Dean Follmann

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc An augmented probit model for missing predictable covariates in quantal bioassay with small sample size
    Dean Follmann
    Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive MSC 7609, Bethesda, Maryland 20892, USA
    Biometrics 67:1127-34. 2011
  2. doi request reprint Chop-lump tests for vaccine trials
    Dean Follmann
    Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, MSC 7609, Bethesda, Maryland 20892, USA
    Biometrics 65:885-93. 2009
  3. pmc Endpoints and regulatory issues in HIV vaccine clinical trials: lessons from a workshop
    Dean Follmann
    National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Acquir Immune Defic Syndr 44:49-60. 2007
  4. ncbi request reprint Exact inference for complex clustered data using within-cluster resampling
    Dean Follmann
    Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Biopharm Stat 20:850-69. 2010
  5. pmc Augmented designs to assess immune response in vaccine trials
    Dean Follmann
    Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive MSC 7609, Bethesda, Maryland 20892, USA
    Biometrics 62:1161-9. 2006
  6. ncbi request reprint Multiple outputation: inference for complex clustered data by averaging analyses from independent data
    Dean Follmann
    National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive MSC 7609, Bethesda, Maryland 20892, USA
    Biometrics 59:420-9. 2003
  7. pmc HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells
    Marta Catalfamo
    Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation and Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:19851-6. 2008
  8. pmc CCR5 deficiency is a risk factor for early clinical manifestations of West Nile virus infection but not for viral transmission
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, Laboratory of Cellular and Molecular Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 201:178-85. 2010
  9. ncbi request reprint A nonparametric likelihood test for detecting discordance between two measurements with application to censored viral load determinations
    Zonghui Hu
    Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 7609, USA
    Stat Med 27:4489-501. 2008
  10. pmc Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals
    Manuela Fogli
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 4:e1000101. 2008

Detail Information

Publications40

  1. pmc An augmented probit model for missing predictable covariates in quantal bioassay with small sample size
    Dean Follmann
    Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive MSC 7609, Bethesda, Maryland 20892, USA
    Biometrics 67:1127-34. 2011
    ..In simulations, we compare the pseudo-likelihood estimates with regression calibration and a full joint likelihood approach...
  2. doi request reprint Chop-lump tests for vaccine trials
    Dean Follmann
    Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, MSC 7609, Bethesda, Maryland 20892, USA
    Biometrics 65:885-93. 2009
    ..The chop-lump tests are compared to established tests via simulation for planned HIV and malaria vaccine trials. A reanalysis of the first phase III HIV vaccine trial is used to illustrate the method...
  3. pmc Endpoints and regulatory issues in HIV vaccine clinical trials: lessons from a workshop
    Dean Follmann
    National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Acquir Immune Defic Syndr 44:49-60. 2007
    ..Use of acquisition and a postinfection surrogate as coprimary endpoints was supported, along with use of composite endpoints and exploration of heterogeneity in vaccine efficacy by characteristics of the host and virus...
  4. ncbi request reprint Exact inference for complex clustered data using within-cluster resampling
    Dean Follmann
    Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Biopharm Stat 20:850-69. 2010
    ..We discuss both exact and Monte Carlo versions of the approach and apply it to several data sets. WCR permutation can be applied in quite general settings when within cluster correlation is a nuisance and exact inference is necessary...
  5. pmc Augmented designs to assess immune response in vaccine trials
    Dean Follmann
    Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive MSC 7609, Bethesda, Maryland 20892, USA
    Biometrics 62:1161-9. 2006
    ..Such designs may help elucidate the role of immune response in preventing infections. More pointedly, they could be helpful in the decision to improve or abandon an HIV vaccine with mediocre performance in a phase III trial...
  6. ncbi request reprint Multiple outputation: inference for complex clustered data by averaging analyses from independent data
    Dean Follmann
    National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive MSC 7609, Bethesda, Maryland 20892, USA
    Biometrics 59:420-9. 2003
    ..It is especially suited to settings where methods for clustered data are impractical, but can also be applied generally as a quick and simple tool...
