L W Fisher

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Molecular evolution of dentin phosphoprotein among toothed and toothless animals
    Dianalee A McKnight
    Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, Bethesda MD 20892, USA
    BMC Evol Biol 9:299. 2009
  2. pmc DMP1 and DSPP: evidence for duplication and convergent evolution of two SIBLING proteins
    Larry W Fisher
    Matrix Biochemistry Section, Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, Bethesda, MD, USA
    Cells Tissues Organs 194:113-8. 2011
  3. ncbi request reprint Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins
    Larry W Fisher
    Matrix Biochemistry Unit, Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, HHS, Bethesda, Maryland 20892 4320, USA
    Connect Tissue Res 44:33-40. 2003
  4. ncbi request reprint Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontin
    L W Fisher
    Craniofacial and Skeletal Diseases Branch, NIH, Bethesda, Maryland, 20892 4320, USA
    Biochem Biophys Res Commun 280:460-5. 2001
  5. ncbi request reprint Comparison of stem-cell-mediated osteogenesis and dentinogenesis
    S Batouli
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Dent Res 82:976-81. 2003
  6. ncbi request reprint Small integrin binding ligand N-linked glycoprotein gene family expression in different cancers
    Larry W Fisher
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Clin Cancer Res 10:8501-11. 2004
  7. pmc The potential functional interaction of biglycan and WISP-1 in controlling differentiation and proliferation of osteogenic cells
    Colette A Inkson
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS Bethesda, Bethesda, MD 20892 4320, USA
    Cells Tissues Organs 189:153-7. 2009
  8. pmc Dentin matrix protein 1 enhances invasion potential of colon cancer cells by bridging matrix metalloproteinase-9 to integrins and CD44
    Abdullah Karadag
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Res 65:11545-52. 2005
  9. ncbi request reprint Expression of SIBLINGs and their partner MMPs in salivary glands
    K U E Ogbureke
    Craniofacial and Skeletal Diseases Branch, Building 30, Room 228, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, 9000 Rockville Pike, Bethesda, MD 20892 4320, USA
    J Dent Res 83:664-70. 2004
  10. pmc Overlapping DSPP mutations cause dentin dysplasia and dentinogenesis imperfecta
    D A McKnight
    Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, 9000 Rockville Pike, Bldg 30, Bethesda, MD 20892, USA
    J Dent Res 87:1108-11. 2008

Collaborators

Detail Information

Publications39

  1. pmc Molecular evolution of dentin phosphoprotein among toothed and toothless animals
    Dianalee A McKnight
    Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, Bethesda MD 20892, USA
    BMC Evol Biol 9:299. 2009
    ....
  2. pmc DMP1 and DSPP: evidence for duplication and convergent evolution of two SIBLING proteins
    Larry W Fisher
    Matrix Biochemistry Section, Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, Bethesda, MD, USA
    Cells Tissues Organs 194:113-8. 2011
    ..A similar analysis of the origins of the other 4 SIBLINGs will require even more detailed analysis as genome sequences of various fish and amphibia become available...
  3. ncbi request reprint Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins
    Larry W Fisher
    Matrix Biochemistry Unit, Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, HHS, Bethesda, Maryland 20892 4320, USA
    Connect Tissue Res 44:33-40. 2003
    ..Two possible mechanisms for inhibiting the lytic pathway of alternate complement are presented...
  4. ncbi request reprint Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontin
    L W Fisher
    Craniofacial and Skeletal Diseases Branch, NIH, Bethesda, Maryland, 20892 4320, USA
    Biochem Biophys Res Commun 280:460-5. 2001
    ..These proteins often function by bridging two proteins of fixed structures into a biologically active complex...
  5. ncbi request reprint Comparison of stem-cell-mediated osteogenesis and dentinogenesis
    S Batouli
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Dent Res 82:976-81. 2003
    ....
