Jerome L Fleg

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Detection of high-risk atherosclerotic plaque: report of the NHLBI Working Group on current status and future directions
    Jerome L Fleg
    Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA
    JACC Cardiovasc Imaging 5:941-55. 2012
  2. doi request reprint Age-associated changes in cardiovascular structure and function: a fertile milieu for future disease
    Jerome L Fleg
    Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Bethesda, MD 20892, USA
    Heart Fail Rev 17:545-54. 2012
  3. ncbi request reprint Aerobic exercise in the elderly: a key to successful aging
    Jerome L Fleg
    Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Discov Med 13:223-8. 2012
  4. ncbi request reprint Accelerated longitudinal decline of aerobic capacity in healthy older adults
    Jerome L Fleg
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Circulation 112:674-82. 2005
  5. doi request reprint Cardiovascular drug therapy in the elderly: benefits and challenges
    Jerome L Fleg
    Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Bethesda, MD 20892, USA
    Nat Rev Cardiol 8:13-28. 2011
  6. ncbi request reprint Exercise therapy for elderly heart failure patients
    Jerome L Fleg
    Division of Cardiovascular Diseases, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 8126, Bethesda, MD 20892 7936, USA
    Clin Geriatr Med 23:221-34. 2007
  7. pmc The sex-specific impact of systolic hypertension and systolic blood pressure on arterial-ventricular coupling at rest and during exercise
    Paul D Chantler
    Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21225, USA
    Am J Physiol Heart Circ Physiol 295:H145-53. 2008
  8. pmc Use of the Frank-Starling mechanism during exercise is linked to exercise-induced changes in arterial load
    Paul D Chantler
    Intramural Research Program, National Institute on Aging, Baltimore, Maryland 21225, USA
    Am J Physiol Heart Circ Physiol 302:H349-58. 2012
  9. pmc Abnormalities in arterial-ventricular coupling in older healthy persons are attenuated by sodium nitroprusside
    Paul D Chantler
    Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Am J Physiol Heart Circ Physiol 300:H1914-22. 2011
  10. pmc Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging
    Samer S Najjar
    Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
    J Am Coll Cardiol 51:1377-83. 2008

Detail Information

Publications57

  1. pmc Detection of high-risk atherosclerotic plaque: report of the NHLBI Working Group on current status and future directions
    Jerome L Fleg
    Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA
    JACC Cardiovasc Imaging 5:941-55. 2012
    ....
  2. doi request reprint Age-associated changes in cardiovascular structure and function: a fertile milieu for future disease
    Jerome L Fleg
    Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Bethesda, MD 20892, USA
    Heart Fail Rev 17:545-54. 2012
    ..Although these cardiovascular aging changes are considered "normative", they lower the threshold for the development of cardiovascular disease, which affects the majority of older adults...
  3. ncbi request reprint Aerobic exercise in the elderly: a key to successful aging
    Jerome L Fleg
    Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Discov Med 13:223-8. 2012
    ..A major challenge to physicians and society is to increase the low participation rates of older adults in both home-based exercise and supervised exercise rehabilitation programs...
  4. ncbi request reprint Accelerated longitudinal decline of aerobic capacity in healthy older adults
    Jerome L Fleg
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Circulation 112:674-82. 2005
    ..Although peak aerobic capacity is widely recognized to decline with age, its rate of decline has been estimated primarily from cross-sectional studies that may provide misleading, overly optimistic estimates of aging changes...
  5. doi request reprint Cardiovascular drug therapy in the elderly: benefits and challenges
    Jerome L Fleg
    Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Bethesda, MD 20892, USA
    Nat Rev Cardiol 8:13-28. 2011
    ..The high prevalence of polypharmacy among older adults with cardiovascular disease, coupled with age-associated physiological changes and comorbidities, provides major challenges in adherence and avoidance of drug-related adverse events...
  6. ncbi request reprint Exercise therapy for elderly heart failure patients
    Jerome L Fleg
    Division of Cardiovascular Diseases, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 8126, Bethesda, MD 20892 7936, USA
    Clin Geriatr Med 23:221-34. 2007
    ..This article reviews the accumulated literature in this area, with specific emphasis on the effects of exercise training in older patients who have HF, a subset that may have the most to gain from such training...
  7. pmc The sex-specific impact of systolic hypertension and systolic blood pressure on arterial-ventricular coupling at rest and during exercise
    Paul D Chantler
    Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21225, USA
    Am J Physiol Heart Circ Physiol 295:H145-53. 2008
    ..Whether a smaller E(a)I/E(LV)I reserve leads to functional limitations warrants further examination...
