Research Topics
Genomes and Genes | L W FisherSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Molecular evolution of dentin phosphoprotein among toothed and toothless animalsDianalee A McKnight
Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, Bethesda MD 20892, USA
BMC Evol Biol 9:299. 2009....- DMP1 and DSPP: evidence for duplication and convergent evolution of two SIBLING proteinsLarry W Fisher
Matrix Biochemistry Section, Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, Bethesda, MD, USA
Cells Tissues Organs 194:113-8. 2011..A similar analysis of the origins of the other 4 SIBLINGs will require even more detailed analysis as genome sequences of various fish and amphibia become available... 
Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteinsLarry W Fisher
Matrix Biochemistry Unit, Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, HHS, Bethesda, Maryland 20892 4320, USA
Connect Tissue Res 44:33-40. 2003..Two possible mechanisms for inhibiting the lytic pathway of alternate complement are presented...- Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontinL W Fisher
Craniofacial and Skeletal Diseases Branch, NIH, Bethesda, Maryland, 20892 4320, USA
Biochem Biophys Res Commun 280:460-5. 2001..These proteins often function by bridging two proteins of fixed structures into a biologically active complex... - Comparison of stem-cell-mediated osteogenesis and dentinogenesisS Batouli
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Dent Res 82:976-81. 2003.... - Small integrin binding ligand N-linked glycoprotein gene family expression in different cancersLarry W Fisher
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Clin Cancer Res 10:8501-11. 2004..CONCLUSIONS: These results suggest SIBLINGs as potential markers of early disease progression in a number of different cancer types, some of which currently lack vigorous clinical markers... - The potential functional interaction of biglycan and WISP-1 in controlling differentiation and proliferation of osteogenic cellsColette A Inkson
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS Bethesda, Bethesda, MD 20892 4320, USA
Cells Tissues Organs 189:153-7. 2009..These preliminary data suggest that WISP-1 and BGN may functionally interact and control each other's activity, thus regulating the differentiation and proliferation of osteogenic cells... - Dentin matrix protein 1 enhances invasion potential of colon cancer cells by bridging matrix metalloproteinase-9 to integrins and CD44Abdullah Karadag
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
Cancer Res 65:11545-52. 2005.... - Expression of SIBLINGs and their partner MMPs in salivary glandsK U E Ogbureke
Craniofacial and Skeletal Diseases Branch, Building 30, Room 228, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, 9000 Rockville Pike, Bethesda, MD 20892 4320, USA
J Dent Res 83:664-70. 2004.... - Overlapping DSPP mutations cause dentin dysplasia and dentinogenesis imperfectaD A McKnight
Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, 9000 Rockville Pike, Bldg 30, Bethesda, MD 20892, USA
J Dent Res 87:1108-11. 2008..Furthermore, the consistent kindred presentation of the DD or DGI phenotype appears to be dependent on an as-yet-undescribed genetic modifier closely linked to DSPP... - Dentin sialophosphoprotein (DSPP) is cleaved into its two natural dentin matrix products by three isoforms of bone morphogenetic protein-1 (BMP1)Zofia Von Marschall
Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, Bethesda, MD, USA
Matrix Biol 29:295-303. 2010..In summary, three isoforms of BMP1 process both DSPP and DMP1 at the MQX/DDP motif, but the identity of a protein that can enhance the cleavage of the two SIBLING proteins remains elusive... - Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs)Kalu U E Ogbureke
Matrix Biochemistry Section, Craniofacial and Skeletal Disease Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, Maryland 20982 4320, USA
Kidney Int 68:155-66. 2005..The present study examined the expression patterns of both the SIBLINGs and their MMP partners in adult kidney... - Dentin matrix protein-1 isoforms promote differential cell attachment and migrationZofia Von Marschall
Craniofacial and Skeletal Diseases Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892 4320, USA
