Research Topics
Genomes and Genes
Species | Jonine D FigueroaSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristicsJonine D Figueroa
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Breast Cancer Res Treat 121:727-35. 2010..These results warrant analysis in studies of clinical outcomes accounting for age, ER status and treatment...
Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control studyRoger L Milne
Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
Breast Cancer Res 12:R110. 2010....- Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association ConsortiumJonine D Figueroa
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Hum Mol Genet 20:4693-706. 2011..Our results underscore the need for large pooling efforts with tumor pathology data to help refine risk estimates for SNP associations with susceptibility to different subtypes of breast cancer... 
Genetic variation in the base excision repair pathway and bladder cancer riskJonine D Figueroa
Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA
Hum Genet 121:233-42. 2007..24 (1.02-1.51) and 1.30 (1.04-1.62), respectively. In summary, data from this large case-control study suggested bladder cancer risk associations with selected BER SNPs, which need to be confirmed in other study populations...- Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpressionJonine D Figueroa
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Cancer Causes Control 20:361-8. 2009..Further research on these tumors is needed to identify molecular markers associated with variations in the risk factor profiles... - Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genesJonine D Figueroa
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
Carcinogenesis 29:1955-62. 2008..These results indicate that genetic variation in carcinogen-metabolizing genes, particularly AKR1C3, could be associated with bladder cancer risk... - Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumorsJonine D Figueroa
Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA
Cancer Causes Control 19:917-29. 2008..02. Caution in interpretation is warranted until findings are replicated in other studies; however, the results suggest that genetic variation in CYP1A1 may be associated with nonseminoma... - Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer riskJonine D Figueroa
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
Carcinogenesis 28:1788-93. 2007..17 (1.00-1.36). Results from this study provide evidence for associations between variants in genes in the DSBR pathway and bladder cancers risk that warrant replication in other study populations... - TNF polymorphisms and prostate cancer riskKim N Danforth
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20852, USA
Prostate 68:400-7. 2008..Inflammation has been hypothesized to increase prostate cancer risk. Tumor necrosis factor (TNF) is an important mediator of the inflammatory process, but the relationship between TNF variants and prostate cancer remains unclear... - Likelihood ratio test for detecting gene (G)-environment (E) interactions under an additive risk model exploiting G-E independence for case-control dataSummer S Han
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
Am J Epidemiol 176:1060-7. 2012..5-fold. The authors illustrate their method by applying it to data from a bladder cancer study... - Common genetic variants in the PSCA gene influence gene expression and bladder cancer riskYi Ping Fu
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 109:4974-9. 2012.... - Analysis of terminal duct lobular unit involution in luminal A and basal breast cancersXiaohong R Yang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Breast Cancer Res 14:R64. 2012..Accordingly, we performed a masked microscopic assessment of TDLU involution in benign tissues associated with luminal A and CBP breast cancers diagnosed among women less than age 55 years... - Estrogen receptor and progesterone receptor expression in normal terminal duct lobular units surrounding invasive breast cancerXiaohong R Yang
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Blvd, Bethesda, MD USA
Breast Cancer Res Treat 137:837-47. 2013..Analyses of mapped TDLUs may provide information about the sequence of molecular changes occurring in breast carcinogenesis... - Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancerWei Tang
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Hum Mol Genet 21:1918-30. 2012..1 protein. Our study shows an example of genetic and functional role of an uncommon protective genetic variant in a complex human disease, such as bladder cancer... - Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European backgroundIdan Menashe
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 7:e29396. 2012..Identification of the aromatic amine metabolism pathway provides support for the ability of this approach to identify pathways with established relevance to bladder carcinogenesis... - Sex steroid hormone levels in breast adipose tissue and serum in postmenopausal womenRoni T Falk
Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA
Breast Cancer Res Treat 131:287-94. 2012..Measurement of sex hormones in serum and in the microenvironment may help in understanding the hormonal etiology of breast cancer, suggest methods for prevention, and have value in gauging treatment response and prognosis... - Fine mapping of 14q24.1 breast cancer susceptibility locusPhoebe Lee
Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Hum Genet 131:479-90. 2012..Therefore, we conclude that rs999737 is an optimal tag SNP for common variants in the 14q24.1 region and thus narrow the candidate variants that should be investigated in follow-up laboratory evaluation... - A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European backgroundMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
Pharmacogenet Genomics 21:231-6. 2011..Further studies are required to determine the functional implications of rs1495741 and the structure and evolution of the haplotype on which it resides... - A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility lociNathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Nat Genet 42:978-84. 2010..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis... - Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in PolandSarah J Nyante
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
Breast Cancer Res 13:R42. 2011..Thus, we examined the relationship between single nucleotide polymorphisms (SNPs) in PRL and PRLR, serum prolactin levels and breast cancer risk in a population-based case-control study... - A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3Montserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Hum Mol Genet 20:4282-9. 2011..Our findings suggest that genetic variation in SLC14A1 could provide new etiological insights into bladder carcinogenesis... - Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in SpainKenneth P Cantor
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
Environ Health Perspect 118:1545-50. 2010..Bladder cancer has been linked with long-term exposure to disinfection by-products (DBPs) in drinking water... - Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genesHannah P Yang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
Carcinogenesis 31:827-33. 2010..Associations with variants in other genes have been suggested, but findings have been inconsistent... - Assessment of automated image analysis of breast cancer tissue microarrays for epidemiologic studiesKelly L Bolton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 19:992-9. 2010..We assessed agreement between automated and pathologist scores of a diverse set of immunohistochemical assays done on breast cancer tissue microarrays (TMA)... - Detectable clonal mosaicism and its relationship to aging and cancerKevin B Jacobs
Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
Nat Genet 44:651-8. 2012..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases... - Pathway analysis of breast cancer genome-wide association study highlights three pathways and one canonical signaling cascadeIdan Menashe
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD20852 7244, USA
Cancer Res 70:4453-9. 2010..0051, FDR = 0.07). These results suggest that genetic alterations associated with these three pathways and one canonical signaling cascade may contribute to breast cancer susceptibility... - Nonsteroidal anti-inflammatory drugs and other analgesic use and bladder cancer in northern New EnglandDalsu Baris
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, North Bethesda, MD 20852, USA
Int J Cancer 132:162-73. 2013..We observed a previously unrecognized risk associated with use of COX-2 inhibitors, which merits further evaluation... - The Susan G. Komen for the Cure Tissue Bank at the IU Simon Cancer Center: a unique resource for defining the "molecular histology" of the breastMark E Sherman
Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Rockville, Maryland, USA
Cancer Prev Res (Phila) 5:528-35. 2012..As research projects are completed, results will be posted on the Bank's website... - Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studiesKim N Danforth
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
Carcinogenesis 29:568-72. 2008.... - Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survivalMaria Teresa Landi
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland, USA
PLoS ONE 3:e1651. 2008..Tobacco smoking is responsible for over 90% of lung cancer cases, and yet the precise molecular alterations induced by smoking in lung that develop into cancer and impact survival have remained obscure...