Research Topics
Genomes and Genes | Julie F FoleySummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Detection of human CYP2C8, CYP2C9, and CYP2J2 in cardiovascular tissuesTracy C DeLozier
National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
Drug Metab Dispos 35:682-8. 2007..The expression of CYP2J2 and CYP2C8 in human heart, and CYPC9 and CYP2J2 in aorta and coronary artery is consistent with a physiological role for these enzymes in these tissues...- Transcriptomic analysis of pathways regulated by toll-like receptor 4 in a murine model of chronic pulmonary inflammation and carcinogenesisAlison K Bauer
Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, USA
Mol Cancer 8:107. 2009..This study was designed to identify TLR4-mediated gene expression pathways that may be used as prognostic indicators of susceptibility to lung tumorigenesis in mice and provide insight into the mechanism... - Optimal sampling of rat liver tissue for toxicogenomic studiesJulie F Foley
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 34:795-801. 2006..Additionally, a powdered sample provided the advantages of a homogenous sample pool and the ability to use sample aliquots for other analyses to include proteomics, metabonomics, and other molecular techniques... 
Gene expression analysis offers unique advantages to histopathology in liver biopsy evaluationsAlexandra N Heinloth
National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Toxicol Pathol 35:276-83. 2007....- Gastrointestinal hyperplasia with altered expression of DNA polymerase betaKatsuhiko Yoshizawa
Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
PLoS ONE 4:e6493. 2009..Altered expression of DNA polymerase beta (Pol beta) has been documented in a large percentage of human tumors. However, tumor prevalence or predisposition resulting from Pol beta over-expression has not yet been evaluated in a mouse model... - Testing an aflatoxin B1 gene signature in rat archival tissuesB Alex Merrick
Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
Chem Res Toxicol 25:1132-44. 2012..We conclude that an evaluation of gene signatures in archival tissues can be an important toxicological tool for evaluating critical molecular events associated with chemical exposures... - Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heartMatthew L Edin
Division of Intramural Research, National Institute for Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
FASEB J 25:3436-47. 2011..These data demonstrate that increased ROS generation and enhanced DiHOME synthesis by endothelial CYP2C8 impair functional recovery and mask the beneficial effects of increased EET production following I/R... - Mechanisms of exocrine pancreatic toxicity induced by oral treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Harlan Sprague-Dawley RatsKatsuhiko Yoshizawa
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 85:594-606. 2005..Changes in the expression of CYP or CCKAR may have induced the acinar-cell tumors by initiating proliferation... - Follicular epithelial cell hypertrophy induced by chronic oral administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Harlan Sprague-Dawley ratsYoshiro Tani
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 32:41-9. 2004..These results indicate that the follicular cell response was hypertrophic and reversible. This information should contribute to diagnosis of nonneoplastic thyroid follicular lesions in rats... - Ocular expression of vascular cell adhesion molecule (VCAM-1) in 2-butoxyethanol-induced hemolysis and thrombosis in female ratsAbraham Nyska
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 9998, USA
Exp Toxicol Pathol 55:231-6. 2003..No change in ICAM-1 or P-selectin expression was seen. This immunolabeling distribution suggests that VCAM-1 functions in the pathogenesis of BE-related thrombosis by promoting adhesion of erythrocytes to the endothelium... - Histology atlas of the developing mouse hepatobiliary system with emphasis on embryonic days 9.5-18.5Laura Wilding Crawford
1Cellular and Molecular Pathology Branch, NIEHS, NIH, Research Triangle Park, NC 27709, USA
Toxicol Pathol 38:872-906. 2010..Authors' note: All digital images can be viewed online at https://niehsimagesepl-inc.com with the username "ToxPathLiver" and the password "embryolivers.".. - Immunohistochemical markers for the rodent immune systemJerrold M Ward
Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892 8135, USA
Toxicol Pathol 34:616-30. 2006.... - Histology atlas of the developing mouse heart with emphasis on E11.5 to E18.5Saija M Savolainen
