Research Topics
| Gordon P FlakeSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Detection of pre-invasive lung cancer: technical aspects of the LIFE projectGordon P Flake
Laboratory of Experimental Pathology, National Institute of Environmental Sciences, NIH, Research Triangle Park, NC 27709, USA
Toxicol Pathol 35:65-74. 2007....- Cell proliferation and apoptosis in human uterine leiomyomas and myometriaDarlene Dixon
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MDC2 09, Research Triangle Park, NC 27709, USA
Virchows Arch 441:53-62. 2002..We conclude that increased cell proliferation is the most significant contributor to growth and that the proliferative state is autonomous for each tumor in a given patient and is independent of tumor size... 
Respiratory toxicity of diacetyl in C57BL/6 miceDaniel L Morgan
Respiratory Toxicology, Laboratory of Molecular Toxicology, National Toxicology Program National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Toxicol Sci 103:169-80. 2008..Collectively these results indicate that clinically relevant diacetyl exposures result in a pattern of injury that replicates features of human OB...- Association of race, age and body mass index with gross pathology of uterine fibroidsAlicia B Moore
Laboratory of Experimental Pathology and Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
J Reprod Med 53:90-6. 2008..To determine the associations of race, age and body mass index (BMI) with the gross pathology parameters of uterine leiomyomas in premenopausal women undergoing hysterectomy or myomectomy... - Etiology and pathogenesis of uterine leiomyomas: a reviewGordon P Flake
Comparative Pathobiology Group, Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Environ Health Perspect 111:1037-54. 2003..These data offer clues to the etiology and pathogenesis of this common condition, which we have analyzed and summarized in this review... - Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammationJeffrey W Card
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA
J Immunol 177:621-30. 2006..These gender differences are mediated, at least in part, by effects of androgens... - Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosisJeffrey W Card
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, NC 27709, USA
Am J Respir Cell Mol Biol 37:300-8. 2007..Collectively, these data suggest an important regulatory role for COX-2 in the maintenance of lung function in the setting of lung fibrosis, but not in the progression of the fibrotic process per se... - Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosisJames W Voltz
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Am J Respir Cell Mol Biol 39:45-52. 2008..Sex differences should be carefully considered when designing and interpreting experimental models of pulmonary fibrosis in mice... - Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient miceMichelle A Carey
Division of Intramural Research, NIH NIEHS, Triangle Park, NC 27709, USA
Am J Respir Crit Care Med 175:126-35. 2007..Airway hyperresponsiveness is a critical feature of asthma. Substantial epidemiologic evidence supports a role for female sex hormones in modulating lung function and airway hyperresponsiveness in humans... - Accentuated T helper type 2 airway response after allergen challenge in cyclooxygenase-1-/- but not cyclooxygenase-2-/- miceMichelle A Carey
National Institute of Environmental Health Sciences/NIH, 111 TW Alexander Drive, Building 101, Research Triangle Park, NC 27709, USA
Am J Respir Crit Care Med 167:1509-15. 2003..These data suggest that genetic deficiency of COX-1 but not COX-2 modulates T cell recruitment, Th2 cytokine secretion, and lung function in the allergic airway... - Expression and regulation of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) in human and mouse tissueKyung-Su Kim
Laboratories of Molecular Carcinogenesis, Experimental Pathology, and Environmental Carcinogenesis/Mutagenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, USA
Gastroenterology 122:1388-98. 2002..CONCLUSIONS: Based on these results, we propose that NAG-1 acts as a mediator of apoptosis in intestinal cells and may contribute to cancer chemoprevention by NSAIDs... - Mutational analysis of the androgen receptor using laser capture microdissection and direct sequencingSheila Greene
Division of Urology, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Methods Mol Biol 218:287-302. 2003..Methods for DNA extraction, androgen receptor amplification and exon sequencing have been optimized. These methods should be adaptable for molecular analysis of DNA, RNA and protein from other complex tissues...