  8. pmc Use of the Frank-Starling mechanism during exercise is linked to exercise-induced changes in arterial load
    Paul D Chantler
    Intramural Research Program, National Institute on Aging, Baltimore, Maryland 21225, USA
    Am J Physiol Heart Circ Physiol 302:H349-58. 2012
    ..These findings provide interesting insights into the dynamic cardiovascular alterations during exercise...
  9. pmc Abnormalities in arterial-ventricular coupling in older healthy persons are attenuated by sodium nitroprusside
    Paul D Chantler
    Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Am J Physiol Heart Circ Physiol 300:H1914-22. 2011
    ..This is relevant to common conditions in older subjects associated with a significant impairment of exercise performance such as frailty or heart failure with preserved ejection fraction...
  10. pmc Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging
    Samer S Najjar
    Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
    J Am Coll Cardiol 51:1377-83. 2008
    ..This study sought to evaluate whether pulse wave velocity (PWV), a noninvasive index of arterial stiffness, is a predictor of the longitudinal changes in systolic blood pressure (SBP) and of incident hypertension...
  11. ncbi request reprint Exaggerated exercise blood pressure is related to impaired endothelial vasodilator function
    Kerry J Stewart
    Department of Medicine, Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
    Am J Hypertens 17:314-20. 2004
    ..The mechanisms that explain this relationship are unknown. We examined the relationships of endothelial vasodilator function and of aortic stiffness with exercise BP...
  12. ncbi request reprint Role of nondiagnostic exercise-induced ST-segment abnormalities in predicting future coronary events in asymptomatic volunteers
    Tomasz M Rywik
    Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Circulation 106:2787-92. 2002
    ..Whether exercise-induced ST-segment depression <1 mm is an independent predictor of future coronary events (CEs) in asymptomatic subjects is unknown...
  13. ncbi request reprint Oxygen pulse during exercise is related to resting systolic and diastolic left ventricular function in older persons with mild hypertension
    Jimmy G Lim
    Division of Cardiology, Department of Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Am Heart J 150:941-6. 2005
    ....
  14. ncbi request reprint Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements
    Hidetaka Hougaku
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    Am J Physiol Endocrinol Metab 290:E234-42. 2006
    ..05). Thus the adverse influence of low T on the cardiovascular system in men may be mediated in part via the effects of T on vascular structure and function...
  15. ncbi request reprint Effect of exercise on blood pressure in older persons: a randomized controlled trial
    Kerry J Stewart
    Divisions of Cardiology, Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Arch Intern Med 165:756-62. 2005
    ..Few exercise studies in older persons have evaluated BP changes in relation to changes in body composition or fitness...
  16. pmc Relationship of glycemia control to lipid and blood pressure lowering and atherosclerosis: the SANDS experience
    Mihriye Mete
    MedStar Health Research Institute, Hyattsville, MD 20782, USA
    J Diabetes Complications 25:362-7. 2011
    ..This post hoc analysis from the Stop Atherosclerosis in Native Diabetics Study examines the role of baseline glycemia in achieving standard and aggressive targets and outcomes after 36 months...
  17. ncbi request reprint Age and gender affect ventricular-vascular coupling during aerobic exercise
    Samer S Najjar
    Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
    J Am Coll Cardiol 44:611-7. 2004
    ....
  18. ncbi request reprint Regional bone mineral density after resistive training in young and older men and women
    Alice S Ryan
    Department of Medicine, University of Maryland School of Medicine, Baltimore VA Medical Center, Baltimore, MD 21201, USA
    Scand J Med Sci Sports 14:16-23. 2004
    ..The purpose of this study was to determine the effects of 6 months of whole-body resistive training (RT) on total and regional bone mineral density (BMD) and bone mineral content (BMC) by age and gender in young and older men and women...
  19. doi request reprint Safety and feasibility of achieving lower systolic blood pressure goals in persons with type 2 diabetes: the SANDS trial
    Matthew R Weir
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Clin Hypertens (Greenwich) 11:540-8. 2009
    ..The authors conclude that both standard and more aggressive systolic blood pressure reduction can be achieved with excellent safety and good tolerability in patients with type 2 diabetes mellitus...
  20. ncbi request reprint Effects of normal aging on left ventricular lusitropic, inotropic, and chronotropic responses to dobutamine
    Paul S Hees
    Department of Medicine and Division of Cardiology, School of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Am Coll Cardiol 47:1440-7. 2006
    ..The purpose of this study was to characterize how aging impacts the left ventricular (LV) functional reserve...