NIEHS, Cellular and Molecular Pathology Branch, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 37:395-414. 2009..5-18.5) is available on the CD enclosed in this issue of Toxicologic Pathology. All digital images can be viewed online at https://niehsimages.epl-inc.com with the username "ToxPath" and the password "embryohearts.".. - Acute hemorrhagic myocardial necrosis and sudden death of rats exposed to a combination of ephedrine and caffeineAbraham Nyska
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 83:388-96. 2005..Our work shows the direct relationship between combined ephedrine and caffeine exposure and cardiac pathology... - Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combinationSherine S L Chan
Laboratory of Molecular Genetics, National Institute of Environmental HealthSciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
Environ Mol Mutagen 48:190-200. 2007..Our data suggest that AZT/3TC combination treatment produces greater mtDNA damage than either agent individually, and that female mice are more sensitive than males to AZT/3TC-induced mtDNA damage... - Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in miceAparna Purushotham
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Mol Cell Biol 32:1226-36. 2012..Taken together, our findings indicate that SIRT1 plays a vital role in the regulation of hepatic bile acid homeostasis through the HNF1α/FXR signaling pathway... - Cyclooxygenase-1 overexpression decreases Basal airway responsiveness but not allergic inflammationJeffrey W Card
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709
J Immunol 177:4785-93. 2006..Collectively, these data indicate that COX-1 overexpression attenuates airway responsiveness under basal conditions but does not influence allergic airway inflammation... - Regulated over-expression of DNA polymerase beta mediates early onset cataract in miceRobert W Sobol
Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
DNA Repair (Amst) 2:609-22. 2003..These results suggest that either a beta-pol expression imbalance negatively affects overall fidelity and/or BER capacity or that beta-pol has a role in lens epithelial cell differentiation... 
Apparent alveolar bronchiolar tumors arising in the mediastinum of F344 ratsPaul Howroyd
Experimental Pathology Laboratories, Inc, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 37:351-8. 2009....- The hepatic endothelial carcinogen riddelliine induces endothelial apoptosis, mitosis, S phase, and p53 and hepatocytic vascular endothelial growth factor expression after short-term exposureAbraham Nyska
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Appl Pharmacol 184:153-64. 2002..Endothelial proliferation may also have been promoted through endothelial arrest at S phase, which was associated with endothelial karyo- and cytomegaly, resulting in hepatocytic hypoxia, triggering VEGF induction... - Induction of interleukin-1beta, tumour necrosis factor-alpha and apoptosis in mouse organs by amphotericin B is neutralized by conjugation with arabinogalactanRama Falk
Department of Clinical Microbiology and Infectious Diseases, The Hebrew University-Hadassah Medical Center, PO Box 12000, Jerusalem 91120, Israel
J Antimicrob Chemother 55:713-20. 2005..CONCLUSIONS: AMB-related toxicity is associated with induction of IL-1beta, TNF-alpha and apoptosis in organs. These effects were not observed with AMB-AG conjugate, suggesting its potential as a safer formulation for therapy... - Involvement of tumor necrosis factor-alpha in sulfur mustard-induced skin lesion; effect of topical iodineUri Wormser
Department of Pharmacology, School of Pharmacy Faculty of Medicine, Berman Building, Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, 91904 Jerusalem, Israel
Arch Toxicol 79:660-70. 2005..The combination of iodine and antiTNF-alpha antibodies might constitute a new approach for treatment of SM-exposed individuals... - Transplacental carcinogenicity of 3'-azido-3'-deoxythymidine in B6C3F1 mice and F344 ratsDale M Walker
Experimental Pathology Laboratories, Inc, Herndon, Virginia, USA
Environ Mol Mutagen 48:283-98. 2007.... - Failure of catalase to protect against aflatoxin B1-induced mouse lung tumorigenicityKatherine A Guindon
Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada K7L 3N6
Toxicol Appl Pharmacol 227:179-83. 2008..These results demonstrate that PEG-CAT is not protective against AFB(1) carcinogenicity in mouse lung despite preventing DNA oxidation... - Comparative prevalence, multiplicity, and progression of spontaneous and vinyl carbamate-induced liver lesions in five strains of male miceMimasa Takahashi
Nippon Veterinary and Animal Science University, Tokyo, Japan
Toxicol Pathol 30:599-605. 2002....