Research Topics
| Jessica H FongSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Protein subfamily assignment using the Conserved Domain DatabaseJessica H Fong
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA
BMC Res Notes 1:114. 2008..Here, we propose a method for assigning NCBI-curated domains from the Curated Domain Database (CDD) that takes into account the organization of the domains into hierarchies of homologous domain models...
CORAL: aligning conserved core regions across domain familiesJessica H Fong
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Bioinformatics 25:1862-8. 2009..To improve accuracy in aligning such protein families, we propose a profile-profile method CORAL that aligns individual core regions as gap-free units...
Intrinsic disorder and protein multibinding in domain, terminal, and linker regionsJessica H Fong
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Mol Biosyst 6:1821-8. 2010..In particular, they support the hypothesis that protein domains with many interacting partners should have a pleiotropic effect on functional pathways and consequently might be more constrained in evolution...
Intrinsic protein disorder in human pathwaysJessica H Fong
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA
Mol Biosyst 8:320-6. 2012..Finally we find that relations involving protein activation and to some extent inhibition are characterized by low disorder content...
IBIS (Inferred Biomolecular Interaction Server) reports, predicts and integrates multiple types of conserved interactions for proteinsBenjamin A Shoemaker
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Building 38A, Bethesda, MD 20894, USA
Nucleic Acids Res 40:D834-40. 2012..The IBIS server is available at http://www.ncbi.nlm.nih.gov/Structure/ibis/ibis.cgi and updated biweekly...
Inferred Biomolecular Interaction Server--a web server to analyze and predict protein interacting partners and binding sitesBenjamin A Shoemaker
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Nucleic Acids Res 38:D518-24. 2010..IBIS is updated regularly and is freely accessible via http://www.ncbi.nlm.nih.gov/Structure/ibis/ibis.html...
CDD: a Conserved Domain Database for the functional annotation of proteinsAron Marchler-Bauer
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA
Nucleic Acids Res 39:D225-9. 2011..CDD can be accessed via http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml...
CDD: specific functional annotation with the Conserved Domain DatabaseAron Marchler-Bauer
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA
Nucleic Acids Res 37:D205-10. 2009....
Intrinsic disorder in protein interactions: insights from a comprehensive structural analysisJessica H Fong
National Center for Biotechnology Information, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Comput Biol 5:e1000316. 2009..The fascinating diversity of roles of disordered regions in various biological processes and protein oligomeric forms shown in our study may be a subject of future endeavors in this area...
MMDB: 3D structures and macromolecular interactionsThomas Madej
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA
Nucleic Acids Res 40:D461-4. 2012..MMDB can be accessed at http://www.ncbi.nlm.nih.gov/structure...
Modeling the evolution of protein domain architectures using maximum parsimonyJessica H Fong
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA
J Mol Biol 366:307-15. 2007..Domain architecture "neighbors" identified in this way may lead to new insights about the evolution of protein function...