  21. ncbi request reprint Changes in leisure time physical activity and risk of all-cause mortality in men and women: the Baltimore Longitudinal Study of Aging
    Laura A Talbot
    Graduate School of Nursing, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    Prev Med 45:169-76. 2007
    ..Higher levels of leisure time physical activity (LTPA) are associated with reduced mortality. However it is unclear how changes in LTPA over time impact all-cause mortality in men and women...
  22. ncbi request reprint Comparison of cardiorespiratory fitness versus leisure time physical activity as predictors of coronary events in men aged < or = 65 years and > 65 years
    Laura A Talbot
    The Johns Hopkins University, School of Nursing, Baltimore, Maryland 21205 2110, USA
    Am J Cardiol 89:1187-92. 2002
    ..For older men, high-intensity LTPA and fitness appear to be of similar importance in reducing coronary risk...
  23. ncbi request reprint Effect of light-to-moderate alcohol consumption on age-associated arterial stiffening
    Hidetaka Hougaku
    Clinical Research Branch, Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
    Am J Cardiol 95:1006-10. 2005
    ..A U-shaped relation was found between alcohol intake and a stiffness index, with the lowest index in moderate drinkers, which may partially explain the relation between alcohol and cardiovascular disease...
  24. ncbi request reprint MRI and echocardiographic assessment of the diastolic dysfunction of normal aging: altered LV pressure decline or load?
    Paul S Hees
    Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Am J Physiol Heart Circ Physiol 286:H782-8. 2004
    ..This effect also explains the prolonged IVRT. We postulate that changes in LA active or passive properties may contribute to development of the abnormal relaxation pattern during the aging process...
  25. ncbi request reprint Attenuated cardiovascular reserve during prolonged submaximal cycle exercise in healthy older subjects
    Luis C L Correia
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Am Coll Cardiol 40:1290-7. 2002
    ..The goal of this study was to determine the effect of age on the hemodynamic response to prolonged submaximal aerobic exercise in healthy volunteers...
  26. ncbi request reprint Secular trends in leisure-time physical activity in men and women across four decades
    Laura A Talbot
    The Johns Hopkins University, School of Nursing, Baltimore, MD 21205 2110, USA
    Prev Med 37:52-60. 2003
    ..We examined secular trends in leisure-time physical activities (LTPA) in health-conscious men (n = 1359) from 1958 to 1998 and in women (n = 839) from 1978 to 1998, who were participants of the Baltimore Longitudinal Study of Aging (BLSA)...
  27. ncbi request reprint Oxidative stress and hemorheological changes induced by acute treadmill exercise
    Ranjeet S Ajmani
    National Institute on Aging, National Institutes of Health, Molecular Dynamics Section and the Laboratory of Cardiovascular Sciences, Baltimore, MD 21224, USA
    Clin Hemorheol Microcirc 28:29-40. 2003
    ..9+/-18.6 mm/h to 22.5+/-15.9 mm/h (p<0.01). The findings suggest that acute aerobic exercise induces oxidative damage to red blood cells and adversely affects rheological properties of the peripheral blood...
  28. ncbi request reprint Estimating cardiorespiratory fitness in well-functioning older adults: treadmill validation of the long distance corridor walk
    Eleanor M Simonsick
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 54:127-32. 2006
    ..g., heart rate (HR) and systolic blood pressure (SBP) response) in older adults...
  29. pmc Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes: the SANDS (Stop Atherosclerosis in Native Diabetics Study) trial
    Jerome L Fleg
    National Heart, Lung, and Blood Institute, Bethesda, Maryland
    J Am Coll Cardiol 52:2198-205. 2008
    ....
  30. pmc New York Heart Association functional class predicts exercise parameters in the current era
    Stuart D Russell
    Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am Heart J 158:S24-30. 2009
    ..Using baseline data from the HF-ACTION (Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing) study, we examined this relationship...
  31. ncbi request reprint Nitric oxide inhibition as a mechanism for blood pressure increase during salt loading in normotensive postmenopausal women
    Angelo Scuteri
    Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, Maryland, USA
    J Hypertens 21:1339-46. 2003
    ..We determined whether changes in endothelium-dependent vasodilation (EDD) and plasma ADMA predict changes in blood pressure (BP) after salt loading in normotensive postmenopausal women (PMW)...
