T Finkel

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Redox-dependent transcriptional regulation
    Hongjun Liu
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Circ Res 97:967-74. 2005
  2. ncbi request reprint Stem cell aging: what bleach can teach
    Jie Liu
    Nat Med 12:383-4. 2006
  3. ncbi request reprint Intracellular redox regulation by the family of small GTPases
    Toren Finkel
    Cardiology Branch, National Heart Lungs and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    Antioxid Redox Signal 8:1857-63. 2006
  4. ncbi request reprint Cell biology: a clean energy programme
    Toren Finkel
    Nature 444:151-2. 2006
  5. pmc Free radicals and senescence
    Teng Lu
    Translational Medicine Branch, NHLBI, NIH, Building 10 CRC 5 3330, Bethesda, MD 20892, USA
    Exp Cell Res 314:1918-22. 2008
  6. pmc Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy
    J Julie Wu
    Translational Medicine Branch, National Heart Lung and Blood Institute, NIH, Bethesda, MD 20892, USA
    Aging (Albany NY) 1:425-37. 2009
  7. pmc Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor
    Takehiro Torisu
    1 Center for Molecular Medicine, National Heart, Lung and Blood Institute NHLBI, National Institutes of Health NIH, Bethesda, Maryland, USA 2
    Nat Med 19:1281-7. 2013
  8. pmc Relief with rapamycin: mTOR inhibition protects against radiation-induced mucositis
    Toren Finkel
    Center for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Stem Cell 11:287-8. 2012
  9. pmc Signal transduction by mitochondrial oxidants
    Toren Finkel
    Center for Molecular Medicine, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:4434-40. 2012
  10. ncbi request reprint Reactive oxygen species and signal transduction
    T Finkel
    Laboratory of Molecular Biology, NHLBI, NIH, Bethesda, MD 20814 1622, USA
    IUBMB Life 52:3-6. 2001

Detail Information

Publications58

  1. ncbi request reprint Redox-dependent transcriptional regulation
    Hongjun Liu
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Circ Res 97:967-74. 2005
    ..This review summarizes the recent progress on how cellular redox status can regulate transcription-factor activity and the implications of this regulation for cardiovascular disease...
  2. ncbi request reprint Stem cell aging: what bleach can teach
    Jie Liu
    Nat Med 12:383-4. 2006
  3. ncbi request reprint Intracellular redox regulation by the family of small GTPases
    Toren Finkel
    Cardiology Branch, National Heart Lungs and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    Antioxid Redox Signal 8:1857-63. 2006
    ....
  4. ncbi request reprint Cell biology: a clean energy programme
    Toren Finkel
    Nature 444:151-2. 2006
  5. pmc Free radicals and senescence
    Teng Lu
    Translational Medicine Branch, NHLBI, NIH, Building 10 CRC 5 3330, Bethesda, MD 20892, USA
    Exp Cell Res 314:1918-22. 2008
    ..Although these data tend to support a role for ROS in mediating senescence, significant questions remain as to whether ROS act in a random or specific fashion and what precise oxidant species acts as the potential senescence trigger...
  6. pmc Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy
    J Julie Wu
    Translational Medicine Branch, National Heart Lung and Blood Institute, NIH, Bethesda, MD 20892, USA
    Aging (Albany NY) 1:425-37. 2009
    ..Taken together, these results demonstrate the potential role of mitochondrial dysfunction and oxidative stress in autophagy related pathology...
  7. pmc Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor
    Takehiro Torisu
    1 Center for Molecular Medicine, National Heart, Lung and Blood Institute NHLBI, National Institutes of Health NIH, Bethesda, Maryland, USA 2
    Nat Med 19:1281-7. 2013
    ..Thus, autophagy regulates endothelial VWF secretion, and transient pharmacological inhibition of autophagic flux may be a useful strategy to prevent thrombotic events. ..
  8. pmc Relief with rapamycin: mTOR inhibition protects against radiation-induced mucositis
    Toren Finkel
    Center for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Stem Cell 11:287-8. 2012
    ..In normal tissues, rapamycin prevents epithelial stem cell senescence by reducing oxidative stress through increased MnSOD...
  9. pmc Signal transduction by mitochondrial oxidants
    Toren Finkel
    Center for Molecular Medicine, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:4434-40. 2012
    ....
  10. ncbi request reprint Reactive oxygen species and signal transduction
    T Finkel
    Laboratory of Molecular Biology, NHLBI, NIH, Bethesda, MD 20814 1622, USA
    IUBMB Life 52:3-6. 2001
    ..This review will focus on the progress in the rapid emerging area of oxidant or redox-dependent signal transduction and speculate how these insights might alter our view and treatment of diseases thought to be caused by oxidative stress...