  7. pmc HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells
    Marta Catalfamo
    Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation and Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:19851-6. 2008
    ..Taken together these data demonstrate that at least two different pathways lead to immune activation of T cells in patients with HIV infection and these pathways differentially influence CD4 and CD8 T cell subsets...
  8. pmc CCR5 deficiency is a risk factor for early clinical manifestations of West Nile virus infection but not for viral transmission
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, Laboratory of Cellular and Molecular Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 201:178-85. 2010
    ....
  9. ncbi request reprint A nonparametric likelihood test for detecting discordance between two measurements with application to censored viral load determinations
    Zonghui Hu
    Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 7609, USA
    Stat Med 27:4489-501. 2008
    ..The plasma samples are used to determine viral load and a large portion of data are left censored due to a lower detection limit...
  10. pmc Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals
    Manuela Fogli
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 4:e1000101. 2008
    ....
  11. ncbi request reprint Dynamic comparison of Kaplan-Meier proportions: monitoring a randomized clinical trial with a long-term binary endpoint
    Erica Brittain
    Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Biometrics 64:189-97. 2008
    ..In contrast, a fixed time KM comparison and the log-rank test are both shown to be more variable in performance. Practical considerations of implementing the DKM method are discussed...
  12. ncbi request reprint Cluster without fluster: The effect of correlated outcomes on inference in randomized clinical trials
    Michael Proschan
    Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    Stat Med 27:795-809. 2008
    ..It is nonetheless possible to obtain a 'bad' randomization such that members of a cluster tend to be assigned to the same treatment. Conditioned on such a bad randomization, the type 1 error rate is increased...
  13. ncbi request reprint Antithymocyte globulin and cyclosporine for severe aplastic anemia: association between hematologic response and long-term outcome
    Stephen Rosenfeld
    Hematology Branch, Bldg 10, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    JAMA 289:1130-5. 2003
    ..In most patients, aplastic anemia results from T-cell-mediated immune destruction of bone marrow. Aplastic anemia can be effectively treated by stem cell transplantation or immunosuppression...
  14. ncbi request reprint Compromised B cell responses to influenza vaccination in HIV-infected individuals
    Angela Malaspina
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Infect Dis 191:1442-50. 2005
    ..We assessed the impact of HIV disease on B cell responses to influenza vaccination...
  15. doi request reprint A hierarchical rank test for crossover trials with censored data
    Erica Brittain
    Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Stat Med 30:3507-19. 2011
    ..We additionally feel that the hierarchical ranking method should be more clinically relevant in many settings. The method can also be applied to continuous outcomes censored by a limit of detection, such as HIV viremia...
  16. pmc Long-term administration of valacyclovir reduces the number of Epstein-Barr virus (EBV)-infected B cells but not the number of EBV DNA copies per B cell in healthy volunteers
    Yo Hoshino
    Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 83:11857-61. 2009
    ..Valacyclovir reduces the frequency of EBV-infected B cells when administered over a long period and, in theory, might allow eradication of EBV from the body if reinfection does not occur...
  17. ncbi request reprint A comparative analysis of the results from 4 trials of beta-blocker therapy for heart failure: BEST, CIBIS-II, MERIT-HF, and COPERNICUS
    Michael J Domanski
    Clinical Trials Group, National Heart, Lung, and Blood Institute NIH, 6701 Rockledge Drive, Room 8146, Bethesda, MD 20892 7936, USA
    J Card Fail 9:354-63. 2003
    ..These findings are further compared with COPERNICUS, which entered patients with more severe heart failure...
  18. pmc Dynamics of intermittent viremia during highly active antiretroviral therapy in patients who initiate therapy during chronic versus acute and early human immunodeficiency virus type 1 infection
    Michele Di Mascio
    Theoretical Division, Los Alamos National Laboratory, New Mexico, USA
    J Virol 78:10566-73. 2004
    ..Finally, in PHI patients the VL set point was a significant predictor of blip frequency during treatment...