  6. ncbi request reprint Small integrin binding ligand N-linked glycoprotein gene family expression in different cancers
    Larry W Fisher
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Clin Cancer Res 10:8501-11. 2004
    ....
  7. pmc The potential functional interaction of biglycan and WISP-1 in controlling differentiation and proliferation of osteogenic cells
    Colette A Inkson
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS Bethesda, Bethesda, MD 20892 4320, USA
    Cells Tissues Organs 189:153-7. 2009
    ..These preliminary data suggest that WISP-1 and BGN may functionally interact and control each other's activity, thus regulating the differentiation and proliferation of osteogenic cells...
  8. pmc Dentin matrix protein 1 enhances invasion potential of colon cancer cells by bridging matrix metalloproteinase-9 to integrins and CD44
    Abdullah Karadag
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Res 65:11545-52. 2005
    ....
  9. ncbi request reprint Expression of SIBLINGs and their partner MMPs in salivary glands
    K U E Ogbureke
    Craniofacial and Skeletal Diseases Branch, Building 30, Room 228, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, 9000 Rockville Pike, Bethesda, MD 20892 4320, USA
    J Dent Res 83:664-70. 2004
    ....
  10. pmc Overlapping DSPP mutations cause dentin dysplasia and dentinogenesis imperfecta
    D A McKnight
    Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, 9000 Rockville Pike, Bldg 30, Bethesda, MD 20892, USA
    J Dent Res 87:1108-11. 2008
    ..Furthermore, the consistent kindred presentation of the DD or DGI phenotype appears to be dependent on an as-yet-undescribed genetic modifier closely linked to DSPP...
  11. pmc Dentin sialophosphoprotein (DSPP) is cleaved into its two natural dentin matrix products by three isoforms of bone morphogenetic protein-1 (BMP1)
    Zofia Von Marschall
    Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, Bethesda, MD, USA
    Matrix Biol 29:295-303. 2010
    ..In summary, three isoforms of BMP1 process both DSPP and DMP1 at the MQX/DDP motif, but the identity of a protein that can enhance the cleavage of the two SIBLING proteins remains elusive...
  12. ncbi request reprint Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs)
    Kalu U E Ogbureke
    Matrix Biochemistry Section, Craniofacial and Skeletal Disease Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, Maryland 20982 4320, USA
    Kidney Int 68:155-66. 2005
    ..The present study examined the expression patterns of both the SIBLINGs and their MMP partners in adult kidney...
  13. pmc Dentin matrix protein-1 isoforms promote differential cell attachment and migration
    Zofia Von Marschall
    Craniofacial and Skeletal Diseases Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892 4320, USA
    J Biol Chem 283:32730-40. 2008
    ..The sequence specificity of the proposed BMP1-cleavage site of DMP1 was verified by mutation analysis. Direct comparison of the three proteins showed that cells discriminate among these SIBLINGs and among DMP1 isoforms...
  14. ncbi request reprint TM14 is a new member of the fibulin family (fibulin-7) that interacts with extracellular matrix molecules and is active for cell binding
    Susana de Vega
    Laboratory of Cell and Developmental Biology, NIDCR, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
    J Biol Chem 282:30878-88. 2007
    ..Because of its protein characteristics, TM14 can be classified as a new member of the fibulin family: fibulin-7...
  15. ncbi request reprint Bone sialoprotein, matrix metalloproteinase 2, and alpha(v)beta3 integrin in osteotropic cancer cell invasion
    Abdullah Karadag
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 4320, USA
    J Natl Cancer Inst 96:956-65. 2004
    ..Its role in tumor biology, however, remains unclear. We investigated whether BSP enhances cancer cell invasiveness by forming a trimolecular complex with MMP-2 and cell-surface integrin alpha(v)beta3...
  16. ncbi request reprint The small leucine-rich proteoglycan biglycan modulates BMP-4-induced osteoblast differentiation
    Xiao Dong Chen
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 18:948-58. 2004
    ..However, the response of bgn-deficient osteoblasts to BMP-4 was completely rescued by reintroduction of biglycan by viral transfection. We propose that biglycan modulates BMP-4-induced signaling to control osteoblast differentiation...
