Paul M D Foster

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Mode of action: impaired fetal leydig cell function--effects on male reproductive development produced by certain phthalate esters
    Paul M D Foster
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Crit Rev Toxicol 35:713-9. 2005
  2. pmc Workgroup report: National Toxicology Program workshop on Hormonally Induced Reproductive Tumors - Relevance of Rodent Bioassays
    Kristina A Thayer
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 115:1351-6. 2007
  3. ncbi request reprint Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters
    Paul M D Foster
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Androl 29:140-7; discussion 181-5. 2006
  4. ncbi request reprint Changes in androgen-mediated reproductive development in male rat offspring following exposure to a single oral dose of flutamide at different gestational ages
    Paul M D Foster
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 85:1024-32. 2005
  5. ncbi request reprint Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat
    Christopher J Bowman
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 74:393-406. 2003
  6. ncbi request reprint Effects of in utero linuron exposure on rat Wolffian duct development
    Barry S McIntyre
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Reprod Toxicol 16:131-9. 2002
  7. ncbi request reprint Altered gene expression during rat Wolffian duct development following di(n-butyl) phthalate exposure
    Christopher J Bowman
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 86:161-74. 2005
  8. ncbi request reprint Altered gene expression during rat Wolffian duct development in response to in utero exposure to the antiandrogen linuron
    Katie J Turner
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 74:114-28. 2003
  9. pmc Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potency
    Bethany R Hannas
    Reproductive Toxicology Branch, Toxicology Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 125:544-57. 2012
  10. ncbi request reprint Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate
    Norman J Barlow
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 73:431-41. 2003

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Mode of action: impaired fetal leydig cell function--effects on male reproductive development produced by certain phthalate esters
    Paul M D Foster
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Crit Rev Toxicol 35:713-9. 2005
    ....
  2. pmc Workgroup report: National Toxicology Program workshop on Hormonally Induced Reproductive Tumors - Relevance of Rodent Bioassays
    Kristina A Thayer
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 115:1351-6. 2007
    ..Breakout group reports and additional information on the workshop, including participants, presentations, public comments and background materials, are posted on the NTP website...
  3. ncbi request reprint Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters
    Paul M D Foster
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Androl 29:140-7; discussion 181-5. 2006
    ..However humans are exposed to and produce the critical phthalate metabolites that have been detected in blood of the general population, in children and also human amniotic fluid...
  4. ncbi request reprint Changes in androgen-mediated reproductive development in male rat offspring following exposure to a single oral dose of flutamide at different gestational ages
    Paul M D Foster
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 85:1024-32. 2005
    ....
  5. ncbi request reprint Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat
    Christopher J Bowman
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 74:393-406. 2003
    ..In summary, prenatal exposure to finasteride specifically inhibited DHT-mediated development with little to no change in T-mediated development...
  6. ncbi request reprint Effects of in utero linuron exposure on rat Wolffian duct development
    Barry S McIntyre
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Reprod Toxicol 16:131-9. 2002
    ..However, the absence of testicular lesions or alterations in fetal testosterone levels would suggest that the effect of linuron on the developing Wolffian ducts is distinctly different from DBP or DEHP...
  7. ncbi request reprint Altered gene expression during rat Wolffian duct development following di(n-butyl) phthalate exposure
    Christopher J Bowman
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 86:161-74. 2005
    ....
  8. ncbi request reprint Altered gene expression during rat Wolffian duct development in response to in utero exposure to the antiandrogen linuron
    Katie J Turner
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 74:114-28. 2003
    ..The EGF, Notch, IGF-1, BMP4, and FGF signaling pathways may be involved in normal testosterone-mediated development of the Wolffian duct...
  9. pmc Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potency
    Bethany R Hannas
    Reproductive Toxicology Branch, Toxicology Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 125:544-57. 2012
    ..Finally, the observed mixture interaction was adequately modeled by the dose-addition model for most of the affected genes. Together, these data advance our understanding of the collective reproductive toxicity of the PE compounds...
  10. ncbi request reprint Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate
    Norman J Barlow
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 73:431-41. 2003
    ..Diminished Leydig cell lipid content and alteration of cholesterol transport genes also support altered cholesterol metabolism and transport as a potential mechanism for decreased T synthesis following exposure to DBP...
  11. ncbi request reprint Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate
    Norman J Barlow
    CIIT Centers for Health Research, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 32:79-90. 2004
    ..While the morphology and incidence of this DBP-induced testicular developmental lesion has been fully characterized by this study, the detailed pathogenesis warrants further investigation...
