Jonine D Figueroa

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res Treat 121:727-35. 2010
  2. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
  3. ncbi request reprint Genetic variation in the base excision repair pathway and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA
    Hum Genet 121:233-42. 2007
  4. pmc Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Hum Mol Genet 20:4693-706. 2011
  5. pmc Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 20:361-8. 2009
  6. pmc Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 29:1955-62. 2008
  7. doi request reprint Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumors
    Jonine D Figueroa
    Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 19:917-29. 2008
  8. ncbi request reprint Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 28:1788-93. 2007
  9. doi request reprint TNF polymorphisms and prostate cancer risk
    Kim N Danforth
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20852, USA
    Prostate 68:400-7. 2008
  10. pmc Likelihood ratio test for detecting gene (G)-environment (E) interactions under an additive risk model exploiting G-E independence for case-control data
    Summer S Han
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
    Am J Epidemiol 176:1060-7. 2012

Detail Information

Publications37

  1. ncbi request reprint Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res Treat 121:727-35. 2010
    ..These results warrant analysis in studies of clinical outcomes accounting for age, ER status and treatment...
  2. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
    ....
  3. ncbi request reprint Genetic variation in the base excision repair pathway and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA
    Hum Genet 121:233-42. 2007
    ..24 (1.02-1.51) and 1.30 (1.04-1.62), respectively. In summary, data from this large case-control study suggested bladder cancer risk associations with selected BER SNPs, which need to be confirmed in other study populations...
  4. pmc Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Hum Mol Genet 20:4693-706. 2011
    ..Our results underscore the need for large pooling efforts with tumor pathology data to help refine risk estimates for SNP associations with susceptibility to different subtypes of breast cancer...
  5. pmc Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 20:361-8. 2009
    ..Further research on these tumors is needed to identify molecular markers associated with variations in the risk factor profiles...
  6. pmc Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 29:1955-62. 2008
    ..These results indicate that genetic variation in carcinogen-metabolizing genes, particularly AKR1C3, could be associated with bladder cancer risk...
  7. doi request reprint Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumors
    Jonine D Figueroa
    Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 19:917-29. 2008
    ..02. Caution in interpretation is warranted until findings are replicated in other studies; however, the results suggest that genetic variation in CYP1A1 may be associated with nonseminoma...
  8. ncbi request reprint Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 28:1788-93. 2007
    ..17 (1.00-1.36). Results from this study provide evidence for associations between variants in genes in the DSBR pathway and bladder cancers risk that warrant replication in other study populations...
  9. doi request reprint TNF polymorphisms and prostate cancer risk
    Kim N Danforth
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20852, USA
    Prostate 68:400-7. 2008
    ..Inflammation has been hypothesized to increase prostate cancer risk. Tumor necrosis factor (TNF) is an important mediator of the inflammatory process, but the relationship between TNF variants and prostate cancer remains unclear...
  10. pmc Likelihood ratio test for detecting gene (G)-environment (E) interactions under an additive risk model exploiting G-E independence for case-control data
    Summer S Han
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
    Am J Epidemiol 176:1060-7. 2012
    ..5-fold. The authors illustrate their method by applying it to data from a bladder cancer study...
  11. doi request reprint Estrogen receptor and progesterone receptor expression in normal terminal duct lobular units surrounding invasive breast cancer
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Blvd, Bethesda, MD USA
    Breast Cancer Res Treat 137:837-47. 2013
    ..Analyses of mapped TDLUs may provide information about the sequence of molecular changes occurring in breast carcinogenesis...
  12. pmc Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk
    Yi Ping Fu
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:4974-9. 2012
    ....
  13. pmc Analysis of terminal duct lobular unit involution in luminal A and basal breast cancers
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res 14:R64. 2012
    ..Accordingly, we performed a masked microscopic assessment of TDLU involution in benign tissues associated with luminal A and CBP breast cancers diagnosed among women less than age 55 years...
  14. pmc Common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Res 73:2211-20. 2013
    ..Our findings could have implications for targeted prevention strategies. However, other smoking-related diseases, as well as practical and ethical considerations, need to be considered before any recommendations could be made...
  15. pmc Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer
    Wei Tang
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Hum Mol Genet 21:1918-30. 2012
    ..1 protein. Our study shows an example of genetic and functional role of an uncommon protective genetic variant in a complex human disease, such as bladder cancer...
  16. pmc Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European background
    Idan Menashe
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e29396. 2012
    ..Identification of the aromatic amine metabolism pathway provides support for the ability of this approach to identify pathways with established relevance to bladder carcinogenesis...
  17. ncbi request reprint Genome-wide interaction study of smoking and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA, Institute for Cancer Research, London, UK, Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA, Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain, Municipal Institute of Medical Research, Barcelona, Spain, CIBER Epidemiologia y Salud Pública CIBERESP, Barcelona, Spain, National School of Public Health, Athens, Greece, Maine Cancer Registry, Augusta, ME, USA, Spanish National Cancer Research Centre CNIO, Madrid, Spain, Vermont Cancer Registry, Burlington, VT, USA, Center for Genomics Research, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD, USA, Information Management Services, Inc, Rockville, MD, USA, Imperial College London, London, UK, Department of Preventive Medicine and Department of Obstetrics and Gynecology, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA
    Carcinogenesis 35:1737-44. 2014
    ..Our findings provide additional evidence of gene-environment interactions for tobacco and bladder cancer. ..
  18. pmc Prolactin receptor expression and breast cancer: relationships with tumor characteristics among pre- and post-menopausal women in a population-based case-control study from Poland
    Jessica M Faupel-Badger
    Cancer Prevention Fellowship Program, National Cancer Institute, 9609 Medical Center Drive, 2W 172, Bethesda, MD, 20892, USA
    Horm Cancer 5:42-50. 2014
    ..These data provide new avenues from which to explore the associations of the prolactin/prolactin receptor signaling network with breast tumorigenesis. ..
  19. doi request reprint Sex steroid hormone levels in breast adipose tissue and serum in postmenopausal women
    Roni T Falk
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA
    Breast Cancer Res Treat 131:287-94. 2012
    ..Measurement of sex hormones in serum and in the microenvironment may help in understanding the hormonal etiology of breast cancer, suggest methods for prevention, and have value in gauging treatment response and prognosis...
  20. doi request reprint Fine mapping of 14q24.1 breast cancer susceptibility locus
    Phoebe Lee
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Genet 131:479-90. 2012
    ..Therefore, we conclude that rs999737 is an optimal tag SNP for common variants in the 14q24.1 region and thus narrow the candidate variants that should be investigated in follow-up laboratory evaluation...
  21. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis...
  22. pmc A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Pharmacogenet Genomics 21:231-6. 2011
    ..Further studies are required to determine the functional implications of rs1495741 and the structure and evolution of the haplotype on which it resides...
  23. pmc Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain
    Kenneth P Cantor
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
    Environ Health Perspect 118:1545-50. 2010
    ..Bladder cancer has been linked with long-term exposure to disinfection by-products (DBPs) in drinking water...
  24. doi request reprint Breast cancer susceptibility risk associations and heterogeneity by E-cadherin tumor tissue expression
    HISANI N HORNE
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Breast Cancer Res Treat 143:181-7. 2014
    ....
  25. pmc Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland
    Sarah J Nyante
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Breast Cancer Res 13:R42. 2011
    ..Thus, we examined the relationship between single nucleotide polymorphisms (SNPs) in PRL and PRLR, serum prolactin levels and breast cancer risk in a population-based case-control study...
  26. pmc A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hum Mol Genet 20:4282-9. 2011
    ..Our findings suggest that genetic variation in SLC14A1 could provide new etiological insights into bladder carcinogenesis...
  27. pmc Assessment of automated image analysis of breast cancer tissue microarrays for epidemiologic studies
    Kelly L Bolton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 19:992-9. 2010
    ..We assessed agreement between automated and pathologist scores of a diverse set of immunohistochemical assays done on breast cancer tissue microarrays (TMA)...
  28. pmc Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes
    Hannah P Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Carcinogenesis 31:827-33. 2010
    ..Associations with variants in other genes have been suggested, but findings have been inconsistent...
  29. pmc Genome-wide association study identifies multiple loci associated with bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hum Mol Genet 23:1387-98. 2014
    ....
  30. pmc Detectable clonal mosaicism and its relationship to aging and cancer
    Kevin B Jacobs
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
    Nat Genet 44:651-8. 2012
    ..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...
  31. pmc Pathway analysis of breast cancer genome-wide association study highlights three pathways and one canonical signaling cascade
    Idan Menashe
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD20852 7244, USA
    Cancer Res 70:4453-9. 2010
    ..0051, FDR = 0.07). These results suggest that genetic alterations associated with these three pathways and one canonical signaling cascade may contribute to breast cancer susceptibility...
  32. pmc Nonsteroidal anti-inflammatory drugs and other analgesic use and bladder cancer in northern New England
    Dalsu Baris
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, North Bethesda, MD 20852, USA
    Int J Cancer 132:162-73. 2013
    ..We observed a previously unrecognized risk associated with use of COX-2 inhibitors, which merits further evaluation...
  33. ncbi request reprint The Susan G. Komen for the Cure Tissue Bank at the IU Simon Cancer Center: a unique resource for defining the "molecular histology" of the breast
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Rockville, Maryland, USA
    Cancer Prev Res (Phila) 5:528-35. 2012
    ..As research projects are completed, results will be posted on the Bank's website...
  34. ncbi request reprint Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies
    Kim N Danforth
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Carcinogenesis 29:568-72. 2008
    ....
  35. pmc Breast cancer in Sub-Saharan Africa: opportunities for prevention
    Louise A Brinton
    National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rm 7E 102, MSC 9774, Bethesda, MD, 20892 9774, USA
    Breast Cancer Res Treat 144:467-78. 2014
    ..It will also be essential to understand reasons why women delay seeking care after the onset of symptoms and for there to be educational campaigns about the importance of early detection. ..
  36. pmc Relationship of mammographic density and gene expression: analysis of normal breast tissue surrounding breast cancer
    Xuezheng Sun
    Authors Affiliations Department of Epidemiology Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland Department of Biology, Trinity University, San Antonio, Texas Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    Clin Cancer Res 19:4972-82. 2013
    ..To evaluate how mammographic density and breast tissue composition relate to extratumoral microenvironment gene expression, we used data on 121 patients with breast cancer from the population-based Polish Women's Breast Cancer Study...
  37. pmc Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival
    Maria Teresa Landi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland, USA
    PLoS ONE 3:e1651. 2008
    ..Tobacco smoking is responsible for over 90% of lung cancer cases, and yet the precise molecular alterations induced by smoking in lung that develop into cancer and impact survival have remained obscure...