J Biol Chem 283:32730-40. 2008..The sequence specificity of the proposed BMP1-cleavage site of DMP1 was verified by mutation analysis. Direct comparison of the three proteins showed that cells discriminate among these SIBLINGs and among DMP1 isoforms... - TM14 is a new member of the fibulin family (fibulin-7) that interacts with extracellular matrix molecules and is active for cell bindingSusana de Vega
Laboratory of Cell and Developmental Biology, NIDCR, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
J Biol Chem 282:30878-88. 2007..Because of its protein characteristics, TM14 can be classified as a new member of the fibulin family: fibulin-7... - Bone sialoprotein, matrix metalloproteinase 2, and alpha(v)beta3 integrin in osteotropic cancer cell invasionAbdullah Karadag
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 4320, USA
J Natl Cancer Inst 96:956-65. 2004..Its role in tumor biology, however, remains unclear. We investigated whether BSP enhances cancer cell invasiveness by forming a trimolecular complex with MMP-2 and cell-surface integrin alpha(v)beta3... - The small leucine-rich proteoglycan biglycan modulates BMP-4-induced osteoblast differentiationXiao Dong Chen
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
FASEB J 18:948-58. 2004..However, the response of bgn-deficient osteoblasts to BMP-4 was completely rescued by reintroduction of biglycan by viral transfection. We propose that biglycan modulates BMP-4-induced signaling to control osteoblast differentiation... - A novel technique based on a PNA hybridization probe and FRET principle for quantification of mutant genotype in fibrous dysplasia/McCune-Albright syndromeAbdullah Karadag
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 4320, USA
Nucleic Acids Res 32:e63. 2004.... - Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA libraryA R DeRubeis
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Gene 255:195-203. 2000.... - Stem cell properties of human dental pulp stem cellsS Gronthos
Craniofacial and Skeletal Diseases Branch, Building 30, Room 228, NIDCR, NIH, Bethesda, MD 20892, USA
J Dent Res 81:531-5. 2002..Taken together, these results demonstrate that DPSCs possess stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation... - Three small integrin binding ligand N-linked glycoproteins (SIBLINGs) bind and activate specific matrix metalloproteinasesNeal S Fedarko
Division of Geriatrics, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
FASEB J 18:734-6. 2004..These data suggest that the SIBLING family offers an alternative method of controlling the activity of at least three MMPs... - Bone sialoprotein enhances migration of bone marrow stromal cells through matrices by bridging MMP-2 to alpha(v)beta3-integrinAbdullah Karadag
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4320, USA
J Bone Miner Res 21:1627-36. 2006..BSP enhances osteogenic cell migration through basement membrane and collagen matrices in vitro by localizing MMP-2 on the cell surface through alpha(v)beta(3)-integrin... - SHED: stem cells from human exfoliated deciduous teethMasako Miura
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:5807-12. 2003..Thus, exfoliated teeth may be an unexpected unique resource for stem-cell therapies including autologous stem-cell transplantation and tissue engineering... - Small integrin-binding proteins as serum markers for prostate cancer detectionAlka Jain
Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Clin Cancer Res 15:5199-207. 2009..Previous studies have separately reported elevated expression of BSP, OPN, or DSPP in prostate tumor paraffin sections. We hypothesized that SIBLINGs may be informative serum markers for subjects with prostate cancer... - Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in miceT Xu
Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 20:78-82. 1998..These mice may serve as an animal model to study the role of ECM proteins in osteoporosis... - TGF-beta1 and WISP-1/CCN-4 can regulate each other's activity to cooperatively control osteoblast functionColette A Inkson
Craniofacial and Skeletal Diseases Branch, National Institutes of Craniofacial and Dental Research, National Institutes of Heath, DHHS, Bethesda, Maryland 20892, USA
J Cell Biochem 104:1865-78. 2008..Our data indicates that full-length WISP-1 and its variant WISP-1va are modulators of proliferation and osteogenic differentiation, and may be novel regulators of TGF-beta1 signaling in osteoblast-like cells... - Decorin is processed by three isoforms of bone morphogenetic protein-1 (BMP1)Zofia Von Marschall
Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, Bethesda, MD, USA
Biochem Biophys Res Commun 391:1374-8. 2010.... 