  17. pmc A novel technique based on a PNA hybridization probe and FRET principle for quantification of mutant genotype in fibrous dysplasia/McCune-Albright syndrome
    Abdullah Karadag
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 4320, USA
    Nucleic Acids Res 32:e63. 2004
    ....
  18. ncbi request reprint Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library
    A R DeRubeis
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Gene 255:195-203. 2000
    ....
  19. ncbi request reprint Stem cell properties of human dental pulp stem cells
    S Gronthos
    Craniofacial and Skeletal Diseases Branch, Building 30, Room 228, NIDCR, NIH, Bethesda, MD 20892, USA
    J Dent Res 81:531-5. 2002
    ..Taken together, these results demonstrate that DPSCs possess stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation...
  20. ncbi request reprint Three small integrin binding ligand N-linked glycoproteins (SIBLINGs) bind and activate specific matrix metalloproteinases
    Neal S Fedarko
    Division of Geriatrics, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    FASEB J 18:734-6. 2004
    ..These data suggest that the SIBLING family offers an alternative method of controlling the activity of at least three MMPs...
  21. ncbi request reprint Bone sialoprotein enhances migration of bone marrow stromal cells through matrices by bridging MMP-2 to alpha(v)beta3-integrin
    Abdullah Karadag
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4320, USA
    J Bone Miner Res 21:1627-36. 2006
    ..BSP enhances osteogenic cell migration through basement membrane and collagen matrices in vitro by localizing MMP-2 on the cell surface through alpha(v)beta(3)-integrin...
  22. pmc SHED: stem cells from human exfoliated deciduous teeth
    Masako Miura
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:5807-12. 2003
    ..Thus, exfoliated teeth may be an unexpected unique resource for stem-cell therapies including autologous stem-cell transplantation and tissue engineering...
  23. pmc Small integrin-binding proteins as serum markers for prostate cancer detection
    Alka Jain
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Clin Cancer Res 15:5199-207. 2009
    ..Previous studies have separately reported elevated expression of BSP, OPN, or DSPP in prostate tumor paraffin sections. We hypothesized that SIBLINGs may be informative serum markers for subjects with prostate cancer...
  24. ncbi request reprint Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice
    T Xu
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 20:78-82. 1998
    ..These mice may serve as an animal model to study the role of ECM proteins in osteoporosis...
  25. pmc TGF-beta1 and WISP-1/CCN-4 can regulate each other's activity to cooperatively control osteoblast function
    Colette A Inkson
    Craniofacial and Skeletal Diseases Branch, National Institutes of Craniofacial and Dental Research, National Institutes of Heath, DHHS, Bethesda, Maryland 20892, USA
    J Cell Biochem 104:1865-78. 2008
    ..Our data indicates that full-length WISP-1 and its variant WISP-1va are modulators of proliferation and osteogenic differentiation, and may be novel regulators of TGF-beta1 signaling in osteoblast-like cells...
  26. pmc Decorin is processed by three isoforms of bone morphogenetic protein-1 (BMP1)
    Zofia Von Marschall
    Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, Bethesda, MD, USA
    Biochem Biophys Res Commun 391:1374-8. 2010
    ....
  27. doi request reprint A comprehensive analysis of normal variation and disease-causing mutations in the human DSPP gene
    Dianalee A McKnight
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research NIDCR, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland 20892, USA
    Hum Mutat 29:1392-404. 2008
    ..Analysis of 37 haplotypes of the highly variable DSPP gene from geographically diverse people suggests it may be a useful autosomal marker in human migration studies...
  28. pmc Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling
    Zofia Von Marschall
    Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, Bethesda, MD, USA
    Biochem Biophys Res Commun 400:299-304. 2010
    ..These results support sFRP2's role as an enhancer of Wnt/β-catenin signaling, a result with biological impact for both normal development and diverse pathologies such as tumorigenesis...
