Research Topics
Species | Paul M D FosterSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Mode of action: impaired fetal leydig cell function--effects on male reproductive development produced by certain phthalate estersPaul M D Foster
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Crit Rev Toxicol 35:713-9. 2005....- Disruption of reproductive development in male rat offspring following in utero exposure to phthalate estersPaul M D Foster
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Int J Androl 29:140-7; discussion 181-5. 2006..However humans are exposed to and produce the critical phthalate metabolites that have been detected in blood of the general population, in children and also human amniotic fluid... - Changes in androgen-mediated reproductive development in male rat offspring following exposure to a single oral dose of flutamide at different gestational agesPaul M D Foster
Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 85:1024-32. 2005.... - Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male ratChristopher J Bowman
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 74:393-406. 2003..In summary, prenatal exposure to finasteride specifically inhibited DHT-mediated development with little to no change in T-mediated development... - Effects of in utero linuron exposure on rat Wolffian duct developmentBarry S McIntyre
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
Reprod Toxicol 16:131-9. 2002..However, the absence of testicular lesions or alterations in fetal testosterone levels would suggest that the effect of linuron on the developing Wolffian ducts is distinctly different from DBP or DEHP... - Altered gene expression during rat Wolffian duct development following di(n-butyl) phthalate exposureChristopher J Bowman
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 86:161-74. 2005.... - Altered gene expression during rat Wolffian duct development in response to in utero exposure to the antiandrogen linuronKatie J Turner
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
Toxicol Sci 74:114-28. 2003..The EGF, Notch, IGF-1, BMP4, and FGF signaling pathways may be involved in normal testosterone-mediated development of the Wolffian duct... - Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalateNorman J Barlow
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 73:431-41. 2003..Diminished Leydig cell lipid content and alteration of cholesterol transport genes also support altered cholesterol metabolism and transport as a potential mechanism for decreased T synthesis following exposure to DBP... 
Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potencyBethany R Hannas
Reproductive Toxicology Branch, Toxicology Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 125:544-57. 2012..Finally, the observed mixture interaction was adequately modeled by the dose-addition model for most of the affected genes. Together, these data advance our understanding of the collective reproductive toxicity of the PE compounds...- Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalateNorman J Barlow
CIIT Centers for Health Research, Research Triangle Park, North Carolina, USA
Toxicol Pathol 32:79-90. 2004..While the morphology and incidence of this DBP-induced testicular developmental lesion has been fully characterized by this study, the detailed pathogenesis warrants further investigation... - Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to Di(n-butyl) phthalateNorman J Barlow
CIIT Centers for Health Research, Six Davis Drive, PO Box 12137, Research Triangle Park, North Carolina 27709-2137, USA
Toxicol Pathol 31:397-410. 2003..The pathogenesis of lesion development from the fetus to the adult is important for comparison of antiandrogens with differing modes of action... - Effects of in utero exposure to the organophosphate insecticide fenitrothion on androgen-dependent reproductive development in the Crl:CD(SD)BR ratKatie J Turner
CIIT Centers for Health Research, P O Box 12137, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 68:174-83. 2002..Based on observed fetotoxicity at 20 mg/kg/day, the lowest observed adverse effect level (LOAEL) for developmental effects can be lowered from 25 to 20 mg/kg/day... - Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalateKim P Lehmann
CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA
Toxicol Sci 81:60-8. 2004..Alterations in gene and protein expression and testosterone synthesis may serve as sensitive indicators of testicular response to DBP... - Critical window of male reproductive tract development in rats following gestational exposure to di-n-butyl phthalateChristina M Carruthers
National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Birth Defects Res B Dev Reprod Toxicol 74:277-85. 2005..This study was conducted to identify the critical days for the abnormal development of the male reproductive tract, specifically the testis and epididymis... - Endocrine active agents: implications of adverse and non-adverse changesPaul M D Foster
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
Toxicol Pathol 30:59-65. 2002.... - Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalateEve Mylchreest
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
Reprod Toxicol 16:19-28. 2002..The overall decrease in androgen concentration is not corrected and results in reproductive tract malformations. The multinuclearity and proliferation of gonocytes suggests an underlying Sertoli cell dysfunction... - Dipentyl phthalate dosing during sexual differentiation disrupts fetal testis function and postnatal development of the male Sprague-Dawley rat with greater relative potency than other phthalatesBethany R Hannas
National Research Council Fellowship Program, National Health and Environmental Effects Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 120:184-93. 2011.... - Male rats exposed to linuron in utero exhibit permanent changes in anogenital distance, nipple retention, and epididymal malformations that result in subsequent testicular atrophyBarry S McIntyre
CIIT Centers for Health Research, P. O. Box 12137, Research Triangle Park, North Carolina 27709-2137, USA
Toxicol Sci 65:62-70. 2002.... - Determination of the di-(2-ethylhexyl) phthalate NOAEL for reproductive development in the rat: importance of the retention of extra animals to adulthoodChad R Blystone
Department of Health andHuman Services, National Institute of Environmental Health, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 116:640-6. 2010.... - Toxicity and carcinogenicity of androstenedione in F344/N rats and B6C3F1 miceChad R Blystone
National Toxicology Program, National Institutes of Environmental Health Sciences, National Institute of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, United States
Food Chem Toxicol 49:2116-24. 2011..In conclusion, androstenedione was determined to be carcinogenic in male and female mice, and may have been carcinogenic in rats... - Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. II: Chronic dosing causes developmental delayDavid R Bell
School of Biology, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
Toxicol Sci 99:224-33. 2007.... - Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. I: No decrease in epididymal sperm count after a single acute doseDavid R Bell
School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
Toxicol Sci 99:214-23. 2007..These data show that TCDD is a potent developmental toxin after exposure of the developing fetus but that acute developmental exposure to TCDD on GD15 caused no decrease in sperm counts... - Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity dataJennifer Seed
US Environmental Protection Agency, Washington, DC, USA
Crit Rev Toxicol 35:664-72. 2005.... - Relationships between tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mRNAs, and toxicity in the developing male Wistar(Han) ratDavid R Bell
School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
Toxicol Sci 99:591-604. 2007..These data characterize the maternal and fetal disposition of TCDD, induction of CYP1A1 RNA as a measure of AhR activation, and suggest that lactational transfer of TCDD determines the difference in delay in BPS between the two studies...