  19. ncbi request reprint Intracellular interferon-gamma in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia
    Elaine Sloand
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1652, USA
    Blood 100:1185-91. 2002
    ..IFN-gamma is increased in the PB lymphocytes of many patients with AA, and these cells decline with therapy. The presence of intracellular IFN-gamma may predict response to immunosuppressive treatment and also the onset of relapse...
  20. ncbi request reprint T-cell large granular lymphocyte leukemia is characterized by massive TCRBV-restricted clonal CD8 expansion and a generalized overexpression of the effector cell marker CD57
    J Joseph Melenhorst
    Stem Cell Allotransplantation Section, NHLBI, NIH, Bethesda, MD 20892, USA
    Hematol J 4:18-25. 2003
    ..We previously demonstrated that the clone can be found in both CD8+CD57+ and CD8+CD57- cells, indicating that the LGL clone also resides in the CD57- fraction...
  21. ncbi request reprint G-CSF-induced spleen size changes in peripheral blood progenitor cell donors
    David Stroncek
    Department of Transfusion Medicine, National Institutes of Health, Warren G Magnuson Clinical Center, Building 10, Room 1C711, 10 Center Drive MSC 1184, Bethesda, MD 20892 1184, USA
    Transfusion 43:609-13. 2003
    ..This study evaluated the incidence and time course of splenic enlargement in PBPC concentrate donors and assessed factors affecting size changes...
  22. ncbi request reprint The effect of diabetes on outcomes of patients with advanced heart failure in the BEST trial
    Michael Domanski
    Clinical Trials Group, National Heart, Lung, and Blood Institute NIH, 6701 Rockledge Drive, Bethesda, MD 20892, USA
    J Am Coll Cardiol 42:914-22. 2003
    ..This was a retrospective analysis to determine the effect of diabetes on outcome in patients with advanced heart failure (HF), and to determine the effect of beta-blockade in patients with HF with and without diabetes mellitus...
  23. ncbi request reprint Molecular and flow cytometric characterization of the CD4 and CD8 T-cell repertoire in patients with myelodysplastic syndrome
    J Joseph Melenhorst
    Hematology Branch, and Office of Biostatistics Research, NHLBI, NIH, Bethesda 20892, USA
    Br J Haematol 119:97-105. 2002
    ..Together, these data support the hypothesis of the involvement of T cells in the pathogenesis of MDS...
  24. ncbi request reprint Statistical methods for active extension trials
    Zonghui Hu
    Biostatistics Research Branch, National Institute of Allergy and Infectious Disease, National Institutes of Health, 6700A Rockledge Drive, MSC 7609, Bethesda, MD, USA
    Stat Med 26:2433-48. 2007
    ..In general, the proposed period 2 procedure can provide an efficient way to supplement but not supplant the usual period 1 analysis...
  25. pmc Osteopenia in X-linked hyper-IgM syndrome reveals a regulatory role for CD40 ligand in osteoclastogenesis
    Eduardo Lopez-Granados
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:5056-61. 2007
    ..These results show that CD40L can influence RANKL signaling through T cell priming, and thus they demonstrate a regulatory role for CD40L in bone mineralization that is absent in patients with X-linked hyper-IgM syndrome...
  26. doi request reprint Design and analysis of crossover trials for absorbing binary endpoints
    Martha Nason
    Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Disease, Bethesda, Maryland 20892, USA
    Biometrics 66:958-65. 2010
    ..Simulations are used to compare the different designs and an example is provided to explore practical issues in implementation...
  27. ncbi request reprint Persisting posttransplantation cytomegalovirus antigenemia correlates with poor lymphocyte proliferation to cytomegalovirus antigen and predicts for increased late relapse and treatment failure
    Ryotaro Nakamura
    Stem Cell Allogenetic Transplant Unit, Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA
    Biol Blood Marrow Transplant 10:49-57. 2004
    ..The higher relapse rate may reflect poor immune reconstitution in ID patients or an adverse effect of prolonged antiviral treatment...