  29. ncbi request reprint Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attack
    Alka Jain
    Division of Geriatrics, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Biol Chem 277:13700-8. 2002
    ..The required order of the assembly of the complex suggests that this cofactor activity is limited to short diffusional distances...
  30. pmc Zoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibition
    Michael Chaplet
    Metastasis Research Laboratory, Center of Experimental Cancer Research, University of Liege, 4000 Liege, Belgium
    Biochem J 384:591-8. 2004
    ..Our study demonstrates that ZOL induces BSP expression in osteoblast-like cells through inactivation of Rho GTPases and provides a potential mechanism to explain the favourable effects of ZOL treatment on bone mass and integrity...
  31. ncbi request reprint Expression of dentin sialophosphoprotein in human prostate cancer and its correlation with tumor aggressiveness
    Michael Chaplet
    Metastasis Research Laboratory, Center of Experimental Cancer Research, University of Liege, 4000 Liege, Belgium
    Int J Cancer 118:850-6. 2006
    ..The expression of this SIBLING protein strongly correlates with conventional histopathological prognostic indicators of prostate cancer progression...
  32. ncbi request reprint Up-regulation of SIBLING proteins and correlation with cognate MMP expression in oral cancer
    Kalu U E Ogbureke
    Department of Oral Biology and Maxillofacial Pathology, AD1442, Medical College of Georgia, 1120 Fifteenth Avenue, Augusta, GA 30912, USA
    Oral Oncol 43:920-32. 2007
    ..While the production of these SIBLINGs is independent of T, they correlate with oral location of tumor, cognate MMP expression, and for DSPP, the degree of tumor differentiation...
  33. pmc Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer
    Akeila Bellahcene
    Metastasis Research Laboratory, University of Liege, Tour de Pathologie, 1, Bat B23, Sart Tilman via 4000 Liege, Belgium
    Nat Rev Cancer 8:212-26. 2008
    ....
  34. ncbi request reprint SIBLING expression patterns in duct epithelia reflect the degree of metabolic activity
    Kalu U E Ogbureke
    Department of Oral Biology and Maxillofacial Pathology, AD1442, School of Dentistry, Medical College of Georgia, 1120 Fifteenth Street, Augusta, GA 30912, USA
    J Histochem Cytochem 55:403-9. 2007
    ..This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
  35. pmc Structural requirements for bone sialoprotein binding and modulation of matrix metalloproteinase-2
    Alka Jain
    Johns Hopkins University School of Medicine, USA
    Biochemistry 47:10162-70. 2008
    ....
  36. ncbi request reprint In vitro chromosome aberration tests using human dental pulp cells to detect the carcinogenic potential of chemical agents
    Takeo W Tsutsui
    Department of Pharmacology, The Nippon Dental University School of Life Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Odontology 94:44-50. 2006
    ....
  37. pmc Bone sialoprotein binding to matrix metalloproteinase-2 alters enzyme inhibition kinetics
    Alka Jain
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Biochemistry 47:5986-95. 2008
    ..BSP modulation of MMP-2 activity and inhibition may define its biological role in promoting tumor progression...
  38. ncbi request reprint In vitro effects of dentin matrix protein-1 on hydroxyapatite formation provide insights into in vivo functions
    Philippe H Tartaix
    Columbia University School of Dental and Oral Surgery, New York, New York 10032, USA
    J Biol Chem 279:18115-20. 2004
    ..These data suggest that, in its native form, DMP1 inhibits mineralization, but when cleaved or dephosphorylated, it initiates mineralization. These in vitro data are consistent with the findings in the DMP1 knockout mouse...
  39. pmc Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer
    Jeong Seok Nam
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, MD 20892 5055, USA
    Cancer Res 66:6327-35. 2006
    ....