Gordon P Flake

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Detection of pre-invasive lung cancer: technical aspects of the LIFE project
    Gordon P Flake
    Laboratory of Experimental Pathology, National Institute of Environmental Sciences, NIH, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 35:65-74. 2007
  2. ncbi request reprint Cell proliferation and apoptosis in human uterine leiomyomas and myometria
    Darlene Dixon
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MDC2 09, Research Triangle Park, NC 27709, USA
    Virchows Arch 441:53-62. 2002
  3. pmc Respiratory toxicity of diacetyl in C57BL/6 mice
    Daniel L Morgan
    Respiratory Toxicology, Laboratory of Molecular Toxicology, National Toxicology Program National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Sci 103:169-80. 2008
  4. ncbi request reprint Association of race, age and body mass index with gross pathology of uterine fibroids
    Alicia B Moore
    Laboratory of Experimental Pathology and Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    J Reprod Med 53:90-6. 2008
  5. pmc Etiology and pathogenesis of uterine leiomyomas: a review
    Gordon P Flake
    Comparative Pathobiology Group, Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:1037-54. 2003
  6. pmc Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    J Immunol 177:621-30. 2006
  7. pmc Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosis
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, NC 27709, USA
    Am J Respir Cell Mol Biol 37:300-8. 2007
  8. pmc Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosis
    James W Voltz
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Respir Cell Mol Biol 39:45-52. 2008
  9. pmc Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice
    Michelle A Carey
    Division of Intramural Research, NIH NIEHS, Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 175:126-35. 2007
  10. ncbi request reprint Accentuated T helper type 2 airway response after allergen challenge in cyclooxygenase-1-/- but not cyclooxygenase-2-/- mice
    Michelle A Carey
    National Institute of Environmental Health Sciences NIH, 111 TW Alexander Drive, Building 101, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 167:1509-15. 2003

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Detection of pre-invasive lung cancer: technical aspects of the LIFE project
    Gordon P Flake
    Laboratory of Experimental Pathology, National Institute of Environmental Sciences, NIH, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 35:65-74. 2007
    ....
  2. ncbi request reprint Cell proliferation and apoptosis in human uterine leiomyomas and myometria
    Darlene Dixon
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MDC2 09, Research Triangle Park, NC 27709, USA
    Virchows Arch 441:53-62. 2002
    ..We conclude that increased cell proliferation is the most significant contributor to growth and that the proliferative state is autonomous for each tumor in a given patient and is independent of tumor size...
  3. pmc Respiratory toxicity of diacetyl in C57BL/6 mice
    Daniel L Morgan
    Respiratory Toxicology, Laboratory of Molecular Toxicology, National Toxicology Program National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Sci 103:169-80. 2008
    ..Collectively these results indicate that clinically relevant diacetyl exposures result in a pattern of injury that replicates features of human OB...
  4. ncbi request reprint Association of race, age and body mass index with gross pathology of uterine fibroids
    Alicia B Moore
    Laboratory of Experimental Pathology and Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    J Reprod Med 53:90-6. 2008
    ..To determine the associations of race, age and body mass index (BMI) with the gross pathology parameters of uterine leiomyomas in premenopausal women undergoing hysterectomy or myomectomy...
  5. pmc Etiology and pathogenesis of uterine leiomyomas: a review
    Gordon P Flake
    Comparative Pathobiology Group, Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:1037-54. 2003
    ..These data offer clues to the etiology and pathogenesis of this common condition, which we have analyzed and summarized in this review...
  6. pmc Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    J Immunol 177:621-30. 2006
    ..These gender differences are mediated, at least in part, by effects of androgens...
  7. pmc Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosis
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, NC 27709, USA
    Am J Respir Cell Mol Biol 37:300-8. 2007
    ..Collectively, these data suggest an important regulatory role for COX-2 in the maintenance of lung function in the setting of lung fibrosis, but not in the progression of the fibrotic process per se...
  8. pmc Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosis
    James W Voltz
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Respir Cell Mol Biol 39:45-52. 2008
    ..Sex differences should be carefully considered when designing and interpreting experimental models of pulmonary fibrosis in mice...
  9. pmc Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice
    Michelle A Carey
    Division of Intramural Research, NIH NIEHS, Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 175:126-35. 2007
    ..Airway hyperresponsiveness is a critical feature of asthma. Substantial epidemiologic evidence supports a role for female sex hormones in modulating lung function and airway hyperresponsiveness in humans...
  10. ncbi request reprint Accentuated T helper type 2 airway response after allergen challenge in cyclooxygenase-1-/- but not cyclooxygenase-2-/- mice
    Michelle A Carey
    National Institute of Environmental Health Sciences NIH, 111 TW Alexander Drive, Building 101, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 167:1509-15. 2003
    ..These data suggest that genetic deficiency of COX-1 but not COX-2 modulates T cell recruitment, Th2 cytokine secretion, and lung function in the allergic airway...
  11. ncbi request reprint Expression and regulation of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) in human and mouse tissue
    Kyung Su Kim
    Laboratories of Molecular Carcinogenesis, Experimental Pathology, and Environmental Carcinogenesis Mutagenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, USA
    Gastroenterology 122:1388-98. 2002
    ..However, NAG-1 expression and its relationship with apoptosis in human and mouse intestinal tract have not been determined...
  12. ncbi request reprint Mutational analysis of the androgen receptor using laser capture microdissection and direct sequencing
    Sheila Greene
    Division of Urology, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Methods Mol Biol 218:287-302. 2003
    ..Methods for DNA extraction, androgen receptor amplification and exon sequencing have been optimized. These methods should be adaptable for molecular analysis of DNA, RNA and protein from other complex tissues...