  11. ncbi request reprint The common biology of cancer and ageing
    Toren Finkel
    Cardiology Branch, NIH, NHLBI, Building 10 CRC 5 3330, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nature 448:767-74. 2007
    ..Here we review the series of key observations that has led to a complex but growing convergence between our understanding of the biology of ageing and the mechanisms that underlie cancer...
  12. ncbi request reprint Oxidant signals and oxidative stress
    Toren Finkel
    Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1622, USA
    Curr Opin Cell Biol 15:247-54. 2003
    ..These new studies have significantly altered our understanding of how reactive oxygen species participate in diverse processes from tumourigenesis to ageing...
  13. ncbi request reprint Radical medicine: treating ageing to cure disease
    Toren Finkel
    Cardiovascular Branch ofthe National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 6:971-6. 2005
    ....
  14. ncbi request reprint Oxidants, oxidative stress and the biology of ageing
    T Finkel
    Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, Maryland 20892 1622, USA
    Nature 408:239-47. 2000
    ..Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span...
  15. pmc Signal transduction by reactive oxygen species
    Toren Finkel
    Center for Molecular Medicine, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 194:7-15. 2011
    ....
  16. ncbi request reprint Redox-dependent signal transduction
    T Finkel
    Laboratory of Molecular Biology, National Heart Lung and Blood Institute, National Institutes of Health, Bldg 10 6N 240, 10 Center Drive, 20892 1622, Bethesda, MD, USA
    FEBS Lett 476:52-4. 2000
    ..This review will focus on the effects of ROS on signal transduction pathways, the molecules that regulate intracellular ROS production and the potential protein targets of oxidants...
  17. doi request reprint Bmi1 regulates mitochondrial function and the DNA damage response pathway
    Jie Liu
    Translational Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 459:387-92. 2009
    ....
  18. ncbi request reprint Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
    Shino Nemoto
    Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Building 10 6N 240, 10 Center Drive, Bethesda, MD 20892 1622, USA
    Science 295:2450-2. 2002
    ..These results demonstrate an important functional relation between three distinct elements linked to aging: forkhead proteins, p66shc, and intracellular oxidants...
  19. ncbi request reprint Endothelial progenitor cells and endothelial dysfunction
    J M Hill
    The Laboratory of Molecular Biology Cardiology Branch of the National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Vox Sang 87:31-7. 2004
  20. ncbi request reprint Reactive oxygen species as mediators of cellular senescence
    Renata Colavitti
    Cardiovascular Branch, NHLBI, NIH, Bethesda, Maryland 20892 1454, USA
    IUBMB Life 57:277-81. 2005
    ..In particular, we review the concept that intracellular reactive oxygen species function as signalling molecules and that oxidants play a central role as mediators of cellular senescence...
  21. ncbi request reprint Endothelial progenitor cells
    Aarif Y Khakoo
    National Institutes of Health, National Heart, Lung, and Blood Institute, Cardiovascular Branch, Laboratory of Molecular Biology, Bethesda, Maryland 21284, USA
    Annu Rev Med 56:79-101. 2005
    ..We review experimental results obtained from both animal studies and recent clinical trials that suggest this cell type may have tremendous therapeutic potential for a wide range of human diseases...
  22. pmc The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine
    Leslie G Biesecker
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 19:1665-74. 2009
    ..The early experiences with ClinSeq illustrate how large-scale medical sequencing can be a practical, productive, and critical component of research in genomic medicine...
  23. pmc A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency
    Liu Cao
    Translational Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 35:534-41. 2009
    ..These observations may have important implications for Brca1-mediated tumor formation as well as for the molecular pathway leading from genomic instability to organismal aging...
  24. pmc 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
    Samuel F Bunting
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 141:243-54. 2010
    ..Our results illustrate that HR and NHEJ compete to process DNA breaks that arise during DNA replication and that shifting the balance between these pathways can be exploited to selectively protect or kill cells harboring Brca1 mutations...
  25. pmc Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report
    Serpil Erzurum
    Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Respir Crit Care Med 182:1554-62. 2010
    ..Recommendations from this workshop will be used within the Lung Vascular Biology and Disease Extramural Research Program for planning and strategic implementation purposes...
  26. ncbi request reprint A role for mitochondria as potential regulators of cellular life span
    Dong Xu
    Cardiovascular Branch, NHLBI, NIH, Building 10 6N 240, 10 Center Drive, Bethesda, MD 20892 1622, USA
    Biochem Biophys Res Commun 294:245-8. 2002
    ..These results suggest that mitochondria appear to play a central role in regulating cellular life span...
