 2010
    ..We tested the hypothesis that pericardial fat, a unique fat deposit in close anatomic proximity to cardiac structures and autonomic fibers, is associated with prevalent AF...
  66. pmc Prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat depots in the Framingham heart study
    George Thanassoulis
    National Institutes of Health National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, MA, Boston, USA
    Circ Cardiovasc Imaging 3:559-66. 2010
    ..We sought to determine the prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat deposits...
  67. ncbi request reprint Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community
    Ravi Dhingra
    Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702 5803, USA
    Circulation 116:480-8. 2007
    ..Consumption of soft drinks has been linked to obesity in children and adolescents, but it is unclear whether it increases metabolic risk in middle-aged individuals...
  68. pmc Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism
    G A Walford
    Center for Human Genetic Research, Simches Research Building CPZN 5 250, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    Diabetologia 55:331-9. 2012
    ..We hypothesised that a subset of these variants may have different effects on the transition from normal fasting glucose (NFG) to impaired fasting glucose (IFG) than on that from IFG to diabetes...
  69. ncbi request reprint Low-grade albuminuria and the risks of hypertension and blood pressure progression
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Circulation 111:1370-6. 2005
    ....
  70. ncbi request reprint Impact of impaired fasting glucose on cardiovascular disease: the Framingham Heart Study
    Yamini S Levitzky
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    J Am Coll Cardiol 51:264-70. 2008
    ..We sought to determine whether impaired fasting glucose (IFG) predicts cardiovascular disease (CVD) events...
  71. pmc Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study
    Susan Cheng
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes 59:242-8. 2010
    ..Few studies relating vitamin D deficiency to obesity have included direct measures of adiposity. Furthermore, the degree to which vitamin D is associated with metabolic traits after adjusting for adiposity measures is unclear...
  72. pmc Relations of insulin resistance and glycemic abnormalities to cardiovascular magnetic resonance measures of cardiac structure and function: the Framingham Heart Study
    Raghava S Velagaleti
    National Heart, Lung, and Blood Institute and the NHLBI Framingham Heart Study, Framingham, MA 01702, USA
    Circ Cardiovasc Imaging 3:257-63. 2010
    ..We sought to apply volumetric cardiovascular magnetic resonance (CMR) in a free-living cohort to potentially clarify these associations...
  73. pmc Association of parental obesity with concentrations of select systemic biomarkers in nonobese offspring: the Framingham Heart Study
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes 58:134-7. 2009
    ..Parental obesity is a risk factor for offspring obesity. It is unclear whether parental obesity also confers risk for obesity-associated conditions (e.g., a proinflammatory or prothrombotic state) in the absence of offspring obesity...
  74. pmc TCF7L2 variants associate with CKD progression and renal function in population-based cohorts
    Anna Kottgen
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Soc Nephrol 19:1989-99. 2008
    ..In conclusion, several population-based samples suggest that variants in the TCF7L2 gene are associated with reduced kidney function or CKD progression, overall and specifically among participants without diabetes...
  75. pmc Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality
    Wolfgang Lieb
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Arterioscler Thromb Vasc Biol 30:1849-54. 2010
    ..Experimental evidence identified the osteoprotegerin (OPG)/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand (RANKL) pathway as a candidate system modulating vascular remodeling and cardiovascular disease (CVD)...
  76. ncbi request reprint Mitral annular calcification is a predictor for incident atrial fibrillation
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, MA 01702 5827, USA
    Atherosclerosis 173:291-4. 2004
    ..Mitral annular calcification (MAC) has been associated with adverse cardiovascular disease outcomes and stroke in longitudinal and community-based cohorts. Prospective data are limited on its association with atrial fibrillation (AF)...
  77. ncbi request reprint Prevalence and prognostic impact of subclinical cardiovascular disease in individuals with the metabolic syndrome and diabetes
    Erik Ingelsson
    National Heart, Lung, and Blood Institute s Framingham Study, Framingham, Massachusetts 01702 5803, USA
    Diabetes 56:1718-26. 2007
    ..93 [1.15-3.24]). In our community-based sample, individuals with MetS have a high prevalence of subclinical atherosclerosis that likely contributes to the increased risk of overt CVD associated with the condition...
  78. pmc Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study
    Elliot S Stolerman
    Center for Human Genetic Research and Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 57:1971-7. 2008
    ..We set out to confirm the association of ENPP1 K121Q with hyperglycemia, expand this association to insulin resistance traits, and determine whether the association stems from K121Q or another variant in linkage disequilibrium with it...
  79. pmc Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study
    Marie France Hivert
    General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 58:750-6. 2009
    ..Using comprehensive linkage disequilibrium mapping, we genotyped tag single nucleotide polymorphisms (SNPs) in RETN and tested associations with plasma resistin levels, risk of diabetes, and glycemic traits...
  80. pmc Association between single-slice measurements of visceral and abdominal subcutaneous adipose tissue with volumetric measurements: the Framingham Heart Study
    T Irlbeck
    Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Int J Obes (Lond) 34:781-7. 2010
    ....
  81. pmc The ratio of visceral to subcutaneous fat, a metric of body fat distribution, is a unique correlate of cardiometabolic risk
    B M Kaess
    National Heart, Lung and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave Suite no 2, Framingham, MA 01702, USA
    Diabetologia 55:2622-30. 2012
    ..We hypothesised that the propensity to store energy in VAT relative to SAT depots may be a correlate of cardiometabolic risk, and tested this hypothesis using the VAT/SAT ratio as a metric of fat distribution...