  28. pmc Enhanced effector function of CD8(+) T cells from healthy controls and HIV-infected patients occurs through thrombin activation of protease-activated receptor 1
    Amanda Hurley
    CMRS Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1360, USA
    J Infect Dis 207:638-50. 2013
    ..These findings suggest that thrombin mediates cross-talk between the coagulation system and the adaptive immune system at sites of vascular injury through increased T-cell motility and production of proinflammatory cytokines...
  29. ncbi request reprint Contribution of TCR-beta locus and HLA to the shape of the mature human Vbeta repertoire
    J Joseph Melenhorst
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 180:6484-9. 2008
    ..We therefore conclude that the correlation in Vbeta expression patterns between CD4(+) and CD8(+) T cells can be explained predominantly by germline TCR-beta locus factors and not TCR-beta allelic or HLA effects...
  30. ncbi request reprint IL-2-induced CD4+ T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation
    Irini Sereti
    Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 104:775-80. 2004
    ..These data suggest that decreased T-cell proliferation is central in the CD4+ T-cell expansions induced by IL-2...
  31. pmc Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection
    Domenico Mavilio
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:2339-50. 2006
    ....
  32. pmc Discordant minimum inhibitory concentration analysis: a new path to licensure for anti-infective drugs
    Dean Follmann
    aBiostatistics Research Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    Clin Trials 10:876-85. 2013
    ..The margin must be based on historical studies that estimate the magnitude of the benefit of drug A over placebo. This approach hampers drug development because the obligatory evidence for margin determination is often nonexistent...
  33. pmc A statistical method for adjusting covariates in linkage analysis with sib pairs
    Colin O Wu
    Office of Biostatistics, DECA, National Heart, Lung, and Blood Institute, 2 Rockledge Center, Bethesda, Maryland, USA
    BMC Genet 4:S51. 2003
    ....
  34. pmc Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    PLoS Pathog 5:e1000321. 2009
    ..0001). Together, these data identify OAS1 SNP rs10774671 as a host genetic risk factor for initial infection with WNV in humans...
  35. pmc The number of herpes simplex virus-infected neurons and the number of viral genome copies per neuron correlate with the latent viral load in ganglia
    Yo Hoshino
    Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    Virology 372:56-63. 2008
    ....
  36. pmc High dose atorvastatin decreases cellular markers of immune activation without affecting HIV-1 RNA levels: results of a double-blind randomized placebo controlled clinical trial
    Anuradha Ganesan
    Division of Infectious Diseases, National Naval Medical Center, Uniformed Services University, Bethesda, Maryland, USA
    J Infect Dis 203:756-64. 2011
    ..Studies evaluating the antiviral activity of statins have yielded conflicting results...
  37. ncbi request reprint Kinetics of G-CSF-induced granulocyte mobilization in healthy subjects: effects of route of administration and addition of dexamethasone
    David F Stroncek
    Department of Transfusion Medicine, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1184, USA
    Transfusion 42:597-602. 2002
    ..The purpose of this study was to assess the kinetics of G-CSF plus dexamethasone neutrophil mobilization to determine whether the neutrophils can be mobilized and collected the same day...
  38. pmc Longitudinal change in the BODE index predicts mortality in severe emphysema
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0360, USA
    Am J Respir Crit Care Med 178:491-9. 2008
    ..We hypothesized that decrease in a modified BODE (mBODE) would predict survival in National Emphysema Treatment Trial (NETT) patients...
  39. ncbi request reprint Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial
    Peter B Gilbert
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    J Infect Dis 191:666-77. 2005
    ....
  40. doi request reprint Continuous oxygen use in nonhypoxemic emphysema patients identifies a high-risk subset of patients: retrospective analysis of the National Emphysema Treatment Trial
    Michael B Drummond
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Chest 134:497-506. 2008
    ..Little is known regarding the clinical characteristics and survival of nonhypoxemic emphysema patients using continuous oxygen. Analysis of data from the National Emphysema Treatment Trial (NETT) offers insight into this population...