  27. ncbi request reprint Signal transduction by reactive oxygen species in non-phagocytic cells
    T Finkel
    National Institutes of Health, Bethesda, Maryland 20892 1650, USA
    J Leukoc Biol 65:337-40. 1999
    ..Nonetheless, numerous recent studies have implicated a dynamic change in the intracellular redox state as an important determinant in a host of cellular decisions ranging from growth, to apoptosis, to cellular senescence...
  28. ncbi request reprint Apoptosis in vascular disease: opportunities for genetic therapeutic intervention
    T M Johnson
    Cardiology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA gov
    Semin Interv Cardiol 1:195-202. 1996
    ..These observations suggest that the transfer of apoptosis-inducing genes into vascular lesions may be a feasible, non-inflammatory strategy to eliminate the cellular components of restenotic and atherosclerotic plaques...
  29. ncbi request reprint Mitochondria, oxidants, and aging
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 120:483-95. 2005
    ..Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging...
  30. ncbi request reprint Redox regulation of Cdc25C
    Pavel A Savitsky
    Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1622, USA
    J Biol Chem 277:20535-40. 2002
    ..These results suggest that oxidative stress may induce cell cycle arrest in part through the degradation of Cdc25C...
  31. ncbi request reprint Circulating endothelial progenitor cells, vascular function, and cardiovascular risk
    Jonathan M Hill
    Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1622, USA
    N Engl J Med 348:593-600. 2003
    ....
  32. pmc Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis
    Rui Hong Wang
    Genetics of Development and Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Mol Cell 32:11-20. 2008
    ..These findings suggest that resveratrol treatment serves as an excellent strategy for targeted therapy for BRCA1-associated breast cancer...
  33. ncbi request reprint Augmented Wnt signaling in a mammalian model of accelerated aging
    Hongjun Liu
    Cardiology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA
    Science 317:803-6. 2007
    ..Both in vitro and in vivo, continuous Wnt exposure triggered accelerated cellular senescence. Thus, klotho appears to be a secreted Wnt antagonist and Wnt proteins have an unexpected role in mammalian aging...
  34. ncbi request reprint TOR and aging: less is more
    Stefan M Schieke
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 5:233-5. 2007
    ..A new study in this issue of Cell Metabolism (Bonawitz et al., 2007) suggests that the TOR pathway controls mitochondrial respiration in yeast and that the harder mitochondria work, the longer yeast live...
  35. ncbi request reprint The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism
    Shino Nemoto
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg 10 6N 240, 10 Center Drive, Bethesda, MD 20892 1622, USA
    J Biol Chem 281:10555-60. 2006
    ..These results demonstrate that p66(shc) regulates mitochondrial oxidative capacity and suggest that p66(shc) may extend life span by repartitioning metabolic energy conversion away from oxidative and toward glycolytic pathways...
  36. ncbi request reprint Regulation of endothelial cell adherens junctions by a Ras-dependent signal transduction pathway
    D D Hegland
    Cardiology Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland, 20892, USA
    Biochem Biophys Res Commun 260:371-6. 1999
    ....
  37. ncbi request reprint Ras regulates NFAT3 activity in cardiac myocytes
    M Ichida
    Laboratory of Molecular Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:3524-30. 2001
    ..Taken together, these results imply that, in cardiac myocytes, a Ras-regulated pathway involving stimulation of mitogen-activated protein kinase regulates NFAT3 activity...
  38. pmc A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
    In Hye Lee
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 105:3374-9. 2008
    ..These results suggest that the Sirt1 deacetylase is an important in vivo regulator of autophagy and provide a link between sirtuin function and the overall cellular response to limited nutrients...
  39. ncbi request reprint Detection and affinity purification of oxidant-sensitive proteins using biotinylated glutathione ethyl ester
    Daniel M Sullivan
    Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Methods Enzymol 353:101-13. 2002
  40. pmc A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
    Bong Hyun Ahn
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:14447-52. 2008
    ..These results implicate protein acetylation as an important regulator of Complex I activity and demonstrate that Sirt3 functions in vivo to regulate and maintain basal ATP levels...
  41. ncbi request reprint Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
    Shino Nemoto
    Cardiovascular Branch, National Heart, Lung, and Blood Institute NHLBI, Bethesda, MD 20892, USA
    Science 306:2105-8. 2004
    ..SIRT1 expression was not induced in starved p53-deficient mice. Thus, in mammalian cells, p53, Foxo3a, and SIRT1, three proteins separately implicated in aging, constitute a nutrient-sensing pathway...