  32. pmc Epidemiology of arrhythmias and conduction disorders in older adults
    Grant V Chow
    Division of Cardiology, Johns Hopkins Medical Institutions, Johns Hopkins University School of Medicine, Carnegie 568, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Clin Geriatr Med 28:539-53. 2012
    ..Conduction disorders also become more common with age, and may either be asymptomatic, or cause hemodynamic changes requiring treatment. The epidemiology of common arrhythmias and conduction disorders in the elderly is reviewed...
  33. ncbi request reprint The relation of fasting and 2-h postchallenge plasma glucose concentrations to mortality: data from the Baltimore Longitudinal Study of Aging with a critical review of the literature
    John D Sorkin
    National Institute on Aging, Intramural Research Program, Gerontology Research Center, Baltimore, Maryland, USA
    Diabetes Care 28:2626-32. 2005
    ..It is not known if the 2-h plasma glucose (2hPG) concentration from an oral glucose tolerance test (OGTT) adds to the predictive power of FPG...
  34. ncbi request reprint Body mass index and the risk of COPD
    Raida I Harik-Khan
    Longitudinal Study Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Chest 121:370-6. 2002
    ..However, it is not clear whether low body weight is a risk factor for COPD or a consequence of established disease...
  35. ncbi request reprint A more efficient magnetic resonance imaging-based strategy for measuring quadriceps muscle volume
    Brian L Tracy
    Department of Kinesiology, University of Maryland, College Park, MD, USA
    Med Sci Sports Exerc 35:425-33. 2003
    ..To determine the accuracy of several magnetic resonance imaging (MRI)-based strategies for assessment of quadriceps muscle volume (MV) and changes in MV with training...
  36. ncbi request reprint Left ventricular remodeling with age in normal men versus women: novel insights using three-dimensional magnetic resonance imaging
    Paul S Hees
    Department of Medicine and Division of Cardiology, School of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA
    Am J Cardiol 90:1231-6. 2002
    ..In women, increased LV wall thickness offsets the decreasing LV length, whereas in men, LV wall thickness fails to compensate, resulting in decreased LV mass with age...
  37. ncbi request reprint Can exercise conditioning be effective in older heart failure patients?
    Jerome L Fleg
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Heart Fail Rev 7:99-103. 2002
    ..A major challenge for the future is the inclusion of representative proportions of elderly individuals in heart failure training trials...
  38. pmc Reproducibility of peak oxygen uptake and other cardiopulmonary exercise testing parameters in patients with heart failure (from the Heart Failure and A Controlled Trial Investigating Outcomes of exercise traiNing)
    Daniel R Bensimhon
    LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina, USA
    Am J Cardiol 102:712-7. 2008
    ..Therefore, in multicenter trials, there is no need to perform >1 baseline cardiopulmonary exercise test...
  39. ncbi request reprint Improving exercise tolerance in chronic heart failure: a tale of inspiration?
    Jerome L Fleg
    J Am Coll Cardiol 51:1672-4. 2008
  40. ncbi request reprint Effects of aerobic exercise training in community-based subjects aged 80 and older: a pilot study
    Peter V Vaitkevicius
    Division of Geriatrics and Cardiology, University of Michigan Medical School and Veterans Affairs Ann Arbor Healthcare System Geriatric Research Education and Clinical Center 11G, Ann Arbor 48105, USA
    J Am Geriatr Soc 50:2009-13. 2002
    ..To assess the ability of sedentary, frail subjects aged 80 and older to train in a community-based exercise program and to evaluate clinical factors that predict improvements in peak oxygen consumption (VO2peak)...
  41. ncbi request reprint Physical activity as anti-inflammatory therapy for cardiovascular disease
    Jerome L Fleg
    Prev Cardiol 8:8-10. 2005
  42. ncbi request reprint Exercise and heart failure: A statement from the American Heart Association Committee on exercise, rehabilitation, and prevention
    Ileana L Pina
    Circulation 107:1210-25. 2003
  43. pmc Predictors of mortality and hospitalization in women with heart failure in the Digitalis Investigation Group trial
    Ali Ahmed
    Division of Gerontology and Geriatric Medicine, Department of Medicine, School of Medicine, Center for Aging and Geriatric Heart Failure Clinic, University of Alabama at Birmingham, Alabama, USA
    Am J Ther 13:325-31. 2006
    ....
  44. pmc Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis investigation group trial
    Ali Ahmed
    University of Alabama at Birmingham, 1530 3rd Ave S, CH 19, Suite 219, Birmingham AL 35294 2041, USA
    Circulation 114:397-403. 2006
    ..Although digoxin was tested in an appreciable number of diastolic heart failure patients in the Digitalis Investigation Group ancillary trial, detailed findings from this important study have not previously been published...