A comprehensive analysis of normal variation and disease-causing mutations in the human DSPP geneDianalee A McKnight
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research NIDCR, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland 20892, USA
Hum Mutat 29:1392-404. 2008..Analysis of 37 haplotypes of the highly variable DSPP gene from geographically diverse people suggests it may be a useful autosomal marker in human migration studies...- Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signalingZofia Von Marschall
Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, Bethesda, MD, USA
Biochem Biophys Res Commun 400:299-304. 2010..These results support sFRP2's role as an enhancer of Wnt/β-catenin signaling, a result with biological impact for both normal development and diverse pathologies such as tumorigenesis... - Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attackAlka Jain
Division of Geriatrics, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
J Biol Chem 277:13700-8. 2002..The required order of the assembly of the complex suggests that this cofactor activity is limited to short diffusional distances... - Zoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibitionMichael Chaplet
Metastasis Research Laboratory, Center of Experimental Cancer Research, University of Liege, 4000 Liege, Belgium
Biochem J 384:591-8. 2004..Our study demonstrates that ZOL induces BSP expression in osteoblast-like cells through inactivation of Rho GTPases and provides a potential mechanism to explain the favourable effects of ZOL treatment on bone mass and integrity... - Expression of dentin sialophosphoprotein in human prostate cancer and its correlation with tumor aggressivenessMichael Chaplet
Metastasis Research Laboratory, Center of Experimental Cancer Research, University of Liege, 4000 Liege, Belgium
Int J Cancer 118:850-6. 2006..The expression of this SIBLING protein strongly correlates with conventional histopathological prognostic indicators of prostate cancer progression... - Up-regulation of SIBLING proteins and correlation with cognate MMP expression in oral cancerKalu U E Ogbureke
Department of Oral Biology and Maxillofacial Pathology, AD1442, Medical College of Georgia, 1120 Fifteenth Avenue, Augusta, GA 30912, USA
Oral Oncol 43:920-32. 2007..While the production of these SIBLINGs is independent of T, they correlate with oral location of tumor, cognate MMP expression, and for DSPP, the degree of tumor differentiation... - Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancerAkeila Bellahcene
Metastasis Research Laboratory, University of Liege, Tour de Pathologie, 1, Bat B23, Sart Tilman via 4000 Liege, Belgium
Nat Rev Cancer 8:212-26. 2008.... - SIBLING expression patterns in duct epithelia reflect the degree of metabolic activityKalu U E Ogbureke
Department of Oral Biology and Maxillofacial Pathology, AD1442, School of Dentistry, Medical College of Georgia, 1120 Fifteenth Street, Augusta, GA 30912, USA
J Histochem Cytochem 55:403-9. 2007..This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials... - Structural requirements for bone sialoprotein binding and modulation of matrix metalloproteinase-2Alka Jain
Johns Hopkins University School of Medicine, USA
Biochemistry 47:10162-70. 2008.... - In vitro chromosome aberration tests using human dental pulp cells to detect the carcinogenic potential of chemical agentsTakeo W Tsutsui
Department of Pharmacology, The Nippon Dental University School of Life Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan
Odontology 94:44-50. 2006.... - Bone sialoprotein binding to matrix metalloproteinase-2 alters enzyme inhibition kineticsAlka Jain
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Biochemistry 47:5986-95. 2008..BSP modulation of MMP-2 activity and inhibition may define its biological role in promoting tumor progression... - In vitro effects of dentin matrix protein-1 on hydroxyapatite formation provide insights into in vivo functionsPhilippe H Tartaix
Columbia University School of Dental and Oral Surgery, New York, New York 10032, USA
J Biol Chem 279:18115-20. 2004..These data suggest that, in its native form, DMP1 inhibits mineralization, but when cleaved or dephosphorylated, it initiates mineralization. These in vitro data are consistent with the findings in the DMP1 knockout mouse... - Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancerJeong-Seok Nam
Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, MD 20892-5055, USA
Cancer Res 66:6327-35. 2006....