  42. ncbi request reprint Regulation of cellular oncosis by uncoupling protein 2
    Edward M Mills
    Cardiovascular Branch, NHLBI National Institutes of Health, 10 Center Drive, Bldg 10 6N 240, Bethesda, MD 20892, USA
    J Biol Chem 277:27385-92. 2002
    ..These results suggest that distinct genetic programs may regulate the cellular response to either apoptotic or oncotic stimuli...
  43. ncbi request reprint Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2
    Toshio Ohtsubo
    Cardiovascular Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892 1622, USA
    Circ Res 95:1118-24. 2004
    ..In addition, these results suggest a novel molecular link between cellular injury and the inflammatory response...
  44. ncbi request reprint Oxidants painting the cysteine chapel: redox regulation of PTPs
    Dong Xu
    Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 2:251-2. 2002
    ..A new study now demonstrates that ligand-stimulated intracellular hydrogen peroxide can specifically and reversibly regulate the activity of protein tyrosine phosphatases...
  45. ncbi request reprint Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor gamma Coactivator-1 alpha (PGC-1alpha)
    Masaru Ichida
    Laboratory of Molecular Biology, Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 277:50991-5. 2002
    ..In addition, our results suggest that other co-activators might also have specific repressors, thereby identifying another layer of combinatorial complexity in transcriptional regulation...
  46. ncbi request reprint Vascular effects following homozygous disruption of p47(phox) : An essential component of NADPH oxidase
    E Hsich
    Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute, and the Laboratory of Host Defenses, National Institute of Health, Bethesda, MD 20892, USA
    Circulation 101:1234-6. 2000
    ..We tested the contribution of this specific oxidase to the progression of atherosclerosis and the regulation of blood pressure...
  47. pmc Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity
    Wanli W Smith
    Molecular Neurobiology Unit, Laboratory of Cellular and Molecular Biology, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Cell Biol 169:331-9. 2005
    ..These findings underscore the potential usefulness of JNK, p66Shc, and forkhead proteins as therapeutic targets for AD...
  48. ncbi request reprint Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease
    Tiffany M Powell
    Cardiovascular Branch, National Heart, Lung, and Blood Institute and the Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1650, USA
    Arterioscler Thromb Vasc Biol 25:296-301. 2005
    ..We reasoned that EPC number and function may be increased by granulocyte colony-stimulating factor (G-CSF) used to mobilize hematopoietic progenitor cells in healthy donors...
  49. pmc Recent progress in the biology and physiology of sirtuins
    Toren Finkel
    Translational Medicine Branch, National Heart Lung and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 460:587-91. 2009
    ..Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live...
  50. ncbi request reprint SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}
    Shino Nemoto
    Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    J Biol Chem 280:16456-60. 2005
    ..These results provide a direct link between the sirtuins, a family of proteins linked to lifespan determination and PGC-1alpha, a coactivator that regulates cellular metabolism...
  51. ncbi request reprint Neutrophils with a license to kill: permeabilized, not stirred
    Toren Finkel
    Cardiovascular Branch, NHLBI, NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Dev Cell 4:146-8. 2003
    ..Relatively little is known about the intracellular assembly or activation of the oxidase, but Brown et al. in the January issue of Molecular Cell provide a useful strategy involving permeabilized neutrophils to tackle this question...
  52. ncbi request reprint Pharmacology: uncoupling the agony from ecstasy
    Edward M Mills
    Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1622, USA
    Nature 426:403-4. 2003
    ..Our findings indicate that UCP-3 is important in MDMA-induced hyperthermia and point to a new therapeutic direction for solving an increasing public-health problem...
  53. pmc Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
    Aarif Y Khakoo
    Laboratory of Molecular Biology, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:1235-47. 2006
    ....
  54. ncbi request reprint Mitochondrial signaling, TOR, and life span
    Stefan M Schieke
    Cardiology Branch, National Heart, Lung, and Blood Institute, NHLBI, National Institutes of Health, Bethesda, MD 20892 1622, USA
    Biol Chem 387:1357-61. 2006
    ..This brief review summarizes the recent progress on how mitochondrial signaling might contribute to the aging process with a particular emphasis on TOR signaling from invertebrates to humans...
  55. ncbi request reprint Ageing and the mystery at Arles
    Shino Nemoto
    Nature 429:149-52. 2004
  56. ncbi request reprint Cancer gets the Chk'ered flag
    Liu Cao
    Nat Med 12:1354-6. 2006
  57. ncbi request reprint Effect of a histone deacetylase inhibitor on human cardiac mass
    Yukitaka Shizukuda
    Cardiovasc Drugs Ther 19:89-90. 2005