  45. ncbi request reprint Examination of lower targets for low-density lipoprotein cholesterol and blood pressure in diabetes--the Stop Atherosclerosis in Native Diabetics Study (SANDS)
    Marie Russell
    Phoenix Indian Medical Center, Phoenix, AZ, USA
    Am Heart J 152:867-75. 2006
    ....
  46. pmc Outcomes in ambulatory chronic systolic and diastolic heart failure: a propensity score analysis
    Ali Ahmed
    University of Alabama at Birmingham and VA Medical Center, Birmingham, AL 35294 2041, USA
    Am Heart J 152:956-66. 2006
    ..In this analysis, we examined long-term mortality and hospitalization in a propensity score matched cohort of ambulatory chronic systolic and diastolic HF patients...
  47. ncbi request reprint Secondary prevention of coronary heart disease in the elderly (with emphasis on patients > or =75 years of age): an American Heart Association scientific statement from the Council on Clinical Cardiology Subcommittee on Exercise, Cardiac Rehabilitation, a
    Mark A Williams
    Circulation 105:1735-43. 2002
  48. ncbi request reprint Heart failure and a controlled trial investigating outcomes of exercise training (HF-ACTION): design and rationale
    David J Whellan
    Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA
    Am Heart J 153:201-11. 2007
    ..Although there are limited clinical data to support the use of exercise training as a means to reduce mortality and morbidity in patients with heart failure, current guidelines state that exercise is beneficial...
  49. pmc Hospitalizations due to unstable angina pectoris in diastolic and systolic heart failure
    Ali Ahmed
    University of Alabama at Birmingham, Alabama, USA
    Am J Cardiol 99:460-4. 2007
    ..As in patients with systolic HF, those with diastolic HF should be routinely evaluated for myocardial ischemia and managed accordingly...
  50. ncbi request reprint The combination of high fruit and vegetable and low saturated fat intakes is more protective against mortality in aging men than is either alone: the Baltimore Longitudinal Study of Aging
    Katherine L Tucker
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Nutr 135:556-61. 2005
    ..In addition, they extend these findings by demonstrating that the combination of both behaviors is more protective than either alone, suggesting that their beneficial effects are mediated by different mechanisms...
  51. ncbi request reprint Transdermal 17 beta-oestradiol reduces salt sensitivity of blood pressure in postmenopausal women
    Angelo Scuteri
    J Hypertens 21:2419-20. 2003
  52. pmc Serum digoxin concentration and outcomes in women with heart failure: A bi-directional effect and a possible effect modification by ejection fraction
    Ali Ahmed
    Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Eur J Heart Fail 8:409-19. 2006
    ..The association between serum digoxin concentration (SDC) and outcomes in women with heart failure (HF) has not been well studied...
  53. pmc Higher New York Heart Association classes and increased mortality and hospitalization in patients with heart failure and preserved left ventricular function
    Ali Ahmed
    Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Alabama, Birmingham, AL, USA
    Am Heart J 151:444-50. 2006
    ..The association between higher New York Heart Association (NYHA) class and outcomes in patients with heart failure and preserved systolic function is not well known...
  54. ncbi request reprint Evolution of the lipid trial protocol of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial
    Henry N Ginsberg
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Cardiol 99:56i-67i. 2007
    ..The current protocol is designed to provide an ethically justifiable test of combined statin plus fibrate treatment consistent with the highest level of safety and lipid treatment standards of care...
  55. ncbi request reprint Location of cardiac arrests in the public access defibrillation trial
    David B Reed
    Department of Emergency Medicine, State University of New York, Upstate Medical University, Syracuse, NY, USA reeddahscyr edu
    Prehosp Emerg Care 10:61-76. 2006
    ....
  56. ncbi request reprint Heart failure with preserved ejection fraction
    Ali Ahmed
    N Engl J Med 355:1829-30; author reply 1830-1. 2006
  57. doi request reprint Effect of lower targets for blood pressure and LDL cholesterol on atherosclerosis in diabetes: the SANDS randomized trial
    Barbara V Howard
    MedStar Research Institute, 6495 New Hampshire Ave, Suite 201, Hyattsville, MD 20783, USA
    JAMA 299:1678-89. 2008
    ..Individuals with diabetes are at increased risk for cardiovascular disease (CVD), but more aggressive targets for risk factor control have not been tested...