  12. ncbi request reprint Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to Di(n-butyl) phthalate
    Norman J Barlow
    CIIT Centers for Health Research, Six Davis Drive, PO Box 12137, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Pathol 31:397-410. 2003
    ..The pathogenesis of lesion development from the fetus to the adult is important for comparison of antiandrogens with differing modes of action...
  13. ncbi request reprint Effects of in utero exposure to the organophosphate insecticide fenitrothion on androgen-dependent reproductive development in the Crl:CD(SD)BR rat
    Katie J Turner
    CIIT Centers for Health Research, P O Box 12137, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 68:174-83. 2002
    ..Based on observed fetotoxicity at 20 mg/kg/day, the lowest observed adverse effect level (LOAEL) for developmental effects can be lowered from 25 to 20 mg/kg/day...
  14. ncbi request reprint Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate
    Kim P Lehmann
    CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA
    Toxicol Sci 81:60-8. 2004
    ..Alterations in gene and protein expression and testosterone synthesis may serve as sensitive indicators of testicular response to DBP...
  15. ncbi request reprint Critical window of male reproductive tract development in rats following gestational exposure to di-n-butyl phthalate
    Christina M Carruthers
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Birth Defects Res B Dev Reprod Toxicol 74:277-85. 2005
    ..This study was conducted to identify the critical days for the abnormal development of the male reproductive tract, specifically the testis and epididymis...
  16. ncbi request reprint Endocrine active agents: implications of adverse and non-adverse changes
    Paul M D Foster
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Pathol 30:59-65. 2002
    ....
  17. ncbi request reprint Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate
    Eve Mylchreest
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Reprod Toxicol 16:19-28. 2002
    ..The overall decrease in androgen concentration is not corrected and results in reproductive tract malformations. The multinuclearity and proliferation of gonocytes suggests an underlying Sertoli cell dysfunction...
  18. pmc Dipentyl phthalate dosing during sexual differentiation disrupts fetal testis function and postnatal development of the male Sprague-Dawley rat with greater relative potency than other phthalates
    Bethany R Hannas
    National Research Council Fellowship Program, National Health and Environmental Effects Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 120:184-93. 2011
    ....
  19. ncbi request reprint Male rats exposed to linuron in utero exhibit permanent changes in anogenital distance, nipple retention, and epididymal malformations that result in subsequent testicular atrophy
    Barry S McIntyre
    CIIT Centers for Health Research, P O Box 12137, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 65:62-70. 2002
    ....
  20. pmc Toxicity and carcinogenicity of androstenedione in F344/N rats and B6C3F1 mice
    Chad R Blystone
    National Toxicology Program, National Institutes of Environmental Health Sciences, National Institute of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, United States
    Food Chem Toxicol 49:2116-24. 2011
    ..In conclusion, androstenedione was determined to be carcinogenic in male and female mice, and may have been carcinogenic in rats...
  21. pmc Determination of the di-(2-ethylhexyl) phthalate NOAEL for reproductive development in the rat: importance of the retention of extra animals to adulthood
    Chad R Blystone
    Department of Health andHuman Services, National Institute of Environmental Health, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 116:640-6. 2010
    ....
  22. ncbi request reprint Laboratory animal science issues in the design and conduct of studies with endocrine-active compounds
    Jeffrey I Everitt
    GlaxoSmithKline Pharmaceutical Research and Development, Research Triangle Park, NC, USA
    ILAR J 45:417-24. 2004
    ..Several key animal care and use issues that are important to consider in endocrine experiments with rodent models are described...
  23. ncbi request reprint Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. II: Chronic dosing causes developmental delay
    David R Bell
    School of Biology, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
    Toxicol Sci 99:224-33. 2007
    ....
  24. ncbi request reprint Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. I: No decrease in epididymal sperm count after a single acute dose
    David R Bell
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Toxicol Sci 99:214-23. 2007
    ..These data show that TCDD is a potent developmental toxin after exposure of the developing fetus but that acute developmental exposure to TCDD on GD15 caused no decrease in sperm counts...
  25. ncbi request reprint Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity data
    Jennifer Seed
    US Environmental Protection Agency, Washington, DC, USA
    Crit Rev Toxicol 35:664-72. 2005
    ....
  26. ncbi request reprint Relationships between tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mRNAs, and toxicity in the developing male Wistar(Han) rat
    David R Bell
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    Toxicol Sci 99:591-604. 2007
    ..These data characterize the maternal and fetal disposition of TCDD, induction of CYP1A1 RNA as a measure of AhR activation, and suggest that lactational transfer of TCDD determines the difference in delay in BPS between the two studies...