  82. pmc TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study
    E S Stolerman
    Simches Research Building CPZN 5 250, Diabetes Unit Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, 02114, USA
    Diabetologia 52:614-20. 2009
    ..We reproduced the association of diabetes-associated variants with proinsulin/insulin ratios, and also examined the association of a TCF7L2 haplotype with obesity in the Framingham Heart Study (FHS)...
  83. pmc Plasma leptin levels and incidence of heart failure, cardiovascular disease, and total mortality in elderly individuals
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes Care 32:612-6. 2009
    ..We tested the hypothesis that leptin levels are associated with greater risk of CHF, CVD, and mortality in elderly individuals...
  84. pmc Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study
    Thomas M Tadros
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:1039-45. 2010
    ..Multiple markers of inflammation and oxidative stress correlated with pericardial and intrathoracic fat volumes, extending the known association between regional adiposity and inflammation and oxidative stress...
  85. pmc Multiple loci associated with indices of renal function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 41:712-7. 2009
    ..Our findings provide new insights into CKD pathogenesis and underscore the importance of common genetic variants influencing renal function and disease...
  86. ncbi request reprint Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study
    Erik Ingelsson
    Framingham Heart Study, Boston University School of Medicine, Framingham, MA 01702 5803, USA
    Circulation 116:984-92. 2007
    ..We evaluated the relative contributions of circulating biomarkers representing distinct biological pathways to the incidence of MetS and to longitudinal changes of its constituent risk factors...
  87. pmc Arterial stiffness in mild-to-moderate CKD
    Ashish Upadhyay
    Renal Section, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:2044-53. 2009
    ..Baseline arterial measures did not associate with incident CKD or incident microalbuminuria. In summary, arterial stiffness correlates with albuminuria but not with mild-to-moderate CKD...
  88. pmc Long-term trends in myocardial infarction incidence and case fatality in the National Heart, Lung, and Blood Institute's Framingham Heart study
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 119:1203-10. 2009
    ..We hypothesized that this paradox is due partly to the advent of increasingly sensitive biomarkers for AMI diagnosis...
  89. ncbi request reprint Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: the Framingham Heart Study
    Johan Arnlov
    Framingham Heart Study, National Heart, Lung and Blood Institute, Bethesda, MD, USA
    Circulation 112:969-75. 2005
    ..Data are limited with regard to the relations of low-grade albuminuria (below the microalbuminuria threshold) and incidence of cardiovascular disease (CVD) events in nondiabetic, nonhypertensive individuals...
  90. ncbi request reprint Parental occurrence of premature cardiovascular disease predicts increased coronary artery and abdominal aortic calcification in the Framingham Offspring and Third Generation cohorts
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:1473-81. 2007
    ..We related validated parental premature CVD with the subclinical measures of coronary artery (CAC) and abdominal aortic (AAC) calcification in the community...
  91. ncbi request reprint Comparison of anthropometric, area- and volume-based assessment of abdominal subcutaneous and visceral adipose tissue volumes using multi-detector computed tomography
    P Maurovich-Horvat
    Radiology Department, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Obes (Lond) 31:500-6. 2007
    ....
  92. ncbi request reprint Undertreatment of hyperlipidemia in a cohort of United States kidney dialysis patients
    C S Fox
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD 21205, USA
    Clin Nephrol 61:299-307. 2004
    ..Actual treatment patterns of hyperlipidemia are not well studied...
  93. pmc New loci associated with kidney function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:376-84. 2010
    ..These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney...
  94. pmc Parental obesity and offspring serum alanine and aspartate aminotransferase levels: the Framingham heart study
    Rohit Loomba
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
    Gastroenterology 134:953-9. 2008
    ..We sought to examine the relations between parental obesity and the serum ALT and AST levels among offspring in a community-based sample...
  95. ncbi request reprint Absence of association between polymorphisms in the hemostatic factor pathway genes and carotid intimal medial thickness: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Stroke 35:e65-7. 2004
    ..We sought to test whether carotid IMT is associated with polymorphisms in several well-characterized genes in the hemostatic factor pathways...
  96. pmc Neck circumference as a novel measure of cardiometabolic risk: the Framingham Heart study
    Sarah Rosner Preis
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA
    J Clin Endocrinol Metab 95:3701-10. 2010
    ..Neck circumference, a proxy for upper-body sc fat, may be a unique fat depot that confers additional cardiovascular risk above and beyond central body fat...
  97. ncbi request reprint Cross-classification of microalbuminuria and reduced glomerular filtration rate: associations between cardiovascular disease risk factors and clinical outcomes
    Meredith C Foster
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Arch Intern Med 167:1386-92. 2007
    ..Concordance between reduced eGFR and MA and associated cardiovascular disease (CVD) and all-cause mortality according to these definitions is uncertain...
  98. pmc Trends in cardiovascular disease risk factors in individuals with and without diabetes mellitus in the Framingham Heart Study
    Sarah Rosner Preis
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Circulation 120:212-20. 2009
    ..Our objective was to examine CVD risk factor level changes among individuals with and without type 2 diabetes mellitus from 1970 to 2005 in the Framingham Heart Study...
  99. pmc Sex and age specific effects of chromosomal regions linked to body mass index in the Framingham Study
    Larry D Atwood
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Genet 7:7. 2006
    ..We performed variance components linkage analysis on these intersection datasets and on their sex-specific subsets...
  100. pmc Eligibility of individuals with subclinical coronary artery calcium and intermediate coronary heart disease risk for reclassification (from the Framingham Heart Study)
    Sarah Rosner Preis
    Center for Population Studies, National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 103:1710-5. 2009
    ..Approximately 25% of intermediate-risk individuals have high CAC scores and may be eligible for reclassification into a higher-risk category...
  101. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
    ..Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension...