Research Topics
| B FisherSummaryAffiliation: National Surgical Adjuvant Breast and Bowel Project Country: USA Publications
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Detail Information
Publications
Tamoxifen and chemotherapy for axillary node-negative, estrogen receptor-negative breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-23B Fisher
National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212 5234, USA
J Clin Oncol 19:931-42. 2001....- From Halsted to prevention and beyond: advances in the management of breast cancer during the twentieth centuryB Fisher
National Surgical Adjuvant Breast and Bowel Project, 4 Allegheny Center, Pittsburgh, Pennsylvania 15212 5234, USA
Eur J Cancer 35:1963-73. 1999..Perhaps the most important accomplishment of the twentieth century relates to the change in the pro.. - Tamoxifen, radiation therapy, or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or lessBernard Fisher
National Surgical Adjuvant Breast and Bowel Project Biostatistical Center, Division of Pathology, and Breast Committee, Pittsburgh, PA, USA
J Clin Oncol 20:4141-9. 2002.... - Prognosis and treatment of patients with breast tumors of one centimeter or less and negative axillary lymph nodesB Fisher
B Fisher, National Surgical Adjuvant Breast and Bowel Project NSABP, Pittsburgh, PA, USA
J Natl Cancer Inst 93:112-20. 2001.... - Further evaluation of intensified and increased total dose of cyclophosphamide for the treatment of primary breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-25B Fisher
National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212 5234, USA
J Clin Oncol 17:3374-88. 1999..B-25 was initiated to determine whether further intensifying and increasing the cyclophosphamide dose would yield more favorable results... - Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiationBernard Fisher
National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212 5234, USA
N Engl J Med 347:567-75. 2002..We report 25-year findings of a randomized trial initiated in 1971 to determine whether less extensive surgery with or without radiation therapy was as effective as the Halsted radical mastectomy... - Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancerBernard Fisher
National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212 5234, USA
N Engl J Med 347:1233-41. 2002..In 1976, we initiated a randomized trial to determine whether lumpectomy with or without radiation therapy was as effective as total mastectomy for the treatment of invasive breast cancer... - Treatment of lymph-node-negative, oestrogen-receptor-positive breast cancer: long-term findings from National Surgical Adjuvant Breast and Bowel Project randomised clinical trialsBernard Fisher
Operations Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA
Lancet 364:858-68. 2004..We present long-term findings from those trials and relate them to age, menopausal status, and tumour oestrogen-receptor concentrations. We also discuss the extent of progress made in the treatment of such patients... - Five versus more than five years of tamoxifen for lymph node-negative breast cancer: updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trialB Fisher
National Surgical Adjuvant Breast and Bowel Project, and Department of Surgery, University of Pittsburgh, PA 15212 5234, USA
J Natl Cancer Inst 93:684-90. 2001.... - Treatment of axillary lymph node-negative, estrogen receptor-negative breast cancer: updated findings from National Surgical Adjuvant Breast and Bowel Project clinical trialsBernard Fisher
National Surgical Adjuvant Breast and Bowel Project, Operations Center, USA
J Natl Cancer Inst 96:1823-31. 2004..This report presents updated findings from those trials, relates the results to age and menopausal status, and estimates the extent of progress made in treating such patients... - Sequential methotrexate and fluorouracil for the treatment of node-negative breast cancer patients with estrogen receptor-negative tumors: eight-year results from National Surgical Adjuvant Breast and Bowel Project (NSABP) B-13 and first report of findingB Fisher
National Surgical Adjuvant Breast and Bowel Project Scientific Director s Office, Pittsburgh, PA 15261, USA
J Clin Oncol 14:1982-92. 1996.... - Effect of preoperative chemotherapy on local-regional disease in women with operable breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-18B Fisher
Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Shadyside Hospital, PA, USA
J Clin Oncol 15:2483-93. 1997..To determine whether preoperative doxorubicin and cyclophosphamide (AC) permits more lumpectomies to be performed and decreases the incidence of positive nodes in women with primary breast cancer... - Effect of preoperative chemotherapy on the outcome of women with operable breast cancerB Fisher
National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA, USA
J Clin Oncol 16:2672-85. 1998.... - Postoperative adjuvant chemotherapy or BCG for colon cancer: results from NSABP protocol C-01N Wolmark
University of Pittsburgh, PA
J Natl Cancer Inst 80:30-6. 1988.... - Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: results from NSABP protocol R-01B Fisher
University of Pittsburgh, PA
J Natl Cancer Inst 80:21-9. 1988..The observed advantage was restricted to males. Postoperative radiation therapy reduced the incidence of local-regional recurrence, but it failed to affect overall disease-free survival and survival... - Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomised controlled trialB Fisher
National Surgical Adjuvant Breast and Bowel Project, Allegheny University of the Health Sciences, Pittsburgh, PA 15212 5234, USA
Lancet 353:1993-2000. 1999..We did a double-blind randomised controlled trial to find out whether lumpectomy, radiation therapy, and tamoxifen was of more benefit than lumpectomy and radiation therapy alone for DCIS... - erbB-2 and response to doxorubicin in patients with axillary lymph node-positive, hormone receptor-negative breast cancerS Paik
National Surgical Adjuvant Breast and Bowel Project, Department of Human Oncology, Allegheny University of Health Sciences, Pittsburgh, PA 15212 5234, USA
J Natl Cancer Inst 90:1361-70. 1998..Overexpression of the erbB-2 protein by breast cancer cells has been suggested to be a predictor of response to doxorubicin. A retrospective study was designed to test this hypothesis... - Clinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes' B and C carcinoma of the colon: results from National Surgical Adjuvant BreastN Wolmark
National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212, USA
J Clin Oncol 17:3553-9. 1999..To compare the efficacy of leucovorin-modulated fluorouracil (FU+LV) with that of fluorouracil and levamisole (FU+LEV) or with the combination of FU+LV and levamisole (FU+LV+LEV)... - Prevention of invasive breast cancer in women with ductal carcinoma in situ: an update of the National Surgical Adjuvant Breast and Bowel Project experienceB Fisher
National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA
Semin Oncol 28:400-18. 2001..It does suggest, however, that, in the treatment of DCIS, the appropriate use of current and better therapeutic agents that become available could diminish the significance of breast cancer as a public health problem... - Fifteen-year prognostic discriminants for invasive breast carcinoma: National Surgical Adjuvant Breast and Bowel Project Protocol-06E R Fisher
National Surgical Adjuvant Breast and Bowel Project Pathology Center, Pittsburgh, Pennsylvania, USA
Cancer 91:1679-87. 2001.... - Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 StudyB Fisher
National Surgical Adjuvant Breast and Bowel Project, Allegheny University of the Health Sciences, Pittsburgh, PA 15212 5234, USA
J Natl Cancer Inst 90:1371-88. 1998..To test this hypothesis, the National Surgical Adjuvant Breast and Bowel Project initiated the Breast Cancer Prevention Trial (P-1) in 1992... - Randomized trial of postoperative adjuvant chemotherapy with or without radiotherapy for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02N Wolmark
N Wolmark, D L Wickerham, E R Fisher, B Fisher, National Surgical Adjuvant Breast and Bowel Project NSABP Operations Center, Pittsburgh, PA 15212, USA
J Natl Cancer Inst 92:388-96. 2000..This study was carried out to address this issue. An additional aim was to determine whether leucovorin (LV)-modulated 5-fluorouracil (5-FU) is superior to the combination of 5-FU, semustine, and vincristine (MOF) in men... - Long-term tamoxifen citrate use and potential ocular toxicityM B Gorin
Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
Am J Ophthalmol 125:493-501. 1998..To estimate the prevalence of abnormalities in visual function and ocular structures associated with the long-term use of tamoxifen citrate... - S-phase fraction combined with other patient and tumor characteristics for the prognosis of node-negative, estrogen-receptor-positive breast cancerJ Bryant
NSABP, University of Pittsburgh, PA 15213, USA
Breast Cancer Res Treat 51:239-53. 1998..The diversity of risk in the B-14 population was more extreme than is generally recognized. The prognostic capabilities of S-phase, tumor size, and PgR status were sharply attenuated as the time from surgery increased... - Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP-P1) Breast Cancer Prevention TrialM C King
University of Washington, Seattle, WA 98195, USA
JAMA 286:2251-6. 2001..The effect of tamoxifen on breast cancer incidence among women at extremely high risk due to inherited BRCA1 or BRCA2 mutations is unknown... - The dose-volume interaction in adult supratentorial low-grade glioma: higher radiation dose is beneficial among patients with partial resectionC Leighton
Division of Radiation Oncology, London Regional Cancer Centre Program, London Health Sciences Hospital, and Department of Medical Oncology, University of Western Ontario, London, Ontario, Canada
J Neurooncol 82:165-70. 2007..To evaluate the hypothesis that adults with partially resected (PR<50% resection) supratentorial low-grade glioma (LGG) benefit from higher doses of radiation... - A National Cancer Institute of Canada Clinical Trials Group Study--IND.135: Phase I/II study of irinotecan (camptosar), oxaliplatin and raltitrexed (tomudex) (COT) in patients with advanced colorectal cancerJ A Maroun
Medical Oncology, The Ottawa Hospital Regional Cancer Centre, 501 Smyth Road, Ottawa, Ont, Canada K1H 8L6
Eur J Cancer 42:193-9. 2006..3%) experienced partial response. Further evaluation in a randomized study compared to sequential doublets is warranted. Triple combinations could be relevant in curative settings for high-risk patients... - Helical tomotherapy for craniospinal radiationG Bauman
Department of Radiation Oncology, London Regional Cancer Centre, Ontario, Canada
Br J Radiol 78:548-52. 2005..On the basis of this case study, further evaluation of HT for craniospinal radiotherapy seems justified... - Randomized phase II study of two doses of gefitinib in hormone-refractory prostate cancer: a trial of the National Cancer Institute of Canada-Clinical Trials GroupC M Canil
Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, 610 University Ave, Toronto, Ontario M5G 2M9, Canada
J Clin Oncol 23:455-60. 2005..CONCLUSION: Gefitinib did not result in any responses in PSA or objective measurable disease at either dose level. Gefitinib has minimal single-agent activity in HRPC... - Preoperative (neoadjuvant) chemotherapy in patients with breast cancerE P Mamounas
Department of Surgery, Case Western Reserve University and Aultman Cancer Center, Canton, OH 44710, USA
Semin Oncol 28:389-99. 2001..The potential advantages and disadvantages of each approach, as well as surgical considerations and current and future directions in the use of preoperative chemotherapy, are also discussed... - Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trialW Roa
Cross Cancer Institute, 11560 University Ave, Edmonton, Alberta, Canada T6G 1Z2
J Clin Oncol 22:1583-8. 2004..To prospectively compare standard radiation therapy (RT) with an abbreviated course of RT in older patients with glioblastoma multiforme (GBM)... - A phase I study of OSI-211 and cisplatin as intravenous infusions given on days 1, 2 and 3 every 3 weeks in patients with solid cancersM J MacKenzie
Hamilton Regional Cancer Centre, Hamilton, Ontario, Canada
Ann Oncol 15:665-70. 2004..7 mg/m(2) OSI-211 with 25 mg/m(2) cisplatin given as an intravenous infusion on days 1, 2 and 3 of a 21-day cycle. The main toxicity was myelosuppression. Preliminary evidence of antitumor activity was seen... - Intensive blood glucose control and vascular outcomes in patients with type 2 diabetesAnushka Patel
N Engl J Med 358:2560-72. 2008..5% yielded a 10% relative reduction in the combined outcome of major macrovascular and microvascular events, primarily as a consequence of a 21% relative reduction in nephropathy. (ClinicalTrials.gov number, NCT00145925.)..